21 research outputs found
Improved method to obtain pfaffic acid as a marker for quality control
Get PDFPfaffic acid, a marker of Hebanthe eriantha (Brazilian ginseng), was first isolated in 1983 but is not yet commercially available. This lack of availability compromises the quality control of this plant and its derivatives. This paper proposes a process for pfaffic acid isolation from roots of H. eriantha at a purity suitable for analytical purposes. The steps involved in this process included extraction, hydrolysis, fractionation and purification by preparative HPLC. This process led to isolation of pfaffic acid with a chromatographic purity of 98.5% in a 0.25% yield from dried roots of H. eriantha; this yield is more than forty times higher than that of the current method in the literature.72572
Uma Cumarina, Ácidos Graxos e o Agente Antitumoral e Hepatoprotetor, Genipina, Detectados na Fruta de Genipa americana (Rubiaceae) da Região de Manaus-AM
No full textRe-Investigação do Extrato Hexânico do Caule da Picrolemma pseudocoffea (Simaroubaceae) por Cromatografia Gasosa Acoplada à Espectrometria de Massas: Detecção de Estigmasta-5,23-dien-3-ol, Estigmast-5-en-3-ol, Ergost-4-en-3-ona e Estigmast-4-en-3-ona
No full textDetecção de Quassinóides no Extrato Hexânico do Caule de Picrolemma pseudocoffea (Simaroubaceae)
No full textInvestigação do Teor de Artemisinina em Folhas de Artemisia annua L. (Asteraceae) ensaiadas na Região Amazônica - Brasil
No full textInorganic and GC-MS Profiles of the Amazonian Medicinal Plant Picrolemma pseudocoffea (Simaroubaceae) from Manaus, Amazonas
No full textImproved method to obtain pfaffic acid as a marker for quality control
No full textPfaffic acid, a marker of Hebanthe eriantha (Brazilian ginseng), was first isolated in 1983 but is not yet commercially available. This lack of availability compromises the quality control of this plant and its derivatives. This paper proposes a process for pfaffic acid isolation from roots of H. eriantha at a purity suitable for analytical purposes. The steps involved in this process included extraction, hydrolysis, fractionation and purification by preparative HPLC. This process led to isolation of pfaffic acid with a chromatographic purity of 98.5% in a 0.25% yield from dried roots of H. eriantha; this yield is more than forty times higher than that of the current method in the literature
Processo De Obtenção De Artemisinina A Partir De Artemisia Annua L.
No full textPROCESSO DE OBTENÇÃO DE ARTEMISININA A PARTIR DE ARTEMISIA ANNUA L, compreendendo o emprego de um processo de extração clássica, juntamente com um processo de extração em série, de modo que as soluções obtidas destes dois processos sejam tratadas com carvão ativado por aproximadamente 1,5 horas a temperatura ambiente, e em seguida filtradas sobre terra diatomita; obtendo-se uma solução de coloração amarelo escuro, na qual foi adicionada uma porção de sílica precipitada; sendo que o solvente é destilado e o sólido obtido (Farofa) é colocado em um extrator adaptado com agitador mecânico; a etuição desta farofa com hexano e subsequente hexano/acetato de etila 15% permitiu obter artemisinina com 91 % e pureza.BR9804730 (B1); BR9804730 (A)A61P33/06A61K35/78A61P33/06BR19989804730A61P33/06A61K35/78A61P33/0
