74 research outputs found

    Aplicación del aprendizaje basado en problemas y aula invertida en la asignatura de cultura emprendedora del NMS, la transversalidad y apoyo de la TIC

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    Las reformas en la educación en México presentan diversas influencias para realizar cambios sustantivos en la forma de trabajar en el aula. En el nivel medio superior se trabaja bajo competencias, con la aplicación de estrategias de enseñanza – aprendizaje con apoyo de la TIC que permitan vincular la teoría con la practica en su contexto real del estudiante. Aunado a la aplicación del aula invertida que representa una extraordinaria manera de reforzar las actividades de los jóvenes. Al permitir vincular diversas asignaturas mediante la estrategia del ABP aprendizaje basado en problemas para el desarrollo de conocimientos, habilidades y actitudes en los estudiantes del sexto semestre

    The Nontoxic Cholera B Subunit Is a Potent Adjuvant for Intradermal DC-Targeted Vaccination

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    CD4+ T cells are major players in the immune response against several diseases; including AIDS, leishmaniasis, tuberculosis, influenza and cancer. Their activation has been successfully achieved by administering antigen coupled with antibodies, against DC-specific receptors in combination with adjuvants. Unfortunately, most of the adjuvants used so far in experimental models are unsuitable for human use. Therefore, human DC-targeted vaccination awaits the description of potent, yet nontoxic adjuvants. The nontoxic cholera B subunit (CTB) can be safely used in humans and it has the potential to activate CD4+ T cell responses. However, it remains unclear whether CTB can promote DC activation and can act as an adjuvant for DC-targeted antigens. Here, we evaluated the CTB's capacity to activate DCs and CD4+ T cell responses, and to generate long-lasting protective immunity. Intradermal (i.d.) administration of CTB promoted late and prolonged activation and accumulation of skin and lymphoid-resident DCs. When CTB was co-administered with anti-DEC205-OVA, it promoted CD4+ T cell expansion, differentiation, and infiltration to peripheral nonlymphoid tissues, i.e., the skin, lungs and intestine. Indeed, CTB promoted a polyfunctional CD4+ T cell response, including the priming of Th1 and Th17 cells, as well as resident memory T (RM) cell differentiation in peripheral nonlymphoid tissues. It is worth noting that CTB together with a DC-targeted antigen promoted local and systemic protection against experimental melanoma and murine rotavirus. We conclude that CTB administered i.d. can be used as an adjuvant to DC-targeted antigens for the induction of broad CD4+ T cell responses as well as for promoting long-lasting protective immunity

    Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study

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    Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide

    Ingreso a nivel superior, indicador de desarrollo de competencias en los alumnos de nivel medio superior

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    En la actualidad el ingreso a nivel superior en Universidades públicas es un problema, pues la cobertura es muy baja, por ejemplo en la Universidad Nacional Autónoma de México (UNAM)  el 91.06 % de los sustentantes son rechazados y en la Universidad Autónoma del Estado de México (UAEMex) son rechazados el 66.8% de los aspirantes. El objetivo de la investigación fue determinar el ingreso a nivel superior de los egresados del Plantel Pablo González Casanova de la UAEMex en el EXANI II 2016. Los resultados obtenidos indican que sustentaron 506 egresados del Plantel Pablo González Casanova,  el 69.8% fueron rechazados. Los alumnos aceptados representan el 30.2%. Las habilidades evaluadas son pensamiento matemático (PMA), pensamiento analítico (PAN)  y  las competencias comunicativas del español: estructura lengua (ELE)  y comprensión lectora (CLE).  En promedio se obtuvo 54.1% para PMA, 54.8% para PAN, 54.6%  ELE y  64.0% CLE, estos resultados superan la media nacional y estatal  cuyos valores están por debajo 52.0 puntos en cada habilidad evaluada. El  60.7 % de los sustentantes obtuvieron menos 60 puntos  y pertenecen al nivel insuficiente,  el 31.0 % de los sustentantes obtuvieron un puntaje entre 61 a 80 puntos incluidos en el nivel suficiente y el  8.3 % de los sustentantes obtuvo un puntaje entre 81 a 100 puntos pertenecientes al nivel de sobresaliente. Ante esta situación los directivos y docentes deben realizar trabajo colaborativo y diseñar estrategias para incrementar el número de aceptados a nivel superior, centradas en el desarrollo de las habilidades evaluadas. 
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