Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT3 receptor antagonists

PURPOSE: The ferret cisplatin emesis model has been used for ~30 years and enabled identification of clinically used anti-emetics. We provide an objective assessment of this model including efficacy of 5-HT(3) receptor antagonists to assess its translational validity. METHODS: A systematic review identified available evidence and was used to perform meta-analyses. RESULTS: Of 182 potentially relevant publications, 115 reported cisplatin-induced emesis in ferrets and 68 were included in the analysis. The majority (n = 53) used a 10 mg kg(−1) dose to induce acute emesis, which peaked after 2 h. More recent studies (n = 11) also used 5 mg kg(−1), which induced a biphasic response peaking at 12 h and 48 h. Overall, 5-HT(3) receptor antagonists reduced cisplatin (5 mg kg(−1)) emesis by 68% (45–91%) during the acute phase (day 1) and by 67% (48–86%) and 53% (38–68%, all P < 0.001), during the delayed phase (days 2, 3). In an analysis focused on the acute phase, the efficacy of ondansetron was dependent on the dosage and observation period but not on the dose of cisplatin. CONCLUSION: Our analysis enabled novel findings to be extracted from the literature including factors which may impact on the applicability of preclinical results to humans. It reveals that the efficacy of ondansetron is similar against low and high doses of cisplatin. Additionally, we showed that 5-HT(3) receptor antagonists have a similar efficacy during acute and delayed emesis, which provides a novel insight into the pharmacology of delayed emesis in the ferret

Connecting Health and Technology (CHAT): protocol of a randomized controlled trial to improve nutrition behaviours using mobile devices and tailored text messaging in young adults

Background: Increasing intakes of fruits and vegetables intake, in tandem with reducing consumption of energy-dense and nutrient poor foods and beverages are dietary priorities to prevent chronic disease. Although most adults do not eat enough fruit and vegetables, teenagers and young adults tend to have the lowest intakes. Young adults typically consume a diet which is inconsistent with the dietary recommendations. Yet little is known about the best approaches to improve dietary intakes and behaviours among this group. This randomised controlled trial aims to evaluate the effectiveness of using a mobile device to assess dietary intake, provide tailored dietary feedback and text messages to motivate changes in fruit, vegetable and junk food consumption among young adults

Food consumption frequency and perceived stress and depressive symptoms among students in three European countries

Mikolajczyk RT, El Ansari W, Maxwell AE. Food consumption frequency and perceived stress and depressive symptoms among students in three European countries. Nutrition Journal. 2009;8(1):31.Background: Certain foods might be more frequently eaten under stress or when higher levels of depressive symptoms are experienced. We examined whether poor nutritional habits are associated with stress and depressive symptoms and whether the relationships differ by country and gender in a sample from three European countries collected as part of a Cross National Student Health Survey. Methods: A cross-sectional survey was conducted among first-year students in Germany (N = 696), Poland (N = 489) and Bulgaria (N = 654). Self-administered questionnaires included a 12-item food frequency questionnaire, Cohen's Perceived Stress Scale, and a modified Beck Depression Index. Linear regression analyses were conducted for two outcomes, perceived stress and depressive symptoms. Results: Food consumption frequencies differed by country and gender, as did depressive symptoms and perceived stress. For male students, none of the food consumption groups were associated with perceived stress or depressive symptoms. In females, perceived stress was associated with more frequent consumption of sweets/fast foods and less frequent consumption of fruits/vegetables. Additionally, depressive symptoms were associated with less frequent consumption of fruits/vegetables and meat. Conclusion: Our data show consistent associations between unhealthy food consumption and depressive symptoms and perceived stress among female students from three European countries, but not among male students. This suggests that efforts to reduce depressive symptoms and stress among female students may also lead to the consumption of healthier foods and/or vice-versa

Abordagem do modelo transteórico no comportamento alimentar Transtheoretical model approach in eating behavior

O estudo do comportamento alimentar tem despertado grande interesse por se tratar de um elemento importante para o sucesso de intervenções nutricionais. Considerando-se a complexidade do tema e as inúmeras influências a que está submetido, sugere-se que o aprofundamento de pesquisas sobre os determinantes do comportamento alimentar possibilite maior impacto nas ações de promoção de práticas alimentares saudáveis. A adoção cada vez mais freqüente de uma alimentação inadequada no Brasil e no mundo leva a um questionamento sobre o impacto das intervenções nutricionais tradicionalmente utilizadas em âmbito populacional. Diversas estratégias de educação nutricional são atualmente descritas na literatura; contudo, alcançar a motivação da população para uma mudança efetiva do padrão alimentar ainda é um dos grandes desafios para a saúde pública. A aplicação do modelo transteórico parece ter um papel promissor em relação à melhor compreensão da mudança de comportamento alimentar, almejada nas intervenções nutricionais. Estratégias que envolvam o direcionamento para cada estágio de mudança de comportamento, identificado segundo essa teoria, podem ser mais eficazes quanto à motivação dos indivíduos a adotar práticas alimentares mais saudáveis.<br>The study of eating behavior has been much interest, as this is an essential element for the success of dietary interventions. In view of the complexity of the subject and the countless influences to which it is subject, it is suggested that an in-depth exploration of eating behavior determinants enhances the impact of programs promoting healthy dietary practices. Increasingly more frequent, the adoption of inadequate diets in Brazil and elsewhere in the world leads to questions about the impact of dietary interventions traditionally applied to population groups. Many nutritional education strategies are currently described in the literature; however, motivating people to change their eating habits is still a major public health challenge. Applying the transtheoretical model seems to have a promising role for an enhanced understanding of changes in eating habits that are targeted by dietary interventions. Strategies that are tailored to each step in these changes, as identified by this theory, can motivate people more effectively to adopt healthier eating habits