Cloud service-oriented dashboard for work cell management in RFID-enabled ubiquitous manufacturing

This article aims at developing a service-oriented dashboard for operators and supervisors of manufacturing shopfloor work-cells to realize information visibility and traceability effectively with cloud and RFID (radio frequency identification) technologies. The work is based on a case of an illustrative assembly line consisting of a number of work cells. The dashboard is deployed for facilitating assembly operations in ubiquitous manufacturing environment. The utilization of the system leads to significant improvements in work cell productivity and quality, operational flexibility and decision efficiency. © 2013 IEEE.published_or_final_versio

Towards product customization and personalization in IoT-enabled cloud manufacturing

Customized/personalized products are gaining more shares in today\u2019s product market. Such products need collective efforts from consumers, manufacturers and third parties. This requirement has not been well addressed due to both market and technology factors. On the other hand, the Internet of Things (IoT) provides real-time sensing/actuating ability and fast transmission capability of data/information, so that remote operation of manufacturing activities and efficient collaboration among stakeholders are greatly facilitated. This provides great opportunities to address the requirement mentioned above. Thus we propose a full-connection model of product design and manufacturing in the IoT-enabled cloud manufacturing environment. The proposed model uses social networks to connect multiple parties and facilitate open innovations, and use IoT to glue physical space to cyber space and cloud manufacturing to provide various elastic services, so that the on-demand workspace, interaction, information sharing or collective problem solving are enabled. We also propose a supporting infrastructure for this model using the latest information and communication technologies. Finally, we present a case study of an RFID enabled production system for customized and personalized product with the ability to enable a new paradigm of \u201cdynamic processes and close collaborations among different roles\u201d and ensure robust production.Peer reviewed: YesNRC publication: Ye

Bitter Taste Receptors Influence Glucose Homeostasis

TAS1R- and TAS2R-type taste receptors are expressed in the gustatory system, where they detect sweet- and bitter-tasting stimuli, respectively. These receptors are also expressed in subsets of cells within the mammalian gastrointestinal tract, where they mediate nutrient assimilation and endocrine responses. For example, sweeteners stimulate taste receptors on the surface of gut enteroendocrine L cells to elicit an increase in intracellular Ca2+ and secretion of the incretin hormone glucagon-like peptide-1 (GLP-1), an important modulator of insulin biosynthesis and secretion. Because of the importance of taste receptors in the regulation of food intake and the alimentary responses to chemostimuli, we hypothesized that differences in taste receptor efficacy may impact glucose homeostasis. To address this issue, we initiated a candidate gene study within the Amish Family Diabetes Study and assessed the association of taste receptor variants with indicators of glucose dysregulation, including a diagnosis of type 2 diabetes mellitus and high levels of blood glucose and insulin during an oral glucose tolerance test. We report that a TAS2R haplotype is associated with altered glucose and insulin homeostasis. We also found that one SNP within this haplotype disrupts normal responses of a single receptor, TAS2R9, to its cognate ligands ofloxacin, procainamide and pirenzapine. Together, these findings suggest that a functionally compromised TAS2R receptor negatively impacts glucose homeostasis, providing an important link between alimentary chemosensation and metabolic disease

The Transcriptomes of Two Heritable Cell Types Illuminate the Circuit Governing Their Differentiation

The differentiation of cells into distinct cell types, each of which is heritable for many generations, underlies many biological phenomena. White and opaque cells of the fungal pathogen Candida albicans are two such heritable cell types, each thought to be adapted to unique niches within their human host. To systematically investigate their differences, we performed strand-specific, massively-parallel sequencing of RNA from C. albicans white and opaque cells. With these data we first annotated the C. albicans transcriptome, finding hundreds of novel differentially-expressed transcripts. Using the new annotation, we compared differences in transcript abundance between the two cell types with the genomic regions bound by a master regulator of the white-opaque switch (Wor1). We found that the revised transcriptional landscape considerably alters our understanding of the circuit governing differentiation. In particular, we can now resolve the poor concordance between binding of a master regulator and the differential expression of adjacent genes, a discrepancy observed in several other studies of cell differentiation. More than one third of the Wor1-bound differentially-expressed transcripts were previously unannotated, which explains the formerly puzzling presence of Wor1 at these positions along the genome. Many of these newly identified Wor1-regulated genes are non-coding and transcribed antisense to coding transcripts. We also find that 5′ and 3′ UTRs of mRNAs in the circuit are unusually long and that 5′ UTRs often differ in length between cell-types, suggesting UTRs encode important regulatory information and that use of alternative promoters is widespread. Further analysis revealed that the revised Wor1 circuit bears several striking similarities to the Oct4 circuit that specifies the pluripotency of mammalian embryonic stem cells. Additional characteristics shared with the Oct4 circuit suggest a set of general hallmarks characteristic of heritable differentiation states in eukaryotes

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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