4,719 research outputs found

    Argent facile. Argent piégé. Pour comprendre les situations de surendettement personnel

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    Therapeutic Vascular Compliance Change May Cause Significant Variation in Coronary Perfusion: A Numerical Study

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    In some pathological conditions like aortic stiffening and calcific aortic stenosis (CAS), the microstructure of the aortic root and the aortic valve leaflets are altered in response to stress resulting in changes in tissue thickness, stiffness, or both. This aortic stiffening and CAS are thought to affect coronary blood flow. The goal of the present paper was to include the flow in the coronary ostia in the previous fluid structure interaction model we have developed and to analyze the effect of diseased tissues (aortic root stiffening and CAS) on coronary perfusion. Results revealed a significant impact on the coronary perfusion due to a moderate increase in the aortic wall stiffness and CAS (increase of the aortic valve leaflets thickness). A marked drop of coronary peak velocity occurred when the values of leaflet thickness and aortic wall stiffness were above a certain threshold, corresponding to a threefold of their normal value. Consequently, mild and prophylactic treatments such as smoking cessation, exercise, or diet, which have been proven to increase the aortic compliance, may significantly improve the coronary perfusion

    Isolation and characterization of a spontaneously immortalized bovine retinal pigmented epithelial cell line

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    <p>Abstract</p> <p>Background</p> <p>The Retinal Pigmented Epithelium (RPE) is juxtaposed with the photoreceptor outer segments of the eye. The proximity of the photoreceptor cells is a prerequisite for their survival, as they depend on the RPE to remove the outer segments and are also influenced by RPE cell paracrine factors. RPE cell death can cause a progressive loss of photoreceptor function, which can diminish vision and, over time, blindness ensues. Degeneration of the retina has been shown to induce a variety of retinopathies, such as Stargardt's disease, Cone-Rod Dystrophy (CRD), Retinitis Pigmentosa (RP), Fundus Flavimaculatus (FFM), Best's disease and Age-related Macular Degeneration (AMD). We have cultured primary bovine RPE cells to gain a further understanding of the mechanisms of RPE cell death. One of the cultures, named tRPE, surpassed senescence and was further characterized to determine its viability as a model for retinal diseases.</p> <p>Results</p> <p>The tRPE cell line has been passaged up to 150 population doublings and was shown to be morphologically similar to primary cells. They have been characterized to be of RPE origin by reverse transcriptase PCR and immunocytochemistry using the RPE-specific genes <it>RPE65 </it>and <it>CRALBP </it>and RPE-specific proteins RPE65 and Bestrophin. The tRPE cells are also immunoreactive to vimentin, cytokeratin and zonula occludens-1 antibodies. Chromosome analysis indicates a normal diploid number. The tRPE cells do not grow in suspension or in soft agar. After <sup>3</sup>H thymidine incorporation, the cells do not appear to divide appreciably after confluency.</p> <p>Conclusion</p> <p>The tRPE cells are immortal, but still exhibit contact inhibition, serum dependence, monolayer growth and secrete an extra-cellular matrix. They retain the <it>in-vivo </it>morphology, gene expression and cell polarity. Additionally, the cells endocytose exogenous melanin, A2E and purified lipofuscin granules. This cell line may be a useful <it>in-vitro </it>research model for retinal maculopathies.</p

    The Holographic Dual of 2+1 Dimensional QFTs with N=1 SUSY and Massive Fundamental Flavours

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    The Maldacena Nastase solution is generalised to include massive fundamental matter through the addition of a flavour profile. This gives a holographic dual to N=1 SYM-CS with massive fundamental matter with a singularity free IR. We study this solution in some detail confirming confinement and asymptotic freedom. A recently proposed solution generating technique is then applied which results in a new type-IIA supergravity solution. In a certain limit the geometry of this solution is asymptotically AdS_4X Y, where Y is the metric at the base of the Bryant-Salamon G_2 cone, which has topology S^3XS^3.Comment: 31 pages plus appendices, 6 figures. v3: Typos corrected, version to appear in JHE

    On the Interacting Chiral Gauge Field Theory in D=6 and the Off-Shell Equivalence of Dual Born-Infeld-Like Actions

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    A canonical action describing the interaction of chiral gauge fields in D=6 Minkowski space-time is constructed. In a particular partial gauge fixing it reduces to the action found by Perry and Schwarz. The additional gauge symmetries are used to show the off-shell equivalence of the dimensional reduction to D=5 Minkowski space-time of the chiral gauge field canonical action and the Born-Infeld canonical action describing an interacting D=5 Abelian vector field. Its extension to improve the on-shell equivalence arguments of dual D-brane actions to off-shell ones is discussed.Comment: 18 page

    Gaugino Condensation with S-Duality and Field-Theoretical Threshold Corrections

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    We study gaugino condensation in the presence of an intermediate mass scale in the hidden sector. S-duality is imposed as an approximate symmetry of the effective supergravity theory. Furthermore, we include in the K\"ahler potential the renormalization of the gauge coupling and the one-loop threshold corrections at the intermediate scale. It is shown that confinement is indeed achieved. Furthermore, a new running behaviour of the dilaton arises which we attribute to S-duality. We also discuss the effects of the intermediate scale, and possible phenomenological implications of this model.Comment: 19 pages, LaTeX, 3 postscript figures include

    Transient sex-related changes in the mice hypothalamo–pituitary–adrenal (HPA) axis during the acute phase of the inflammatory process

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    The potential role of endogenous sex hormones in regulating hypothalamo–pituitary–adrenal (HPA) axis function was investigated after a single injection of endotoxin in adult (8 week old) BALB/c mice of both sexes. The effect of LPS on plasma ACTH, corticosterone (B), testosterone and oestradiol (E) levels and on anterior pituitary (AP) ACTH and adrenal B contents at different times after treatment was studied. The results indicate that: (a) basal B but not ACTH plasma levels were significantly higher in female than in male mice; (b) LPS significantly increased both ACTH and B plasma levels over the baseline 2 h after injection, both hormone levels being higher in female than in male mice; (c) although plasma ACTH concentrations recovered the basal value at 72 h after LPS in animals of both sexes, plasma B levels returned to the baseline only at 120 h after treatment; (d) E plasma levels significantly increased 2 h after LPS and returned to the baseline at 72 h post-treatment, in both sexes; (e) at 2 h after LPS, testosterone plasma levels significantly decreased in male mice and increased in female mice, recovering the baseline level at 120 and 72 h after LPS, respectively; (f) AP ACTH content was similar in both sexes in basal condition and it was significantly diminished 72 h post-treatment without sex difference; whereas AP ACTH returned to basal content 120 h after LPS in males, it remained significantly decreased in females; (g) basal adrenal B content was higher in female than in male mice, and it significantly increased in both sexes 2 h post-LPS, maintaining this sex difference. Whereas adrenal B returned to basal content 72 h after treatment in male mice, it remained significantly enhanced up to 120 h post-LPS in female animals. The data demonstrate the existence of a clear sexual dimorphism in basal condition and during the acute phase response as well as in the recovery of the HPA axis function shortly after infection

    Making Ends Meet: String Unification and Low-Energy Data

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    A long-standing problem in string phenomenology has been the fact that the string unification scale disagrees with the GUT scale obtained by extrapolating low-energy data within the framework of the minimal supersymmetric standard model (MSSM). In this paper we examine several effects that may modify the minimal string predictions and thereby bring string-scale unification into agreement with low-energy data. These include heavy string threshold corrections, non-standard hypercharge normalizations, light SUSY thresholds, intermediate gauge structure, and thresholds arising from extra matter beyond the MSSM. We explicitly evaluate these contributions within a variety of realistic free-fermionic string models, including the flipped SU(5), SO(6) x SO(4), and various SU(3) x SU(2) x U(1) models, and find that most of these sources do not substantially alter the minimal string predictions. Indeed, we find that the only way to reconcile string unification with low-energy data is through certain types of extra matter. Remarkably, however, many of the realistic string models contain precisely this required matter in their low-energy spectra.Comment: 10 pages, standard LaTeX, 1 figure (Encapsulated PostScript), version published in Phys. Rev. Lett. 75 (1995) 264

    E7(7) invariant Lagrangian of d=4 N=8 supergravity

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    We present an E7(7) invariant Lagrangian that leads to the equations of motion of d=4 N=8 supergravity without using Lagrange multipliers. The superinvariance of this new action and the closure of the supersymmetry algebra are proved explicitly for the terms that differ from the Cremmer--Julia formulation. Since the diffeomorphism symmetry is not realized in the standard way on the vector fields, we switch to the Hamiltonian formulation in order to prove the invariance of the E7(7) invariant action under general coordinate transformations. We also construct the conserved E7(7)-Noether current of maximal supergravity and we conclude with comments on the implications of this manifest off-shell E7(7)-symmetry for quantizing d=4 N=8 supergravity, in particular on the E7(7)-action on phase space.Comment: 45 pages, references adde

    Associations of maternal caffeine intake during pregnancy with abdominal and liver fat deposition in childhood

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    Background: Maternal caffeine intake during pregnancy is associated with an increased risk of childhood obesity. Studies in adults suggest that caffeine intake might also directly affect visceral and liver fat deposition, which are strong risk factors for cardio-metabolic disease. Objective: To assess the associations of maternal caffeine intake during pregnancy with childhood general, abdominal, and liver fat mass at 10 years of age. Methods: In a population-based cohort from early pregnancy onwards among 4770 mothers and children, we assessed maternal caffeine intake during pregnancy and childhood fat mass at age 10 years. Results: Compared with children whose mothers consumed <2 units of caffeine per day during pregnancy, those whose mothers consumed 4-5.9 and ≥6 units of caffeine per day had a higher body mass index, total body fat mass index, android/gynoid fat mass ratio, and abdominal subcutaneous and visceral fat mass indices. Children whose mothers consumed 4-5.9 units of caffeine per day had a higher liver fat fraction. The associations with abdominal visceral fat and liver fat persisted after taking childhood total body fat mass into account. Conclusions: High maternal caffeine intake during pregnancy was associated with higher childhood body mass index, total body fat, abdominal visceral fat, and liver fat. The associations with childhood abdominal visceral fat and liver fat fraction were independent of childhood total body fat. This suggests differential fat accumulation in these depots, which may increase susceptibility to cardio-metabolic disease in later life
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