1,167 research outputs found
Conceptual techniques for reducing parasitic current gain of lateral pnp transistors
Two techniques have been conceptually proposed as possible means of reducing parasitic beta in lateral p-n-p transistors. One method uses a degenerate substrate and high concentration P /plus/ guard-ring diffusion, another places the base contact at the center of an annular ring structure
Ultraviolet/X-ray variability and the extended X-ray emission of the radio-loud broad absorption line quasar PG 1004+130
We present the results of recent Chandra, XMM-Newton, and Hubble Space
Telescope observations of the radio-loud (RL), broad absorption line (BAL)
quasar PG 1004+130. We compare our new observations to archival X-ray and UV
data, creating the most comprehensive, high signal-to-noise, multi-epoch,
spectral monitoring campaign of a RL BAL quasar to date. We probe for
variability of the X-ray absorption, the UV BAL, and the X-ray jet, on
month-year timescales. The X-ray absorber has a low column density of
cm when it is assumed to be fully
covering the X-ray emitting region, and its properties do not vary
significantly between the 4 observations. This suggests the observed absorption
is not related to the typical "shielding gas" commonly invoked in BAL quasar
models, but is likely due to material further from the central black hole. In
contrast, the CIV BAL shows strong variability. The equivalent width (EW) in
2014 is EW=11.240.56 \AA, showing a fractional increase of =1.160.11 from the 2003 observation, 3183 days earlier
in the rest-frame. This places PG 1004+130 among the most highly variable BAL
quasars. By combining Chandra observations we create an exposure 2.5 times
deeper than studied previously, with which to investigate the nature of the
X-ray jet and extended diffuse X-ray emission. An X-ray knot, likely with a
synchrotron origin, is detected in the radio jet ~8 arcsec (30 kpc) from the
central X-ray source with a spatial extent of ~4 arcsec (15 kpc). No similar
X-ray counterpart to the counterjet is detected. Asymmetric, non-thermal
diffuse X-ray emission, likely due to inverse Compton scattering of Cosmic
Microwave Background photons, is also detected.Comment: 15 pages, 7 figures, 3 tables. Accepted for publication in Ap
Pneumococcal conjugate vaccine dose-ranging studies in humans: A systematic review
Background:
Streptococcus pneumoniae is one of the most common bacterial pathogens of infants and young children. Antibody responses against the pneumococcal polysaccharide capsule are the basis of vaccine-mediated protection. We examined the relationship between the dose of polysaccharide in pneumococcal conjugate vaccines (PCVs) and immunogenicity.
Methods:
A systematic search of English publications that evaluated the immunogenicity of varying doses of pneumococcal conjugate vaccines was performed in Medline and Embase (Ovid Sp) databases in August 2019. We included only articles that involved administration of pneumococcal conjugate vaccine in humans and assessed the immunogenicity of more than one serotype-specific saccharide dose. Results were synthesised descriptively due to the heterogeneity of product valency, product content and vaccine schedule.
Results:
We identified 1691 articles after de-duplication; 9 studies met our inclusion criteria; 2 in adults, 6 in children and 1 in both. Doses of polysaccharide evaluated ranged from 0.44 mcg to 17.6 mcg. In infants, all doses tested elicited IgG geometric mean concentrations (GMCs) above the established correlate of protection (COP; 0.35 mcg/ml). A month after completion of the administered vaccine schedule, 95% confidence intervals of only three out of all the doses evaluated had GMCs that crossed below the COP. In the adult studies, all adults achieved GMCs that would be considered protective in children who have received 3 standard vaccine doses.
Conclusion:
For some products, the mean antibody concentrations induced against some pneumococcal serotypes increased with increasing doses of the polysaccharide conjugate, but for other serotypes, there were no clear dose–response relationships or the dose response curves were negative. Fractional doses of polysaccharide which contain less than is included in currently distributed formulations may be useful in the development of higher valency vaccines, or dose-sparing delivery for paediatric use
CIV Emission and the Ultraviolet through X-ray Spectral Energy Distribution of Radio-Quiet Quasars
In the restframe UV, two of the parameters that best characterize the range
of emission-line properties in quasar broad emission-line regions are the
equivalent width and the blueshift of the CIV line relative to the quasar rest
frame. We explore the connection between these emission-line properties and the
UV through X-ray spectral energy distribution (SED) for radio-quiet (RQ)
quasars. Our sample consists of a heterogeneous compilation of 406 quasars from
the Sloan Digital Sky Survey and Palomar-Green survey that have well-measured
CIV emission-line and X-ray properties (including 164 objects with measured
Gamma). We find that RQ quasars with both strong CIV emission and small CIV
blueshifts can be classified as "hard-spectrum" sources that are (relatively)
strong in the X-ray as compared to the UV. On the other hand, RQ quasars with
both weak CIV emission and large CIV blueshifts are instead "soft-spectrum"
sources that are (relatively) weak in the X-ray as compared to the UV. This
work helps to further bridge optical/soft X-ray "Eigenvector 1" relationships
to the UV and hard X-ray. Based on these findings, we argue that future work
should consider systematic errors in bolometric corrections (and thus accretion
rates) that are derived from a single mean SED. Detailed analysis of the CIV
emission line may allow for SED-dependent corrections to these quantities.Comment: AJ, in press; 39 pages, 11 figures, 3 table
Spectral Energy Distributions and Multiwavelength Selection of Type 1 Quasars
We present an analysis of the mid-infrared (MIR) and optical properties of type 1 (broad-line) quasars detected by the Spitzer Space Telescope. The MIR color-redshift relation is characterized to z ~ 3, with predictions to z = 7. We demonstrate how combining MIR and optical colors can yield even more efficient selection of active galactic nuclei (AGNs) than MIR or optical colors alone. Composite spectral energy distributions (SEDs) are constructed for 259 quasars with both Sloan Digital Sky Survey and Spitzer photometry, supplemented by near-IR, GALEX, VLA, and ROSAT data, where available. We discuss how the spectral diversity of quasars influences the determination of bolometric luminosities and accretion rates; assuming the mean SED can lead to errors as large as 50% for individual quasars when inferring a bolometric luminosity from an optical luminosity. Finally, we show that careful consideration of the shape of the mean quasar SED and its redshift dependence leads to a lower estimate of the fraction of reddened/obscured AGNs missed by optical surveys as compared to estimates derived from a single mean MIR to optical flux ratio
Unification of Luminous Type 1 Quasars through CIV Emission
Using a sample of 30,000 quasars from SDSS-DR7, we explore the range of
properties exhibited by high-ionization, broad emission lines, such as CIV
1549. Specifically we investigate the anti-correlation between L_UV and
emission line EQW (the Baldwin Effect) and the "blueshifting" of
high-ionization emission lines. The blueshift of the CIV emission line is
nearly ubiquitous, with a mean shift of 810 km/s for radio-quiet (RQ) quasars
and 360 km/s for radio-loud (RL) quasars, and the Baldwin Effect is present in
both RQ and RL samples. Composite spectra are constructed as a function of CIV
emission line properties in attempt to reveal empirical relationships between
different line species and the SED. Within a two-component disk+wind model of
the broad emission line region (BELR), where the wind filters the continuum
seen by the disk component, we find that RL quasars are consistent with being
dominated by the disk component, while BALQSOs are consistent with being
dominated by the wind component. Some RQ objects have emission line features
similar to RL quasars; they may simply have insufficient black hole (BH) spin
to form radio jets. Our results suggest that there could be significant
systematic errors in the determination of L_bol and BH mass that make it
difficult to place these findings in a more physical context. However, it is
possible to classify quasars in a paradigm where the diversity of BELR
parameters are due to differences in an accretion disk wind between quasars
(and over time); these differences are underlain primarily by the SED, which
ultimately must be tied to BH mass and accretion rate.Comment: 51 pages, 18 figures, accepted by AJ, revised version includes
various modifications based on the referee's comment
Towards a developmental state? Provincial economic policy in South Africa
This paper explores the meaning of the developmental state for spatial economic policy in South Africa. Two main questions are addressed: do provincial governments have a role to play in promoting economic prosperity, and to what extent do current provincial policies possess the attributes of a developmental state? These attributes are defined as the ability to plan longer term, to focus key partners on a common agenda, and to mobilise state resources to build productive capabilities. The paper argues that the developmental state must harness the power of government at every level to ensure that each part of the country develops to its potential. However, current provincial capacity is uneven, and weakest where support is needed most. Many provinces seem to have partial strategies and lack the wherewithal for sustained implementation. Coordination across government appears to be poor. The paper concludes by suggesting ways provincial policies could be strengthened
Dental periodontal procedures: a systematic review of contamination (splatter, droplets and aerosol) in relation to COVID-19
Introduction
The emergence of the SARS-CoV-2 virus and subsequent COVID-19 pandemic has had a significant effect on the delivery of routine dentistry; and in particular, periodontal care across the world. This systematic review examines the literature relating to splatter, droplet settle and aerosol for periodontal procedures and forms part of a wider body of research to understand the risk of contamination in relation to periodontal care procedures relevant to COVID-19.
Methods
A search of the literature was carried out using key terms and MeSH words relating to the review questions. Sources included Medline (OVID), Embase (OVID), Cochrane Central Register of Controlled Trials, Scopus, Web of Science and LILACS, ClinicalTrials.Gov. Studies meeting inclusion criteria were screened in duplicate and data extraction was carried out using a template. All studies were assessed for methodological quality and sensitivity. Narrative synthesis was undertaken.
Results
Fifty studies were included in the review with procedures including ultrasonic scaling (n = 44), air polishing (n = 4), prophylaxis (n = 2) and hand scaling (n = 3). Outcomes included bacterial (colony-forming units e.g. on settle plates) or blood contamination (e.g. visible splatter) and non bacterial, non blood (e.g. chemiluminescence or coloured dyes) contamination. All studies found contamination at all sites although the contamination associated with hand scaling was very low. Contamination was identified in all of the studies even where suction was used at baseline. Higher power settings created greater contamination. Distribution of contamination varied in relation to operator position and was found on the operator, patient and assistant with higher levels around the head of the operator and the mouth and chest of the patient. Settle was identified 30 min after treatments had finished but returned to background levels when measured at or after an hour. The evidence was generally low to medium quality and likely to underestimate contamination.
Conclusion
Ultrasonic scaling, air polishing and prophylaxis procedures produce contamination (splatter, droplets and aerosol) in the presence of suction, with a small amount of evidence showing droplets taking between 30 min and 1 h to settle. Consideration should be given to infection control, areas of cleaning particularly around the patient and appropriate personal protective equipment, with particular attention to respiratory, facial and body protection for these procedures. In addition, the use of lower power settings should be considered to reduce the amount and spread of contamination
Effects of the 2017 Solar Eclipse on HF Radio Propagation and the D-Region Ionosphere: Citizen Science Investigation
August 21, 2017 provided a unique opportunity to investigate the effects of the total solar eclipse on high frequency (HF) radio propagation and ionospheric variability. In Marshall Space Flight Center's partnership with the US Space and Rocket Center (USSRC) and Austin Peay State University (APSU), we engaged students and citizen scientists in an investigation of the eclipse effects on the mid-latitude ionosphere. Activities included implementing and configuring software, monitoring the HF Amateur Radio frequency bands and collecting radio transmission data on days before, the day of, and days after the eclipse to build a continuous record of changing propagation conditions as the moon's shadow marched across the United States. Post-eclipse radio propagation analysis provided insights into ionospheric variability due to the eclipse. We report on results, interpretation, and conclusions of these investigations
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