144 research outputs found
MESURE DES GRADIENTS DE DENSITÉ DANS L'INTERACTION LASER-PLASMA
Nous étudions la densité électronique et son gradient dans l'interaction d'un laser à CO2 avec une cible plane de polyéthylène, pour un flux laser de 1012 W/cm2. L'étude par interférométrie Jamin des profils de densité et la mesure strioscopique de son gradient, couplées à l'étude de l'image en rayons X du plasma conduisent à une valeur de 220 ± 80 µm de la longueur du gradient de densité. Ceci est confirmé par des mesures indirectes obtenues à partir du bilan optique de l'interaction et du seuil de génération de l'harmonique 3/2 ω0 du laser à CO2. Les conséquences de ces résultats sur les conditions de l'interaction sont discutées
The near-critical planar FK-Ising model
We study the near-critical FK-Ising model. First, a determination of the
correlation length defined via crossing probabilities is provided. Second, a
phenomenon about the near-critical behavior of FK-Ising is highlighted, which
is completely missing from the case of standard percolation: in any monotone
coupling of FK configurations (e.g., in the one introduced in
[Gri95]), as one raises near , the new edges arrive in a
self-organized way, so that the correlation length is not governed anymore by
the number of pivotal edges at criticality.Comment: 34 pages, 8 figures. This is a streamlined version; the previous one
contains more explanations and additional material on exceptional times in FK
models with general . Furthermore, the statement and proof of Theorem 1.2
have slightly change
Explicit formulae in probability and in statistical physics
We consider two aspects of Marc Yor's work that have had an impact in
statistical physics: firstly, his results on the windings of planar Brownian
motion and their implications for the study of polymers; secondly, his theory
of exponential functionals of Levy processes and its connections with
disordered systems. Particular emphasis is placed on techniques leading to
explicit calculations.Comment: 14 pages, 2 figures. To appear in Seminaire de Probabilites, Special
Issue Marc Yo
Noise Sensitivity in Continuum Percolation
We prove that the Poisson Boolean model, also known as the Gilbert disc
model, is noise sensitive at criticality. This is the first such result for a
Continuum Percolation model, and the first for which the critical probability
p_c \ne 1/2. Our proof uses a version of the Benjamini-Kalai-Schramm Theorem
for biased product measures. A quantitative version of this result was recently
proved by Keller and Kindler. We give a simple deduction of the
non-quantitative result from the unbiased version. We also develop a quite
general method of approximating Continuum Percolation models by discrete models
with p_c bounded away from zero; this method is based on an extremal result on
non-uniform hypergraphs.Comment: 42 page
Functionals of the Brownian motion, localization and metric graphs
We review several results related to the problem of a quantum particle in a
random environment.
In an introductory part, we recall how several functionals of the Brownian
motion arise in the study of electronic transport in weakly disordered metals
(weak localization).
Two aspects of the physics of the one-dimensional strong localization are
reviewed : some properties of the scattering by a random potential (time delay
distribution) and a study of the spectrum of a random potential on a bounded
domain (the extreme value statistics of the eigenvalues).
Then we mention several results concerning the diffusion on graphs, and more
generally the spectral properties of the Schr\"odinger operator on graphs. The
interest of spectral determinants as generating functions characterizing the
diffusion on graphs is illustrated.
Finally, we consider a two-dimensional model of a charged particle coupled to
the random magnetic field due to magnetic vortices. We recall the connection
between spectral properties of this model and winding functionals of the planar
Brownian motion.Comment: Review article. 50 pages, 21 eps figures. Version 2: section 5.5 and
conclusion added. Several references adde
Comparison of the Hemostatic Efficacy of Pathogen-Reduced Platelets vs Untreated Platelets in Patients With Thrombocytopenia and Malignant Hematologic Diseases: A Randomized Clinical Trial
Importance: Pathogen reduction of platelet concentrates may reduce transfusion-transmitted infections but is associated with qualitative impairment, which could have clinical significance with regard to platelet hemostatic capacity.
Objective: To compare the effectiveness of platelets in additive solution treated with amotosalen-UV-A vs untreated platelets in plasma or in additive solution in patients with thrombocytopenia and hematologic malignancies.
Design, Setting, and Participants: The Evaluation of the Efficacy of Platelets Treated With Pathogen Reduction Process (EFFIPAP) study was a randomized, noninferiority, 3-arm clinical trial performed from May 16, 2013, through January 21, 2016, at 13 French tertiary university hospitals. Clinical signs of bleeding were assessed daily until the end of aplasia, transfer to another department, need for a specific platelet product, or 30 days after enrollment. Consecutive adult patients with bone marrow aplasia, expected hospital stay of more than 10 days, and expected need of platelet transfusions were included.
Interventions: At least 1 transfusion of platelets in additive solution with amotosalen-UV-A treatment, in plasma, or in additive solution.
Main Outcomes and Measures: The proportion of patients with grade 2 or higher bleeding as defined by World Health Organization criteria.
Results: Among 790 evaluable patients (mean [SD] age, 55 [13.4] years; 458 men [58.0%]), the primary end point was observed in 126 receiving pathogen-reduced platelets in additive solution (47.9%; 95% CI, 41.9%-54.0%), 114 receiving platelets in plasma (43.5%; 95% CI, 37.5%-49.5%), and 120 receiving platelets in additive solution (45.3%; 95% CI, 39.3%-51.3%). With a per-protocol population with a prespecified margin of 12.5%, noninferiority was not achieved when pathogen-reduced platelets in additive solution were compared with platelets in plasma (4.4%; 95% CI, -4.1% to 12.9%) but was achieved when the pathogen-reduced platelets were compared with platelets in additive solution (2.6%; 95% CI, -5.9% to 11.1%). The proportion of patients with grade 3 or 4 bleeding was not different among treatment arms.
Conclusions and Relevance: Although the hemostatic efficacy of pathogen-reduced platelets in thrombopenic patients with hematologic malignancies was noninferior to platelets in additive solution, such noninferiority was not achieved when comparing pathogen-reduced platelets with platelets in plasma.
Trial Registration: clinicaltrials.gov Identifier: NCT01789762
MKS3/TMEM67 mutations are a major cause of COACH syndrome, a joubert syndrome related disorder with liver involvement
The acronym COACH defines an autosomal recessive condition of Cerebellar vermis hypo/
aplasia, Oligophrenia, congenital Ataxia, Coloboma and Hepatic fibrosis. Patients present the
“molar tooth sign”, a midbrain-hindbrain malformation pathognomonic for Joubert Syndrome (JS) and Related Disorders (JSRDs). The main feature of COACH is congenital hepatic fibrosis (CHF), resulting from malformation of the embryonic ductal plate. CHF is invariably found also in Meckel syndrome (MS), a lethal ciliopathy already found to be allelic with JSRDs at the CEP290 and RPGRIP1L genes. Recently, mutations in the MKS3 gene (approved symbol TMEM67), causative of about 7% MS cases, have been detected in few Meckel-like and pure JS patients. Analysis of MKS3 in 14 COACH families identified mutations in 8 (57%). Features such as colobomas and nephronophthisis were found only in a subset of mutated cases. These data confirm COACH as a distinct JSRD subgroup with core features of JS plus CHF, which major gene is MKS3, and further strengthen gene-phenotype correlates in JSRDs
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