5 research outputs found
Resposta in vitro e suscetibilidade ao Agrobacterium de duas cultivares de Stylosanthes guianensis
- Author
- BARROS L.M.G.
- BENETKA V.
- BINNS A.
- BRASILEIRO A.C.M.
- BROER I.
- DEBLAERE R.
- DORNELAS M.C.
- DORNELAS M.C.
- GAUDIN V.
- GHISI O.M.A.
- GLORIA B.A. da
- GOLDS T.J.
- HOPKINSON J.M.
- KONCZ C.
- LIN J.
- LUCIA VIEIRA HOFFMANN
- MARIA LUCIA CARNEIRO VIEIRA
- MATHIS N.L.
- MEIJER E.G.
- MEIJER E.G.M.
- MEIJER E.G.M.
- MESA A.R.
- MONTOYA A.L.
- MURASHIGE T.
- PETIT A.
- SALEM K.M.S.A.
- SARMA K.S.
- SILVA B.A.
- STOMP A.M.
- TEPFER M.
- VIEIRA M.L.C.
- WEISING K.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M.S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G.R.
- Abecasis G.R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N.S.
- Acquilini D.
- Adams C.
- Adams E.L.
- Adams K.
- Adamsara A.
- Adanini O.
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- Thanasi M.
- Thankachen M.
- Thirlwall Y.
- Thirumaran M.
- Thomas A.
- Thomas A.
- Thomas B.
- Thomas E.
- Thomas H.
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- Thwaites V.
- Thwaites V.
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- Tierney C.
- Tilbey S.
- Tilney E.
- Timlick E.
- Timmers P.R.H.J.
- Ting L.
- Tiseo G.
- Tita R.
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- Todd A.
- Todd L.
- Tolson M.
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- Tommasi A.
- Tonks L.
- Torky M.S.
- Torrents D.
- Torvorapanit P.
- Tracy B.
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- Underwood S.J.
- Vaghi M.
- Vaida M.
- Valente S.
- Valentine J.
- Valentino F.
- van Blokland I.
- van Heel D.A.
- van Koutrik L.
- Varghese M.
- Vecchia M.
- Vedage D.
- Veerapen K.
- Venkatesh H.
- Venn L.D.
- Venturelli S.
- Vergori A.
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- Verma A.
- Verma A.
- Verma S.S.
- Vertue M.
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- Verzuri A.
- Vigurs C.
- Villalonga J.M.
- Vincent R.
- Vincenti A.
- Virgilio E.
- Vitart V.
- Vizcaychipi M.P.
- Vochin A.
- Voide C.
- von Frenckell C.
- von Hohenstaufen K.A.
- Vonk J.M.
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- Vuylsteke A.
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- Wadams B.
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- Wagstaff V.
- Wain L.V.
- Waite A.A.C.
- Wakefield P.
- Wakinshaw F.
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- Walker S.
- Walker S.
- Wall A.
- Walsh T.
- Walsh T.
- Walters R.K.
- Walton O.
- Wang B.
- Wang J.
- Wang X.
- Wanying Z.
- Ward G.
- Ward L.
- Ward M.
- Warden S.
- Warmerdam R.
- Warren D.
- Wassall H.
- Wasson C.
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- Watson E.
- Watson G.
- Watson J.
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- Webster A.
- Webster D.
- Webster K.
- Wei S.
- Weiss S.T.
- Weldon C.H.
- Wells C.
- Welters I.D.
- Weston H.
- Whileman A.
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- White I.
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- Whittle H.
- Whitton C.
- Whyte C.
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- Wild L.
- Wilding L.
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- Wilkins J.
- Wilkinson A.
- Wilkinson B.
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- Williams A.
- Williams A.
- Williams A.T.
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- Wulandari R.
- Wyllie D.H.
- Wynter I.
- Xavier K.
- Xue X.
- Yadav A.
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- Yassen A.M.
- Yates B.
- Ye C.
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- Zainy T.
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- Zaki A.
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- Zanella I.
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- Zechner M.
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- Zhao J.H.
- Zheng C.
- Zhou W.
- Zitter L.
- Zlatopolsky M.
- Zongo O.
- Zucchi P.
- Zyndorf M.
- Zöllner S.
- Åsvold B.O.
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Plant regeneration in Arachis stenosperma Krapov. and W. C. Gregory from roots and calluses derived from leaflets of in vitro plants
- Author
- A. Koroch
- A. Krapovickas
- B. Bhagwat
- B.A. Gloria da
- B.B. Johnson
- C. D’Onofrio
- C. Nef-Campa
- E.E. Benson
- Elisabeth Mansur
- G. Pacheco
- Georgia Pacheco
- H.Y. Rey
- J.B. Morris
- José Francisco Montenegro Valls
- K.B. Dunbar
- K.B. Dunbar
- Leonardo Alves Carneiro
- M. Hosseini-Nasr
- M.C. Dornelas
- N.R. Grosso
- P. Subrahmanyam
- P.A. Wadegaonkar
- R.F. Gagliardi
- R.N. Pittman
- R.N. Pittman
- Rachel Fatima Gagliardi
- S.B. Sharma
- T. Murashige
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Brazilian Flora 2020: Leveraging the power of a collaborative scientific network
- Author
- Abreu Fernanda
- Abreu Maria
- Abreu Vanessa H.R.
- Acuña‐castillo Rafael
- Afonso Edgar A.L.
- Agra Leandro A.N.N.
- Agra Maria
- Aguiar Daniel P.P.
- Aires Elisa
- Almeda Frank
- Almeida Eduardo
- Almeida Gracineide S.S.
- Almeida Mariana
- Almeida Nicolli B.C.
- Almeida Rafael
- Almeida Roberto B.P.
- Almeida Thaís
- Alves Daniela
- Alves Flávio
- Alves Karina N.L.
- Alves Maria B.B.
- Alves Rodolfo
- Amaral André L.S.
- Amaral Maria C.E.
- Amorim André M.A.
- Amorim Bruno
- Amorim Eduardo
- Amorim Vivian
- Amélio Leandro
- Andrade Ivanilza
- Andrade Ray
- Andreata Regina H.P.
- Andrino Caroline
- André Thiago
- Anjos Cassiane
- Antar Guilherme
- Antonicelli Mirian C.A.
- Antunes Lorena l.C.
- Aona Lidyanne Y.S.
- Arana Marcelo
- Aranha João L.M.
- Araujo Andréa
- Araujo Cintia A.T.
- Araujo Flávia
- Araújo Anderson G.A.
- Araújo Camila
- Araújo Mário H.T.
- Arbo Maria
- Arnou Emily
- Asprino Renata
- Assis Francine
- Assis Leandro C.S.
- Assis Marta
- Athayde Filho Francisco
- Athiê‐souza Sarah
- Azevedo Igor H.F.
- Bacci Lucas
- Barbosa Camilo V.O.
- Barbosa Juliana
- Barbosa Maria Regina V.
- Barbosa‐silva Rafael
- Barboza Gloria
- Barcellos Ian
- Barcelos Flávia R.B.
- Barcelos Laísa
- Barreto Kamilla l.
- Barros Fábio
- Barros Thamires l.A.
- Barros‐barreto Maria B.B.
- Bastos Cid J.P.
- Bastos Cláudia
- Batista João A.N.
- Batista Marcella M.I.
- Baumgratz José Fernando A.
- Bautista Hortencia
- Benelli Adarilda
- Berguecio Nicolás
- Bernacci Luís
- Beyer Maila
- Bezerra Andrea C.C.
- Bezerra Luísa M.P.A.
- Bezerra Yuri R.L.
- Bianchetti Luciano
- Bicudo Carlos E.M.
- Bigio Narcísio
- Biral Leonardo
- Bissoli Vinícius
- Bittencourt Felipe
- Bochorny Thuane
- Bohn Amabily
- Bohs Lynn
- Bojacá Gabriel F.P.
- Boldorini Abril
- Boldrini Ilsi
- Bolson Mônica
- Bordin Juçara
- Bordon Natali
- Borges Rafael A.X.
- Borges Rodrigo l.
- Bortoluzzi Roseli l.C.
- Bove Claudia
- Bovini Massimo
- Braga João M.A.
- Braga Nayara S.S.
- Branco Suema
- Brauner Laiana
- Braz Denise
- Bringel João B.A.
- Brito Antonio l.V.T.
- Brito Eliete
- Bruniera Carla
- Buchoski Monica
- Buck William
- Bueno Norma
- Bueno Vinicius
- Buril‐vital Maria T.A.
- Burton George
- Büneker Henrique
- Bünger Mariana
- Cabral Andressa
- Cabral Elsa l.
- Cabral Fernanda
- Cabral Tiara
- Caddah Mayara
- Caires Claudenir
- Caires Taiara
- Calazans Luana S.B.
- Caldas Diana K.D.
- Calió Maria
- Calvo Joel
- Camargo Rodrigo
- Camelo Mel
- Campos‐rocha Antonio
- Canestraro Bianca
- Canto‐dorow Thais
- Cantuária Patrick
- Cara Álison l.
- Cardoso Andréia
- Cardoso Domingos B.O.S.
- Cardoso Jesiane
- Cardoso Leandro J.T.
- Cardoso Pedro
- Cardozo Andrey l.
- Carmo Dimas
- Carmo João A.M.
- Carneiro Camila
- Carneiro Cláudia
- Carrijo Tatiana
- Caruzo Maria B.R.
- Carvalho Catarina
- Carvalho Dariane A.S.
- Carvalho Fernanda
- Carvalho Jefferson
- Carvalho Maria l.S.
- Carvalho‐silva Micheline
- Castello Ana C.D.
- Castro E Silva Isabella
- Castro Márcia
- Catenacci Fernanda
- Cavalcanti Laise
- Cavalcanti Taciana
- Cavalheiro Larissa
- Cervi Armando
- Chacon Roberta
- Chagas Aline
- Chagas Earl C.O.
- Chautems Alain
- Chauveau Olivier
- Chequín Renata
- Christ Anderson l.
- Christ Jheniffer
- Cidrão Bruno
- Clark Lynn
- Coelho Alexa A.O.P.
- Coelho Guilherme
- Coelho Marcus A.N.
- Coelho Rubens l.G.
- Colletta Gabriel
- Colli‐silva Matheus
- Conceição Adilva
- Conceição Tulio
- Condack João P.S.
- Contro Fernanda l.
- Cordeiro Inês
- Cordeiro Luciana
- Cordeiro Wesley P.F.S.
- Costa E Silva Maria
- Costa Andrea
- Costa Daniel
- Costa Denise
- Costa Fabiane
- Costa Fernanda S.N.
- Costa Francisco C.P.
- Costa Géssica A.G.
- Costa Isabelle G.C.M.
- Costa Itayguara
- Costa Jeferson
- Costa Jorge A.S.
- Costa José G.S.
- Costa Maria T.R.
- Costa Mitchel I.A.
- Costa Suzana
- Costa Thiago
- Costa Tiago
- Costa‐lima James l.
- Cota Matheus M.T.
- Couceiro Yuri S.V.
- Coutinho Thales
- Couto Dayvid
- Couto Ricardo
- Couvo Anielly
- Cyrillo Stephany
- Cárdenas Gabriela
- Câmara Paulo E.A.S.
- Cândido Elisa
- Côrtes Ana l.A.
- Dal Molin Luis
- Dalastra Claudenice
- Dalcin Eduardo Couto
- Damasceno Rafaella G.L.
- de Lazzari Lara R.P.
- Deble Leonardo
- Delfini Carolina
- Delgado Junior Geadelande
- Delgado‐salinas Alfonso
- Della Aline
- Delprete Piero
- Dematteis Massimiliano
- Dettke Greta
- Devecchi Marcelo
- Dewes Talita
- Di Maio Fernando
- Dias Kauê N.L.
- Dias Micheli
- Dias Pedro
- Dittrich Vinícius A.O.
- Domínguez Yoannis
- Dorneles Mariane
- Dressler Stefan
- Duarte Marilia
- Duran Juan D.T.
- Dutilh Julie H.A.
- Dutra Letícia l.
- Dutra Valquíria
- Díaz Yani C.A.
- Dórea Marcos
- Echternacht Livia
- Eggers Lilian
- Erkens Roy H.J.
- Eslabão Marcelo
- Espírito Santo Fábio
- Esser Hans‐joachim
- Essi Liliana
- Esteves Gerleni l.
- Esteves Roberto l.
- Everling Joel
- Ezcurra Cecilia
- Facco Marlon
- Fader Andrea A.C.
- Falcão Marcus J.A.
- Fantecelle Laura
- Farco Gabriela
- Faria Allan l.A.
- Faria Ana P.G.
- Faria Aparecida
- Faria Jair
- Faria Maria
- Farias Sabrina
- Farias‐singer Rosana
- Farinaccio Maria
- Fernandes Aluisio
- Fernandes Ana
- Fernandes Fernando
- Fernandes José
- Fernandes Rozijane
- Fernandes Thiago
- Fernandes Ulisses
- Fernando Emanoel M.P.
- Ferreira Carlos D.M.
- Ferreira Fabrício
- Ferreira Gabriel
- Ferreira João P.R.
- Ferreira Priscila P.A.
- Ferreira Silvana
- Ferrucci María
- Fiaschi Pedro
- Fidanza Karina
- Filardi Fabiana L.R.
- Filgueiras Tarciso
- Firetti Fabiana
- Fleischmann Andreas
- Florentín Javier
- Florentín Mariela
- Flores Andréia
- Flores Jerônimo M.M.
- Flores Thiago
- Fonseca Luiz H.M.
- Fontelas Jean
- Fontella‐pereira Jorge
- Forster Wellington
- Forzza Rafaela
- Fraga Claudio
- Fraga Fernanda R.M.
- Fraga Santiago
- Francisco Jéssica N.C.
- França Flávio
- França Juliana R.K.G.
- Freire‐fierro Alina
- Freitas Fernanda
- Freitas Joelcio
- Freitas Maria
- Fritsch Peter
- Funez Luís
- Furtado Samyra
- Gaem Paulo
- Gaglioti André l.
- Gagnon Edeline
- Gama Beatriz R.A.
- Garcia Flávia C.P.
- Gasper André l.
- Gerace Samuele
- Giacomin Leandro l.
- Giaretta Augusto
- Gil André S.B.
- Gissi Danilo
- Giuffre Pamela M.W.
- Giulietti Ana
- Giussani Liliana
- Goebel Gabriela
- Goes Monique
- Goldenberg Renato
- Gomes Beatriz
- Gomes Fernanda
- Gomes Mario
- Gomes‐da‐silva Janaína
- Gomes‐klein Vera l.
- Gonella Paulo
- Gonzaga Augusto F.N.
- Gonzaga Diego
- Gonzatti Felipe
- González Favio
- Gonçalez Victor
- Gonçalves Ana P.S.
- Gonçalves Deise J.P.
- Gouvêa Yuri
- Graham Shirley A.T.
- Gregório Bernarda
- Grings Martin
- Groppo Milton
- Grossi Mariana
- Guarçoni Elidio A.E.
- Guedes Felipe
- Guedes Juliana
- Guerra Ethiéne
- Guimarães Elsie
- Guimarães Leonardo R.S.
- Guimarães Paulo J.F.
- Gurgel Ely S.C.
- Gutiérrez Diego
- Góes Luiz A.A.
- Hall Climbiê
- Harley Raymond
- Hassemer Gustavo
- Hattori Eric K.O.
- Hechenleitner Paulina
- Hefler Sonia
- Heiden Gustavo
- Henning Tilo
- Henriques Diego
- Hensold Nancy
- Hinoshita Lucas K.R.
- Hirai Regina
- Hirao Yasmin
- Hiriart Florencia
- Hopkins Michael J.G.
- Hoyos‐gómez Saúl
- Huamantupa Isau
- Hurbath Fernanda
- Iganci João R.V.
- Ilkiu‐borges Anna l.
- Imig Daniela
- Indriunas Alexandre
- Inácio Camila
- Jacques Eliane l.
- Jacques Suara S.A.
- Jaimes Juliana
- Jardim Jomar
- Jesus Jôane
- Jesus Priscila
- Jiménez‐mejías Pedro
- Johnson David
- Jordão Lucas S.B.
- Jordão Valner M.M.
- Jorge Taciane
- Kaehler Miriam
- Kameyama Cíntia
- Kataoka Eric
- Kessous Igor
- Kilipper Julia
- Kinoshita Luiza
- Klein Viviane
- Klitgaard Bente
- Knapp Sandra
- Koch Ana
- Koch Ingrid
- Kochanovski Fábio
- Kominami Gabriel F.G.
- Konno Tatiana U.P.
- Koschnitzke Cristiana
- Kotovski Emília
- Kriebel Ricardo
- Külkamp Josimar
- Labiak Paulo
- Leal Brígida
- Leal Eduardo
- Leite Wellerson
- Leite Áurea C.F.
- Leitman Paula
- Lewis Gwilym
- Lima Adriana
- Lima Alexandre
- Lima Duane F.S.
- Lima Eliene
- Lima Haroldo
- Lima Jessica
- Lima Laura C.P.
- Lima Laíce F.G.
- Lima Letícia
- Lima Lucas
- Lima Luis F.P.
- Lima Rita
- Lima Vanessa l.
- Link‐perez Melanie
- Lirio Elton
- Lobão Adriana
- Loeuille Benoit F.P.
- Lohmann Lúcia
- Loiola Maria I.B.
- Lombardi Julio
- Longhi‐wagner Hilda
- Lopes Gabriel S.R.
- Lopes Jenifer
- Lopes Letícia
- Lopes Raimundo
- Lopes Rosana
- Lorencini Tiago
- Lorenzi Harri
- Lourenço Ana R.L.
- Lourenço Arthur
- Louzada Rafael
- Lovo Juliana
- Lozano Eduardo
- Luber Jaquelini
- Lucas Dióber
- Lucas Eve
- Luebert Federico
- Lughadha Eimear Nic
- Luizi‐ponzo Andrea
- Luna Bruna
- Luna Naédja K.M.
- Luz Cíntia l.S.
- López Maria
- Lüdtke Raquel
- M.D. Cardozo Nállarett
- Machado Anderson F.P.
- Machado Evandro
- Machado Talita
- Maciel Jefferson
- Maciel Sebastião
- Magalhães Rodrigo
- Magenta Mara A.G.
- Maia Leonor
- Maia Talita
- Mamede Maria C.H.
- Mansano Vidal
- Marchioretto Maria
- Margalho Luciano
- Marinho Lucas
- Marques Danilo
- Marquete Ronaldo
- Marra Raquel
- Martins Angela
- Martins Marcos B.S.
- Martins Milena
- Martins Márcio l.L.
- Martins Renata
- Martins Suzana
- Masson Victória
- Matias Ligia
- Matos Agnes M.M.V.
- Matos Andreza
- Matos Fernando
- Matozinhos Carolina
- Mattos Cilene M.J.
- Mattos Leticia
- Matzenauer William
- Mauad Anna V.S.R.
- Maya‐lastra Carlos
- Mayo Simon
- Mazine Fiorella
- Medeiros Débora
- Medeiros Erika V.S.S.
- Medeiros Herison
- Medeiros Maria C.M.P.
- Meerow Alan
- Meireles Jose
- Meireles Leonardo
- Meirelles Julia
- Melchor‐castro Briggitthe
- Mello Zelia
- Mello‐silva Renato
- Melo André l.
- Melo Caio V.V.D.
- Melo Efigenia
- Melo José I.M.
- Mendes Jone C.R.
- Mendes Maria C.Q.
- Mendes‐silva Ingrid
- Meneguzzo Thiago E.C.
- Menezes Cristine
- Menezes Felipe G.P.
- Menezes Mariângela
- Menini Neto Luiz
- Mentz Lilian
- Mesquita Antônio l.
- Messias Patrícia
- Mezzonato‐pires Ana
- Michelangeli Fabián
- Miguel João
- Miguel Laila
- Milward‐de‐azevedo Michaele
- Miotto Silvia T.S.
- Miranda Cecília
- Miranda Vitor F.O.
- Mitchell John
- Molina José M.P.
- Mondin Cláudio
- Monge Marcelo
- Monteiro Daniele
- Monteiro Fernanda K.S.
- Monteiro Raquel
- Monteiro Silvana H.N.
- Monteiro Thiago
- Monzoli João V.L.
- Moore Paloma G.P.
- Mora Martha
- Moraes Marta
- Moraes Mónica
- Morales Juan
- Morales Matías
- Moran Robbin
- Moreira Andréia D.R.
- Moreira André l.C.
- Moreira Ariane
- Moreira Bianca
- Moreira Giselle l.
- Moreira Kassio V.C.
- Moreira Pablo F.F.
- Morim Marli
- Morokawa Rosemeri
- Moroni Pablo
- Mota Aline
- Mota Michelle C.A.
- Mota Nara F.O.
- Moura Beryl E.L.
- Moura Carlos Wallace N.
- Moura Ingridy
- Moura Luíza
- Moura Ricardo l.
- Moura Tania
- Mundim Júlia
- Muniz Filho Eduardo
- Muniz Francisca
- Muniz Leticia
- Mynssen Claudine
- Nakajima Jimi
- Nascimento Janaina G.A.
- Nascimento José
- Nascimento Silvia
- Nepomuceno Francisco A.A.
- Nervo Michelle
- Nery Eduardo
- Neves Beatriz
- Nogueira Matheus G.C.
- Nunes Annelise
- Nunes Clebiana
- Nunes Teonildes
- Nóbrega Giseli
- O'Leary Nataly
- Oellgaard Benjamin
- Oliveira Adriana l.R.
- Oliveira Ana C.S.
- Oliveira Andreza G.S.
- Oliveira Aron
- Oliveira Bárbara
- Oliveira Caetano
- Oliveira Fernanda M.C.
- Oliveira Filipe G.A.
- Oliveira Gleison
- Oliveira Gustavo
- Oliveira Hermeson
- Oliveira Iasmin l.C.
- Oliveira José F.C.
- Oliveira Joésili C.P.
- Oliveira Juliana
- Oliveira Juliana R.P.M.
- Oliveira Leticia G.R.
- Oliveira Lilian F.A.
- Oliveira Lorena
- Oliveira Luciana S.D.
- Oliveira Marcia C.R.
- Oliveira Marcos G.M.
- Oliveira Marise H.V.
- Oliveira Marla I.U.
- Oliveira Márcio l.B.
- Oliveira Regina
- Oliveira Renata
- Oliveira Reyjane
- Oliveira Rodrigo C.G.
- Oliveira Sylvia
- Oliveira Ykaro
- Orlandini Priscila
- Orsolano Guilherme
- Pacífico Ricardo
- Paglia Isis
- Paiva Gabrielle C.P.
- Paixão Liliane
- Pastore José F.B.
- Pastore Mayara
- Pastori Tamara
- Paucar Jenny O.A.
- Paula‐souza Juliana
- Pederneiras Leandro
- Peichoto Myriam
- Peixoto Ariane l.
- Pell Susan
- Pellegrini Marco O.O.
- Pena Nelson T.L.
- Pennington Richard
- Peralta Denilson
- Pereira Amanda P.N.
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- Pereira Maria
- Pereira Paulo E.E.
- Pereira Sidney
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- Perez Ana P.F.
- Pessoa Cleiton
- Pessoa Clenia
- Pessoa Edlley
- Pessoa Maria C.R.
- Petrongari Fernanda
- Philbrick Thomas
- Pignal Marc
- Pimenta Karena
- Pinto Rafael
- Pioner Natália
- Pirani José
- Pizzardo Raquel
- Plos Anabela
- Ponce Marta
- Pontes Juliana
- Pontes Ricardo A.S.
- Pontes Tiago
- Pontes‐pires Aline
- Pott Vali
- Prado Jefferson
- Prado Thainá
- Praia Talita
- Prance Ghillean
- Prange Carolina
- Prata Ana P.N.
- Prochazka Luana
- Proença Carolyn E.B.
- Prudêncio Renato X.A.
- Pscheidt Allan
- Quaresma Aclebia
- Quaresma Aline
- Queiroz George
- Queiroz Luciano
- Queiroz Rubens
- Quinet Alexandre
- Ramos Eliana
- Ramos Geraldo J.P.
- Rando Juliana
- Rebouças Natanael
- Reginato Marcelo
- Reis Miguel M.R.
- Reis Priscila
- Reis‐silva Genilson
- Ribas Osmar
- Ribeiro André R.O.
- Ribeiro Carolina l.
- Ribeiro José E.L.S.
- Ribeiro Michel
- Ribeiro Pétala
- Ribeiro Rayane T.M.
- Ribeiro Ricardo
- Ribeiro Rogério
- Riina Ricarda
- Ritter Mara
- Rivadavia Fernando
- Rivera Vanessa l.
- Rizzo Beatriz
- Rocha Antônio E.S.
- Rocha Lamarck
- Rocha Maria J.R.
- Rodrigues Carine
- Rodrigues Christchellyn
- Rodrigues Izabella M.C.
- Rodrigues Marianna
- Rodrigues Rodrigo Sampaio
- Rodrigues Rodrigo Schütz
- Rodríguez Juan F.C.
- Rodríguez Pedro
- Rollim Isis
- Romanini Rebeca
- Romero María
- Romero Rosana
- Romão Gerson
- Romão Marcos V.V.
- Roque Nádia
- Rosa Bárbara
- Rosa Patrícia
- Rosa Priscila
- Rossa Iago
- Rossetto Elson F.S.
- Rossi Lucia
- Rossini Josiene
- Rosário Alessandro
- Royer Carla
- Rua Gabriel
- Saavedra Mariana
- Saka Mariana
- Sakuragui Cassia
- Salas Roberto
- Sales Margareth
- Salgado Vanina
- Salimena Fátima R.G.
- Salino Alexandre
- Salvador Rafael
- Sampaio Daniela
- Sancho Gisela
- Sano Paulo
- Santana Jéssica C.O.
- Santana Karoline
- Santana Mariana
- Santiago Augusto C.P.
- Santos Alessandra
- Santos Amanda P.B.
- Santos Ana C.A.S.
- Santos Andrea K.A.
- Santos Carlos A.G.
- Santos Emanuelle l.
- Santos Felipe
- Santos Fernanda
- Santos João U.M.
- Santos Karin
- Santos Leidiana l.
- Santos Matheus
- Santos Otilene
- Santos Rafaela
- Santos Renata G.P.
- Santos Thaíla V.A.
- Santos Thiago
- Santos Vanessa
- Santos‐silva Fernanda
- Santos‐silva Juliana
- Saraiva Deisy
- Sarkinen Tiina
- Sartori Ângela l.B.
- Sassone Agostina
- Sauthier Luana
- Scalon Viviane
- Scatigna André
- Schaefer Juliana
- Scheidegger Najla M.B.
- Schliewe Marcos
- Schmidt Eduard D.L.
- Schneider Angelo
- Schneider Layla J.C.
- Schuettpelz Eric
- Schwartsburd Pedro
- Schwarz Elizabeth
- Scudeler Ana l.
- Sebastiani Renata
- Secco Ricardo
- Secretti Elisangela
- Segalla Rosane
- Seleme Elidiene
- Semir João
- Senna Luisa
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- Shimizu Gustavo
- Shirasuna Regina
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- Silva Aline V.M.
- Silva Amanda l.
- Silva Anádria
- Silva Caroline C.A.
- Silva Cassio
- Silva Christian
- Silva Cintia
- Silva Diego
- Silva Dilana
- Silva Fabio
- Silva Fernanda
- Silva Francismeire
- Silva Gabriel
- Silva Gledson
- Silva Guilherme
- Silva Gustavo H.L.
- Silva João P.S.
- Silva Juliana l.
- Silva Juliene F.M.
- Silva Leonardo
- Silva Lucas
- Silva Luciana
- Silva Luiza
- Silva Marcio R.P.
- Silva Marcos
- Silva Marcus F.O.
- Silva Maria S.D.
- Silva Maria l.B.
- Silva Márcio
- Silva Nilda M.F.
- Silva Otávio l.M.
- Silva Rafael
- Silva Raphael
- Silva Renata S.A.
- Silva Renato
- Silva Ronaldo
- Silva Saura
- Silva Suelma
- Silva Tatiane
- Silva Thaynara
- Silva Tânia R.S.
- Silva Wanderson l.S.
- Silva‐castro Milene
- Silva‐cobra Gisele
- Silva‐gonçalves Kelly
- Silveira Fernanda
- Silveira João
- Silveira Thamyres
- Simon Marcelo
- Simão‐bianchini Rosangela.
- Simões Ana
- Simões André
- Siniscalchi Carolina
- Siqueira Carlos
- Smidt Eric
- Smith Alan
- Smith Nathan
- Snak Cristiane
- Soares Abel E.R.
- Soares Arthur
- Soares Edson l.C.
- Soares Kelen
- Soares Luanda
- Soares Marcos V.B.
- Soares Maria l.C.
- Soares Polyana
- Soares Raimundo
- Sobrado Sandra
- Sobral Marcos
- Somner Genise
- Sothers Cynthia
- Sousa Ana A.C.
- Sousa Danilo J.L.
- Sousa Francisco
- Sousa Gardene
- Sousa Hian C.F.
- Sousa Leandro O.F.
- Sousa Mayco W.S.
- Sousa Valdeci
- Souza Aline
- Souza Bruno
- Souza Elnatan
- Souza Filipe
- Souza Luzia
- Souza Marcelo
- Souza Maria A.D.
- Souza Raquel M.B.S.
- Souza Vinicius
- Souza Élvia
- Souza‐buturi Fátima
- Spina Andréa
- Stadnik Aline M.S.
- Staggemeier Vanessa
- Stapf María N.S.
- Stefano Rodrigo
- Stehmann João Renato
- Stern Stephen
- Streher Nathália
- Suchoronczek Andréia
- Sundue Michael
- Sylvestre Lana
- Sá Cyl F.C.
- São‐mateus Wallace M.B.
- Takeuchi Cátia
- Tardivo Rosângela
- Taylor Nigel
- Teixeira Michella D.R.
- Teles Aristônio
- Temponi Livia
- Thode Verônica
- Thomas William
- Tierno Lorena
- Tissot‐squalli Mara
- Toledo Cássio A.P.
- Torke Benjamin
- Torres Alicia
- Torres Daniela S.C.
- Torres‐leite Filipe
- Tozzi Ana M.G.A.
- Trad Rafaela
- Trevisan Rafael
- Trierveiler‐pereira Larissa
- Trovó Marcelo
- Tuler Amélia
- Tyrrell Christopher
- Udulutsch Renata
- Uribbe Fernando
- Vahl Daiane
- Valadares Rodrigo
- Valdemarin Karinne
- Valduga Eduardo
- Valente Emilia
- Valls Jose F.M.
- van den Berg Cássio
- Vasconcelos Liziane
- Vasconcelos Thaís N.C.
- Vasques Diego
- Vaz Angela M.S.F.
- Versiane Ana F.A.
- Versieux Leonardo
- Via Do Pico Gisela
- Viana Pedro l.
- Vianna Filho Marcelo D.M.
- Vianna Suelen
- Vidal João
- Vidal Kaio V.A.
- Vieira Fábio C.S.
- Vieira Jaqueline
- Vieira João P.S.
- Vieira Lucas l.A.
- Vieira Tamara A.F.
- Vieira Tiago l.
- Viera‐barreto Jéssica
- Vignoli‐silva Márcia
- Vilas Bôas‐bastos Silvana
- Villarreal Juan
- Vincent Michael
- Vita Marcela
- Vitta Fabio
- Viveros Raquel
- Viviurka Fernanda
- Vogel Ely Cleusa
- Volet Danilo
- Völtz Rafael
- Wallnöfer Bruno
- Walter Bruno M.T.
- Wanderley Maria G.L.
- Watanabe Mauricio T.C.
- Weber Philipy A.P.
- Weigend Maximilian
- Welker Cassiano A.D.
- Windisch Paulo
- Yoshikawa Vania
- Zamengo Henrique
- Zanatta Maria R.V.
- Zannin Ana
- Zappi Daniela
- Zeferino Laís
- Zelenski Andréia
- Zimbrão Geraldo
- Zuloaga Fernando
- Zuntini Alexandre
- Ângulo María
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali Altaf
- Ali I.A.M.
- Ali Syamlan
- Aliannejad Rasoul
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- AlJohani S.
- Alkwai S.
- Allan A.
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- Alldis Zoe
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- Ally S.M.
- AlMalik A.
- Almalki F.
- Almohammed I.
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- Alotaibi S.
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- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease