Control of human cytomegalovirus replication by liver resident natural killer cells

Natural killer cells are considered to be important for control of human cytomegalovirus– a major pathogen in immune suppressed transplant patients. Viral infection promotes the development of an adaptive phenotype in circulating natural killer cells that changes their anti-viral function. In contrast, less is understood how natural killer cells that reside in tissue respond to viral infection. Here we show natural killer cells resident in the liver have an altered phenotype in cytomegalovirus infected individuals and display increased anti-viral activity against multiple viruses in vitro and identify and characterise a subset of natural killer cells responsible for control. Crucially, livers containing natural killer cells with better capacity to control cytomegalovirus replication in vitro are less likely to experience viraemia post-transplant. Taken together, these data suggest that virally induced expansion of tissue resident natural killer cells in the donor organ can reduce the chance of viraemia post-transplant

Control of human cytomegalovirus replication by liver resident natural killer cells

Natural killer cells are considered to be important for control of human cytomegalovirus– a major pathogen in immune suppressed transplant patients. Viral infection promotes the development of an adaptive phenotype in circulating natural killer cells that changes their anti-viral function. In contrast, less is understood how natural killer cells that reside in tissue respond to viral infection. Here we show natural killer cells resident in the liver have an altered phenotype in cytomegalovirus infected individuals and display increased anti-viral activity against multiple viruses in vitro and identify and characterise a subset of natural killer cells responsible for control. Crucially, livers containing natural killer cells with better capacity to control cytomegalovirus replication in vitro are less likely to experience viraemia post-transplant. Taken together, these data suggest that virally induced expansion of tissue resident natural killer cells in the donor organ can reduce the chance of viraemia post-transplant

Visitante profundo.English & Spanis

Immanent Visitor is the first English-language translation of the work of Bolivia's greatest and most visionary twentieth-century poet. A poète maudit, Jaime Saenz rejected the conventions of polite society and became a monk in service of his own imagination. Apocalyptic and occult in his politics, a denizen of slum taverns, unashamedly bisexual, insistently nocturnal in his artistic affairs, and secretive in his leadership of a select group of writers, Saenz mixed the mystical and baroque with the fantastic, the psychological, and the symbolic. In masterly translations by two poet-translators, Kent Johnson and Forrest Gander, Saenz's strange, innovative, and wildly lyrical poems reveal a literary legacy of fierce compassion and solidarity with indigenous Bolivian cultures and with the destitute, the desperate, and the disenfranchised of that unreal city, La Paz. In long lines, in odes that name desire, with Whitmanesque anaphora, in exclamations and repetitions, Saenz addresses the reader, the beloved, and death in one extended lyrical gesture. The poems are brazenly affecting. Their semantic innovation is notable in the odd heterogeneity of formal and tonal structures that careen unabashedly between modes and moods; now archly lyrical, now arcanely symbolic, now colloquial, now trancelike. As Saenz's reputation continues to grow throughout the world, these inspired translations and the accompanying Spanish texts faithfully convey the poet's unique vision and voice to English-speaking readers

\u3cem\u3eThe Ecopoetry Anthology\u3c/em\u3e: A Reading and Discussion

Ann Fisher-Wirth, moderato