2,454 research outputs found

    Cosmological evolution of thermal relic particles in f(R)f(R) gravity

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    By considering f(R)f(R) gravity models, the cosmic evolution is modified with respect to the standard Λ\LambdaCDM scenario. In particular, the thermal history of particles results modified. In this paper, we derive the evolution of relics particles (WIMPs) assuming a reliable f(R)f(R) cosmological solution and taking into account observational constraints. The connection to the PAMELA experiment is also discussed. Results are consistent with constraints coming from BICEP2 and PLANCK experiments.Comment: 8 pages, 4 figure

    Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus

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    During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses against viral infections. We first evaluated the concentration of GSH and cysteine in organs of old mice; then, the effect of the administration of the N-butanoyl GSH derivative (GSH-C4) on the response of aged mice infected with influenza A PR8/H1N1 virus was studied through the determination of GSH concentration in organs, lung viral titer, IgA and IgG1/IgG2a production and Th1/Th2 cytokine profile. Old mice had lower GSH than young mice in organs. Also the gene expression of endoplasmic reticulum (ER) stress markers involved in GSH metabolism and folding of proteins, i.e. Nrf2 and PDI, was reduced. Following infection, GSH content remained low and neither infection nor GSH-C4 treatment affected Nrf2 expression. In contrast, PDI expression was upregulated during infection and appeared counterbalanced by GSH-C4. Moreover, the treatment with GSH-C4 increased GSH content in organs, reduced viral replication and induced a predominant Th1 response. In conclusion, GSH-C4 treatment could be used in the elderly to contrast influenza virus infection by inducing immune response, in particular the Th1 profile

    Dating long thrust systems on Mercury: new clues on the thermal evolution of the planet

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    The global tectonics of Mercury is dominated by contractional features mainly represented by lobate scarps, high relief ridges, and wrinkle ridges. These structures are the expression of thrust faults and are linear or arcuate features widely distributed on Mercury. Locally, these structures are arranged in long systems characterized by a preferential orientation and non-random spatial distribution. In this work we identified five thrust systems, generally longer than 1000 km. They were named after the main structure or crater encompassed by the system as: Thakur, Victoria, Villa Lobos, Al-Hamadhani, and Enterprise. In order to gain clues about their formation, we dated them using the buffered crater counting technique, which can be applied to derive the ages of linear landforms such as faults, ridges and channels. To estimate the absolute age for the end of the thrust system's activity, we applied both Le Feuvre and Wieczorek Production Function and Neukum Production Functions. Moreover, to further confirm the results obtained with the buffered crater counting method, the classic stratigraphic approach has been adopted, in which a faulted and an unfaulted craters were dated for each system. The results gave consistent ages and suggested that the most movements along major structures all over Mercury most likely ended at about 3.6–3.8 Ga. This gives new clues to better understand the tectonics of the planet and, therefore, its thermal evolution. Indeed, the early occurrence of tectonic activity in the planet's history, well before than predicted by the thermophysical models, coupled with the orientation and spatial distribution of the thrust systems, suggests that other processes beside global contraction, like mantle downwelling or tidal despinning, could have contributed to the first stage of the planet's history. Keywords: Mercury, Thrust systems, Crater counting, Thermal evolution, Planetary geology, Structural geolog

    An automated fluorescence videomicroscopy assay for the detection of mitotic catastrophe

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    Mitotic catastrophe can be defined as a cell death mode that occurs during or shortly after a prolonged/aberrant mitosis, and can show apoptotic or necrotic features. However, conventional procedures for the detection of apoptosis or necrosis, including biochemical bulk assays and cytofluorometric techniques, cannot discriminate among pre-mitotic, mitotic and post-mitotic death, and hence are inappropriate to monitor mitotic catastrophe. To address this issue, we generated isogenic human colon carcinoma cell lines that differ in ploidy and p53 status, yet express similar amounts of fluorescent biosensors that allow for the visualization of chromatin (histone H2B coupled to green fluorescent protein (GFP)) and centrosomes (centrin coupled to the Discosoma striata red fluorescent protein (DsRed)). By combining high-resolution fluorescence videomicroscopy and automated image analysis, we established protocols and settings for the simultaneous assessment of ploidy, mitosis, centrosome number and cell death (which in our model system occurs mainly by apoptosis). Time-lapse videomicroscopy showed that this approach can be used for the high-throughput detection of mitotic catastrophe induced by three mechanistically distinct anti-mitotic agents (dimethylenastron (DIMEN), nocodazole (NDZ) and paclitaxel (PTX)), and – in this context – revealed an important role of p53 in the control of centrosome number

    Recuperación y desarrollo de cultivos tradicionales mejora los medios de vida de las comunidades

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    Cuando los cultivos que pueden contribuir a mejorar la alimentación, la salud y los ingresos son abandonados por las comunidades, dejados al margen por la agricultura convencional, ignorados por la investigación y ausentes en las dietas de los consumidores, se produce una perdida a nivel global. Estos cultivos se conocen como especies olvidadas e infrautilizadas o NUS (del inglés Neglected and Underutilized Species). Al fin de sacar la mayor ventaja de estas especies en la lucha contra la pobreza, seguridad alimentaria, y resiliencia a los efecto de los cambios climáticos, es necesario establecer prioridades a nivel de investigación científica y de desarrollo de políticas, junto con la participación activa de diversos actores, como agricultores, investigadores, actores de la cadena productiva y tomadores de decisiones. Una buena campaña de sensibilización sobre la importancia de estos cultivos y su potencial son actividades que pueden ayudar a cambiar el estatus de estos cultivos
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