Democracy, support for democracy and corruption: A longitudinal study of Latin American countries

Although often unable to satisfactorily solve the problem, democracy (especially enduring democracy) is commonly believed to reduce corruption. Yet, both Transparency International and the World Bank continue to attach a high risk of corruption to Latin American countries: corruption and impunity remain prevalent in the area, despite consolidating democratic regimes and recent anticorruption reforms. Using level of democracy and its endurance, as well as information on the perceptions of democratic performance and corruption obtained from the Latinobarometro, we analyzed a panel data covering the period 2005-2010 in 14 Latin American countries. Our main results show that levels of democracy and citizens' assessment of government fairness have a positive impact on corruption. However, satisfaction towards democracy has the opposite effect: when citizens believed democratic governments and public administrations to be efficient, they also perceived that gains against corruption had significantly decreased.<br /

Improving the Protectiveness of 3-Mercaptopropyl-Trimethoxysilane Coatings on Bronze by Addition of Oxidic Nano- and Microparticles

The protectiveness of coatings based on 3-mercaptopropyl-trimethoxysilane (PropS-SH) applied on bronze artworks was enhanced by investigating and tuning a variety of factors. In particular, the coating performances were optimized by proper additive choice among oxide nanoparticles (CeO2, La2O3, TiO2) and microparticles (fly ash (FA)), and by varying the aging time of the nanoparticle suspensions before coating application and the RT curing time of the coatings. Moreover, the possibility of conservation of the silane solution under refrigerated conditions was assessed. The aggressive environment was a tenfold concentrated synthetic acid rain (AR × 10). The techniques adopted comprised electrochemical tests (polarization curve recording and EIS tests) and SEM-Energy Dispersion Spectroscopy (EDS) observations. In the case of FA microparticles, never used before as additives in silane coatings, further tests were performed in FA suspensions in AR × 10 to clarify the contribution of these particles to PropS-SH coating protectiveness. The tests included pH measurements, elemental chemical analyses, and electrochemical tests on bare bronze. Improved performances of PropS-SH coatings were achieved by La2O3, CeO2, and FA addition, with La2O3 affording the best results during 20 days of immersion. The positive influence of FA was connected to its alkaline character and to the release of soluble silicates

Democracy, Support for Democracy and Corruption. A Longitudinal Study of Latin American Countries

Although often unable to satisfactorily solve the problem, democracy (especially enduring democracy) is commonly believed to reduce corruption. Yet, both Transparency International and the World Bank continue to attach a high risk of corruption to Latin American countries: corruption and impunity remain prevalent in the area, despite consolidating democratic regimes and recent anticorruption reforms. Using level of democracy and its endurance, as well as information on the perceptions of democratic performance and corruption obtained from the Latinobarometro, we analyzed a panel data covering the period 2005-2010 in 14 Latin American countries. Our main results show that levels of democracy and citizens' assessment of government fairness have a positive impact on corruption. However, satisfaction towards democracy has the opposite effect: when citizens believed democratic governments and public administrations to be efficient, they also perceived that gains against corruption had significantly decreased

Multimodal treatment for local recurrent malignant gliomas: resurgery and/or reirradiation followed by chemotherapy

The therapeutic management of recurrent malignant gliomas (MGs) is not determined. Therefore, the efficacy of a multimodal approach and a combination systemic therapy was investigated. A retrospective analysis of 26 MGs patients at first relapse treated with multimodal therapy (chemotherapy plus surgery and/or reirradiation) or chemotherapy alone was performed. Second-line chemotherapy consisted of fotemustine (FTM) in combination with bevacizumab (BEV) (cFTM/BEV) or followed by third-line BEV (sFTM/BEV). Subgroup analyses were performed. Multimodal therapy provided a higher overall response rate (ORR) (73 vs. 47%), disease control rate (DCR) (82 vs. 67%), median progression-free survival (mPFS) (11 vs. 7 months; P=0.08) and median overall survival (mOS) (13 vs. 8 months; P=0.04) compared with chemotherapy. Concomitant FTM/BEV resulted in higher ORR (84 vs. 36%), DCR (92 vs. 57%), mPFS (10 vs. 5 months; P=0.22) and mOS (11 vs. 5.2 months; P=0.15) compared with sFTM/BEV. Methylated patients did not experience additional survival benefits with multimodality treatment but had higher mPFS (10 vs 7.1 months; P=0.33) and mOS (11 vs. 8 months; P=0.33) with cFTM/BEV. Unmethylated patients experienced the greatest survival benefit with the multimodal approach (mPFS: 10 vs. 5 months; mOS 11 vs 6 months; both P=0.02) and cFTM/BEV (mPFS: 5 vs. 2 months; mOS 6 vs. 3.2 months; both P=0.01). In conclusion, in recurrent MGs, multimodal therapy and cFTM/BEV provide survival and response benefits. Methylated patients benefit from a cFTM/BEV but not from a multimodal approach. Notably, unmethylated patients had the highest survival benefit with the two strategies

Grand Unification and the Principle of Minimal Flavor Violation

Minimal Flavor Violation is an attractive approach to suppress unacceptably large flavor changing neutral currents from beyond the standard model physics at the TeV scale. It can be used in theories with low energy supersymmetry, multi Higgs doublet theories and other extensions of the minimal standard model. We show how minimal flavor violation can be implemented in Grand Unified theories.Comment: 15 pages, no figure

Populist Governments and the Quality of Governance: A Worldwide Comparison

In spite of recent advances in the literature, there are still fewer empirical works, embracing different regions of the world, that analyze the impact of populist governments on the quality of governance. This paper, which covers 33 countries from five world regions from 1996 until 2019, intends to fill this gap. By using different statistical methods, our data show that periods under populist governments in power had a significantly negative effect on governance quality measured by the WGI data set. For each of the six dimensions of governance, however, (voice and accountability, political stability and the absence of violence, government effectiveness, regulatory quality, rule of law, and control of corruption) we detect exceptions. In addition, exploring the data by geographical region and types of populism (exclusive, neoliberal and inclusive), crucially refines our findings, showing a great deal of differences and revealing that similar types of populism operate in different ways in separate geographical contexts. These variations are explained both by the difficulty of defining slippery concepts, and applying them consistently to historical cases, and by particular traits and historical occurrences that significantly affect the relationship we analyze. Through different fixed regression models, finally, we control for a series of potentially confounding factors and find that our major descriptive findings have been confirmed

Underhand ball-throwing test assessing eye-hand coordination in 6-11yr children

Ball-throwing is a basic open skill common to several physical activities and sports. It is strictly related to eye-hand coordination, a neuromuscular ability affecting many expressions of human movement, including daily living activities (Houwen et al., 2008). The accuracy of underhand ball-throwing task was studied in 538 girls and 583 boys aged 6-11yr, with normal or corrected-to-normal vision. Within range of age, the ages of boys and girls did not differ (ANOVA, p&gt;0.05). Using the dominant hand, each participant performed 2 consecutive sequences of 5 repetitions of a standardized underhand ball-throwing test (UBT). It consisted in underhand throwing a tennis ball into the floor area delimited by a 80cm diameter wooden hoop, lying on the floor 9m apart the standing child (Grassi et al., 2006). Within subject, the centered targets of each sequence were scored. Descriptive statistics of UBT were computed within sequence, age, and sex group. The effects of age and sex, and sex × age interaction on UBT scores were compared by ANOVA (statistical significance 5%). UBT scores significantly increased with age (p=0.003). Boys obtained larger UBT scores than those obtained by the girls of the same age (p=0.002). The age-related differences of UBT scores were similar in boys and girls (p&gt;0.05). On average, UBT scores recorded in the second sequence were larger than those of the first sequence. Differences were significant in boys, and increased with age (p&lt;0.01 for all comparisons). The effects of age was similar in boys and girls (p&gt;0.05). UBT could be used in both sport activities and rehabilitation to quantify either the level of motor learning and training or the effects of physiotherapy treatments

A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions

Bisphosphonates (BPs) are the first-line treatment of bone loss resulting from various pathological conditions. Due to their high affinity to bone they have been used to develop conjugates with pro-Anabolic or anti-catabolic drugs. We recently demontrated that hydrogen sulfide (H2S), promotes osteogenesis and inhibits osteoclast differentiation. Here we developed an innovative molecule, named DM-22, obtained from the combination of alendronate (AL) and the H2S-releasing moiety aryl-isothiocyanate. DM-22 and AL were assayed in vitro in the concentration range 1-33 μM for effects on viability and function of human osteoclasts (h-OCs) and mesenchymal stromal cells (h-MSCs) undergoing osteogenic differentiation. Amperometric measures revealed that DM-22 releases H2S at a slow rate with a thiol-dependent mechanism. DM-22 significantly inhibited h-OCs differentiation and function, maintaining a residual h-OCs viability even at the high dose of 33 μM. Contrary to AL, in h-MSCs DM-22 did not induce cytotoxicity as revealed by LDH assay, significantly stimulated mineralization as measured by Alizarin Red staining and increased mRNA expression of Collagen I as compared to control cultures. In conclusion, DM-22 is a new BP which inhibits h-OCs function and stimulate osteogenic differentiation of h-MSCs, without cytotoxicity. DM-22 is an ideal candidate for a novel family of osteoanabolic drugs

Long-term outcomes of surgical aortic fenestration for complicated acute type B aortic dissections

IntroductionSurgical aortic fenestration has been used for treating ischemic complications of acute type B aortic dissection (ABAD). In the current endovascular era, surgical aortic fenestration may serve as an alternative for these patients after percutaneous failure. The purpose of this study is to describe our surgical suprarenal and infrarenal aortic fenestration technique, and to report the long-term outcomes of this approach in the management of complicated ABAD.MethodsWe retrospectively analyzed the in-hospital and long-term outcomes of 18 patients treated with either suprarenal (n = 10) or infrarenal surgical fenestration (n = 8) for complicated ABAD between 1988 and 2002. Suprarenal fenestration was performed through a thoracoabdominal incision in the 10th intercostal space, whereas patients treated with infrarenal fenestration underwent a midline laparotomy. A longitudinal aortotomy was performed and the true and false lumens were identified, followed by a wide resection of the intimal membrane.ResultsMedian age was 60 years (range, 48-82 years) and 89% (n = 16) were male. The in-hospital mortality was 22% (n = 4), which included two deaths after suprarenal fenestration and two deaths after infrarenal fenestration. In the remaining patients, full visceral, renal, and lower extremity function was recovered, except for 1 patient with paraplegia at admission in which the neurologic deficit was permanent. Median follow-up of the surviving patients was 10.0 years (interquartile range, 12.5; range, 0.5-20 years). During follow-up, none of the patients developed renal or visceral ischemia, or ischemic complications to the lower extremities, and no significant dilatations of the treated aortic segments were noted. Three of 14 patients with ABAD who were discharged alive expired during the follow-up period due to causes unrelated to the surgical procedure.ConclusionSurgical aortic fenestration represents an effective and durable option for treating ischemic complications of ABAD. Actually, this conservative surgical technique may serve as the alternative treatment in case of contraindications or failure of endovascular management of complicated ABAD