Il letterato, la storia e la legge in USA. Due vite parallele tra storia e politica americana: "Oro contro Lavoro" in Ezra Pound e Gore Vidal

Nonostante le apparenti differenze di età, ceto, idee politiche e orientamento sessuale, Ezra Pound e Gore Vidal condividono inaspettate similitudini sia nelle loro vite che nelle loro opere. Esaminando le loro biografie e la loro produzione letteraria si può constatare come entrambi siano amanti del proprio Paese, appassionati studiosi di storia e profondamente convinti del decadimento generale degli U.S.A.Notwithstanding the apparent differences in age, census, political ideas e sex behavior, both Ezra Pound and Gore Vida share unexpected similarities in their lives and in their works. Focusing on their biographies and their published books you can understand how they are deeply in love with their country, and how well they have studied American history in order to criticize the present state of facts, which they judge terrible

Focus on headache as an adverse reaction to drugs

There are a large number of drugs inducing headache as an adverse reaction. Nevertheless, headaches as adverse reactions to drugs have received limited attention. Non-serious adverse reactions, such as headache, are not quantified and described as accurately as serious, life threatening ones. However, non-serious reactions can also be extremely troublesome, above all when they are chronic: they can affect patients' quality of life and contribute to non-compliance. It is absolutely possible that the number of patients with headache as an adverse reaction, which is going to increase, considering the growing use of medications. Physicians should, therefore, be aware of this issue. Indeed, it is difficult to attribute the diagnosis of adverse drug reaction to a condition, headache, which is also a very common symptom in general population

Le serie tv e la rivoluzione dell'immaginario

L'articolo analizza i nuovi paradigmi delle serie televisive americane, soffermandosi sulla storia della serialità televisiva, sugli elementi che la caratterizzano e sull'evoluzione che questa ha compiuto negli ultimi vent'ann

Fondaparinux vs warfarin for the treatment of unsuspected pulmonary embolism in cancer patients.

Introduction: In cancer patients, the chest computer tomography (CT) can be used to identify asymptomatic pulmonary embolism (APE). In most cases, these patients are treated with anticoagulant drugs for at least 3 months. The American College of Physicians recommend treatment of these patients as patients with symptomatic pulmonary embolism. In this study, we evaluated and compared the efficacy and safety of fondaparinux vs warfarin in the prevention of unsuspected pulmonary embolism in patients with active cancer. Materials and methods: A prospective and parallel group study was performed on 64 cancer patients (29 males and 35 females) with APE. A multidetector CT angiography with high spatial and temporal resolution and quality of arterial opacification was used to make the diagnosis. Lung scintigraphy was reserved to selected patients only. Patients were randomized to either the warfarin (Group A) or the fondaparinux (Group B) for 90 days. The first end point of efficacy was the persistence, reduction, or disappearance of thrombosis after 90 days. The second end point was the reappearance of thrombosis after 1 year. The first end point of safety was the development of major bleeding. Results: We enrolled 32 patients into each treatment group. We reached the first end point of efficacy and safety in Group B which showed that fondaparinux was able to induce the disappearance of thrombotic pulmonary with a lower incidence of major bleeding events compared with warfarin. No difference in the secondary end point was recorded. Conclusion: We suggest that the treatment of cancer patients with APE can be oriented with the administration of a standard dose of fondaparinux until the next CT lung control (3 months). However, the lack of a randomized clinical trial, including a larger patient cohort, does not allow formulation of final recommendations in these patients. A broader study would be desirable, involving a larger number of patients and a longer follow-up period

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