10 research outputs found

    A Genetic-Programming-Based Approach for the Learning of Compact Fuzzy Rule-Based Classification Systems

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    In the design of an interpretable fuzzy rule-based classification system (FRBCS) the precision as much as the simplicity of the extracted knowledge must be considered as objectives. In any inductive learning algorithm, when we deal with problems with a large number of features, the exponential growth of the fuzzy rule search space makes the learning process more difficult. Moreover it leads to an FRBCS with a rule base with a high cardinality. In this paper, we propose a genetic-programming-based method for the learning of an FRBCS, where disjunctive normal form (DNF) rules compete and cooperate among themselves in order to obtain an understandable and compact set of fuzzy rules, which presents a good classification performance with high dimensionality problems. This proposal uses a token competition mechanism to maintain the diversity of the population. The good results obtained with several classification problems support our proposal.Spanish Ministry of Science and Technology TIN-2005-08386-C05-03 and TIN-2005-08386-C05-0

    Experimental Study on 164 Algorithms Available in Software Tools for Solving Standard Non-Linear Regression Problems

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    In the specialized literature, researchers can find a large number of proposals for solving regression problems that come from different research areas. However, researchers tend to use only proposals from the area in which they are experts. This paper analyses the performance of a large number of the available regression algorithms from some of the most known and widely used software tools in order to help non-expert users from other areas to properly solve their own regression problems and to help specialized researchers developing well-founded future proposals by properly comparing and identifying algorithms that will enable them to focus on significant further developments. To sum up, we have analyzed 164 algorithms that come from 14 main different families available in 6 software tools (Neural Networks, Support Vector Machines, Regression Trees, Rule-Based Methods, Stacking, Random Forests, Model trees, Generalized Linear Models, Nearest Neighbor methods, Partial Least Squares and Principal Component Regression, Multivariate Adaptive Regression Splines, Bagging, Boosting, and other methods) over 52 datasets. A new measure has also been proposed to show the goodness of each algorithm with respect to the others. Finally, a statistical analysis by non-parametric tests has been carried out over all the algorithms and on the best 30 algorithms, both with and without bagging. Results show that the algorithms from Random Forest, Model Tree and Support Vector Machine families get the best positions in the rankings obtained by the statistical tests when bagging is not considered. In addition, the use of bagging techniques significantly improves the performance of the algorithms without excessive increase in computational times.This work was supported in part by the University of Córdoba under the project PPG2019-UCOSOCIAL-03, and in part by the Spanish Ministry of Science, Innovation and Universities under Grant TIN2015- 68454-R and Grant TIN2017-89517-P

    Enhancing soft computing techniques to actively address imbalanced regression problems

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    This paper has been supported in part by the ERDF A way of making Europe/Health Institute Carlos III/Spanish Ministry of Science, Innovation and Universities (grant number PI20/00711), by the ERDF A way of making Europe/Regional Government of Andalusia/Ministry of Economic Transformation, Industry, Knowledge and Universities (grant numbers P18-RT-2248 and B-CTS-536-UGR20) and by the MCIN/AEI/10.13039/50110001103 (grant numbers PID2019-107793GB-I00 and PID2020-119478GB-I00). Funding for open access charge: Universidad de Granada / CBUA

    Shared gene expression signatures between visceral adipose and skeletal muscle tissues are associated with cardiometabolic traits in children with obesity

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    Obesity in children is related to the development of cardiometabolic complications later in life, where molecular changes of visceral adipose tissue (VAT) and skeletal muscle tissue (SMT) have been proven to be fundamental. The aim of this study is to unveil the gene expression architecture of both tissues in a cohort of Spanish boys with obesity, using a clustering method known as weighted gene co-expression network analysis. For this purpose, we have followed a multi-objective analytic pipeline consisting of three main approaches; identification of gene co-expression clusters associated with childhood obesity, individually in VAT and SMT (intra-tissue, approach I); identification of gene co-expression clusters associated with obesitymetabolic alterations, individually in VAT and SMT (intra-tissue, approach II); and identification of gene co-expression clusters associated with obesity-metabolic alterations simultaneously in VAT and SMT (intertissue, approach III). In both tissues, we identified independent and inter-tissue gene co-expression signatures associated with obesity and cardiovascular risk, some of which exceeded multiple-test correction filters. In these signatures, we could identify some central hub genes (e.g., NDUFB8, GUCY1B1, KCNMA1, NPR2, PPP3CC) participating in relevant metabolic pathways exceeding multiple-testing correction filters. We identified the central hub genes PIK3R2, PPP3C and PTPN5 associated with MAPK signaling and insulin resistance terms. This is the first time that these genes have been associated with childhood obesity in both tissues. Therefore, they could be potential novel molecular targets for drugs and health interventions, opening new lines of research on the personalized care in this pathology. This work generates interesting hypotheses about the transcriptomics alterations underlying metabolic health alterations in obesity in the pediatric populationERDF/Health Institute Carlos III (grant numbers PI20/00711 and PI20/00563)ERDF/Regional Government of Andalusia/Ministry of Economic Transformation, Industry, Knowledge and Universities (grant numbers P18- RT-2248 and B-CTS-536-UGR20
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