2,284 research outputs found

    Tuning phase-stability and short-range order through Al-doping in (CoCrFeMn)100-xAlx high entropy alloys

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    For (CoCrFeMn)100−x_{100-x}Alx_{x} high-entropy alloys, we investigate the phase evolution with increasing Al-content (0 ≤\le x ≤\le 20 at.%). From first-principles theory, the Al-doping drives the alloy structurally from FCC to BCC separated by a narrow two-phase region (FCC+BCC), which is well supported by our experiments. We highlight the effect of Al-doping on the formation enthalpy and electronic structure of (CoCrFeMn)100−x_{100-x}Alx_{x} alloys. As chemical short-range order (SRO) in multicomponent alloys indicates the nascent local order (and entropy changes), as well as expected low-temperature ordering behavior, we use thermodynamic linear-response within density-functional theory to predict SRO and ordering transformation and temperatures inherent in (CoCrFeMn)100−x_{100-x}Alx_{x}. The predictions agree with our present experimental findings, and other reported ones.Comment: 27 pages, 9 figures, 1 tabl

    Functional and radiological outcome of comminuted shaft of humerus fracture treated by dynamic compression plate

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    Background: Humeral shaft fractures represents between 3% and 5% of all fractures of which a certain number of patients require surgical intervention. This study aims to determine the efficacy of dynamic compression plate in the treatment of humeral shaft fractures.Methods: A prospective study was carried out over a period of 2 years in Sri Ramachandra Medical College, Chennai including 30 cases of shaft of humerus fractures treated by open reduction and internal fixation using Dynamic Compression plate among which both comminuted and segmental closed shaft of humerus fractures were included. While open fractures and ipsilateral forearm and clavicle fractures were excluded. AO classification was used to classify the fractures and the average follow up period was two years. The American Shoulder and Elbow Surgeons (ASES) shoulder score and Romen al series grading were used.Results: We had 93.3% excellent/good result and 6.7% poor results. In our series we had one non-union, one delayed union and one case of deep infection.Conclusions: Proper preoperative planning, minimal soft tissue dissection, strict asepsis, proper postoperative rehabilitation and patient education were essential to obtain excellent results. Early post-operative mobilization following rigid fixation of the fracture of humerus, with DCP lowered the incidence of stiffness and sudecks dystrophy

    The dyad gene is required for progression through female meiosis in Arabidopsis

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    In higher plants the gametophyte consists of a gamete in association with a small number of haploid cells, specialized for sexual reproduction. The female gametophyte or embryo sac, is contained within the ovule and develops from a single cell, the megaspore which is formed by meiosis of the megaspore mother cell. The dyad mutant of Arabidopsis, described herein, represents a novel class among female sterile mutants in plants, dyad ovules contain two large cells in place of an embryo sac. The two cells represent the products of a single division of the megaspore mother cell followed by an arrest in further development of the megaspore. We addressed the question of whether the division of the megaspore mother cell in the mutant was meiotic or mitotic by examining the expression of two markers that are normally expressed in the megaspore mother cell during meiosis. Our observations indicate that in dyad the megaspore mother cell enters but fails to complete meiosis, arresting at the end of meiosis 1 in the majority of ovules, This was corroborated by a direct observation of chromosome segregation during division of the megaspore mother cell, showing that the division is a reductional and not an equational one. In a minority of dqad ovules, the megaspore mother cell does not divide. Pollen development and male fertility in the mutant is normal, as is the rest of the ovule that surrounds the female gametophyte. The embryo sac is also shown to have an influence on the nucellus in wild type. The dyad mutation therefore specifically affects a function that is required in the female germ cell precursor for meiosis. The identification and analysis of mutants specifically affecting female meiosis is an initial step in understanding the molecular mechanisms underlying early events in the pathway of female reproductive development

    Knowledge, attitude, and practices among clinically exposed medical students and interns towards COVID-19 vaccine in a tertiary care hospital, Kanyakumari district: a cross-sectional survey

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    Background: Several COVID-19 vaccines have been approved against coronavirus disease and its distribution to different countries. The study is mainly done to determine the knowledge, attitude, and practice among clinically exposed medical students and interns toward COVID-19 vaccine.Methods: A cross-sectional study was conducted from June 2022 to August 2022 in a tertiary care hospital. Using questionnaires, the knowledge, attitude, and practice among medical students and interns were assessed, and they were then analysed and categorised accordingly. Then the students were given awareness regarding COVID-19 vaccine.Results: The questionnaires were distributed among students and interns, and responses were collected. A total number of participants (n=300), out of which the majority of responders were second-year students 89 (29.6%). Overall, 39.75% had high-grade knowledge, 43.5% had a positive attitude and 37.5% had good practice regarding the COVID-19 vaccine. The results show that 81.2% of interns had high-grade knowledge, 76.6% possess a positive attitude and 71.9% of good practice and preventive measures towards COVID-19 vaccine.Conclusions: Our study concludes that there were certain gaps in knowledge, attitude, and practice among second and third-year medical students when compared with final-year medical students and interns

    Analysis of the Alignment of Micro-Steel Fibers in Admixture-Based Self-Compacting Concrete (MSFR-SCC) using NDT and Evaluation of Its Effect on the Modulus of Rupture

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    Self-compacting concrete (SCC) is a particular type of concrete that flows and becomes consolidated under its own weight. Various have been conducted to enhance its performance. Key developments have been the addition of fibers and replacement of the mineral admixtures; several studies have focused on varying these factors in different proportions to produce a high performance concrete. However, there is no standard mix design for self-compacting concrete containing admixtures. Therefore, optimization of the mix design is very important in order to save time and to develop an economical SCC, but there has been no detailed study of mix design and optimization of materials, and no research into the alignment and orientation of the steel fibers. Along with the uniform dispersion of fibers, few steps have been taken to optimally align the micro steel fibers, with ultrasonic pulse velocity used to justify their distribution and alignment. These factors were taken into consideration in this study. The results show that the addition of steel fibers reduces the rheological properties of the concrete by 40%-55% compared to the control mix (MC1), although all the mixtures (MC1-MX4) justified the guidelines set by EFNARC (European Federation of National Association Representing for Concrete). All the specimens failed under shear. The addition of hooked-end micro steel increased the flexural strength compared to the control mixture and a 60% increase in MX4 and 75% increase in MA7 were observed compared to MC1. The fibers were aligned along the direction of flow and the alignment properties was justified by flexural strength and UPV. A regression equation was finally developed between flexural strength and UPV for future development, which predicts the behavior of micro steel fiber reinforced self-compacting concrete (MSFRSCC)

    Intelligent Integration of a Wind Farm to an Utility Power Network with Improved Voltage Stability

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    The increasing effect of wind energy generation will influence the dynamic behavior of power systems by interacting with conventional generation and loads. Due to the inherent characteristics of wind turbines, non-uniform power production causes variations in system voltage and frequency. Therefore, a wind farm requires high reactive power compensation. Flexible AC transmission systems (FACTS) devices such as SVCs inject reactive power into the system which helps in maintaining a better voltage profile. This paper presents the design of a linear and a nonlinear coordinating controller between a SVC and the wind farm inverter at the point of interconnection. The performances of the coordinating controllers are evaluated on the IEEE 12 bus FACTS benchmark power system where one of the generators is replaced by a wind farm supplying 300 MW. Results are presented to show that the voltage stability of the entire power system during small and large disturbances is improved

    DEVELOPMENT OF OSMOTICALLY CONTROLLED ORAL DRUG DELIVERY SYSTEM FOR NATEGLINIDE AN ANTI-DIABETIC DRUG

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    Objective: The purpose of the present study was to develop an oral push-pull osmotic drug delivery system for the drug Nateglinide which is a bio pharmaceutics classification system (BCS) class II drug. Methods: The tablets were prepared by the wet granulation method using ingredients microcrystalline cellulose (Adsorbent), potassium chloride (Osmotic agent), poly ethylene glycol (4000 and 6000) (Hydrophilic polymer, Plasticizer), starch (Disintegrant), and aerosil. The granules were compacted by double compression method and were coated with eudragit by dipping method. Different batches were prepared to study the effect of the various ingredients and their effect on the release of the drug from the system by varying the concentrations of the ingredients in each batch. Dissolution was assessed using USP dissolution apparatus 2 in phosphate buffer pH 6.8 for 12 h. Results: Certain key findings observed includes a decrease in micro crystalline cellulose content reduced the release of the drug due to the reduction of the hydrophilic content in the tablet which complements the uptake of water from the surroundings, and increase in the ethylene glycol leads to decrease in the release which resulted due to excess swelling and increase in the osmotic agent concentration lead to satisfactory release of the drug and followed zero-order release. Conclusion: To conclude, the push-pull osmotic tablet of Nateglinide was able to deliver the drug in a controlled pattern for a prolonged period of time. This type of formulation can be used in conditions like hyperglycemia where the patient compliance can improve by reducing the dosing frequency and the plasma drug levels can be maintained, the total drug load is also reduced so that the dose related side-effects are also reduced. Keywords: Controlled release, Push-pull osmotic pump, Nateglinid
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