Response Surface Method to Calculate Energy Savings Associated with Thermal Comfort Improvement in Buildings

In developed countries, a large part of the building stock in 2050 will consist of currently existing buildings. Consequently, in order to achieve the objectives in terms of energy efficiency in the building sector we must consider not only new infrastructures but also the old ones. A reduction in energy consumption for climate control of between 50 and 90% can be achieved by rehabilitation and the implementation of different energy efficiency measures. Currently, these measures to reduce energy consumption and associated CO2 emissions can be modelled using computer tools. However, high precision and detail of thermal behaviour models through simulations can mean a great computational cost for companies, which results in a blockage of servers and workers. In this paper, the Response Surface Methodology (RSM) is presented as an innovative methodology for the simplification of models for calculation of the energy savings associated with thermal comfort improvement in buildings. A single-family house model, located in three different climates, is presented as a case study in order to validate the proposed methodology. Different scenarios were simulated, addressing heating and cooling temperature set points and external wall insulation represented by the transmittance (U-value). Results obtained from energy simulation using Design Builder were contrasted against those estimated from the simplified model extracted from the RSM analysis. The results revealed a deviation lower than 3% when comparing both methods. Therefore, the simplified mathematical prediction models are demonstrated to be suitable for the study of the energy performance of buildings, saving computational time, costs and associated human resources. © 2022 by the authors. Licensee MDPI, Basel, Switzerland

Indoor free space optics link under the weak turbulence regime: measurements and model validation

This paper is a postprint of a paper submitted to and accepted for publication in [journal] and is subject to Institution of Engineering and Technology Copyright. The copy of record is available at IET Digital LibraryIn this study, the authors present the measurements performed on a free space optics (FSO) communications link using an indoor atmospheric chamber. In particular, the authors have generated several different optical turbulence conditions, demonstrating how even the weak turbulence regime can strongly affect the FSO link performance. The authors have carried out an in-depth analysis of the data collected during the measurements, and calculated the turbulence strength (i.e. scintillation index and Rytov variance) and the important performance metrics (i.e. the Q-factor and bit error rate) to evaluate the FSO link quality. Moreover, the authors have tested, for the first time, an appositely developed temporally-correlated gamma-gamma channel model to generate the temporal irradiance fluctuations observed at the receiver. This has been accomplished by using a complete analysis tool that enables the authors to fully simulate the experimental FSO link. Finally, the authors compare the generated time-series with the collected experimental data, showing a good agreement and thus proving the effectiveness of the model.This work was supported by the European Space Agency under grant no. 5401001020. We are very grateful to Dr. E. Armandillo for enlightening discussions. J. Perez's work was support by Spanish MINECO Juan de la Cierva Fellowship JCI-2012-14805. This research project falls within the frame of COST ICT Action IC1101 - Optical Wireless Communications - An Emerging Technology (OPTICWISE).Pernice, R.; Ando, A.; Cardinale, M.; Curcio, L.; Stivala, S.; Parisi, A.; Busacca, AC.... (2015). Indoor free space optics link under the weak turbulence regime: measurements and model validation. IET Communications. 9(1):62-70. https://doi.org/10.1049/iet-com.2014.0432S627091Tsukamoto, K., Hashimoto, A., Aburakawa, Y., & Matsumoto, M. (2009). The case for free space. IEEE Microwave Magazine, 10(5), 84-92. doi:10.1109/mmm.2009.933086Suriza, A. Z., Md Rafiqul, I., Wajdi, A. K., & Naji, A. W. (2013). Proposed parameters of specific rain attenuation prediction for Free Space Optics link operating in tropical region. Journal of Atmospheric and Solar-Terrestrial Physics, 94, 93-99. doi:10.1016/j.jastp.2012.11.008Nebuloni, R. (2005). Empirical relationships between extinction coefficient and visibility in fog. Applied Optics, 44(18), 3795. doi:10.1364/ao.44.003795García-Zambrana, A., Castillo-Vázquez, C., & Castillo-Vázquez, B. (2011). Outage performance of MIMO FSO links over strong turbulence and misalignment fading channels. Optics Express, 19(14), 13480. doi:10.1364/oe.19.013480Shokrollahi, A. (2006). Raptor codes. IEEE Transactions on Information Theory, 52(6), 2551-2567. doi:10.1109/tit.2006.874390MacKay, D. J. C. (2005). Fountain codes. IEE Proceedings - Communications, 152(6), 1062. doi:10.1049/ip-com:20050237Uysal, M., Jing Li, & Meng Yu. (2006). Error rate performance analysis of coded free-space optical links over gamma-gamma atmospheric turbulence channels. IEEE Transactions on Wireless Communications, 5(6), 1229-1233. doi:10.1109/twc.2006.1638639Tsiftsis, T. A. (2008). Performance of heterodyne wireless optical communication systems over gamma-gamma atmospheric turbulence channels. Electronics Letters, 44(5), 373. doi:10.1049/el:20083028Popoola, W. O., & Ghassemlooy, Z. (2009). BPSK Subcarrier Intensity Modulated Free-Space Optical Communications in Atmospheric Turbulence. Journal of Lightwave Technology, 27(8), 967-973. doi:10.1109/jlt.2008.2004950Nistazakis, H. E., Tsiftsis, T. A., & Tombras, G. S. (2009). Performance analysis of free-space optical communication systems over atmospheric turbulence channels. IET Communications, 3(8), 1402. doi:10.1049/iet-com.2008.0212Bayaki, E., Schober, R., & Mallik, R. (2009). Performance analysis of MIMO free-space optical systems in gamma-gamma fading. IEEE Transactions on Communications, 57(11), 3415-3424. doi:10.1109/tcomm.2009.11.080168Anguita, J. A., Neifeld, M. A., Hildner, B., & Vasic, B. (2010). Rateless Coding on Experimental Temporally Correlated FSO Channels. Journal of Lightwave Technology, 28(7), 990-1002. doi:10.1109/jlt.2010.2040136Andò, A., Mangione, S., Curcio, L., Stivala, S., Garbo, G., Pernice, R., & Busacca, A. C. (2013). Recovery Capabilities of Rateless Codes on Simulated Turbulent Terrestrial Free Space Optics Channel Model. International Journal of Antennas and Propagation, 2013, 1-8. doi:10.1155/2013/692915Ghassemlooy, Z., Le Minh, H., Rajbhandari, S., Perez, J., & Ijaz, M. (2012). Performance Analysis of Ethernet/Fast-Ethernet Free Space Optical Communications in a Controlled Weak Turbulence Condition. Journal of Lightwave Technology, 30(13), 2188-2194. doi:10.1109/jlt.2012.2194271Xiaoming Zhu, & Kahn, J. M. (2002). Free-space optical communication through atmospheric turbulence channels. IEEE Transactions on Communications, 50(8), 1293-1300. doi:10.1109/tcomm.2002.800829Xu, F., Khalighi, A., Caussé, P., & Bourennane, S. (2009). Channel coding and time-diversity for optical wireless links. Optics Express, 17(2), 872. doi:10.1364/oe.17.00087

American palm ethnomedicine: A meta-analysis

<p>Abstract</p> <p>Background</p> <p>Many recent papers have documented the phytochemical and pharmacological bases for the use of palms (<it>Arecaceae</it>) in ethnomedicine. Early publications were based almost entirely on interviews that solicited local knowledge. More recently, ethnobotanically guided searches for new medicinal plants have proven more successful than random sampling for identifying plants that contain biodynamic ingredients. However, limited laboratory time and the high cost of clinical trials make it difficult to test all potential medicinal plants in the search for new drug candidates. The purpose of this study was to summarize and analyze previous studies on the medicinal uses of American palms in order to narrow down the search for new palm-derived medicines.</p> <p>Methods</p> <p>Relevant literature was surveyed and data was extracted and organized into medicinal use categories. We focused on more recent literature than that considered in a review published 25 years ago. We included phytochemical and pharmacological research that explored the importance of American palms in ethnomedicine.</p> <p>Results</p> <p>Of 730 species of American palms, we found evidence that 106 species had known medicinal uses, ranging from treatments for diabetes and leishmaniasis to prostatic hyperplasia. Thus, the number of American palm species with known uses had increased from 48 to 106 over the last quarter of a century. Furthermore, the pharmacological bases for many of the effects are now understood.</p> <p>Conclusions</p> <p>Palms are important in American ethnomedicine. Some, like <it>Serenoa repens </it>and <it>Roystonea regia</it>, are the sources of drugs that have been approved for medicinal uses. In contrast, recent ethnopharmacological studies suggested that many of the reported uses of several other palms do not appear to have a strong physiological basis. This study has provided a useful assessment of the ethnobotanical and pharmacological data available on palms.</p

MITF deficiency and oncogenic GNAQ each promote proliferation programs in zebrafish melanocyte lineage cells

Uveal melanoma (UM) is the most common primary malignancy of the adult eye but lacks any FDA-approved therapy for the deadly metastatic disease. Thus, there is a great need to dissect the driving mechanisms for UM and develop strategies to evaluate potential therapeutics. Using an autochthonous zebrafish model, we previously identified MITF, the master melanocyte transcription factor, as a tumor suppressor in GNAQQ209L -driven UM. Here, we show that zebrafish mitfa-deficient GNAQQ209L -driven tumors significantly up-regulate neural crest markers, and that higher expression of a melanoma-associated neural crest signature correlates with poor UM patient survival. We further determined how the mitfa-null state, as well as expression of GNAQQ209L , YAPS127A;S381A , or BRAFV600E oncogenes, impacts melanocyte lineage cells before they acquire the transformed state. Specifically, examination 5 days post-fertilization showed that mitfa-deficiency is sufficient to up-regulate pigment progenitor and neural crest markers, while GNAQQ209L expression promotes a proliferative phenotype that is further enhanced by YAPS127A;S381A co-expression. Finally, we show that this oncogene-induced proliferative phenotype can be used to screen chemical inhibitors for their efficacy against the UM pathway. Overall, this study establishes that a neural crest signature correlates with poor UM survival, and describes an in vivo assay for preclinical trials of potential UM therapeutics