Development of n-DoF Preloaded structures for impact mitigation in cobots

A core issue in collaborative robotics is that of impact mitigation, especially when collisions happen with operators. Passively compliant structures can be used as the frame of the cobot, although, usually, they are implemented by means of a single-degree-offreedom (DoF). However, n-DoF preloaded structures offer a number of advantages in terms of flexibility in designing their behavior. In this work, we propose a comprehensive framework for classifying n-DoF preloaded structures, including one-, two-, and threedimensional arrays. Furthermore, we investigate the implications of the peculiar behavior of these structures-which present sharp stiff-to-compliant transitions at designdetermined load thresholds-on impact mitigation. To this regard, an analytical n-DoF dynamic model was developed and numerically implemented. A prototype of a 10DoF structure was tested under static and impact loads, showing a very good agreement with the model. Future developments will see the application of n-DoF preloaded structures to impact-mitigation on cobots and in the field of mobile robots, as well as to the field of novel architected materials

On the Application of GIS-based Decision Support Systems to study climate change impacts on coastal systems and associated ecosystems

One of the most remarkable achievements by scientists in the field of global change in recent years is the improvedunderstanding of climate change issues. Its effects on human environments, particularly coastal zones and associated watersystems, are now a huge challenge to environmental resource managers and decision makers. International and regionalregulatory frameworks have been established to guide the implementation of interdisciplinary methodologies, useful toanalyse water-related systems issues and support the definition of management strategies against the effects of climatechange. As a response to these concerns, several decision support systems (DSS) have been developed and applied toaddress climate change through geographical information systems (GIS) and multi-criteria decision analysis (MCDA)techniques; linking the DSS objectives with specific functionalities leading to key outcomes, and aspects of the decisionmaking process involving coastal and waters resources. An analysis of existing DSS focusing on climate change impacts oncoastal and related ecosystems was conducted by surveying the open literature. Consequently, twenty DSS were identifiedand are comparatively discussed according to their specific objectives and functionalities, including a set of criteria (generaltechnical, specific technical and applicability) in order to better inform potential users and concerned stakeholders throughthe evaluation of a DSS’ actual application.Key words: Climate change, Decision support, GIS, regulations, Environmen

Chapter Inventory of GIS-Based Decision Support Systems Addressing Climate Change Impacts on Coastal Waters and Related Inland Watersheds

Cosmology & the univers

A multi-risk methodology for the assessment of climate change impacts in coastal zones

Climate change threatens coastal areas, posing significant risks to natural and human systems, including coastal erosion and inundation. This paper presents a multi-risk approach integrating multiple climate-related hazards and exposure and vulnerability factors across different spatial units and temporal scales. The multi-hazard assessment employs an influence matrix to analyze the relationships among hazards (sea-level rise, coastal erosion, and storm surge) and their disjoint probability. The multi-vulnerability considers the susceptibility of the exposed receptors (wetlands, beaches, and urban areas) to different hazards based on multiple indicators (dunes, shoreline evolution, and urbanization rate). The methodology was applied in the North Adriatic coast, producing a ranking of multi-hazard risks by means of GIS maps and statistics. The results highlight that the higher multi-hazard score (meaning presence of all investigated hazards) is near the coastline while multi-vulnerability is relatively high in the whole case study, especially for beaches, wetlands, protected areas, and river mouths. The overall multi-risk score presents a trend similar to multi-hazard and shows that beaches is the receptor most affected by multiple risks (60% of surface in the higher multi-risk classes). Risk statistics were developed for coastal municipalities and local stakeholders to support the setting of adaptation priorities and coastal zone management plans

Inventory of GIS-Based Decision Support Systems Addressing Climate Change Impacts on Coastal Waters and Related Inland Watersheds

A Decision Support System (DSS) is a computer-based software that can assist decision makers in their decision process, supporting rather than replacing their judgment and, at length, improving effectiveness over efficiency. Environmental DSS are models based tools that cope with environmental issues and support decision makers in the sustainable management of natural resources and in the definition of possible adaptation and mitigation measures [2]. DSS have been developed and used to address complex decision-based problems in varying fields of research. For instance, in environmental resource management, DSS are generally classified into two main categories: Spatial Decision Support Systems (SDSS) and Environmental Decision Supports Systems (EDSS) [3-5]. SDSS provide the necessary platform for decision makers to analyse geographical information in a flexible manner, while EDSS integrate the relevant environmental models, database and assessment tools – coupled within a Graphic User Interface (GUI) – for functionality within a Geographical Information System (GIS) [1,4-6]. In some detail, GIS is a set of computer tools that can capture, manipulate, process and display spatial or geo-referenced data in which the enhancement of spatial data integration, analysis and visualization can be conducted [8-9]. These functionalities make GIS-tools useful for efficient development and effective implementation of DSS within the management process. For this purpose they are used either as data managers (i.e. as a spatial geo-database tool) or as an end in itself (i.e. media to communicate information to decision makers)

The KULTURisk Regional Risk Assessment methodology for water-related natural hazards – Part 1: Physical–environmental assessment

Abstract. In recent years, the frequency of catastrophes induced by natural hazards has increased, and flood events in particular have been recognized as one of the most threatening water-related disasters. Severe floods have occurred in Europe over the last decade, causing loss of life, displacement of people and heavy economic losses. Flood disasters are growing in frequency as a consequence of many factors, both climatic and non-climatic. Indeed, the current increase of water-related disasters can be mainly attributed to the increase of exposure (elements potentially at risk in flood-prone area) and vulnerability (i.e. economic, social, geographic, cultural and physical/environmental characteristics of the exposure). Besides these factors, the undeniable effect of climate change is projected to strongly modify the usual pattern of the hydrological cycle by intensifying the frequency and severity of flood events at the local, regional and global scale. Within this context, the need for developing effective and pro-active strategies, tools and actions which allow one to assess and (possibly) to reduce the flood risks that threatens different relevant receptors becomes urgent. Several methodologies to assess the risk posed by water-related natural hazards have been proposed so far, but very few of them can be adopted to implement the last European Flood Directive (FD). This paper is intended to introduce and present a state-of-the-art Regional Risk Assessment (RRA) methodology to appraise the risk posed by floods from a physical–environmental perspective. The methodology, developed within the recently completed FP7-KULTURisk Project (Knowledge-based approach to develop a cULTUre of Risk prevention – KR) is flexible and can be adapted to different case studies (i.e. plain rivers, mountain torrents, urban and coastal areas) and spatial scales (i.e. from catchment to the urban scale). The FD compliant KR-RRA methodology is based on the concept of risk being function of hazard, exposure and vulnerability. It integrates the outputs of various hydrodynamic models with site-specific bio-geophysical and socio-economic indicators (e.g. slope, land cover, population density, economic activities etc.) to develop tailored risk indexes and GIS-based maps for each of the selected receptors (i.e. people, buildings, infrastructure, agriculture, natural and semi-natural systems, cultural heritage) in the considered region. It further compares the baseline scenario with alternative scenarios, where different structural and/or non-structural mitigation measures are planned and eventually implemented. As demonstrated in the companion paper (Part 2, Ronco et al., 2014), risk maps, along with related statistics, allow one to identify and classify, on a relative scale, areas at risk which are more likely to be affected by floods and support the development of strategic adaptation and prevention measures to minimizing flood impacts. In addition, the outcomes of the RRA can be eventually used for a further socio-economic assessment, considering the tangible and intangible costs as well as the human dimension of vulnerability

Budesonide increases TLR4 and TLR2 expression in Treg lymphocytes of allergic asthmatics

Background: Reduced innate immunity responses as well as reduced T regulatory activities characterise bronchial asthma. Objectives: In this study the effect of budesonide on the expression of TLR4 and TLR2 in T regulatory lymphocyte sub-population was assessed. Methods: TLR4 and TLR2 expression in total peripheral blood mononuclear cells (PBMC), in CD4+/CD25+ and in CD4+/CD25- was evaluated, by flow cytometric analysis, in mild intermittent asthmatics (n = 14) and in controls (n = 11). The in vitro effects of budesonide in modulating: TLR4 and TLR2 expression in controls and in asthmatics; IL-10 expression and cytokine release (IL-6 and TNF-\u3b1 selected by a multiplex assay) in asthmatics were also explored. Results: TLR4 and TLR2 were reduced in total PBMC from asthmatics in comparison to PBMC from controls. CD4+CD25+ cells expressed at higher extent TLR2 and TLR4 in comparison to CD4+CD25- cells. Budesonide was able to increase the expression of TLR4, TLR2 and IL-10 in CD4+/CD25highly+ cells from asthmatics. TLR4 ligand, LPS induced Foxp3 expression. Budesonide was also able to reduce the release of IL-6 and TNF-\u3b1 by PBMC of asthmatics. Conclusions: Budesonide potentiates the activity of Treg by increasing TLR4, TLR2 and IL-10 expression. This event is associated to the decreased release of IL-6 and TNF-\u3b1 in PBMC treated with budesonide. These findings shed light on new mechanisms by which corticosteroids, drugs widely used for the clinical management of bronchial asthma, control T lymphocyte activation