An investigation into stakeholders' approaches to copyright ownership in university-produced scholarly works and the effect on access to UK scholarship

This thesis considers the various perspectives of universities, academic staff and publishers to the copyright ownership of teaching and research outputs produced by UK universities, with a particular focus on how this affects the provision of online and/or open access to those outputs by university libraries. It presents ten papers written over a twenty year time frame that consider these issues within the context of a number of practitioner research projects and demonstrate how practices are changing over time. The papers employ a range of methodologies including questionnaire surveys, comparative design studies, interviews and content analyses. The key findings relating to research outputs (the scholarly royalty-free literature) are that rights are still mainly relinquished to academic staff by UK HEIs, although some HEIs are beginning to assert the right to re-use those works in various ways. Whilst academics are relied upon to either retain copyright or communicate their HEI s copyright policy terms to publishers, in most cases they (reluctantly) assign copyright to publishers. Publishers are increasingly allowing green open access to their scholarly works in some form, but under a growing array of restrictions and conditions principally embargo periods. Publishers terms of re-use for such works (when made explicit) are often restrictive, however most academics would be happy for their works to be re-used non-commercially as long as their moral rights remain protected. This situation creates challenges for both Institutional Repository Managers and copyright clearance staff in Libraries to manage access to, and re-use of, these outputs. The key findings relating to teaching outputs are that copyright mainly lies with HEIs although there are signs that HEIs are moving towards a shared ownership position through licensing. Academics seem to expect some degree of shared ownership, but as with research outputs, are principally concerned that their moral rights are protected. UK HEI copyright policies in this area are fledgling and do not comprehensively address either moral rights issues or other key copyright issues pertaining to OERs. Failure of universities to address these issues is impacting on the motivation of academics to share OERs

Clearing the way: copyright clearance in UK libraries

Libraries today face a problem. Their raison d’etre: to provide access to information for their users is on the one hand being enabled by new technologies and developments, and on the other is being hindered by copyright restrictions. New developments in libraries, learning and teaching, such as electronic short loan collections, computer aided learning packages, distance learning packages and so on, all seek to provide better educational support for students. However to include readypublished material in all these services requires copyright clearance. Quotes such as “Copyright was seen as a major barrier to the scaling up of electronic short loan”1, and “one of the most taxing concerns for courseware developers…is to...obtain the legitimate use of existing copyright works to include in new products”2 abound in the library and related literature. In fact, the current legal and legislative framework makes copyright clearance an essential library activity

Pseudo-marginal Bayesian inference for Gaussian process latent variable models

A Bayesian inference framework for supervised Gaussian process latent variable models is introduced. The framework overcomes the high correlations between latent variables and hyperparameters by collapsing the statistical model through approximate integration of the latent variables. Using an unbiased pseudo estimate for the marginal likelihood, the exact hyperparameter posterior can then be explored using collapsed Gibbs sampling and, conditional on these samples, the exact latent posterior can be explored through elliptical slice sampling. The framework is tested on both simulated and real examples. When compared with the standard approach based on variational inference, this approach leads to significant improvements in the predictive accuracy and quantification of uncertainty, as well as a deeper insight into the challenges of performing inference in this class of models

Project ACORN final report

Project ACORN was funded by the Joint Information Systems Committee for eighteen months under the “Electronic Short Loan Collection” strand of the eLib (Electronic Libraries) programme. During the course of the project period it met all of its initial aims and objectives, listed below, as well as setting for itself, and meeting, many more. The Project has taken dissemination very seriously and has published over 35 reports and documents on its web site, in addition to writing a large number of journal articles and giving many papers and presentations. As the written report output of the Project has been so full, this Final Report can only serve to summarise the key findings of those reports, and direct the reader to the full reports for more detailed information

Ways of evaluating the chosen rights solution

Our motivational survey highlighted that easily available support would be a motivator for depositors to contribute their teaching materials into a repository. Support with rights issues is particularly important because of the confusion over rights that exists within UK Higher Education Institutions (HEIs). We have identified possible support that depositors and end users could receive. Some potential evaluation criteria have been identified to assess the licences that we have put in place. We aim to evaluate the experience of the depositor and the end user and assess each licence in terms of suitability and accuracy

Acumulación de Cu y Zn por célular microalgales marinas de Nannochloropsis gaditana (Eustigmatophyceae) inmovilizadas en alginato de calcio

13 páginas, 5 figuras, 2 tablas.[EN] Different experiments about the accumulation capacity for copper and zinc were carried out on the marine microalgae Nannochloropsis gaditana Lubián (Eustigmatophyceae). A 24-hour study of the evolution of accumulated metal in the beads revealed two possible accumulation phases. Accumulation differences between free and immobilized microalgal cells were investigated finding no differences for copper, and little differences for zinc. Free cells accumulated practically 100% Cu or Zn in the media under experimental conditions. Experiments in order to compare the accumulation capacity of living vs. dead cells were designed too, obtaining the largest accumulation levels for both metals in the beads containing immobilized living microalgae. In experiments carried out in continuous-flow reactors, beads with entrapped cells showed to be more efficient removing Cu and Zn than beads without cells. In all the experiments, the calcium alginate beads showed strong affinity for Cu. Similar results were obtained when accumulation by packed beads in columns was tested, but efficacy was higher if this design was used (beads with cells retain 80% of Cu introduced in the column).[ES] Se han realizado distintos experimentos sobre la capacidad de acumulación de cobre y zinc por parte de la microalga marina Nannochloropsis gaditana Lubián (Eustigmatophyceae). Un estudio de la evolución del metal acumulado durante 24 horas reveló la existencia de dos posibles fases de acumulación. Se investigaron las diferentes capacidades de acumulación de células microalgales libres e inmovilizadas, no encontrándose diferencias para el cobre y pequeñas diferencias para el zinc. Las células libres acumularon prácticamente el 100% del Cu o Zn presentes en el medio, en las condiciones experimentales. Se desarrollaron experimentos encaminados a determinar la capacidad de acumulación de estos metales por parte de algas inmovilizadas vivas frente a la de algas inmovilizadas muertas, encontrándose los niveles acumulativos más altos para ambos metales en las gotas de alginato que contenían algas vivas. En experimentos realizados en reactores de flujo continuo, las gotas de alginato con células inmovilizadas en su interior demostraron ser más eficientes en cuanto a la retirada de Cu y Zn del medio que las gotas sin algas. En todos los experimentos realizados se observa una fuerte afinidad del Cu por el alginato de calcio. Se obtuvieron resultados similares cuando se ensayó la acumulación de metales en gotas de alginato dispuestas en columnas llenas, aunque la eficacia fue mayor cuando se usó este último diseño (las gotas de alginato con células retuvieron el 80% del Cu introducido en la columna).Peer reviewe

A surrogate modelling approach based on nonlinear dimension reduction for uncertainty quantification in groundwater flow models

In this paper, we develop a surrogate modelling approach for capturing the output field (e.g., the pressure head) from groundwater flow models involving a stochastic input field (e.g., the hy- draulic conductivity). We use a Karhunen-Lo`eve expansion for a log-normally distributed input field, and apply manifold learning (local tangent space alignment) to perform Gaussian process Bayesian inference using Hamiltonian Monte Carlo in an abstract feature space, yielding outputs for arbitrary unseen inputs. We also develop a framework for forward uncertainty quantification in such problems, including analytical approximations of the mean of the marginalized distri- bution (with respect to the inputs). To sample from the distribution we present Monte Carlo approach. Two examples are presented to demonstrate the accuracy of our approach: a Darcy flow model with contaminant transport in 2-d and a Richards equation model in 3-d

Targeted activation of toll-like receptors: conjugation of a toll-like receptor 7 agonist to a monoclonal antibody maintains antigen binding and specificity

Therapeutic activation of Toll-like receptors (TLR) has potential for cancer immunotherapy, for augmenting the activity of anti-tumor monoclonal antibodies (mAbs), and for improved vaccine adjuvants. A previous attempt to specifically target TLR agonists to dendritic cells (DC) using mAbs failed because conjugation led to non-specific binding and mAbs lost specificity. We demonstrate here for the first time the successful conjugation of a small molecule TLR7 agonist to an anti-tumour mAb (the anti-hCD 20 rituximab) without compromising antigen specificity. The TLR7 agonist UC-1V150 was conjugated to rituximab using two conjugation methods and yield, molecular substitution ratio, retention of TLR7 activity and specificity of antigen binding were compared. Both conjugation methods produced rituximab-UC-1V150 conjugates with UC-1V150 : rituximab ratio ranging from 1:1 to 3:1 with drug loading quantified by UV spectroscopy and drug substitution ratio verified by MALDI TOF mass spectroscopy. The yield of purified conjugates varied with conjugation method, and dropped as low as 31% using a method previously described for conjugating UC-1V150 to proteins, where a bifunctional crosslinker was firstly reacted with rituximab, and secondly to the TLR7 agonist. We therefore developed a direct conjugation method by producing an amine-reactive UV active version of UC-1V150, termed NHS:UC-1V150. Direct conjugation with NHS:UC-1V150 was quick and simple and gave improved conjugate yields of 65-78%. Rituximab-UC-1V150 conjugates had the expected pro-inflammatory activity in vitro (EC50 28-53 nM) with a significantly increased activity over unconjugated UC-1V150 (EC50 547 nM). Antigen binding and specificity of the rituxuimab-UC-1V150 conjugates was retained, and after incubation with human peripheral blood leukocytes, all conjugates bound strongly only to CD20-expressing B cells whilst no non-specific binding to CD20-negative cells was observed. Selective targeting of Toll-like receptor activation directly within tumors or to DC is now feasible

The curse of conservation: empirical evidence demonstrating that changes in land-use legislation drove catastrophic bushfires in Southeast Australia

Protecting “wilderness” and removing human involvement in “nature” was a core pillar of the modern conservation movement through the 20th century. Conservation approaches and legislation informed by this narrative fail to recognise that Aboriginal people have long valued, used, and shaped most landscapes on Earth. Aboriginal people curated open and fire-safe Country for millennia with fire in what are now forested and fire-prone regions. Settler land holders recognised the importance of this and mimicked these practices. The Land Conservation Act of 1970 in Victoria, Australia, prohibited burning by settler land holders in an effort to protect natural landscapes. We present a 120-year record of vegetation and fire regime change from Gunaikurnai Country, southeast Australia. Our data demonstrate that catastrophic bushfires first impacted the local area immediately following the prohibition of settler burning in 1970, which allowed a rapid increase in flammable eucalypts that resulted in the onset of catastrophic bushfires. Our data corroborate local narratives on the root causes of the current bushfire crisis. Perpetuation of the wilderness myth in conservation may worsen this crisis, and it is time to listen to and learn from Indigenous and local people, and to empower these communities to drive research and management agendas.1. Introduction 1.1. Study Region 1.2. A confluence of Factors 2. Materials and Methods 2.1. Core Collection & Chronology 2.2. Pollen 2.3. Macroscopic Charcoal & Charanalysis 2.4. Magnetic Susceptibility 2.5. Numerical Data Analysis 3. Results 3.1. Chronology 3.2. Pollen 3.3. Macroscopic Charcoal & Charanalysis 3.4. Magnetic Susceptibility 3.5. Numerical Data Analysis 4. Discussion 4.1. Landscape Change between ca. 1900–2021 4.2. The Environmental Impact of Legislation 4.3. The Curse of Conservation That Ignores People as Managers and History as a Prelud