Autoantibodies against type I IFNs in patients with critical influenza pneumonia

In an international cohort of 279 patients with hypoxemic influenza pneumonia, we identified 13 patients (4.6%) with autoantibodies neutralizing IFN-alpha and/or -omega, which were previously reported to underlie 15% cases of life-threatening COVID-19 pneumonia and one third of severe adverse reactions to live-attenuated yellow fever vaccine. Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-alpha 2 alone (five patients) or with IFN-omega (eight patients) from a cohort of 279 patients (4.7%) aged 6-73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-alpha 2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-omega. The patients' autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients 70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-alpha 2 and IFN-omega (OR = 11.7, P = 1.3 x 10(-5)), especially those <70 yr old (OR = 139.9, P = 3.1 x 10(-10)). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for similar to 5% of cases of life-threatening influenza pneumonia in patients <70 yr old

Approche de la modelisation de la dynamique de population de la pyrale du maies (Ostrinia nubilalis Hbn.) Lepidoptera : Pyralidae dans le Bassin parisien

SIGLECNRS T 58506 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Temperature-dependent model for European corn borer (Lepidoptera : Pyralidae) development

36 ref.International audienc

Sensibilisation aux problemes statistiques en modelisation

National audienc

Validation of the european corn borer damage model on maize with X rays

National audienc

Utilisation de critères métaboliques et morphogénétiques pour l'analyse de la diapause de populations naturelles d'Ostrinia nubilalis Hbn. (Lep., Pyralidae)

International audienc

Les territoires urbains rouennais : inégalités objectives et pratiques subjectives

Bussi Michel, Dutot François, Got Brigitte, Prevotat Xavier, Demczuk Aline, Gosselin Isabelle. Les territoires urbains rouennais : inégalités objectives et pratiques subjectives. In: Études Normandes, 48e année, n°1-2, 1999. Le puzzle rouennais - Géoscopie du Grand Rouen. pp. 125-150

Field evaluation of and modeling the impact of three control methods on the larval dynamics of Ostrinia nubilalis ( Lepidoptera :Pyralidae ).

International audienc

Collapse of a Planktothrix agardhii perennial bloom and microcystin dynamics in response to reduced phosphate concentrations in a temperate lake

International audiencePlanktothrix agardhii dynamics, microcystin concentration and limnological variables were monitored every 2 weeks for 2 years (2004-2006) in a shallow hypereutrophic artificial lake (BNV, Viry-Chatillon, France). Time-series analysis identified two components in the P. agardhii biomass dynamics: (1) a significant decreasing trend in P. agardhii biomass (65% of the overall variance) and (2) a residual component without significant seasonal periodicity. A path-analysis model was built to determine the main factors controlling the P. agardhii dynamics over the period studied. The model explained 66% of P. agardhii biomass changes. The decreasing trend in P. agardhii biomass was significantly related to a decrease in the PO(4)(3-) concentration resulting from an improved treatment of the incoming watershed surface water. The residual component was related to zooplankton dynamics (cyclopoid abundances), supporting the hypothesis of a top-down control of P. agardhii, but only when the biomass was low. Forty-nine percent of the variability in the microcystin (MC) concentration (min:< 0.1 mu g equivalent MC-LR L(-1); max: 7.4 mu g equivalent MC-LR L(-1)) could be explained by changes in the P. agardhii biomass. The highest toxin content was observed when P. agardhii biomass was the lowest, which suggests changes in the proportion of microcystin-producing and -nonproducing subpopulations and/or the physiological status of cells

Manuel Consistent System CS

*INRA, Biometrie, Mission Informatique, Centre de Jouy en Josas Diffusion du document : INRA, Biometrie, Mission Informatique, Centre de Jouy en JosasNational audienc