PLGA NANOPARTICLES LOADED MUCOADHESIVE AND THERMOSENSITIVE HYDROGEL AS A POTENTIAL PLATFORM FOR THE TREATMENT OF ORAL MUCOSITIS

Objective: The objective of this study was to design an effective topical treatment for oral mucositis.Methods: Poly-(DL-lactide-co-glycolide) (PLGA) nanoparticles (NPs) and Poloxamer407 (PLX)/Hydroxy propyl methyl cellulose (HPMC) hydrogel matrix (HG) were used as combined carriers for benzydamine HCL (BNZ). BNZ loaded PLGA nanoparticles were assessed for their particle size, PDI, zeta potential and entrapment efficiency. Scanning electron microscopy, thermosensitivity study, mucoadhesion study, in vitro release and in vivo investigation were used to characterize the combined BZN loaded PLGA NPs HG.Results: Negatively charged NPs with an average diameter of 139±4.92 nm were incorporated into PLX/HPMC HG bases. The gelation temperature of BZN-PLGA-NPs-HGs ranged between 31°C and 36.5°C. When diluted with saliva simulated fluid, BZN-PLGA-NPs-HGs preserved their gelation properties. Mucoadhesion was found lower for formulations prepared with PLX without HPMC. An increase in the concentrations of PLX from 10 to 30% resulted in an increase in adhesion. Both PLGA-NPs and PLGA-NPs-HG provided a biphasic drug release profile while BZN-HG provided monophasic zero order release pattern. The in vivo study showed that animal groups treated with BZN-HG and BZN-PLGA-NPs-HG showed a significantly higher reduction percentage in ulcer surface area compared to those treated with BZN-PLGA-NPs. BZN-PLGA-NPs-HG group needed 10 d of treatment to complete healing versus 16 d, 14 d and 12 d for the complete healing of groups with no treatment, treated with BZN-PLGA-NPs and treated with BZN-HG, respectively.Conclusion: BZN-PLGA-NPs-HG could represent a promising mean for the effective treatment of oral mucositis induced by cancer therapy

Stabilization of active acetylene by-product via sequestration of co\u3csub\u3e2\u3c/sub\u3e

© 2020 Taylor & Francis Group, London, UK. The rising rates of carbide lime waste (CLW), the by-product of acetylene production, cause environmental problems and need for the repurposing of the said material. The high content of calcium in such by-products (60–80%) is the main reason for its utilization in CO2 sequestration. This study focused on using of CLW to form simple, reliable, cost-efficient process, applying direct solid-liquid-gas carbonation reaction, which consists of bubbling CO2 gas through an aqueous slurry of slaked CLW with different solid /water ratios. The experimental conditions were adjusted for maximum carbonation efficiency. Experimental results indicated that CLW has the potential to store CO2 in the form of stable carbonates. Considering the total calcium content, an amount of 0.5833 kg CO2 /kg CLW was achieved. The influence of solid/water ratio on the precipitation of calcium carbonate was investigated using SEM that showed a difference in crystal carbonate sizes and morphologies

Modifikasi Perkalian Bersusun untuk Menentukan Koefisien Trinomial Serta Konstruksinya pada Kerucut

Dalam berbagai literatur pada umumnya untuk menentukan koefisien trinomial dengan mudah dapat ditentukan dengan menggunakan konsep kombinasi dan koefisien binomial, hal ini disebabkan karena koefisien trinomial sangat erat hubungannya dengan koefisien binomial dan konsep kombinasi. Untuk konstruksi koefisien trinomial biasanya dikonstruksi pada limas Pascal yang asalnya adalah dari segitiga Pascal. Pada tulisan ini akan diberikan alternatif menentukan koefisien trinomial dan alternatif konstruksinya. Alternatif yang diberikan adalah dengan modifikasi perkalian bersusun. Modifikasi perkalian bersusun yang dimaksud adalah dengan hanya menuliskan bagian proses perkalian bersusun pada bentuk trinomial, kemudian menyisipkan nol diantara koefisien-koefisien trinomial pada bagian proses perkalian bersusun trinomial pangkat . Selanjutnya alternatif konstruksi koefisien trinomial dikonstruksi pada kerucut

Blepharophimosis, ptosis, epicanthus inversus syndrome type 2 with red hair, lymphedema of lower limbs and kidney stones in an Egyptian patient

We report the case of a 2 month old male, 6th in order of birth of 1st cousin consanguineous marriage with the typical features of blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) including bilateral shortening of the horizontal and vertical dimensions of the palpebral fissures, bilateral eye lids drooping, lateral displacement of inner canthi with a small skin-fold obscuring the inner canthus of the eye. Our patient had normal psychomotor development. His father was similarly affected suggesting autosomal dominant inheritance. The patient had red brown hair, lymphedema of lower limbs and kidney stones which were not reported before with this syndrome. Most probably these additional features are associations with BPES

Perbandingan Model Pemulusan Winter Dengan Arma(p, Q) Untuk Peramalan Stok Beras Bulog Pekanbaru

This article discusses Winter's smoothing and ARMA(p, q) model through numerical computation. Both of these models are used to predict the availability of rice stocks at National Logistics Agency or BULOG in Pekanbaru City by considering the seasonal factor from time series span data. Then a comparison iscarried out for both forecasting models to select the right forecasting model using minimum mean square error

Prolonged grief disorder and its association with perceived social support and depression among university students after the death of a significant person

The response to loss through the death of a loved one may elicit emotional problems such as depression. Family, friends, significant others and academic staff have been considered to be the major sources of social support for university students. The purpose of this study was to examine the association between prolonged grief disorder, perceived social support and severity of depression among Saudi university students after the death of a significant person. A cross-sectional design was used to examine descriptive characteristics, correlational relationships, and statistical mean differences between male and female participants on PGD scores in a convenience sample of Saudi college students. Prolonged Grief Disorder (PG-13), Multidimensional Scale of Perceived Social Support and Beck Depression Inventory (BDI-IA) were completed by 226 Saudi undergraduate students. Data were analyzed using SPSS version 22. Descriptive analysis and Pearson correlation coefficient were used. Student mean age was 20.73 years (SD=7.33), with 93 (41.2%) males and 133 (58.8%) females. One hundred (46.2%) students had experienced a major depressive episode with BDI-IA scores ≥10. Students reported moderate perceived social support from family, friends and significant person. Only 13 (5.8%) reported perceived support from academic staff. Students with the most prolonged grief disorder were the least well-supported and most depressed. The importance of support by friends, significant others and academic staff has been reported. In this study, few students reported receiving support from academics or social workers. The need for academic staff and social workers to provide more social support to grieving students is discussed

Residual and Past Entropies of Concomitants from Lai And Xie Extensions of Case-II of Generalized Order Statistics and its Dual

In this article, we consider a new extensions of Morgenstern family is Lai and Xie extensions and discuss their concomitants for case-II of generalized order statistics and case-II of dual generalized order statistics. Additionally, recurrence relation between moments is found for the recommended models. We have also derived the expression for the joint distribution of concomitants for case-II of generalized order statistics and its dual. The residual and past entropies are shown last

The effect of serum angiotensin II and angiotensin II type 1 receptor gene polymorphism on pediatric lupus nephritis

Background: Angiotensin II (Ang II) is found to perpetuate inflammation and visceral damage in systemic lupus erythematosus (SLE). It mediates most of its actions through Ang II receptor type I (AT1) whose gene polymorphism A1166C (CC genotype) seems to have pathogenic effects. Objective: To measure serum Ang II and the frequency of AT1 receptor CC genotype among a group of Egyptian patients with pediatric onset lupus nephritis (pLN). Methods: This is a case-control cross sectional study which included 24 patients with pLN and 24 age and sex-matched healthy subjects as controls. Clinical evaluation and routine laboratory markers for SLE patients were done. SLE disease activity index (SLEDAI) and the British Isles Lupus Assessment Group (BILAG)-2004 renal score were measured. Serum Ang II was measured by enzyme linked immunosorbent assay and detection of ATI receptor CC genotype by polymerase chain reaction were done for both patients and controls. Results: Patients had significantly higher serum Ang II than the controls (p=0.0001). The frequency of AT1 receptor CC genotype was significantly higher among patients as compared to the control group (p=0.008). Both serum Ang II and AT1 receptor CC genotype were comparable between patients with proliferative LN class III and IV and those with LN class II (p>0.05). Serum Ang II did not correlate significantly with SLEDAI or BILAG-renal score (p>0.05). Conclusion: Serum Ang II and AT1 receptor CC genotype seem to have pathogenic role in pLN but with no deleterious effects on the phenotype of LN for further assessment.Keywords: Lupus nephritis; Angiotensin II; Angiotensin II type 1 receptor; Polymorphism; Pediatrics

Case Report: Meier-Gorlin syndrome: Report of an additional patient with congenital heart disease

We report a 7 year old female child with the classical triad of Meier-Gorlin syndrome (MGS), (microtia, absent patella and short stature). She had the characteristic facial features, with normal mentality and defective speech, skeletal abnormalities, conductive hearing loss, cystitis and normal growth hormone level. She suffered from recurrent chest infection during the first year of life which improved gradually with age. Although congenital heart is rarely observed in MGS, our patient had in addition fenestrated interatrial septal defect.Keywords Meier-Gorlin syndrome; Ear-patella-short stature syndrome; Primordial dwarfism; Microtia; Absent patell