ALTERAÇÃO DA GORDURA CORPORAL E DA FUNÇÃO CARDÍACA COM EXERCÍCIO FÍSICO LEVE PRATICADO COM REGULARIDADE

O objetivo foi verificar as alterações da composição corporal e da capacidade aeróbica de mulheres obesas ao longo de um programa de treinamento regular de exercício aeróbio para redução ponderal. Nove voluntárias do sexo feminino com idade de 39,0±17,8 anos e gordura superior a 30% foram submetidas à avaliação funcional inicial para obtenção dos valores de peso corporal, estatura, dobras cutâneas, percentual de gordura, massa corporal magra e capacidade aeróbica (VO2 máx). Então, iniciaram um programa de caminhada com a intensidade de 50 a 80% da freqüência cardíaca de reserva, duração de 30 a 60 minutos e freqüência de 4 vezes por semana. Após 12 semanas de treinamento foi realizada a avaliação funcional final. A significância das diferenças foi determinada por Teste t de Student (p < 0,05). O peso corporal diminuiu de 77,7±10,9 para 75,8±10,0 Kg, a massa magra aumentou de 48,7±4,5 para 51,0±4,7 Kg e o VO2 max aumentou de 28,8±5,7 para 33,8±5,4 mL.kg-¹.min-¹, porém apenas a gordura diminuiu significativamente de 36,9±4,5 para 32,4±3,9% (p < 0,05). Conclui-se que o treinamento alterou de forma positiva o peso corporal, a massa magra e capacidade aeróbica, mas sobretudo foi eficiente para reduzir a gordura corporal

USO DO KINECT PARA MONITORAMENTO DE EXERCÍCIOS FÍSICOS REALIZADOS POR PESSOAS DE TERCEIRA IDADE

O constante crescimento da população idosa no Brasil e no mundo é um importante indicativo que as pessoas estão vivendo mais, mas não quer dizer que estão vivendo melhor. O processo de envelhecimento está atrelado a importantes perdas da capacidade do indivíduo, tanto das capacidades físicas como também das capacidades funcionais, levando a diminuição da independência do idoso. Estudando a literatura da área, é possível perceber que a prática de exercícios físicos contribui de maneira significativa para a manutenção da aptidão física do idoso. Neste trabalho foram realizados estudos a fim de identificar alternativas para auxiliar o idoso na prática de atividades físicas, por meio da inserção de recursos tecnológicos, como o sensor de movimentos Kinect, para acompanhar a realização dos exercícios, além de torná-la atrativa e motivadora

BARCO DE PVC

Esse trabalho tem como objetivo o auxílio a pessoas, em enchentes que precisem se locomover, mediante a construção de um barco de PVC. Uma grande ocasião foram as enchentes de 1983/1984 na região do vale do Itajaí, onde o rio Itajaí Açu atingiu seu nível máximo (15 metros e 34 centímetros). O barco terá baixo custo e, por isso servirá de barco de emergência para pessoas carentes. As enchentes são devastadoras, mas há várias maneiras de se evitar ou precaver contra esse fenômeno, evitando a poluição das ruas o nível das enchentes já diminuiriam muito, mas isso não é o suficiente para evitar as enchentes. Então uma boa alternativa é o barco de canos de PVC pois é muito barato assim, podendo ajudar a população em áreas de risco. Esse projeto possui como objetivo principal o auxílio a pessoas que não possuem forma de locomoção em enchentes. O projeto possui baixo custo comparado a um barco convencional e, por isso, é uma boa opção para pessoas com baixa renda que queiram se precaver contra enchentes. No projeto, foram utilizados: 4 canos de PVC de 100 milímetros de diâmetro com 2,90 metros de comprimento, 10 tábuas de madeiras de 1 metro por 21 centímetros, 2 tábuas de 2 metros por 20 centímetros, 2 tábuas de 1 metro por 20 centímetros, parafusos, fita de metal e uma parafusadeir

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

La educación y la globalización

Uno de los aspectos importantes que pretende la misión y visión de la Universidad Autónoma de Ciudad Juárez, División Multidisciplinaria de Nuevo Casas Grandes (UACJ-DMNCG) es la de formar profesionales competitivos a nivel internacional a través de programas educativos de calidad. PIDE, (2012, p.32). Para cumplir con este propósito es necesario aplicar investigación, nuevas estrategias didácticas y técnicas de la mejora continua (KAIZEN) a los procesos educativos vigentes de la UACJ-DMNCG

Solitary fibrous tumor of the thigh with epithelioid features: a case

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

UTILIZAÇÃO DOS RECURSOS DO IOS PARA MONITORAR PESSOAS DE TERCEIRA IDADE NA PRÁTICA DE ATIVIDADES FÍSICAS

The growth of the elderly population in recent days is an important indicator of longevity. The aging process is linked to important losses in several physical capabilities, which lead to decreased functional capacity and independence of the elderly In studies in the literature, it is observed that these changes put at risk the quality of life of these people, by limiting their ability to perform, with vigor, their daily activities and put in greater vulnerability to your health. The physical exercise contributes significantly to the maintenance of physical fitness of the elderly, influencing both in their health and in their functional capabilities. However, the physical exercises may present some limitations, due to physiological changes imposed on the aging process. An application was developed in this work to provide a resource for people of old age, so that they can exercise safely with some control over what is happening during this practice. This feature also shows a great attraction for these people, making good use of technology focused on health, in addition to promoting safety, easy physiological monitoring during physical activity

Clinical and treatment outcomes of a second subcutaneous or intravenous anti-TNF in patients with ulcerative colitis treated with two consecutive anti-TNF agents: data from the ENEIDA registry

Background: Infliximab seems to be the most efficacious of the three available anti-TNF agents for ulcerative colitis (UC) but little is known when it is used as the second anti-TNF. Objectives: To compare the clinical and treatment outcomes of a second subcutaneous or intravenous anti-TNF in UC patients. Design: Retrospective observational study. Methods: Patients from the ENEIDA registry treated consecutively with infliximab and a subcutaneous anti-TNF (or vice versa), naïve to other biological agents, were identified and grouped according to the administration route of the first anti-TNF into IVi (intravenous initially) or SCi (subcutaneous initially). Results: Overall, 473 UC patients were included (330 IVi and 143 SCi). Clinical response at week 14 was 42.7% and 48.3% in the IVi and SCi groups (non-statistically significant), respectively. Clinical remission rates at week 52 were 32.8% and 31.4% in the IVi and SCi groups (nonsignificant differences), respectively. A propensity-matched score analysis showed a higher clinical response rate at week 14 in the SCi group and higher treatment persistence in the IVi group. Regarding long-term outcomes, dose escalation and discontinuation due to the primary failure of the first anti-TNF and more severe disease activity at the beginning of the second anti-TNF were inversely associated with clinical remission. Conclusion: The use of a second anti-TNF for UC seems to be reasonable in terms of efficacy, although it is particularly reduced in the case of the primary failure of the first anti-TNF. Whether the second anti-TNF is infliximab or subcutaneous does not seem to affect efficacy