Measuring the Effect of USCG Port Security Advisory Notices On Trade and Port Security Procedures

Overview: The United States Coast Guard’s International Port Security (IPS) Program is the primary port security assessment office and was established in 2003 as part of the U.S. Maritime Transportation Security Act (MTSA) to reduce risks to U.S. ports and ships, and to the entire maritime transport system. Through the assessment of International Ship and Port Facility Security Code implementation and other measures in foreign ports, the International Port Security Program can determine whether or not there is a reasonable and acceptable level of port security at any given foreign port. This report is comprised of qualitative and quantitative research along with two case studies that compare and contrast two countries and/or ports that either succeeded or failed in complying with this program and received a Port Security Advisory (PSA). Hypothesis: Port Security Advisories (PSA) are issued when a port does not meet the International Port Security Program code. They are an instrument to build and sustain port security practices and improvements. PSAs can give standard regulations for those who use ports in compliance with a PSA as well as create maritime security protocols for other countries that do not have strong port standards. As for the economic impacts, there can be both positive and negative factors depending on the country and the situation. However, we hypothesize that overall, PSAs do not significantly influence a country’s volume of trade. Due to non-compliant countries in reporting, there is no discernable method for tracking or ensuring restrictions. Methodology: We will observe quantitative measures of trade to identify negative impacts associated with the issuance of PSAs. We will also look at quantitative data to identify positive impacts associated with PSAs. We will be using USCG’s HOMEPORT website to identify the PSAs and use COMTRADE to examine trade both before and after a PSA was issued. Trade will be compared to similar countries, those which have not received a PSA. Lastly, we will go over local and regional factors and determine what is currently working and what needs to be improved. Conclusions: Our conclusion is that as a system the PSA process is not necessary an influence on trade. There may be correlations between countries with PSAs issued and changes in trade but there are a myriad of other factors that can impact this making the current methodology less than definitive. There also may be certain countries and/or ports where the correlation appears stronger (See Case Study #1); but overall, our conclusion is that PSAs have a negligible impact on a country receiving them in influencing their volume of trade

Perceived competence: a common core for self-efficacy and self-concept?

This study uses Bandura's Multidimensional Scales of Perceived Self-Efficacy (MSPSE; Bandura, 1990) and Harter's Self-Perception Profile for Adolescents (SPPA; Harter, 1988) to examine the extent to which self-efficacy and competency-related elements of the self-concept are independent constructs. Factor analysis of data provided by 778 high school students revealed that when measured using domain-general measures such as the MSPSE and SPPA, self-efficacy and competency self-concept do not represent totally separate, distinct constructs. Overlap of dimensions occurs at both the first- and second-order levels of analysis. The practical and theoretical implications of these findings are discussed

parC Mutations in Fluoroquinolone-Resistant Borrelia burgdorferi

We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum

A re-examination of cremated remains from the archaeological record: an evaluation of the process and application of current methods

Cremation is a burial practice that has been adopted by numerous cultures throughout time. In the past, the fragmented nature of cremated remains gives them the reputation of being difficult and time consuming to analyze. Thus, in archaeological literature such as site reports, data collected about cremated remains is largely lacking. The effect of heat on bone was not originally well understood and it has taken years for research to be conducted on heat altered bone. However, through research in both archaeology and forensic science a good deal is now understood about cremations. This study includes an extensive literature review of studies from both archaeology and forensic science. From these studies, a method was developed to analyze the cremated human remains housed in the University of Alabama's Laboratory of Human Osteology. This research resulted in an increased understanding of the age, sex, health, and cause of death of cremated individuals within this collection. It is hoped that this study's methodology will be replicated to analyze other collections of prehistoric cremated remains or used as a basis for future research to improve the methodologies used in this study (Published By University of Alabama Libraries

CDK8 Kinase Activity Promotes Glycolysis

Summary: Aerobic glycolysis, also known as the Warburg effect, is a hallmark of cancerous tissues. Despite its importance in cancer development, our understanding of mechanisms driving this form of metabolic reprogramming is incomplete. We report here an analysis of colorectal cancer cells engineered to carry a single point mutation in the active site of the Mediator-associated kinase CDK8, creating hypomorphic alleles sensitive to bulky ATP analogs. Transcriptome analysis revealed that CDK8 kinase activity is required for the expression of many components of the glycolytic cascade. CDK8 inhibition impairs glucose transporter expression, glucose uptake, glycolytic capacity and reserve, as well as cell proliferation and anchorage-independent growth, both in normoxia and hypoxia. Importantly, CDK8 impairment sensitizes cells to pharmacological glycolysis inhibition, a result reproduced with Senexin A, a dual inhibitor of CDK8/CDK19. Altogether, these results contribute to our understanding of CDK8 as an oncogene, and they justify investigations to target CDK8 in highly glycolytic tumors. : Galbraith et al. use a chemical genetics approach to examine the role of CDK8 kinase activity in cancer cells. CDK8 activity is required for the transcription of multiple genes encoding enzymes required for glucose metabolism. Impaired CDK8 activity reduces glucose uptake and glycolysis and sensitizes cells to the glucose analog 2-deoxy-D-glucose. Keywords: CDK8, CDK19, Mediator, glycolysis, Warburg effect, chemical genetics, HCT116, SW480, A549, H46