Citizenship status and career self-efficacy: An intersectional study of biomedical trainees in the United States

This study examines the intersectional role of citizenship and gender with career self-efficacy amongst 10,803 doctoral and postdoctoral trainees in US universities. These biomedical trainees completed surveys administered by 17 US institutions that participated in the National Institutes of Health Broadening Experiences in Scientific Training (NIH BEST) Programs. Findings indicate that career self-efficacy of non-citizen trainees is significantly lower than that of US citizen trainees. While lower career efficacy was observed in women compared with men, it was even lower for non-citizen female trainees. Results suggest that specific career interests may be related to career self-efficacy. Relative to US citizen trainees, both male and female non-citizen trainees showed higher interest in pursuing a career as an academic research investigator. In comparison with non-citizen female trainees and citizen trainees of all genders, non-citizen male trainees expressed the highest interest in research-intensive (and especially principal investigator) careers. The authors discuss potential causes for these results and offer recommendations for increasing trainee career self-efficacy which can be incorporated into graduate and postdoctoral training

Career self-efficacy disparities in underrepresented biomedical scientist trainees

The present study examines racial, ethnic, and gender disparities in career self-efficacy amongst 6077 US citizens and US naturalized graduate and postdoctoral trainees. Respondents from biomedical fields completed surveys administered by the National Institutes of Health Broadening Experiences in Scientific Training (NIH BEST) programs across 17 US institutional sites. Graduate and postdoctoral demographic and survey response data were examined to evaluate the impact of intersectional identities on trainee career self-efficacy. The study hypothesized that race, ethnicity and gender, and the relations between these identities, would impact trainee career self-efficacy. The analysis demonstrated that racial and ethnic group, gender, specific career interests (academic principal investigator vs. other careers), and seniority (junior vs. senior trainee level) were, to various degrees, all associated with trainee career self-efficacy and the effects were consistent across graduate and postdoctoral respondents. Implications for differing levels of self-efficacy are discussed, including factors and events during training that may contribute to (or undermine) career self-efficacy. The importance of mentorship for building research and career self-efficacy of trainees is discussed, especially with respect to those identifying as women and belonging to racial/ethnic populations underrepresented in biomedical sciences. The results underscore the need for change in the biomedical academic research community in order to retain a diverse biomedical workforce

Study of Hadronic Five-Body Decays of Charmed Mesons

We study the decay of D+ and Ds+ mesons into charged five body final states, and report the discovery of the decay mode D+ -> K+K-Pi+Pi+Pi-, as well as measurements of the decay modes D+ -> K-Pi+Pi+Pi+Pi-, Ds+ -> K+K-Pi+Pi+Pi-, Ds+ -> PhiPi+Pi+Pi- and D+/Ds+ -> Pi+Pi+Pi+Pi-Pi-. An analysis of the resonant substructure is also included, with evidence suggesting that both decays proceed primarily through an a1 vector resonance.Comment: 11 pages, 3 figure

Observation of a 1750 MeV/c^2 Enhancement in the Diffractive Photoproduction of K^+K^-

Using the FOCUS spectrometer with photon beam energies between 20 and 160 \gev, we confirm the existence of a diffractively photoproduced enhancement in $K^+K^-$ at 1750 \mevcc with nearly 100 times the statistics of previous experiments. Assuming this enhancement to be a single resonance with a Breit-Wigner mass shape, we determine its mass to be $1753.5\pm 1.5\pm 2.3$ \mevcc and its width to be $122.2\pm 6.2\pm 8.0$ \mevcc. We find no corresponding enhancement at 1750 \mevcc in $K^*K$, and again neglecting any possible interference effects we place limits on the ratio $\Gamma (X(1750) \to K^*K)/\Gamma (X(1750) \to K^+K^-)$. Our results are consistent with previous photoproduction experiments, but, because of the much greater statistics, challenge the common interpretation of this enhancement as the $\phi (1680)$ seen in $e^+e^-$ annihilation experiments.Comment: 10 pages, 5 figure

Study of the decay mode D^0 -> K-K-K+pi+

Using data from the FOCUS (E831) experiment at Fermilab, we present a new measurement of the branching ratio for the Cabibbo-favored decay mode $D^0 \to K^-K^-K^+\pi^+$. From a sample of $143 \pm 19$ fully reconstructed $D^0 \to K^-K^-K^+\pi^+$ events, we measure $\Gamma(D^0 \to K^-K^-K^+\pi^+)/\Gamma(D^0 \to K^-\pi^-\pi^+\pi^+) = 0.00257 \pm 0.00034(stat.) \pm 0.00024(syst.)$. A coherent amplitude analysis has been performed to determine the resonant substructure of this decay mode. This analysis reveals a dominant contribution from $\phi$ and $\bar K^{*0}(890)$ states.Comment: 15 pages, 4 figures, to be submitted to Physics Letters

Study of the Cabibbo-suppressed decay modes D0-->Pi-pi+ and D0-->K-K+

Using data from the FOCUS (E831) experiment at Fermilab, we present a new measurement for the branching ratios of the Cabibbo-suppressed decay modes D0-->Pi-Pi+ and D0-->K-K+. We measured: Gamma(D0-->K-K+)/Gamma(D0-->Pi-Pi+) = 2.81 +/- 0.10(stat) +/- 0.06(syst), Gamma(D0-->K-K+)/Gamma(D0-->K-Pi+) = 0.0993 +/- 0.0014(stat) +/- 0.0014(syst), and Gamma(D0-->Pi-Pi+)/Gamma(D0-->K-Pi+) = 0.0353 +/- 0.0012 (stat) +/- 0.0006(syst). These values have been combined with other experimental data to extract the ratios of isospin amplitudes and the phase shifts for the D-->KK and D-->PiPi decay channels.Comment: 12 pages, 1 Figure, accepted for publication in Phys.Lett.

Content and performance of the MiniMUGA genotyping array: A new tool to improve rigor and reproducibility in mouse research

The laboratory mouse is the most widely used animal model for biomedical research, due in part to its well-annotated genome, wealth of genetic resources, and the ability to precisely manipulate its genome. Despite the importance of genetics for mouse research, genetic quality control (QC) is not standardized, in part due to the lack of cost-effective, informative, and robust platforms. Genotyping arrays are standard tools for mouse research and remain an attractive alternative even in the era of high-throughput whole-genome sequencing. Here, we describe the content and performance of a new iteration of the Mouse Universal Genotyping Array (MUGA), MiniMUGA, an array-based genetic QC platform with over 11,000 probes. In addition to robust discrimination between most classical and wild-derived laboratory strains, MiniMUGA was designed to contain features not available in other platforms: (1) chromosomal sex determination, (2) discrimination between substrains from multiple commercial vendors, (3) diagnostic SNPs for popular laboratory strains, (4) detection of constructs used in genetically engineered mice, and (5) an easy-to-interpret report summarizing these results. In-depth annotation of all probes should facilitate custom analyses by individual researchers. To determine the performance of MiniMUGA, we genotyped 6899 samples from a wide variety of genetic backgrounds. The performance of MiniMUGA compares favorably with three previous iterations of the MUGA family of arrays, both in discrimination capabilities and robustness. We have generated publicly available consensus genotypes for 241 inbred strains including classical, wild-derived, and recombinant inbred lines. Here, we also report the detection of a substantial number of XO and XXY individuals across a variety of sample types, new markers that expand the utility of reduced complexity crosses to genetic backgrounds other than C57BL/6, and the robust detection of 17 genetic constructs. We provide preliminary evidence that the array can be used to identify both partial sex chromosome duplication and mosaicism, and that diagnostic SNPs can be used to determine how long inbred mice have been bred independently from the relevant main stock. We conclude that MiniMUGA is a valuable platform for genetic QC, and an important new tool to increase the rigor and reproducibility of mouse research