Social Maintenance of Oppressive Structures

This study intends to explore the ways in which religiously based parenting may serve as a vehicle for shaping personal attitudes about sexuality. As a result of their belief systems, increasingly religious parents are likely to adopt different parenting strategies than non-religious parents. When a combination of authoritarian values and a particular adherence to conservative theology characterizes parenting, this may be responsible for the construction of distinct mindsets in young individuals. Parents that score high in fundamentalism and authoritarianism could exhibit a greater chance of raising children with beliefs similar to their own. Through use of quantitative measures, this study sets out to verify the proposed hypothesis by determining if there are significant differences in the level of sexual orientation prejudice among young adults who were raised in highly religious or non-religious contexts

Novel organometallic chloroquine derivative inhibits tumor growth

Autophagy has emerged as a mechanism critical to both tumorigenesis and development of resistance to multiple lines of anti-cancer therapy. Therefore, targeting autophagy and alternative cell death pathways has arisen as a viable strategy for refractory tumors. The anti-malarial 4-aminoquinoline compounds chloroquine and hydroxychloroquine are currently being considered for re-purposing as anti- cancer therapies intended to sensitize different tumors by targeting the lysosomal cell death pathway. Here, we describe a novel organometallic chloroquine derivative, cymanquine, that exhibits enhanced bioactivity compared to chloroquine in both normal, and reduced pH tumor microenvironments, thus overcoming a defined limitation of traditional 4-aminoquinolines. In vitro, cymanquine exhibits greater potency than CQ in a diverse panel of human cancer cell lines, including melanoma, in both normal pH and in reduced pH conditions that mimic the tumor microenvironment. Cymanquine treatment results in greater lysosomal accumulation than chloroquine and induces lysosomal dysfunction leading to autophagy blockade. Using a mouse model of vemurafenib-resistant melanoma, cymanquine slowed tumor growth greater than hydroxychloroquine, and when used in combination with vemurafenib, cymanquine partially restored sensitivity to vemurafenib. Overall, we show that cymanquine exhibits superior lysosomal accumulation and autophagy blockade than either chloroquine or hydroxychloroquine in vitro; and in addition to its high level of tolerability in mice, exhibits superior in vivo efficacy in a model of human melanoma

Changes in Achilles Tendon Thickness Following a 10 – Week Heavy Load Eccentric Exercise Program

Achilles tendinopathy (AT) is a common overuse injury in running or jumping activities where the tendon is unable to properly respond to the load. AT increases tendon thickness while decreasing stiffness and function (1). Studies have shown that tendon properties can be positively influenced by load (5,6). Therefore, AT has typically been treated conservatively through physical therapy, with eccentric calf strengthening exercises as the focus of the treatment (2)

A semimicro method for the determination of phosphorus in organic compounds

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La cultura política como factor causal del predominio asistencialista en la atención a grupos vulnerables: las organizaciones de la sociedad civil pro migrantes en Tijuana

This work aims to define the political culture of Civil Society Organizations in Tijuana pro migrants and its contribution to collective action that organizations perform in response to deported as a vulnerable group. The methodology of this study had a qualitative approach, based on the analytical and comparative methods and it was conducted through structured and unstructured interviews (depth interview) made to 10 organizations. This study contributes to research on the role that civil society organizations have in finding solutions to problems that directly impact on vulnerable social groups in Mexico.Este trabajo pretende definir la cultura política de Organizaciones de la Sociedad Civil (OSC) pro migrantes en Tijuana, y su contribución a la acción colectiva que las organizaciones realizan, en atención a deportados como grupo vulnerable. El proceso metodológico de esta investigación tuvo un enfoque cualitativo, basado en los métodos analítico y comparativo y por medio de entrevistas estructuradas y no estructuradas (entrevista a profundidad) realizadas a 10 organizaciones. Este estudio contribuye a la investigación sobre el rol que la sociedad civil organizada tiene en la búsqueda de soluciones a problemas que impactan directamente a grupos sociales vulnerables en México

Estudio de las propiedades físicas del suelo en una finca de ganadería extensiva: la aplicación de la espectrorradiometría en el análisis del suelo

Existe una demanda creciente de datos actualizados y precisos sobre el estado de los suelos, a corto plazo y sobre amplias extensiones geográficas. La espectrorradiometría de reflectancia difusa es un método que se caracteriza por ser rápido, barato, eficiente y no destructivo. En este trabajo se propone generar un método de trabajo que permita establecer fácilmente estimaciones sobre algunas propiedades edáficas, prescindiendo o complementando a los métodos convencionales de laboratorio. Para ello, se tomaron 59 muestras de suelos de tres fincas de la provincia de Cáceres, Extremadura, España, de las cuales se obtuvieron los espectros de reflectancia con el espectrorradiómetro ASD FieldSpec 4. Para establecer una relación entre los espectros y las propiedades edáficas, se empleó la regresión de mínimos cuadrados parciales (PLSR), junto con la validación cruzada. Los resultados fueron nueve modelos predictivos, evaluados de acuerdo a los parámetros estadísticos más utilizados (r², RMSECV, SECV, RPD y “bias”), por lo que las predicciones fueron buenas para la materia orgánica, nitrógeno total y fósforo disponible (0.81 ≤ r² ≤ 0.91); aproximadas para el potasio intercambiable, capacidad de intercambio catiónico y sodio intercambiable (0.66 ≤ r² ≤ 0.8) y menos precisas para los modelos de pH, calcio y magnesio intercambiables (r² ≤ 0.66). Esto evidencia el potencial de la espectrorradiometría como un método útil para el monitoreo y la evaluación de la calidad de los suelos en áreas de ganadería extensiva de Extremadura.There is an increasing demand for updated, precise and short-term soil data over extensive geographical areas. Diffuse reflectance spectroradiometry is a rapid, inexpensive, efficient and non-destructive method. In this study, a working method is proposed to achieve predictions of soil properties without using traditional chemical methods. In consequence, a total of 59 soil samples were obtained in three farms in the province of Caceres, Extremadura, Spain. The spectra were measured with an ASD FieldSpec 4 portable object spectrometer. In order to establish a relation between spectra and soil properties, partial least squares regression with cross validation was used. The results showed nine predictive models that were assessed according to the most common statistical parameters (r², RMSECV, SECV, RPD and “bias”), so the predictions obtained were good for soil organic matter, total nitrogen and available phosphorus (0.81 ≤ r² ≤ 0.91); approximate predictions were obtained for exchangeable potassium, cation exchange capacity and exchangeable sodium (0.66 ≤ r² ≤ 0.8) and poor predictions were obtained for pH and exchangeable calcium and magnesium (r² ≤ 0.66). Thus, the potential of spectroscopy as a useful method for monitoring and assessing soil quality in areas of Extremadura with extensive livestock rearing has been demonstrated.Grado en Geografía y Ordenación del Territorio. Universidad de Extremadur

Commuter choice Managers and parking Managers coordination

A Report by Prof. Francis Wambalaba, the DVC Research at USIU- AfricaShared use park and ride is defined as park and ride spaces that can be used to serve two or more individual land uses without conflict or encroachment. It represents a unique approach for addressing parking problems, and can offer substantial savings in land and development costs. One of the fundamental factors that determine the success of this approach is the level of coordination that exists between parking managers and transit agencies. Commercial centers and private property owners/managers have traditionally not been enthused or willing to participate in shared use park and ride opportunities based on the assumptions that park and rides create potential for criminal activities, take away space from customers, and may lead to increased insurance rates. Transit agencies on the other hand, believe that there is potential for economic benefits for property managers/owners and the agencies themselves, as well as improved transit service and shopping convenience for their customers. This report is a synthesis of literature on coordinating parking arrangements exist between park and ride managers and transit agencies. It highlights varying interests among stakeholders and respective perceptions about the benefits and challenges of such a relationship. It also provides a baseline for further study to determine the validity of such assumptions.Florida Department of Transportation and the U.S. Department of Transportation

Commuter Choice Managers and Parking Managers Coordination

Shared use park and ride is defined as park and ride spaces that can be used to serve two or more individual land uses without conflict or encroachment. It represents a unique approach for addressing parking problems, and can offer substantial savings in land and development costs. One of the fundamental factors that determine the success of this approach is the level of coordination that exists between parking managers and transit agencies. Commercial centers and private property owners/managers have traditionally not been enthused or willing to participate in shared use park and ride opportunities based on the assumptions that park and rides create potential for criminal activities, take away space from customers, and may lead to increased insurance rates. Transit agencies on the other hand, believe that there is potential for economic benefits for property managers/owners and the agencies themselves, as well as improved transit service and shopping convenience for their customers. This report is a synthesis of literature on coordinating parking arrangements exist between park and ride managers and transit agencies. It highlights varying interests among stakeholders and respective perceptions about the benefits and challenges of such a relationship. It also provides a baseline for further study to determine the validity of such assumptions. The first part of this study involves a literature review in two areas: • a review of nationally published studies of shared use park and ride • a review of studies regarding public transit access to private property as well as shared use park and ride in Florida The literature search revealed that responses to the questions about incentives suggest three key themes: 1. The majority of the concerns are related to the physical attributes of the transit vehicles and the damage that can be caused due to those attributes. 2. Maintenance is one of the most important incentives to developers, and also one of the most frequently given incentives provided by transit agencies. Consequently, this should be a focus area in negotiations. 3. There is need for education among the players in order to alleviate some of the misperceptions of transit services and patrons. The second part is a review of direct feedback from participating private property developers, or owners and managers of shared use Park and Ride in Florida, as well as feedback from transit agencies and other rideshare agencies in Florida. Feedback from private property owners/managers indicated that the most important incentives that can be offered to assure a better working relationship with transit agencies include installation of amenities, maintenance of stops on site, periodic cleanings, and concrete pads. Major concerns included: • Perceived high levels of crime • Ridership that was not part of their customer bas