9 research outputs found
Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC
- Author
- Abi B
- Abud A Abed
- Acciarri R
- Acero MA
- Adames MR
- Adamov G
- Adamowski M
- Adams D
- Adinolfi M
- Aduszkiewicz A
- Aguilar J
- Ahmad Z
- Ahmed J
- Aimard B
- Ali-Mohammadzadeh B
- Alion T
- Allison K
- Alonso MJ Rodriguez
- AlRashed M
- Alt C
- Alton A
- Alvarez R
- Alzas P Barham
- Amedo P
- Anderson J
- Andreopoulos C
- Andreotti M
- Andrews M
- Andrianala F
- Andringa S
- Anfimov N
- Ankowski A
- Antoniassi M
- Antonova M
- Antoshkin A
- Antusch S
- Aranda-Fernandez A
- Arellano L
- Arnold LO
- Arroyave MA
- Asaadi J
- Asquith L
- Aurisano A
- Aushev V
- Autiero D
- Ayala Lara V
- Ayala-Torres M
- Azfar F
- Back A
- Back H
- Back JJ
- Backhouse C
- Bagaturia I
- Bagby L
- Balashov N
- Balasubramanian S
- Baldi P
- Baller B
- Bambah B
- Barao F
- Barenboim G
- Barker G
- Barkhouse W
- Barnes C
- Barr G
- Barranco Monarca J
- Barros A
- Barros N
- Barrow JL
- Basharina-Freshville A
- Bashyal A
- Basque V
- Batchelor C
- Battat JBR
- Battisti F
- Bay F
- Bazetto MCQ
- Bazo Alba JLL
- Beacom JF
- Bechetoille E
- Behera B
- Beigbeder C
- Bellantoni L
- Bellettini G
- Bellini V
- Beltramello O
- Benekos N
- Berger J
- Berkman S
- Bernardini P
- Berner RM
- Bersani A
- Bertolucci S
- Betancourt M
- Betancur Rodriguez A
- Bevan A
- Bezawada Y
- Bezerra TJC
- Bhardwaj A
- Bhatnagar V
- Bhattacharjee M
- Bhattarai D
- Bhuller S
- Bhuyan B
- Biagi S
- Bian J
- Biassoni M
- Biery K
- Bilki B
- Bishai M
- Bitadze A
- Blake A
- Blaszczyk F
- Blazey GC
- Blucher E
- Boissevain J
- Bolognesi S
- Bolton T
- Bomben L
- Bonesini M
- Bongrand M
- Bonilla-Diaz C
- Bonini F
- Booth A
- Boran F
- Bordoni S
- Borkum A
- Bostan N
- Bour P
- Bourgeois C
- Boyden D
- Bracinik J
- Braga D
- Brailsford D
- Branca A
- Brandt A
- Bremer J
- Breton D
- Brew C
- Brice SJ
- Brizzolari C
- Bromberg C
- Brooke J
- Bross A
- Brunetti G
- Brunetti M
- Buchanan N
- Budd H
- Butorov I
- Cagnoli I
- Cai T
- Caicedo DA Martinez
- Caiulo D
- Calabrese R
- Calafiura P
- Calcutt J
- Calin M
- Calvez S
- Calvo E
- Caminata A
- Campanelli M
- Caratelli D
- Carber D
- Carceller JC
- Carini G
- Carlus B
- Carneiro MF
- Carniti P
- Carranza H
- Carroll T
- Castano Forero JF
- Castillo A
- Castromonte C
- Catano-Mur E
- Cattadori C
- Cavalier F
- Cavallaro G
- Cavanna F
- Centro S
- Cerati G
- Cervelli A
- Cervera Villanueva A
- Chalifour M
- Chappell A
- Chardonnet E
- Charitonidis N
- Chatterjee A
- Chattopadhyay S
- Chavarry Neyra MSS
- Chen H
- Chen M
- Chen Y
- Chen Z
- Chen-Wishart Z
- Cheon Y
- Cherdack D
- Chi C
- Childress S
- Chirco R
- Chiriacescu A
- Chisnall G
- Cho K
- Choate S
- Chokheli D
- Chong PS
- Christensen A
- Christian D
- Christodoulou G
- Chukanov A
- Chung M
- Church E
- Cicero V
- Clarke P
- Cline G
- Coan TE
- Cocco AG
- Coelho JAB
- Colton N
- Conley E
- Conley R
- Conrad J
- Convery M
- Copello S
- Cova P
- Cremaldi L
- Cremonesi L
- Crespo-Anadon J
- Crisler M
- Cristaldo E
- Crnkovic J
- Cross R
- Cudd A
- Cuesta C
- Cui Y
- Cussans D
- Dalager O
- DaMotta H
- das Chagas E Batista
- David C
- David Q
- Davies GS
- Davini S
- Dawson J
- De Bonis I
- De Gouvea A
- De Holanda PC
- De Icaza Astiz IL
- De Jong P
- De Lurgio P
- De Mello Neto JRT
- De Roeck A
- De Romeri V
- De Souza G
- de Souza H Vieira
- De K
- De S
- Debbins P
- Decowski MP
- Deisting A
- Delbart A
- Delepine D
- Delgado M
- Delgado MA Ramirez
- Dell'Acqua A
- Delmonte N
- DeMuth DM
- Dennis S
- Densham C
- Deptuch GW
- Devi R
- Dharmapalan R
- Di Domizio S
- Di Giulio L
- Di Noto L
- Dias M
- Diaz F
- Diaz JS
- Ding P
- Dirkx G
- Distefano C
- Diurba R
- Diwan M
- Djurcic Z
- Doering D
- Dolan S
- Dolinski M
- Domine L
- Donon Y
- Douglas D
- Douillet D
- Dragone A
- Drake G
- Drielsma F
- Duarte L
- Duchesneau D
- Duffy K
- Dunne P
- Dutta B
- Duyang H
- Dvornikov O
- Dwyer D
- Dyshkant A
- Eads M
- Earle A
- Edmunds D
- Eisch J
- Emberger L
- Emery S
- Englezos P
- Ereditato A
- Erjavec T
- Escobar C
- Eurin G
- Evans JJ
- Ewart E
- Ezeribe AC
- Fahey K
- Falcone A
- Fani' M
- Farnese C
- Farzan Y
- Fedoseev D
- Felix J
- Feng Y
- Fernandez Menendez P
- Fernandez Morales M
- Fernandez-Martinez E
- Ferraro F
- Fields L
- Filip P
- Filthaut F
- Fiorini M
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- Fitzpatrick RS
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- Fogarty S
- Foreman W
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- Freestone J
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- Friedland A
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- Furman K
- Furmanski AP
- Gabrielli A
- Gago A
- Gallagher H
- Gallas A
- Gallego-Ros A
- Gallice N
- Galymov V
- Gamberini E
- Gamble T
- Ganacim F
- Gandhi R
- Gandrajula R
- Gao S
- Garcia-Gamez D
- Garcia-Peris MA
- Gardiner S
- Gastler D
- Gauvreau J
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- Geffroy N
- Gelli B
- Gendotti A
- Gent S
- Ghorbani-Moghaddam Z
- Giammaria P
- Giammaria T
- Giangiacomi N
- Gibin D
- Gil-Botella I
- Gilligan S
- Girerd C
- Giri AK
- Gnani D
- Gogota O
- Gold M
- Gollapinni S
- Gollwitzer K
- Gomes RA
- Gomez Bermeo L
- Gomez Fajardo LS
- Gonnella F
- Gonzalez-Diaz D
- Gonzalez-Lopez M
- Goodman MC
- Goodwin O
- Goswami S
- Gotti C
- Goudzovski E
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- Gratieri D
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- Greenler L
- Greer J
- Grenard J
- Griffith WC
- Groh M
- Grudzinski J
- Grzelak K
- Gu W
- Guardincerri E
- Guarino V
- Guarise M
- Guenette R
- Guerard E
- Guerzoni M
- Guffanti D
- Guglielmi A
- Guo B
- Gupta A
- Gupta V
- Guthikonda KK
- Gutierrez R
- Guzowski P
- Guzzo MM
- Gwon S
- Ha C
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- Habig A
- Hadavand H
- Haenni R
- Hahn A
- Haiston J
- Hamacher-Baumann P
- Hamernik T
- Hamilton P
- Han J
- Harris DA
- Hartnell J
- Hartnett T
- Harton J
- Hasegawa T
- Hasnip C
- Hatcher R
- Hatfield KW
- Hatzikoutelis A
- Hayes C
- Hayrapetyan K
- Hays J
- Hazen E
- He M
- Heavey A
- Heeger KM
- Heise J
- Henry S
- Herner K
- Hewes J
- Hilgenberg C
- Hill T
- Hillier SJ
- Himmel A
- Hinkle E
- Hirsch LR
- Ho J
- Hoff J
- Holin A
- Hoppe E
- Horton-Smith GA
- Hostert M
- Hourlier A
- Howard B
- Howell R
- Hoyos J
- Hristova I
- Hronek MS
- Huang J
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- Iliescu AM
- Illingworth R
- Ingratta G
- Ioannisian A
- Irwin B
- Isenhower L
- Itay R
- Jackson CM
- James E
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- Jargowsky B
- Jediny F
- Jena D
- Jeong YS
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- Kakorin I
- Kalitkina A
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- Kamiya F
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- Karaman G
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- Kashur L
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- Klustova A
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- Kolupaeva L
- Korablev D
- Kordosky M
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- Kreczko L
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- Kreslo I
- Kropp W
- Kroupova T
- Kubota S
- Kudenko Y
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- Kunze P
- Kurita N
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- Lawrence A
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- LaZur R
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- Le T
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- Learned J
- LeBrun P
- LeCompte T
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- Lee SY
- Lehnert R
- Leigui de Oliveira MA
- Leitner M
- Lepin LM
- Li SW
- Li Y
- Liao H
- Lin CS
- Lin Q
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- Lineros RA
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- Littlejohn BR
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- Lockwitz S
- Loew T
- Lokajicek M
- Lomidze I
- Long K
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- Louis WC
- Lu X-G
- Luk KB
- Lunday B
- Luo X
- Luppi E
- Luzio VP
- Maalmi J
- MacFarlane D
- Machado AA
- Machado P
- Macias CT
- Macier JR
- Maddalena A
- Madera A
- Madigan P
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- Manyam VN
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- Marchan M
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- Matichard F
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- Mawby I
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- McCluskey E
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- McFarland KS
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- Miryala S
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- Testera G
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- Touramanis C
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- Urheim J
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- Valencia E
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- Vazquez W Panduro
- Ventura S
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- Vermeulen MA
- Verzocchi M
- Vicenzi M
- Vignoli C
- Vilela C
- Viren B
- Vrba T
- Wachala T
- Waldron A
- Wallbank M
- Wallis C
- Wang H
- Wang J
- Wang L
- Wang MHLS
- Wang X
- Wang Y
- Wang Y
- Warburton K
- Warner D
- Wascko MO
- Waters D
- Watson A
- Wawrowska K
- Weatherly P
- Weber A
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- Wei H
- Weinstein A
- Wenman D
- Wetstein M
- White A
- Whitehead LH
- Whittington D
- Wilking MJ
- Wilkinson A
- Wilkinson C
- Williams Z
- Wilson F
- Wilson RJ
- Wisniewski W
- Wolcott J
- Wongjirad T
- Wood A
- Wood K
- Worcester E
- Worcester M
- Wresilo K
- Wret C
- Wu W
- Wu W
- Xiao Y
- Xie F
- Yaeggy B
- Yandel E
- Yang G
- Yang K
- Yang T
- Yankelevich A
- Yershov N
- Yonehara K
- Yoon YS
- Young T
- Yu B
- Yu H
- Yu H
- Yu J
- Yu Y
- Yuan W
- Zaki R
- Zalesak J
- Zambelli L
- Zamorano B
- Zani A
- Zazueta L
- Zeller GP
- Zennamo J
- Zeug K
- Zhang C
- Zhang S
- Zhang Y
- Zhao M
- Zhivun E
- Zhu G
- Zimmerman ED
- Zucchelli S
- Zuklin J
- Zutshi V
- Zwaska R
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 16/07/2022
- Field of study
DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6 × 6 × 6 m 3 liquid argon time-projection-chamber (LArTPC) that recorded cosmic-muon data at the CERN Neutrino Platform in 2019-2020 as a prototype of the DUNE Far Detector. Charged particles propagating through the LArTPC produce ionization and scintillation light. The scintillation light signal in these detectors can provide the trigger for non-beam events. In addition, it adds precise timing capabilities and improves the calorimetry measurements. In ProtoDUNE-DP, scintillation and electroluminescence light produced by cosmic muons in the LArTPC is collected by photomultiplier tubes placed up to 7 m away from the ionizing track. In this paper, the ProtoDUNE-DP photon detection system performance is evaluated with a particular focus on the different wavelength shifters, such as PEN and TPB, and the use of Xe-doped LAr, considering its future use in giant LArTPCs. The scintillation light production and propagation processes are analyzed and a comparison of simulation to data is performed, improving understanding of the liquid argon properties
Separation of track- and shower-like energy deposits in ProtoDUNE-SP using a convolutional neural network
- Author
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- Abi B
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- Yankelevich A
- Yershov N
- Yonehara K
- Yoon Y
- Young T
- Yu B
- Yu H
- Yu H
- Yu J
- Yu Y
- Yuan W
- Zaki R
- Zalesak J
- Zambelli L
- Zamorano B
- Zani A
- Zazueta L
- Zeller G
- Zennamo J
- Zeug K
- Zhang C
- Zhang S
- Zhang Y
- Zhao M
- Zhivun E
- Zhu G
- Zimmerman ED
- Zucchelli S
- Zuklin J
- Zutshi V
- Zwaska R
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Liquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments, and is the technology of choice for the Deep Underground Neutrino Experiment (DUNE). In order to perform high precision measurements of neutrinos in the detector, final state particles need to be effectively identified, and their energy accurately reconstructed. This article proposes an algorithm based on a convolutional neural network to perform the classification of energy deposits and reconstructed particles as track-like or arising from electromagnetic cascades. Results from testing the algorithm on experimental data from ProtoDUNE-SP, a prototype of the DUNE far detector, are presented. The network identifies track- and shower-like particles, as well as Michel electrons, with high efficiency. The performance of the algorithm is consistent between experimental data and simulation
Survival of intracellular pathogens within macrophages
- Author
- A Biederbick
- A Blocker
- A Blocker
- A Jahraus
- A Pitt
- A Pitt
- AH Gordon
- AJ Bäumler
- AP Sinai
- AP Sinai
- B Storrie
- BB Finlay
- BB Finlay
- C Alvarez-Dominguez
- C Alvarez-Dominguez
- C Bucci
- C Chastellier de
- C Chastellier de
- C Geoffroy
- C Pacheco-Soares
- CM Alpuche-Aranda
- CM Alpuche-Aranda
- CR Roy
- CR Roy
- CV Harding
- DA Portnoy
- DD Agranoff
- DG Mordue
- DG Russell
- DG Russell
- DJ Bradley
- DL Clemens
- DL Clemens
- DL Kreutzer
- DL Tolson
- E Prina
- E Prina
- F Aniento
- F Garcia-del Portillo
- F Supek
- G Martinez de Tejada
- G Segal
- GAW Rook
- HL Andrews
- IEA Flesch
- J Alexander
- J Burkhardt
- J Cooper
- J Gruenberg
- J Mengaud
- J Pizarro-Cerdá
- J Pizarro-Cerdá
- J Pizarro-Cerdá
- J Plant
- JA Armstrong
- JA Theriot
- JA Vasquez-Boland
- JC Antoine
- JC Antoine
- JC Boucher
- JE Kirby
- JE Kirby
- JE McDade
- JE Vance
- JH Morisaki
- JL Gaillard
- JM Dobrowolski
- JP Gorvel
- JP Vogel
- K Johnson
- KA Joiner
- KA Joiner
- KP Chang
- L Carvahlo de
- L Miao
- LD Sibley
- LE Via
- LE Via
- LP Barker
- LS Mayorga
- M Cellier
- M Cellier
- M Cellier
- M Denis
- M Desjardins
- M Desjardins
- M Desjardins
- M Desjardins
- M Desjardins
- M Leimeister-Wacher
- M Maurin
- M Rabinovitch
- M Rabinovitch
- M Rathman
- M Rathman
- MA Horwitz
- MA Horwitz
- MA Horwitz
- MA Horwitz
- MD Fleming
- MD Fleming
- MF Pupkis
- MG Rittig
- MR Ehlers
- MS Swanson
- N High
- N Riley
- NA Buchmeier
- OG Baca
- P Chavrier
- P Gros
- PD Hart
- PF Pimenta
- PH Elzer
- PJ Trotter
- PL Clerc
- PL Small
- PR Burton
- R Menard
- RA Heinzen
- RN Germain
- RW Leid
- S Flohe
- S Gruenheid
- S Méresse
- S Scianimanico
- S Souza Leao De
- S Sturgill-Koszycki
- S Sturgill-Koszycki
- S Sturgill-Koszycki
- S Xu
- SR Li
- T Lang
- T Lang
- T Lang
- TB McNeely
- TC Jones
- UE Schaible
- V Deretic
- V Pizon
- VL Shepherd
- W Beron
- WA Dunn
- WA Dunn
- Y Feng
- Y Ishibashi
- YK Oh
- YP Li
- Z Hasan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease:: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study)
- Author
- Aalders JCA
- Acartürk E
- Achremczyk P
- Adamus J
- Adgey AAJ
- Ahsan A
- Al-Khafaji M
- Aldershvile J
- Andrade CMS
- Ansmite B
- Antolini R
- Apffel F
- Attali P
- Avgeropoulou C
- Aviles FF
- Azcarate JA
- Azzolini P
- Bada V
- Ball SG
- Barjhoux C
- Baron B
- Barton J
- Baska J
- Bassand JP
- Bassand JP
- Baubiniene A
- Belicova M
- Bellone E
- Belsue FV
- Benito IM
- Berenyi I
- Bermejo MAP
- Berthier Y
- Bertrand M
- Bertrand M
- Berukstis E
- Bilbal A
- Birkhead J
- Bjerregaard-Andersen H
- Bocek P
- Bolinska-Soltysiak H
- Bonnin JS
- Boon N
- Brack M
- Branny M
- Branzi A
- Bridges A
- Bruggeling WAJ
- Brunelli C
- Bubinski R
- Buchalter M
- Caimari RB
- Calder B
- Caliani JSE
- Capponi E
- Capucci A
- Carrageta M
- Casaccia M
- Cecchetti E
- Cech M
- Ceci V
- Celegon L
- Ceremuzynski L
- Charouzek J
- Christakos S
- Cieslinski A
- Cocina EG
- Cokkinos D
- Colombo A
- Cooke RA
- Coronado JLB
- Corr L
- Corsini G
- Cortada JB
- Cowell R
- Crean P
- Cucchini F
- Curzen NP
- Dalla Volta S
- Daly K
- Dambrine P
- Dargie H
- Dariusz D
- Davidson C
- Davies J
- De Belder MA
- De Caterina R
- De Feyter PJ
- De Leeuw MJ
- De Luca I
- De Miguel CM
- De Ros JO
- De Servi S
- De Waard DEP
- De Weerd GJ
- De Zwaan C
- Deckers J
- Decoulx E
- Deshayes P
- Dhiya L
- Di Donato M
- Di Giacomo U
- Di Pasquale G
- Dijkgraaf R
- Doig JC
- Drazka J
- Drexel H
- Droste HT
- Drozdowski P
- Dubiel JS
- Dukat A
- Duprez D
- Duprez D
- Edes I
- Eha J
- Eha J
- Ekdahl S
- Erhardt L
- Erhardt L
- Erikssen J
- Erikssen J
- Fabik L
- Feggos S
- Ferrari R
- Ferrari R
- Ferreira R
- Findlay IN
- Fiorentini C
- Florian J
- Floros S
- Forslund L
- Fotiadis I
- Fouche R
- Fox KM
- Fox KM
- Fox KM
- Francek L
- Francis CM
- Fratacci MD
- Freericks MP
- Gaddi O
- Gailiss E
- Galewicz M
- Garcia PA
- Garcia-Aranda VL
- Genest M
- Gersamija A
- Giannetto M
- Giannuzzi P
- Gil JC
- Giordano A
- Giovannini E
- Glancy JM
- Godard S
- Gombotz G
- Goudevenos I
- Greenwood TW
- Grigoniene L
- Groch L
- Groves P
- Grybauskas P
- Guarnierio M
- Guerrero JJG
- Guillot JP
- Guzelsoy D
- Hagoort-Kok AW
- Halawa B
- Hall AS
- Hamilton G
- Hanania G
- Haq I
- Havranek P
- Heyndrickx GH
- Hildebrandt P
- Hildebrandt P
- Hillebrand F
- Hillman R
- Hradec J
- Hubbard W
- Hudson I
- Hutton I
- Iacono A
- Ilsley C
- Inama G
- Innes M
- Itkonen A
- James M
- Janion M
- Janosi A
- Jansky P
- Jap WTJ
- Jaworska K
- Jennings K
- Jirmar R
- Jochemsen GM
- Johnston G
- Jokl I
- Jones CJH
- Joy M
- Julian D
- Juvonen J
- Kaliska G
- Kalnins U
- Kalnins U
- Kalo E
- Kamensky G
- Kardara D
- Karidis C
- Karmakoski J
- Karpati P
- Karsch K
- Kaszewska I
- Kearney P
- Keeling P
- Keltai M
- Khattar P
- Kibarskis A
- Kiemeney F
- Kilkki E
- Kirkutis A
- Klein W
- Klein W
- Kleinrok A
- Koliopoulos N
- Kooner J
- Kornacewicz-Jach Z
- Kornel S
- Koskela E
- Krawczyk W
- Krejcova H
- Kremastinos D
- Kristensen K
- Krynicki R
- Krzciuk M
- Krzeminska-Pakula M
- Kuch J
- Kuijer PJP
- Kuzniar J
- Kübler W
- Kvasnak M
- Lauer B
- Lawson C
- Leghissa R
- Legrand V
- Leht A
- Lekakis I
- Lerebours G
- Leroy F
- Levy RD
- Ligorit AD
- Lip G
- Liszewska-Pfejfer D
- Loboz-Grudzien K
- Lopez DG
- Lopez FN
- Lorente LJ
- Lorusso R
- Lüscher T
- Madsen JK
- Mannaerts HFJ
- Manolis A
- Mansourati J
- Maratka T
- Marcinek G
- Marcinkus R
- Marinoni G
- Markenvard J
- Marques AL
- Martin ES
- Martinez VB
- Marzilli M
- Mas JO
- Materne P
- Mauri F
- Mayor JLB
- Mclachlan B
- Meany TB
- Meibom J
- Melin J
- Micko K
- Mikes Z
- Milvidaite I
- Moccetti T
- Montero JM
- Montgomery HE
- Moravcova J
- Morley CA
- Mosele GM
- Mulcahy D
- Mulcahy D
- Murdoch DL
- Murray G
- Musial W
- Muthusamy R
- Nedbal P
- Nieminen M
- Nieminen MS
- Norgaard A
- Oakley GDG
- Ohlin H
- Ojeda FB
- Opolski G
- Orcajo NA
- Oto A
- Oto A
- Ozolina MA
- Ozsaruhan O
- Özsaruhan O
- Padial LR
- Palinsky M
- Pap I
- Papanikolaou C
- Papasteriadis E
- Papi S
- Pasyk S
- Paulus W
- Peiro FN
- Pela' G
- Pella D
- Penny W
- Peralta LJP
- Percival R
- Peterka K
- Pettinati G
- Piek JJ
- Pieper M
- Piquemal R
- Piwowarska W
- Polak G
- Polimeni MR
- Portaluppi F
- Povolny J
- Proto C
- Providencia L
- Pulkowski G
- Purvis J
- Pye MP
- Pyrgakis V
- Quigley P
- Quiret JC
- Ramsdale D
- Raynaud P
- Reiber I
- Remme WJ
- Remme WJ
- Renaldini E
- Renker B
- Rettig-Stürmer G
- Riecansky I
- Riecansky I
- Riessen R
- Riva S
- Roberts DH
- Romero PM
- Rondepierre D
- Rosolova H
- Roynard JL
- Rozkovec A
- Rusznak M
- Rutsch W
- Ruzyllo W
- Ruzyllo W
- Rynkiewicz A
- Saelman JPM
- Salcedo JMA
- Salmassi AM
- Saltissi S
- Sanguinetti M
- Sanpera JMA
- Santini M
- Santini U
- Sanz AS
- Sardar S
- Savola R
- Scheibel M
- Schofield PM
- Seabra-Gomes R
- Sechtem U
- Sechtem U
- Sefara P
- Semrad B
- Severi S
- Shakespeare C
- Shapiro LM
- Sigel HA
- Simon R
- Simoons M
- Simoons ML
- Sinagra G
- Sinkiewicz W
- Skoufas P
- Skura M
- Slob FD
- Slowinski S
- Smielak-Korombel W
- Smits WCG
- Sochor K
- Sojka G
- Soler-Soler J
- Spacek R
- Spinar J
- Srivastava S
- Stavridis A
- Steg G
- Stephens J
- Stipal R
- Stravrati A
- Stuchlik K
- Sudhibhasilp S
- Sulda M
- Sulej P
- Suttorp MJ
- Swan JW
- Syribeis S
- Szakacs M
- Tan TB
- Tantalo L
- Targonski R
- Tarjan J
- Tavazzi L
- Tavazzi L
- Teesalu R
- Templin W
- Tendera M
- Terho T
- Thygesen K
- Tildesley G
- Timar S
- Toth K
- Toutouzas P
- Tracz W
- Travill C
- Trusz-Gluza M
- Turkoglu C
- Ulman J
- Urena CG
- Vaclavicek A
- Vahula V
- Vajola SF
- Valderrama JC
- Van Beek GJ
- Van Belle E
- Van den Merkhof LFM
- Van der Heyden R
- Van Hessen MWJ
- Van Langeveld RAM
- Van Mieghem W
- Van Nierop PR
- Van Rey FJW
- Van Straalen MJ
- Vardas P
- Vasiliauskas D
- Vassiliadis I
- Voipio-Pulkki LM
- Vojtisek P
- Volterrani M
- Von Schacky C
- Vos J
- Voudris V
- Werner HA
- Westendorp JJC
- Widimsky P
- Wilkinson PR
- Winkelmann BR
- Wodniecki J
- Zalewski M
- Zinka E
- Zobolos S
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 01/01/2003
- Field of study
Background Treatment with angiotensin-converting-enzyme (ACE) inhibitors reduces the rate of cardiovascular events among patients with left-ventricular dysfunction and those at high risk of such events. We assessed whether the ACE inhibitor perindopril reduced cardiovascular risk in a low-risk population with stable coronary heart disease and no apparent heart failure.Methods We recruited patients from October, 1997, to June, 2000. 13 655 patients were registered with previous myocardial infarction (64%), angiographic evidence of coronary artery disease (61%), coronary revascularisation (55%), or a positive stress test only (5%). After a run-in period of 4 weeks, in which all patients received perindopril, 12 218 patients were randomly assigned perindopril 8 mg once daily (n=6110), or matching placebo (n=6108). The mean follow-up was 4.2 years, and the primary endpoint was cardiovascular death, myocardial infarction, or cardiac arrest. Analysis was by intention to treat.Findings Mean age of patients was 60 years (SD 9), 85% were male, 92% were taking platelet inhibitors, 62% beta blockers, and 58% lipid-lowering therapy. 603 (10%) placebo and 488 (8%) perindopril patients experienced the primary endpoint, which yields a 20% relative risk reduction (95% CI 9-29, p=0.0003) with perindopril. These benefits were consistent in all predefined subgroups and secondary endpoints. Perindopril was well tolerated.Interpretation Among patients with stable coronary heart disease without apparent heart failure, perindopril can significantly improve outcome. About 50 patients need to be treated for a period of 4 years to prevent one major cardiovascular event. Treatment with perindopril, on top of other preventive medications, should be considered in all patients with coronary heart disease
Cardiorenal end points in a trial of aliskiren for type 2 diabetes.
- Author
- 3rd Allison J.
- Abe N
- Abedini S
- Abraham G
- Acker Kv
- Adelberger V
- Adhikari P
- Agarwal N
- Ahmed F
- Aiello A
- Aizemberg D
- Aldigier Jc
- Allemann Y
- Almeida F
- Altes U
- Altschuller A
- Amod A
- Anderson J
- Andre I
- Aniko S
- Antepara N
- Aoki S
- Arakaki R
- Aranda P
- Arango Jl
- Araz M
- Arez L
- Arici M
- Armario P
- Arnouts P
- Aronson R
- Ates K
- Aucello G
- Azize Gm
- Bacariza M
- Badariene J
- Baggen Mg
- Bajaj M
- Bakker Rc
- Bako B
- Banerjee D
- Bantwal G
- Barima Yt
- Barranco E
- Barrera C
- Barrett B
- Barrios V
- Bartolacci I
- Batt R
- Bazzi A
- Beacom M
- Behnke T
- Belobradkova J
- Benacka J
- Berg J
- Berlingieri Jc
- Berrizbeitia M
- Bevilacqua Mt
- Bhana Sa
- Bhattacharyya A
- Bianda T
- Bieler T
- Biernacki W
- Bilazarian S
- Bilous R
- Birne R
- Blacher J
- Blakney E
- Blanco D
- Boermans T
- Bonora E
- Botero R
- Botero R
- Bowden R
- Bowering K
- Branco P
- Brandao A
- Brandstetter R
- Brath H
- Braun Rk
- Brenner Bm
- Bressler P
- Brotons C
- Brown C
- Browne D
- Brunel P
- Bulliard C
- Burkhardt F
- Burnier M
- Burstein D
- Busch R
- Busick E
- Cabrera W
- Calatola P
- Calle A
- Calvert J
- Calviñ
- Calvo C
- Capuano V
- Carillo E
- Carrillo E
- Carugo S
- Carvalho D
- Casalla F
- Casas L
- Catelao Am
- Catena C
- Cerasola G
- Cha D
- Cha J
- Chae D
- Chanchairujira T
- Charles H
- Charpentier G
- Chaturvedi N
- Chen Hc
- Chen J
- Chen Sc
- Chen X
- Cho W
- Chou Cw
- Chouinard G
- Chowdhury S
- Christiansen Js
- Christiansen Js
- Chua T
- Cifkova R
- Cifkova R
- Cocchi R
- Comas A
- Comlekci A
- Comlekci A
- Connery L
- Constam En
- Cooperman M
- Corona V
- Corsi A
- Coucke F
- Cournoyer S
- Cozzolino D
- Craig W
- Culak J
- Cunha R
- Cusachs Ar
- Dö
- D&apos
- D&apos
- da Costa AG
- da Silva GF
- da Silva PM
- Dani S
- Darko D
- Dattani D
- David S
- de Jong A
- de Paula RB
- De Pellegrin A
- de Roa ER
- De Teresa E
- de Zeeuw D
- Deak L
- Del Prato S
- dell Valle MH
- Dellanna F
- Demetry K
- Demirbas B
- Dendale P
- Desai As
- Desai V
- Dharmalingam M
- Diaz M
- Dohnalova L
- Dong J
- Dotta F
- Downey H
- Drexel H
- Dudas M
- Dukat A
- Dukat A
- Dunselman Ph
- Duprez D
- Dzuponova J
- East C
- Eavis P
- Egstrup K
- Eiam Ong S
- Eickhoff F
- Ekoe Jm
- Eng G
- Fabryova L
- Fagan T
- Falcone C
- Fanti P
- Farias E
- Fauvel Jp
- Federici M
- Feenstra Hj
- Feis Wl
- Feitosa G
- Felicio J
- Feng W
- Ferná
- Fernandez G
- Fernandez P
- Fernandez Vl
- Ferri C
- Fery F
- Fiesselmann A
- Filetti S
- Filipova S
- Fisher M
- Fitz Patrick D
- Foeger B
- Fogari R
- Forti A
- Fraile B
- Francesconi C
- Franco C
- Franke F
- Freedman Z
- Frisinghelli A
- Frontoni S
- Fu J
- Fucili A
- Fujita H
- Fukui T
- Fulop T
- Furuland H
- Gaal Lv
- Gabriel J
- Gaillard Ca
- Galceran Jm
- Gallen I
- Gambardella S
- Garceau C
- Garcia Jc
- Garcia M
- Garcia S
- Gerber P
- Gero L
- Gessner S
- Ghigo Ezio
- Gil Dv
- Gilbert J
- Giordano C
- Glorioso N
- Gnudi L
- Godin C
- Goebel R
- Gomez P
- Gonzalez Jm
- Gonzalez R
- Gorson D
- Gorton S
- Gouet D
- Goumenos D
- Graf Hj
- Grandaliano G
- Gregoor Pj
- Grimm R
- Groeschel A
- Groeschel W
- Gronert J
- Groop Ph
- Gu S
- Guarnieri A
- Gudnason S
- Guevara L
- Guija E
- Guneri S
- Gupta M
- Gurgun C
- Ha S
- Haack A
- Haase F
- Haffner Sm
- Haller H
- Haller H
- Hanefeld M
- Hardin P
- Harris Sb
- Hart T
- Harvey J
- Hayoz D
- He R
- Heeg Je
- Helin K
- Hernandez E
- Hernandez F
- Herrada B
- Herrmann Hj
- Hevendehl G
- Hilgenberg J
- Hiremath J
- Hissa Mn
- Hohenstatt T
- Hollanders G
- Hominal M
- Hong T
- Horowitz B
- Ibrik O
- Iglesias Fe
- Iglesias Jn
- Ioannidis G
- Ipp E
- Isart J
- Istad H
- Itou T
- Iwaita Y
- Jacqmein J
- Jamerson K
- Jamerson K
- Jaramillo C
- Jardine A
- Ji Q
- Jia W
- Jimenez Ml
- Jorde R
- Jorde R
- Juhl H
- Juncos L
- Juncos L
- Kaasjager Ha
- Kajiyama S
- Kalender B
- Kananen K
- Kaneko S
- Kang S
- Kapocsi J
- Kasahara H
- Katayama Ss
- Katz L
- Kawahara K
- Ke Y
- Kerrane J
- Kerstein H
- Khandwala H
- Kilbane A.
- Kim S
- Kim S
- Kim Sg
- Kim Y
- Kim Y
- Kiss I
- Kitiyakara C
- Klaff L
- Klausmann G
- Klepzig C
- Koc M
- Kocourkova B
- Koeper D
- Kojima S
- Koleny D
- Komroskova M
- Kooy A
- Kooy A
- Kopyt Np
- Koranyi L
- Kovalchuck Aa
- Krapf R
- Krieger E
- Krishnan U
- Krzesinski Jm
- Kumar J
- Kumar S
- Kuschnir E
- Kvapil M
- Kwak I
- Kwon Y
- Labutiniene Ip
- Lachance P
- Lachin Jm
- Lahtela J
- Lambiase C
- Lanier D
- Larnefelt H
- Lasala G
- Lau T
- Ledger G
- Lee Ct
- Leendert Rj
- Lehmann G
- Leimbach W
- Leira Vm
- Leiter L
- Leiter L
- Lema L
- Lembo G
- Lengyel Z
- Leotta S
- Lerman S
- Lervang Hh
- Leurs Pb
- Levenson D
- Levinson L
- Lié
- Li H
- Li L
- Li Q
- Li Q
- Lieverse Ag
- Lim C
- Limone Pp
- Lin H
- Lin Sh
- Lipetz R
- Litchfield J
- Litwak L
- Liu B
- Liu X
- Liu Z
- Locatelli F
- Lock J
- Lok D
- Lok Dj
- Lopez A
- Lopez I
- Lopez Jm
- Lopez R
- Lu J
- Luik Aj
- Lund R
- Lv X
- Ma J
- Maddux A
- Maeda Y
- Maggioni A
- Maglia G
- Majul C
- Makan H
- Maltezos E
- Mamish Z
- Mancebo Jg
- Mannarino E
- Marchionni N
- Marechaud R
- Margulis F
- Marin M
- Marre M
- Marre M
- Martin D
- Martin E
- Martin J
- Martin J
- Martinez F
- Martinez J
- Martinez V
- Martinka E
- Martins L
- Massari P
- Mateos C
- Mathieu C
- Matsubayashi S
- Matsumoto A
- Mayer G
- McGill J
- McMurray Jj
- Mediavilla Jd
- Medina B
- Medina F
- Medina F
- Meeus G
- Mei C
- Mendez R
- Merke J
- Mersey J
- Michael S
- Middleton A
- Migdalis I
- Miglinas M
- Milesi R
- Minehart C
- Mion D. Jr
- Moccetti T
- Modi Kk
- Mohan V
- Montañ
- Monterroso V
- Morosetti M
- Mos L
- Mostard G
- Moustafa M
- Mueller G
- Muirhead N
- Munger R
- Muros T
- Nadal Jj
- Naicker P
- Nanclares Ms
- Narayan P
- Narimiya M
- Ng Tg
- Nickenig G
- Nickenig G
- Nicolaides M
- Niepen Pv
- Nierop Pr
- Nolen T
- Nour K
- Novo S
- Nyirati G
- O&apos
- Oerter E
- Oestergaard O
- Ogawa Y
- Oh H
- Oigman W
- Okamoto H
- Olivan J
- Olsen H
- Onishi Y
- Ontiveros C
- Ooi Tc
- Orias M
- Oroszlan T
- Ott P
- Ovize M
- Pagkalos E
- Pan C
- Pandey S
- Papadakis I
- Pappas S
- Paragh G
- Parra J
- Parreñ
- Parving Hh
- Pascual J
- Pastrnakova E
- Paulweber B
- Pedersen Tr
- Pedrinelli R
- Pella D
- Pencz I
- Penfornis A
- Peral Jl
- Perez Js
- Pernalete N
- Perrild H
- Persson F
- Persu A
- Perticone F
- Petrillo A
- Petrulioniene Z
- Pettersson P
- Pfeffer Ma
- Phillips A
- Piatti P
- Pichette V
- Pignone Am
- Pino J
- Piskorz D
- Podgorski G
- Pollock J
- Polonia Dj
- Polonia J
- Porta A
- Portnay G
- Poteliuniene V
- Povedano St
- Powell C
- Prager R
- Prager R
- Prasad J
- Providencia Dl
- Puig Jg
- Qi X
- Qiu M
- Quarello F
- Querejeta R
- Quinonez M
- Rambausek M
- Ranjith N
- Rao V
- Ravera M
- Rayner B
- Rayner Bl
- Reboredo A
- Redon J
- Rekhi A
- Remuzzi G
- Reschke K
- Rheeder P
- Ricart W
- Richard A
- Rickli H
- Rinne J
- Rippert R
- Risberg K
- Roberts J
- Robertson D
- Rocha J
- Rodelas R
- Ronchi E
- Ronner E
- Rosenblit P
- Rossing P
- Ruddy M
- Rudofsky G
- Ruige J
- Ruilope L
- Ruilope L
- Ruiz Rivera L
- Rusculleda M
- Sá
- Saari M
- Saavedra A
- Sachson R
- Sadler L
- Sahay R
- Sala J
- Salvador N
- Santoro A
- Saraiva J
- Sarro M
- Saunders K
- Savela K
- Scanferla F
- Schax U
- Scheen A
- Schleyer S
- Schlosser R
- Schmid H
- Schmidt S
- Schmitt H
- Schoch D
- Schoen N
- Schreibmueller F
- Scioli Ga
- Segal S
- Segner A
- Seidner M
- Seino H
- Sekigami T
- Sekiguchi M
- Senftleber I
- Seshiah V
- Sessa H
- Sesti G
- Sethi B
- Sgarbi J
- Sheu W
- Sheu Wh
- Shi B
- Shikata K
- Shimizu H
- Shin Y
- Siamopoulos K
- Siamopoulos K
- Simpson H
- Simsek S
- Sinay I
- Singh N
- Sisting Rt
- Skeie S
- Skjelvan G
- Smith M
- Snorgaard O
- Sobrino J
- Solomon R
- Solomon Sd
- Song J
- Soran H
- Soubriet A
- Spagnuolo V
- Spiering W
- Spisak V
- Sprague A
- Sriratanasathavorn C
- Sritara P
- Sritara P
- Steele Aw
- Steigerwalt S
- Stevlik J
- Stipal R
- Strand J
- Stroembom U
- Stuetz W
- Su B
- Su Sl
- Sukonthasarn A
- Sun Ch
- Sun N
- Supasyndh O
- Surovcikova M
- Suzuki Y
- Swartz S
- Szentivanyi M
- Tachi K
- Taddei S
- Takeda H
- Tanaka S
- Tandon N
- Tatsukawa Y
- Tellier G
- Tentolouris N
- Terns M
- Tesar V
- Thomas N
- Thorsteinsson B
- Tikkanen T
- Tildesley H
- Ting R
- Tits J
- Tobe S
- Tojo A
- Tolosana J
- Tomala T
- Tone A
- Tong N
- Tonolo G
- Toplak H
- Tornero F
- Torvik Dt
- Toto R
- Toto R
- Treille S
- Triana A
- Trias F
- Trimarco B
- Tsapas A
- Tung P
- Turcios E
- Turcot R
- Uhliar R
- Urhammer S
- Usalan C
- Uzu T
- Vö
- Valensi Pe
- Valitutto M
- Valtonen E
- van Bemmel T
- van den Meiracker AH
- van der Zwaan C
- van Hal JM
- van Loon BJ
- Vanuytsel J
- Varthakavi P
- Vasconcelos Mp
- Vaughters B
- Vega Ff
- Veglio Franco
- Velez J
- Vercammen C
- Verma S
- Verpooten G
- Viberti G
- Vico M
- Viergever Pp
- Villa G
- Villafuerte B
- Villamil As
- Vincent Hh
- Vinciguerra A
- Viswanathan V
- Vita N
- Vizcaino J
- Vodnansky P
- Volpe M
- Voors Aa
- Vora J
- Vosskuehler A
- Vriese Ad
- Wahl T
- Wang H
- Wang L
- Wang N
- Wassermann A
- Watschinger B
- Weinstein R
- Weisnagel Sj
- Weiss L
- Weiss L
- Wellmann H
- Widimsky P
- Wiesweg Ck
- Williams T
- Winocour P
- Wins Eh
- Wise J
- Wittmann I
- Woittiez Aj
- Wong Ks
- Wong Ks
- Woo V
- Woolley A
- Wu Cj
- Wu Kd
- Wu X
- Wuethrich R
- Wuethrich R
- Wynne A
- Wyss F
- Xia W
- Xiang Z
- Xu G
- Xu M
- Xu X
- Yajnik C
- Yalouris A
- Yamada K
- Yamada T
- Yan J
- Yan L
- Yan S
- Yang J
- Yang T
- Yang Tc
- Yang W
- Yeoh Ly
- Yuan Z
- Zabuliene L
- Zamora B
- Zamorano Jl
- Zanella M
- Zanella Mt
- Zanette G
- Zangroniz P
- Zaoui P
- Zhan X
- Zhang H
- Zhang J
- Zhang M
- Zhong H
- Zhong L
- Zhou Z
- Zhu D
- Zigrang W
- Zimmermann U
- Zinman B
- Zushi S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2012
- Field of study
Background
This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 dia- betes and chronic kidney disease, cardiovascular disease, or both.
Methods
In a double-blind fashion, we randomly assigned 8561 patients to aliskiren (300 mg daily) or placebo as an adjunct to an angiotensin-converting\u2013enzyme inhibitor or an angiotensin-receptor blocker. The primary end point was a composite of the time to cardiovascular death or a first occurrence of cardiac arrest with resuscitation; nonfatal myocardial infarction; nonfatal stroke; unplanned hospitalization for heart failure; end-stage renal disease, death attributable to kidney failure, or the need for renal-replacement therapy with no dialysis or transplantation available or initiated; or doubling of the baseline serum creatinine level.
Results
The trial was stopped prematurely after the second interim efficacy analysis. After a median follow-up of 32.9 months, the primary end point had occurred in 783 patients (18.3%) assigned to aliskiren as compared with 732 (17.1%) assigned to placebo (hazard ratio, 1.08; 95% confidence interval [CI], 0.98 to 1.20; P=0.12). Effects on secondary renal end points were similar. Systolic and diastolic blood pres- sures were lower with aliskiren (between-group differences, 1.3 and 0.6 mm Hg, respectively) and the mean reduction in the urinary albumin-to-creatinine ratio was greater (between-group difference, 14 percentage points; 95% CI, 11 to 17). The proportion of patients with hyperkalemia (serum potassium level, 656 mmol per liter) was significantly higher in the aliskiren group than in the placebo group (11.2% vs. 7.2%), as was the proportion with reported hypotension (12.1% vs. 8.3%) (P<0.001 for both comparisons).
Conclusions
The addition of aliskiren to standard therapy with renin\u2013angiotensin system block- ade in patients with type 2 diabetes who are at high risk for cardiovascular and renal events is not supported by these data and may even be harmful
Cardiorenal end points in a trial of aliskiren for type 2 diabetes.
- Author
- Abe N
- Abedini S
- Abraham G
- Acker KV
- Adelberger V
- Adhikari P
- Agarwal N
- Ahmed F
- Aiello A
- Aizemberg D
- Aldigier JC
- Allemann Y
- Allison J 3rd
- Almeida F
- Altes U
- Altschuller A
- Amod A
- Anderson J
- Andre I
- Aniko S
- Antepara N
- Aoki S
- Arakaki R
- Aranda P
- Arango JL
- Araz M
- Arez L
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- Armario P
- Arnouts P
- Aronson R
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- Azize GM
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- Badariene J
- Baggen MG
- Bajaj M
- Bakker RC
- Bako B
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- Barima YT
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- Barrios V
- Bartolacci I
- Batt R
- Bazzi A
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- Behnke T
- Belobradkova J
- Benacka J
- Berg J
- Berlingieri JC
- Berrizbeitia M
- Bevilacqua MT
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- Bilazarian S
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- Blakney E
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- Bonora E
- Botero R
- Botero R
- Bowden R
- Bowering K
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- Brandao A
- Brandstetter R
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- Braun RK
- Brenner BM
- Bressler P
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- Bulliard C
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- Burstein D
- Busch R
- Busick E
- Cabrera W
- Calatola P
- Calle A
- Calvert J
- Calvi\uf1o J
- Calvo C
- Capuano V
- Carillo E
- Carrillo E
- Carugo S
- Carvalho D
- Casalla F
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- Chouinard G
- Chowdhury S
- Christiansen JS
- Christiansen JS
- Chua T
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- Cocchi R
- Comas A
- Comlekci A
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- Constam EN
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- Corsi A
- Coucke F
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- Culak J
- Cunha R
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- D'Angelo AR
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- da Silva GF
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- Darko D
- Dattani D
- David S
- de Jong A
- de Paula RB
- De Pellegrin A
- de Roa ER
- De Teresa E
- de Zeeuw D
- Deak L
- Del Prato S
- dell Valle MH
- Dellanna F
- Demetry K
- Demirbas B
- Dendale P
- Desai AS
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- Diaz M
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- Kooy A
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- Kovalchuck AA
- Krapf R
- Krieger E
- Krishnan U
- Krzesinski JM
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- Kwak I
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- Labutiniene IP
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- Leendert RJ
- Lehmann G
- Leimbach W
- Leira VM
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- Lengyel Z
- Leotta S
- Lerman S
- Lervang HH
- Leurs PB
- Levenson D
- Levinson L
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- Li\ue9nart F
- Lieverse AG
- Lim C
- Limone PP
- Lin H
- Lin SH
- Lipetz R
- Litchfield J
- Litwak L
- Liu B
- Liu X
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- Locatelli F
- Lock J
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- Lok DJ
- Lopez A
- Lopez I
- Lopez JM
- Lopez R
- Lu J
- Luik AJ
- Lund R
- Lv X
- Ma J
- Maddux A
- Maeda Y
- Maggioni A
- Maglia G
- Majul C
- Makan H
- Maltezos E
- Mamish Z
- Mancebo JG
- Mannarino E
- Marchionni N
- Marechaud R
- Margulis F
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- Martinka E
- Martins L
- Massari P
- Mateos C
- Mathieu C
- Matsubayashi S
- Matsumoto A
- Mayer G
- McGill J
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- Mediavilla JD
- Medina B
- Medina F
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- Meeus G
- Mei C
- Mendez R
- Merke J
- Mersey J
- Michael S
- Middleton A
- Migdalis I
- Miglinas M
- Milesi R
- Minehart C
- Mion D Jr
- Moccetti T
- Modi KK
- Mohan V
- Monta\uf1a O
- Monterroso V
- Morosetti M
- Mos L
- Mostard G
- Moustafa M
- Mueller G
- Muirhead N
- Munger R
- Muros T
- Nadal JJ
- Naicker P
- Nanclares MS
- Narayan P
- Narimiya M
- Ng TG
- Nickenig G
- Nickenig G
- Nicolaides M
- Niepen PV
- Nierop PR
- Nolen T
- Nour K
- Novo S
- Nyirati G
- O'Hare P
- Oerter E
- Oestergaard O
- Ogawa Y
- Oh H
- Oigman W
- Okamoto H
- Olivan J
- Olsen H
- Onishi Y
- Ontiveros C
- Ooi TC
- Orias M
- Oroszlan T
- Ott P
- Ovize M
- Pagkalos E
- Pan C
- Pandey S
- Papadakis I
- Pappas S
- Paragh G
- Parra J
- Parre\uf1o Lde T
- Parving HH1
- Pascual J
- Pastrnakova E
- Paulweber B
- Pedersen TR
- Pedrinelli R
- Pella D
- Pencz I
- Penfornis A
- Peral JL
- Perez JS
- Pernalete N
- Perrild H
- Persson F
- Persu A
- Perticone F
- Petrillo A
- Petrulioniene Z
- Pettersson P
- Pfeffer MA
- Phillips A
- Piatti P
- Pichette V
- Pignone AM
- Pino J
- Piskorz D
- Podgorski G
- Pollock J
- Polonia DJ
- Polonia J
- Porta A
- Portnay G
- Poteliuniene V
- Povedano ST
- Powell C
- Prager R
- Prager R
- Prasad J
- Providencia DL
- Puig JG
- Qi X
- Qiu M
- Quarello F
- Querejeta R
- Quinonez M
- Rambausek M
- Ranjith N
- Rao V
- Ravera M
- Rayner B
- Rayner BL
- Reboredo A
- Redon J
- Rekhi A
- Remuzzi G
- Reschke K
- Rheeder P
- Ricart W
- Richard A
- Rickli H
- Rinne J
- Rippert R
- Risberg K
- Roberts J
- Robertson D
- Rocha J
- Rodelas R
- Ronchi E
- Ronner E
- Rosenblit P
- Rossing P
- Ruddy M
- Rudofsky G
- Ruige J
- Ruilope L
- Ruilope L
- Ruiz-Rivera L
- Rusculleda M
- S\ue1nchez V
- Saari M
- Saavedra A
- Sachson R
- Sadler L
- Sahay R
- Sala J
- Salvador N
- Santoro A
- Saraiva J
- Sarro M
- Saunders K
- Savela K
- Scanferla F
- Schax U
- Scheen A
- Schleyer S
- Schlosser R
- Schmid H
- Schmidt S
- Schmitt H
- Schoch D
- Schoen N
- Schreibmueller F
- Scioli GA
- Segal S
- Segner A
- Seidner M
- Seino H
- Sekigami T
- Sekiguchi M
- Senftleber I
- Seshiah V
- Sessa H
- Sesti G
- Sethi B
- Sgarbi J
- Sheu W
- Sheu WH
- Shi B
- Shikata K
- Shimizu H
- Shin Y
- Siamopoulos K
- Siamopoulos K
- Simpson H
- Simsek S
- Sinay I
- Singh N
- Sisting RT
- Skeie S
- Skjelvan G
- Smith M
- Snorgaard O
- Sobrino J
- Solomon R
- Solomon SD
- Song J
- Soran H
- Soubriet A
- Spagnuolo V
- Spiering W
- Spisak V
- Sprague A
- Sriratanasathavorn C
- Sritara P
- Sritara P
- Steele AW
- Steigerwalt S
- Stevlik J
- Stipal R
- Strand J
- Stroembom U
- Stuetz W
- Su B
- Su SL
- Sukonthasarn A
- Sun CH
- Sun N
- Supasyndh O
- Surovcikova M
- Suzuki Y
- Swartz S
- Szentivanyi M
- Tachi K
- Taddei S
- Takeda H
- Tanaka S
- Tandon N
- Tatsukawa Y
- Tellier G
- Tentolouris N
- Terns M
- Tesar V
- Thomas N
- Thorsteinsson B
- Tikkanen T
- Tildesley H
- Ting R
- Tits J
- Tobe S
- Tojo A
- Tolosana J
- Tomala T
- Tone A
- Tong N
- Tonolo G
- Toplak H
- Tornero F
- Torvik DT
- Toto R
- Toto R
- Treille S
- Triana A
- Trias F
- Trimarco B
- Tsapas A
- Tung P
- Turcios E
- Turcot R
- Uhliar R
- Urhammer S
- Usalan C
- Uzu T
- V\uf6r\uf6s P
- Valensi PE
- Valitutto M
- Valtonen E
- van Bemmel T
- van den Meiracker AH
- van der Zwaan C
- van Hal JM
- van Loon BJ
- Vanuytsel J
- Varthakavi P
- Vasconcelos MP
- Vaughters B
- Vega FF
- Veglio F
- Velez J
- Vercammen C
- Verma S
- Verpooten G
- Viberti G
- Vico M
- Viergever PP
- Villa G
- Villafuerte B
- Villamil AS
- Vincent HH
- Vinciguerra A
- Viswanathan V
- Vita N
- Vizcaino J
- Vodnansky P
- Volpe M
- Voors AA
- Vora J
- Vosskuehler A
- Vriese AD
- Wahl T
- Wang H
- Wang L
- Wang N
- Wassermann A
- Watschinger B
- Weinstein R
- Weisnagel SJ
- Weiss L
- Weiss L
- Wellmann H
- Widimsky P
- Wiesweg CK
- Williams T
- Winocour P
- Wins EH
- Wise J
- Wittmann I
- Woittiez AJ
- Wong KS
- Wong KS
- Woo V
- Woolley A
- Wu CJ
- Wu KD
- Wu X
- Wuethrich R
- Wuethrich R
- Wynne A
- Wyss F
- Xia W
- Xiang Z
- Xu G
- Xu M
- Xu X
- Yajnik C
- Yalouris A
- Yamada K
- Yamada T
- Yan J
- Yan L
- Yan S
- Yang J
- Yang T
- Yang TC
- Yang W
- Yeoh LY
- Yuan Z
- Zabuliene L
- Zamora B
- Zamorano JL
- Zanella M
- Zanella MT
- Zanette G
- Zangroniz P
- Zaoui P
- Zhan X
- Zhang H
- Zhang J
- Zhang M
- Zhong H
- Zhong L
- Zhou Z
- Zhu D
- Zigrang W
- Zimmermann U
- Zinman B
- Zushi S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2012
- Field of study
BACKGROUND: This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and chronic kidney disease, cardiovascular disease, or both.
METHODS: In a double-blind fashion, we randomly assigned 8561 patients to aliskiren (300 mg daily) or placebo as an adjunct to an angiotensin-converting-enzyme inhibitor or an angiotensin-receptor blocker. The primary end point was a composite of the time to cardiovascular death or a first occurrence of cardiac arrest with resuscitation; nonfatal myocardial infarction; nonfatal stroke; unplanned hospitalization for heart failure; end-stage renal disease, death attributable to kidney failure, or the need for renal-replacement therapy with no dialysis or transplantation available or initiated; or doubling of the baseline serum creatinine level.
RESULTS: The trial was stopped prematurely after the second interim efficacy analysis. After a median follow-up of 32.9 months, the primary end point had occurred in 783 patients (18.3%) assigned to aliskiren as compared with 732 (17.1%) assigned to placebo (hazard ratio, 1.08; 95% confidence interval [CI], 0.98 to 1.20; P=0.12). Effects on secondary renal end points were similar. Systolic and diastolic blood pressures were lower with aliskiren (between-group differences, 1.3 and 0.6 mm Hg, respectively) and the mean reduction in the urinary albumin-to-creatinine ratio was greater (between-group difference, 14 percentage points; 95% CI, 11 to 17). The proportion of patients with hyperkalemia (serum potassium level, 656 mmol per liter) was significantly higher in the aliskiren group than in the placebo group (11.2% vs. 7.2%), as was the proportion with reported hypotension (12.1% vs. 8.3%) (P<0.001 for both comparisons).
CONCLUSIONS: The addition of aliskiren to standard therapy with renin-angiotensin system blockade in patients with type 2 diabetes who are at high risk for cardiovascular and renal events is not supported by these data and may even be harmful
Separation of track- and shower-like energy deposits in ProtoDUNE-SP using a convolutional neural network
- Author
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- Zimmerman ED
- Zucchelli S
- Zuklin J
- Zutshi V
- Zwaska R
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
AbstractLiquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments, and is the technology of choice for the Deep Underground Neutrino Experiment (DUNE). In order to perform high precision measurements of neutrinos in the detector, final state particles need to be effectively identified, and their energy accurately reconstructed. This article proposes an algorithm based on a convolutional neural network to perform the classification of energy deposits and reconstructed particles as track-like or arising from electromagnetic cascades. Results from testing the algorithm on experimental data from ProtoDUNE-SP, a prototype of the DUNE far detector, are presented. The network identifies track- and shower-like particles, as well as Michel electrons, with high efficiency. The performance of the algorithm is consistent between experimental data and simulation.</jats:p
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Doping liquid argon with xenon in ProtoDUNE Single-Phase: effects on scintillation light
- Author
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- Abi B
- Acciarri R
- Acero MA
- Adames MR
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- Zimmerman ED
- Zucchelli S
- Zuklin J
- Zutshi V
- Zwaska R
- Publication venue
- Journal of Instrumentation
- Publication date
- 05/08/2024
- Field of study
Abstract
Doping of liquid argon TPCs (LArTPCs) with a small
concentration of xenon is a technique for light-shifting and
facilitates the detection of the liquid argon scintillation
light. In this paper, we present the results of the first doping
test ever performed in a kiloton-scale LArTPC. From February to May
2020, we carried out this special run in the single-phase DUNE Far
Detector prototype (ProtoDUNE-SP) at CERN, featuring 720 t of total
liquid argon mass with 410 t of fiducial mass. A 5.4 ppm nitrogen
contamination was present during the xenon doping campaign. The goal
of the run was to measure the light and charge response of the
detector to the addition of xenon, up to a concentration of
18.8 ppm. The main purpose was to test the possibility for
reduction of non-uniformities in light collection, caused by
deployment of photon detectors only within the anode planes. Light
collection was analysed as a function of the xenon concentration, by
using the pre-existing photon detection system (PDS) of ProtoDUNE-SP
and an additional smaller set-up installed specifically for this
run. In this paper we first summarize our current understanding of
the argon-xenon energy transfer process and the impact of the
presence of nitrogen in argon with and without xenon dopant. We then
describe the key elements of ProtoDUNE-SP and the injection method
deployed. Two dedicated photon detectors were able to collect the
light produced by xenon and the total light. The ratio of these
components was measured to be about 0.65 as 18.8 ppm of xenon were
injected. We performed studies of the collection efficiency as a
function of the distance between tracks and light detectors,
demonstrating enhanced uniformity of response for the anode-mounted
PDS. We also show that xenon doping can substantially recover light
losses due to contamination of the liquid argon by nitrogen.</jats:p
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
- Author
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- Abe A
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