2 research outputs found
Kidney transplantation in genetic (Factor H deficient) haemolitic-uremic syndrome (HUS)
Interpretation of kidney graft outcome in HUS
is frequently hindered by heterogeneity of case-mix; epidemic, more than
idiopathic, and some mutations in complement system, such as membrane
cofactor protein (MCP), carry a favourable prognosis, when compared with
the more severe forms of factor H and I deficiency. Relapse of basic disease
is common, particularly when calcineurin inhibitors (CNI) are used; rescue
by means of plasma therapy is seldom and temporarily successful. Here we
report a case of transplantation in Factor H deficient HUS