BURNOUT HEAT FLUXES FOR LOW-PRESSURE WATER IN NATURAL CIRCULATION

Twenty-nine experimental determinations of burn-out heat flux were made with water flowing by natural circulaion through electrically heated vertical tubes with and without internal twisted tapes and through rectangular cross sections of three aspect ratios. Heated lengths varied from 10 to 33 in., system pressure at the testsection flow exit from 14.7 to 26.3 psia, inlet subcooling from 36 to 170 deg F, and burn-out heat flux from 13,000 to 218,500 Btu/hr/sq ft. Tests were made with both unrestricted and restricted return flow paths. Three correlations were developed for predicting natural-circulation burn-out heat fluxes for such conditions. Two are useful for rapid estimation but the third involves a more fundamental assessment of the coolant mass velocity at burn-out by a graphical matching of the heat flux that a given flow rate can sustain to the heat flux that will produce that flow rate. For all the data, this approach gave average and maximum deviations of 15 and 38%, respectively. It was found that use of a slip ratio of unity is adequate for burnout prediction, and the reasons for this are discussed in detail. The small burn-out penalty incurred by a substantial restriction of return flow path, experimentally observed, is in complete accord with the theoretical model. (auth

Burnout Heat Fluxes for Low-Pressure Water in Natural Circulation

Twenty-nine experimental determinations of burn-out heat flux were made with water flowing by natural circulaion through electrically heated vertical tubes with and without internal twisted tapes and through rectangular cross sections of three aspect ratios. Heated lengths varied from 10 to 33 in., system pressure at the testsection flow exit from 14.7 to 26.3 psia, inlet subcooling from 36 to 170 deg F, and burn-out heat flux from 13,000 to 218,500 Btu/hr/sq ft. Tests were made with both unrestricted and restricted return flow paths. Three correlations were developed for predicting natural-circulation burn-out heat fluxes for such conditions. Two are useful for rapid estimation but the third involves a more fundamental assessment of the coolant mass velocity at burn-out by a graphical matching of the heat flux that a given flow rate can sustain to the heat flux that will produce that flow rate. For all the data, this approach gave average and maximum deviations of 15 and 38%, respectively. It was found that use of a slip ratio of unity is adequate for burnout prediction, and the reasons for this are discussed in detail. The small burn-out penalty incurred by a substantial restriction of return flow path, experimentally observed, is in complete accord with the theoretical model. (auth

HFIR HEAT-TRANSFER STUDIES OF TURBULENT WATER FLOW IN THIN RECTANGULAR CHANNELS

In support of the High Flux Isotope Reactor program, experimental determinations were made of friction factors, burnout heat fluxes, and average and local nonboiling heattransfer coefficients for forced-convection flow of water through this aluminum and nickel rectangular channels under the following conditions: heat flux = 0.1 x 10/sup 6/ to 7.4 x 10/sup 6/ Btu/hr - ft/sup 2/, velocity = 10 to 85 fps, Reynolds number = 9,000 to 270,000, pressure = 1 to 39 atmospheres absolute, flow gap = 0.043 to 0.057 in., and heated length = 12 and 18 in. A few tests were made to ascertain the effect of an axially oriented cylindrical spacer strip on surface temperature distribution and burnout heat flux. The results of these studies, are in reasonably good agreement with accepted ccrrelations. The friction factors are in satisfactory agreement with the Moody chart for the relative roughness of the test sections used, the burnout heat fluxes are well reproduced by the Soviet Zenkevich-Subbotin correlation, and the local and average heat-transfer coefficients are slightly larger than values predicted by the Hausen and Sieder-Tate equations. Miscellaneous experimental and analytical HFIR heat-transfer studies are included. (auth

Uncertainty estimates and L_2 bounds for the Kuramoto-Sivashinsky equation

We consider the Kuramoto-Sivashinsky (KS) equation in one spatial dimension with periodic boundary conditions. We apply a Lyapunov function argument similar to the one first introduced by Nicolaenko, Scheurer, and Temam, and later improved by Collet, Eckmann, Epstein and Stubbe, and Goodman, to prove that ||u||_2 < C L^1.5. This result is slightly weaker than that recently announced by Giacomelli and Otto, but applies in the presence of an additional linear destabilizing term. We further show that for a large class of Lyapunov functions \phi the exponent 1.5 is the best possible from this line of argument. Further, this result together with a result of Molinet gives an improved estimate for L_2 boundedness of the Kuramoto-Sivashinsky equation in thin rectangular domains in two spatial dimensions.Comment: 17 pages, 1 figure; typos corrected, references added; figure modifie

Hsp70 in mitochondrial biogenesis

The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non-native conformations at distinct stages during their life in the cell. In this paper we review work pertaining to the functions of hsp70 proteins in chaperoning mitochondrial protein biogenesis. Hsp70 proteins function in protein synthesis, protein translocation across mitochondrial membranes, protein folding and finally the delivery of misfolded proteins to proteolytic enzymes in the mitochondrial matrix

AGILE detection of intense gamma-ray emission from the blazar PKS 1510-089

We report the detection by the AGILE (Astro-rivelatore Gamma a Immagini LEggero) satellite of an intense gamma-ray flare from the source AGL J1511-0909, associated with the powerful quasar PKS 1510-089, during ten days of observations from 23 August to 1 September 2007. During the observation period, the source was in optical decrease following a flaring event monitored by the GLAST-AGILE Support Program (GASP) of the Whole Earth Blazar Telescope (WEBT). The simultaneous gamma-ray, optical, and radio coverage allows us to study the spectral energy distribution and the theoretical models based on the synchrotron and inverse Compton (IC) emission mechanisms. AGILE observed the source with its two co-aligned imagers, the Gamma-Ray Imaging Detector and the hard X-ray imager Super-AGILE sensitive in the 30 MeV - 50 GeV and 18 - 60 keV bands, respectively. Between 23 and 27 August 2007, AGILE detected gamma-ray emission from PKS 1510-089 when this source was located about 50 degrees off-axis, with an average flux of (270 +/- 65) x 10^{-8} photons cm^{-2} s^{-1} for photon energy above 100 MeV. In the following period, 28 August - 1 September, after a satellite re-pointing, AGILE detected the source at about 35 degrees off-axis, with an average flux (E > 100 MeV) of (195 +/- 30) x 10^{-8} photons cm^{-2} s^{-1}. No emission was detected by Super-AGILE, with a 3-sigma upper limit of 45 mCrab in 200 ksec. The spectral energy distribution is modelled with a homogeneous one-zone synchrotron self Compton (SSC) emission plus contributions by external photons: the SSC emission contributes primarily to the X-ray band, whereas the contribution of the IC from the external disc and the broad line region match the hard gamma-ray spectrum observed.Comment: 5 pages, 5 figures, accepted for publication in A&

Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial

Background: Semaglutide, a GLP-1 receptor agonist, reduces the risk of major adverse cardiovascular events (MACE) in people with overweight or obesity, but the effects of this drug on outcomes in patients with atherosclerotic cardiovascular disease and heart failure are unknown. We report a prespecified analysis of the effect of once-weekly subcutaneous semaglutide 2·4 mg on ischaemic and heart failure cardiovascular outcomes. We aimed to investigate if semaglutide was beneficial in patients with atherosclerotic cardiovascular disease with a history of heart failure compared with placebo; if there was a difference in outcome in patients designated as having heart failure with preserved ejection fraction compared with heart failure with reduced ejection fraction; and if the efficacy and safety of semaglutide in patients with heart failure was related to baseline characteristics or subtype of heart failure. Methods: The SELECT trial was a randomised, double-blind, multicentre, placebo-controlled, event-driven phase 3 trial in 41 countries. Adults aged 45 years and older, with a BMI of 27 kg/m2 or greater and established cardiovascular disease were eligible for the study. Patients were randomly assigned (1:1) with a block size of four using an interactive web response system in a double-blind manner to escalating doses of once-weekly subcutaneous semaglutide over 16 weeks to a target dose of 2·4 mg, or placebo. In a prespecified analysis, we examined the effect of semaglutide compared with placebo in patients with and without a history of heart failure at enrolment, subclassified as heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, or unclassified heart failure. Endpoints comprised MACE (a composite of non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death); a composite heart failure outcome (cardiovascular death or hospitalisation or urgent hospital visit for heart failure); cardiovascular death; and all-cause death. The study is registered with ClinicalTrials.gov, NCT03574597. Findings: Between Oct 31, 2018, and March 31, 2021, 17 604 patients with a mean age of 61·6 years (SD 8·9) and a mean BMI of 33·4 kg/m2 (5·0) were randomly assigned to receive semaglutide (8803 [50·0%] patients) or placebo (8801 [50·0%] patients). 4286 (24·3%) of 17 604 patients had a history of investigator-defined heart failure at enrolment: 2273 (53·0%) of 4286 patients had heart failure with preserved ejection fraction, 1347 (31·4%) had heart failure with reduced ejection fraction, and 666 (15·5%) had unclassified heart failure. Baseline characteristics were similar between patients with and without heart failure. Patients with heart failure had a higher incidence of clinical events. Semaglutide improved all outcome measures in patients with heart failure at random assignment compared with those without heart failure (hazard ratio [HR] 0·72, 95% CI 0·60-0·87 for MACE; 0·79, 0·64-0·98 for the heart failure composite endpoint; 0·76, 0·59-0·97 for cardiovascular death; and 0·81, 0·66-1·00 for all-cause death; all pinteraction&gt;0·19). Treatment with semaglutide resulted in improved outcomes in both the heart failure with reduced ejection fraction (HR 0·65, 95% CI 0·49-0·87 for MACE; 0·79, 0·58-1·08 for the composite heart failure endpoint) and heart failure with preserved ejection fraction groups (0·69, 0·51-0·91 for MACE; 0·75, 0·52-1·07 for the composite heart failure endpoint), although patients with heart failure with reduced ejection fraction had higher absolute event rates than those with heart failure with preserved ejection fraction. For MACE and the heart failure composite, there were no significant differences in benefits across baseline age, sex, BMI, New York Heart Association status, and diuretic use. Serious adverse events were less frequent with semaglutide versus placebo, regardless of heart failure subtype. Interpretation: In patients with atherosclerotic cardiovascular diease and overweight or obesity, treatment with semaglutide 2·4 mg reduced MACE and composite heart failure endpoints compared with placebo in those with and without clinical heart failure, regardless of heart failure subtype. Our findings could facilitate prescribing and result in improved clinical outcomes for this patient group. Funding: Novo Nordisk

State-of-the-art review of heat-recovery processes. [76 references]

A review was conducted of industrial heat-recovery processes and related equipment of potential benefit to coal-conversion complexes. Major categories of heat-exchange processes and equipment investigated included special shell-and-tube; periodic-flow and rotary regenerators; heat pipe arrays; direct phase contactors; steam and organic Rankine cycles for power generation from waste heat; and heat-pump applications to distillation. The importance of heat recovery and utilization in coal-conversion plants is widely recognized, as are the general problems associated with the design of the exchangers. A review of past experience in operating coal-conversion plants and of some proposed designs indicates that many flows will be in the laminar or transition regimes and that overall heat-transfer coefficients for exchangers involving at least one process stream will be low (less than or equal to 100 Btu/hr.ft/sup 2/./sup 0/F). Discussions with individuals knowledgeable in the process heat-transfer field revealed a relatively high degree of unanimity in that design of these exchangers would be more difficult than would their fabrication. Designs are based on the process and property data provided and construction materials specified by the buyer. No warranties are made concerning material lifetime or effect of fouling on performance. There is a clear need for more physical-property data (especially viscosities), improved heat-transfer correlations for multiphase streams (coal-oil and coal-water slurries, e.g.), and rates of fouling, corrosion, and erosion