Prevalence of chronic cough, its risk factors and population attributable risk in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross-sectional study

© 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)Background: Chronic cough is a common respiratory symptom with an impact on daily activities and quality of life. Global prevalence data are scarce and derive mainly from European and Asian countries and studies with outcomes other than chronic cough. In this study, we aimed to estimate the prevalence of chronic cough across a large number of study sites as well as to identify its main risk factors using a standardised protocol and definition. Methods: We analysed cross-sectional data from 33,983 adults (≥40 years), recruited between Jan 2, 2003 and Dec 26, 2016, in 41 sites (34 countries) from the Burden of Obstructive Lung Disease (BOLD) study. We estimated the prevalence of chronic cough for each site accounting for sampling design. To identify risk factors, we conducted multivariable logistic regression analysis within each site and then pooled estimates using random-effects meta-analysis. We also calculated the population attributable risk (PAR) associated with each of the identifed risk factors. Findings: The prevalence of chronic cough varied from 3% in India (rural Pune) to 24% in the United States of America (Lexington,KY). Chronic cough was more common among females, both current and passive smokers, those working in a dusty job, those with a history of tuberculosis, those who were obese, those with a low level of education and those with hypertension or airflow limitation. The most influential risk factors were current smoking and working in a dusty job. Interpretation: Our findings suggested that the prevalence of chronic cough varies widely across sites in different world regions. Cigarette smoking and exposure to dust in the workplace are its major risk factors.info:eu-repo/semantics/publishedVersio

Prevalence of chronic cough, its risk factors and population attributable risk in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross-sectional study

Background: Chronic cough is a common respiratory symptom with an impact on daily activities and quality of life. Global prevalence data are scarce and derive mainly from European and Asian countries and studies with outcomes other than chronic cough. In this study, we aimed to estimate the prevalence of chronic cough across a large number of study sites as well as to identify its main risk factors using a standardized protocol and definition. Methods: We analyzed cross-sectional data from 33,983 adults (≥40 years), recruited between Jan 2, 2003 and Dec 26, 2016, in 41 sites (34 countries) from the Burden of Obstructive Lung Disease (BOLD) study. We estimated the prevalence of chronic cough for each site accounting for sampling design. To identify risk factors, we conducted multivariable logistic regression analysis within each site and then pooled estimates using random-effects meta-analysis. We also calculated the population-attributable risk (PAR) associated with each of the identified risk factors. Findings: The prevalence of chronic cough varied from 3% in India (rural Pune) to 24% in the United States of America (Lexington, KY). Chronic cough was more common among females, both current and passive smokers, those working in a dusty job, those with a history of tuberculosis, those who were obese, those with a low level of education, and those with hypertension or airflow limitation. The most influential risk factors were current smoking and working in a dusty job. Interpretation: Our findings suggested that the prevalence of chronic cough varies widely across sites in different world regions. Cigarette smoking and exposure to dust in the workplace are its major risk factors.info:eu-repo/semantics/publishedVersio

Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study

Background Chronic obstructive pulmonary disease has been associated with exposures in the workplace. We aimed to assess the association of respiratory symptoms and lung function with occupation in the Burden of Obstructive Lung Disease study. Methods We analysed cross-sectional data from 28 823 adults (≥40 years) in 34 countries. We considered 11 occupations and grouped them by likelihood of exposure to organic dusts, inorganic dusts and fumes. The association of chronic cough, chronic phlegm, wheeze, dyspnoea, forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1)/FVC with occupation was assessed, per study site, using multivariable regression. These estimates were then meta-analysed. Sensitivity analyses explored differences between sexes and gross national income. Results Overall, working in settings with potentially high exposure to dusts or fumes was associated with respiratory symptoms but not lung function differences. The most common occupation was farming. Compared to people not working in any of the 11 considered occupations, those who were farmers for ≥20 years were more likely to have chronic cough (OR 1.52, 95% CI 1.19–1.94), wheeze (OR 1.37, 95% CI 1.16–1.63) and dyspnoea (OR 1.83, 95% CI 1.53–2.20), but not lower FVC (β=0.02 L, 95% CI −0.02–0.06 L) or lower FEV1/FVC (β=0.04%, 95% CI −0.49–0.58%). Some findings differed by sex and gross national income. Conclusion At a population level, the occupational exposures considered in this study do not appear to be major determinants of differences in lung function, although they are associated with more respiratory symptoms. Because not all work settings were included in this study, respiratory surveillance should still be encouraged among high-risk dusty and fume job workers, especially in low- and middle-income countries.publishedVersio

Cohort Profile: Burden of Obstructive Lung Disease (BOLD) study

The Burden of Obstructive Lung Disease (BOLD) study was established to assess the prevalence of chronic airflow obstruction, a key characteristic of chronic obstructive pulmonary disease, and its risk factors in adults (≥40 years) from general populations across the world. The baseline study was conducted between 2003 and 2016, in 41 sites across Africa, Asia, Europe, North America, the Caribbean and Oceania, and collected high-quality pre- and post-bronchodilator spirometry from 28 828 participants. The follow-up study was conducted between 2019 and 2021, in 18 sites across Africa, Asia, Europe and the Caribbean. At baseline, there were in these sites 12 502 participants with high-quality spirometry. A total of 6452 were followed up, with 5936 completing the study core questionnaire. Of these, 4044 also provided high-quality pre- and post-bronchodilator spirometry. On both occasions, the core questionnaire covered information on respiratory symptoms, doctor diagnoses, health care use, medication use and ealth status, as well as potential risk factors. Information on occupation, environmental exposures and diet was also collected

Design & Development of Pedal Operated Multipurpose Food Processing Unit-a Review

This project relates to the design and fabrication of “Design and Development of Pedal Operated Multipurpose FoodProcessing Unit”. This is a technology that may develop as an alternative to the electrically operated stationary machines with high efficiency and portability. The project is related to the food processing unit. Current activities include analysis as well as experimental work. After analysis this project has developed what quantity and what kind of raw material is required to produce different food items. Under experimental work the project deals with the proper functioning of the machine. The machine is run by a person seated on a seat provided, operating the pedal which connects the machine with a chain drive to the different units of the machine, and the machine starts producing the required food items such as potato chips, vermicelli (sevai), slices of various vegetables etc. The main purpose of the machine is not only to eliminate the usage of electricity. The project is portable and consumes less floor area. This project is a welcome edition and a new concept where we thought this as an ideal replacement for the electrically operated stationarymachine

Ocean Surface Trash Collector

This paper describes the design of a robot for collecting waste floating on the water surface. Three important issues for designing the aquatic robots are a cost-effective solution along with robustness and durability. Due to the nature of the cleaning work, we designed the robot structure with car like mechanism that can provide high stability, good ability in maneuver and can easily collect all the waste flowing on the water. The plastic pipe container works best for this case and fulfils all structural stability criteria. For collection of waste, a motor-driven conveyor belt has been designed for collecting the wastes and deploy it into a plastic box connected to the platform. This design provides simple and effective waste removal and accommodates large amounts of waste within a little space. This light-weight and tough structure support the total weight of the collected waste, conveyor as well as the hardware components used. The rotating arms system based a differential drive mechanism has been designed, which allows the robots to require a 360 turn on the spot and provides high thrust. Electronic circuit and motors have been placed on the platform, in order to protect them from water. The robot is automatically controlled by Arduino, sensors, motor driver, GPS and GSM modules. The testing of the robot prototype proved to be effective in waste collecting and getting back to the way-point. The maximum trash loads that robot can bear is up 5 kg. The main aim of the project is to optimize time, energy and overall process speed

Formulation And Evaluation Of Fast Dis-integrating Tablets Of Sertraline Hcl By Using Natural Super Disintegrants

The speed of onset of action of antidepressant is clinically important for several reasons. Objective of this research was to formulate Fast disintegrating tablets of sertraline hydrochloride by using natural superdisintegrants so that it will minimize time of onset of action and also become economic. Direct compression method is use to prepare Fast disintegrating tablets. Paper describes impact of different concentration of natural superdisintegrants like gelatinized starch, treated agar on various parameters of Fast disintegrating tablets of sertraline Hcl. All formulation were evaluated for various parameters such as hardness, friability, drug content, wetting time, dissolution study, disintegration test. An optimized formulation (GS-6) was found to have good hardness of 3.10 kg/cm2, disintegration time of 22.37 second and dissolution of 95 % in 12 min.The conclusion is results obtained clearly indicate that optimized batch GS-6 having remarkable increase in disintegrating and dissolution time for the treatment of depression