12 research outputs found
Genome sequencing reveals Zika virus diversity and spread in the Americas
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests
Pseudoaneurisma de carótida comum secundårio a trauma contuso: opção de tratamento por cirurgia a céu aberto Pseudoaneurysm of common carotid due to trauma: treatment option for open sky surgery
Relato de caso de paciente feminina, com 44 anos de idade, vĂtima de trauma cervical em acidente de trĂąnsito, que apresentou massa cervical dolorosa, rouquidĂŁo e disfagia associados, trĂȘs semanas apĂłs o trauma. Exames complementares identificaram pseudoaneurisma de carĂłtida comum em zona II. Optou-se pelo tratamento por meio de cirurgia convencional a cĂ©u aberto com excelente resultado imediato. Foi realizado um exame de controle apĂłs sete meses do procedimento cirĂșrgico, e os resultados confirmaram o sucesso terapĂȘutico.<br>Case report of a female patient, 44 years-old, victim of cervical trauma in a traffic accident, who had painful cervical mass, associated with hoarseness and dysphagia three weeks after trauma. Additional tests identified the pseudoaneurysm of common carotid artery in zone II. We opted for treatment through the open conventional surgery with excellent immediate result. Control examination was performed seven months after surgery, and the results confirmed the therapeutic success
Moving the Dial to Advance Population Health Equity in New York City Asian American Populations
Parasitism Behavior of Tetrastichus howardi (Hymenoptera: Eulophidae) on Larvae and Pupae of Sugarcane Borers
Patients and informal caregiversâ questions about alveolar bone graft post-operative care
Integrative approach for landscape-based graph connectivity analysis: a case study with the common frog (Rana temporaria) in human-dominated landscapes
Prevalence of stunting and overweight/obesity among Brazilian children according to different epidemiological scenarios: systematic review and meta-analysis
DEA performance assessment of mutual funds
The objectives of this paper are manyfold. First we present a comprehensive review of the literature of DEA models for the performance assessment of mutual funds. Then we discuss the problem of the presence of negative returns in DEA modeling for mutual funds and we identify a DEA model that is financially justified and tackles the issue of negative returns in a natural way. Moreover, we present an empirical application on real market data, considering different risk measures.\ud
We consider also different holding periods, which include both a period of financial crisis and one of financial recovery. Moreover, we compare the results of the DEA performance measure with those obtained with traditional financial indicators