Citizens of the empire: A molding of Victorian childhood identity

The Victorian Era in Great Britain was a time period of dramatic change. The Industrial Revolution was altering the social and economic fabric of society. Socially, Victorians were confronted with new theories that challenged their religious beliefs. The British Isles were progressing steadily in creating a national identity. Finally, the existence of the British Empire made imperialism a factor that cannot be ignored. Yet, many historians have pointed out that the history of the British metropole itself is often disconnected from the political and cultural history of the Empire. It is within this conversation that this project seeks to find a place. This project advocates for the ideological existence of what made an ideal British citizen in an imperial context. The term “Citizen of the Empire” is being used deliberately in this context to describe this ideal British citizen, which existed in conjunction with imperial culture. This ideal identity was one that stemmed from middle class Victorian beliefs about morality, physicality, gender, national identity, and race. This paper attempts to utilize all of these thematic concepts in light of current trends in the fields of world history, British imperial history, and postcolonial discourses. The Citizen of the Empire ideal can be found in numerous cultural sources. However, this paper will investigate two types of primary sources that deal with children. Victorian children were not isolated from these cultural treads. Rather this ideal was so strong that it was inherently embedded in the discourse surrounding various Victorian youth organizations. Furthermore, the Citizen of the Empire ideal can be found in countless examples of children’s literature. This imperial ideal stemmed from a proper combination of middle class Victorian beliefs surrounding morality and physicality. Additionally, being a Citizen of the Empire meant conforming to middle class Victorian gender roles. All of these middle class expectations helped to create an ideal, proper, and thereby superior, model of a British citizen within the metropole. Finally, this superior model was used as a justification for the creation of a hierarchical relationship between the British and other cultures. Thus, the fusion of national identity and race produced a sense of cultural superiority which encouraged the civilizing mission and outright racism

Group testing models with unknown link function

Group testing through the use of pooling has proven to be an efficient method of reducing the time and cost associated with screening for a binary characteristic of interest such as infection status. A topic of key interest in this area involves the development of regression models that relate the individual level covariates to the binary pool testing responses. The research in this area has primarily focused on parametric regression models. In this poster, we will introduce a new estimation method which can handle multi-dimensional covariates while assuming the link is unknown. The asymptotic properties of our estimators are also presented. We investigate the performance of our method through simulation and by applying it to a hepatitis data set obtained from the National Health and Nutrition Examination Survey

A general mechanism for signal propagation in the nicotinic acetylcholine receptor family

Nicotinic acetylcholine receptors (nAChRs) modulate synaptic activity in the central nervous system. The α7 subtype, in particular, has attracted considerable interest in drug discovery as a target for several conditions, including Alzheimer’s disease and schizophrenia. Identifying agonist-induced structural changes underlying nAChR activation is fundamentally important for understanding biological function and rational drug design. Here, extensive equilibrium and nonequilibrium molecular dynamics simulations, enabled by cloud-based high-performance computing, reveal the molecular mechanism by which structural changes induced by agonist unbinding are transmitted within the human α7 nAChR. The simulations reveal the sequence of coupled structural changes involved in driving conformational change responsible for biological function. Comparison with simulations of the α4β2 nAChR subtype identifies features of the dynamical architecture common to both receptors, suggesting a general structural mechanism for signal propagation in this important family of receptors

UV-Optical Pixel Maps of Face-On Spiral Galaxies -- Clues for Dynamics and Star Formation Histories

UV and optical images of the face-on spiral galaxies NGC 6753 and NGC 6782 reveal regions of strong on-going star formation that are associated with structures traced by the old stellar populations. We make NUV--(NUV-I) pixel color-magnitude diagrams (pCMDs) that reveal plumes of pixels with strongly varying NUV surface brightness and nearly constant I surface brightness. The plumes correspond to sharply bounded radial ranges, with (NUV-I) at a given NUV surface brightness being bluer at larger radii. The plumes are parallel to the reddening vector and simple model mixtures of young and old populations, thus neither reddening nor the fraction of the young population can produce the observed separation between the plumes. The images, radial surface-brightness, and color plots indicate that the separate plumes are caused by sharp declines in the surface densities of the old populations at radii corresponding to disk resonances. The maximum surface brightness of the NUV light remains nearly constant with radius, while the maximum I surface brightness declines sharply with radius. An MUV image of NGC 6782 shows emission from the nuclear ring. The distribution of points in an (MUV-NUV) vs. (NUV-I) pixel color-color diagram is broadly consistent with the simple mixture model, but shows a residual trend that the bluest pixels in (MUV-NUV) are the reddest pixels in (NUV-I). This may be due to a combination of red continuum from late-type supergiants and [SIII] emission lines associated with HII regions in active star-forming regions. We have shown that pixel mapping is a powerful tool for studying the distribution and strength of on-going star formation in galaxies. Deep, multi-color imaging can extend this to studies of extinction, and the ages and metallicities of composite stellar populations in nearby galaxies.Comment: LaTeX with AASTeX style file, 29 pages with 12 figures (some color, some multi-part). Accepted for publication in The Astrophysical Journa

Effective Feedback to Improve Primary Care Prescribing Safety (EFIPPS) a pragmatic three-arm cluster randomised trial:designing the intervention (ClinicalTrials.gov registration NCT01602705)

Peer reviewedPublisher PD

Galaxy Populations and Evolution in Clusters IV: Deep HI Observations of Dwarf Ellipticals in the Virgo Cluster

We present in this paper the deepest Arecibo HI observations of Virgo cluster dwarf ellipticals (dEs) taken to date. Based on this data we argue that a significant fraction of Virgo cluster dEs recently underwent evolution. Our new observations consist of HI 21-cm line observations for 22 classified dE galaxies with optical radial velocities consistent with membership in the Virgo cluster. Cluster members VCC 390 and VCC 1713 are detected with HI masses M(HI) = 6*10^7 M_solar and 8*10^7 M_solar, respectively, while M(HI) in the remaining 20 dE galaxies have upper limits as low as 5*10^5 M_solar. We combine our results with those for 27 other Virgo cluster dEs with HI observations in the literature, 7 of which have HI detection claims. New optical images from the WIYN telescope of 5 of these HI-detected dEs, along with archival data, suggest that seven of the claimed detections are real, yielding a ~ 15% detection rate. These HI-detected classified dEs are preferentially located near the periphery of the Virgo cluster. Three Virgo dEs have observed HI velocity widths > 200 km/s, possibly indicating the presence of a large dark matter content, or transient extended HI. We discuss the possible origins of these objects and argue that they originate from field galaxies accreted onto high angular momentum orbits by Virgo in the last few Gyr. As a result these galaxies are slowly transformed within the cluster by gradual gas stripping processes, associated truncation of star formation, and passive fading of stellar populations. Low-mass early-type cluster galaxies are therefore currently being produced as the product of cluster environmental effects. We utilize our results to estimate the recent (past 1-3 Gyr) average mass accretion rate into the Virgo cluster, finding dM/dt ~ 50 M_solar/year.Comment: Accepted to ApJ, 21 page

Stellar Populations in Three Outer Fields of the LMC

We present HST photometry for three fields in the outer disk of the LMC extending approximately four magnitudes below the faintest main sequence turnoff. We cannot detect any strongly significant differences in the stellar populations of the three fields based on the morphologies of the color-magnitude diagrams, the luminosity functions, and the relative numbers of stars in different evolutionary stages. Our observations therefore suggest similar star formation histories in these regions, although some variations are certainly allowed. The fields are located in two regions of the LMC: one is in the north-east field and two are located in the north-west. Under the assumption of a common star formation history, we combine the three fields with ground-based data at the same location as one of the fields to improve statistics for the brightest stars. We compare this stellar population with those predicted from several simple star formation histories suggested in the literature, using a combination of the R-method of Bertelli et al (1992) and comparisons with the observed luminosity function. The only model which we consider that is not rejected by the observations is one in which the star formation rate is roughly constant for most of the LMC's history and then increases by a factor of three about 2 Gyr ago. Such a model has roughly equal numbers of stars older and younger than 4 Gyr, and thus is not dominated by young stars. This star formation history, combined with a closed box chemical evolution model, is consistent with observations that the metallicity of the LMC has doubled in the past 2 Gyr.Comment: 30 pages, includes 10 postscript figures. Figure 1 avaiable at ftp://charon.nmsu.edu/pub/mgeha/LMC. Accepted for publication in Astronomical Journa

Magnify is a universal molecular anchoring strategy for expansion microscopy

Expansion microscopy enables nanoimaging with conventional microscopes by physically and isotropically magnifying preserved biological specimens embedded in a crosslinked water-swellable hydrogel. Current expansion microscopy protocols require prior treatment with reactive anchoring chemicals to link specific labels and biomolecule classes to the gel. We describe a strategy called Magnify, which uses a mechanically sturdy gel that retains nucleic acids, proteins and lipids without the need for a separate anchoring step. Magnify expands biological specimens up to 11 times and facilitates imaging of cells and tissues with effectively around 25-nm resolution using a diffraction-limited objective lens of about 280 nm on conventional optical microscopes or with around 15 nm effective resolution if combined with super-resolution optical fluctuation imaging. We demonstrate Magnify on a broad range of biological specimens, providing insight into nanoscopic subcellular structures, including synaptic proteins from mouse brain, podocyte foot processes in formalin-fixed paraffin-embedded human kidney and defects in cilia and basal bodies in drug-treated human lung organoids

Galaxy Populations and Evolution in Clusters II: Defining Cluster Populations

This paper presents quantitative techniques for studying, in an unbiased manner, the photometric and structural properties of galaxies in clusters, including a means to identify likely background objects in the absence of redshift information. We develop self-consistent and reproducible measurements of fundamental properties of galaxies such as radius, surface brightness, concentration of light and structural asymmetry. We illustrate our techniques through an application to deep UBR images, taken with the WIYN 3.5m telescope, of the central ~173 arcmin^2 (or 0.3 Mpc * 0.3 Mpc) of the cluster Abell 0146 (Perseus). Our techniques allow us to study the properties of the galaxy population in the center of Perseus down to M_B = -11. Using these methods, we describe and characterize a well-defined relation between absolute magnitude and surface brightness for galaxy cluster members across the entire range of galaxy luminosity from M_B = -20 to M_B = -11. The galaxies that are assigned by our techniques to the background show no such tight relationship between apparent magnitude and surface brightness, with the exception of those we identify as being members of a background cluster of galaxies at z ~ 0.55. We, however, find that at the fainter magnitudes, M_B > -16, there is a large scatter about the underlying color--magnitude relation defined by the brighter galaxies. Our analysis also indicates that the vast majority of Perseus galaxies are `normal', with little evidence for features associated with evolution; we however discuss the detailed properties of a handful of unusual galaxies. Finally, the galaxy luminosity function of the Perseus cluster center is computed, with a derived faint end slope of alpha = -1.44+/-0.04, similar to values found in other nearby clusters.Comment: Accepted on Feb. 2, 2002 to the Astronomical Journa

Initial Validation of a Self-Report Measure of the Extent of and Reasons for Medication Nonadherence

Self-report measures of medication nonadherence confound the extent of and reasons for medication nonadherence. Each construct is assessed with a different type of psychometric model, which dictates how to establish reliability and validity