3,966 research outputs found
A novel polyphase multipole square-wave permanent magnet motor drive for electric vehicles
A novel high-power-density permanent magnet (PM) motor drive for electric vehicles (EVs) is proposed. The motor is a polyphase multipole square-wave PM motor, which can be classified as a kind of PM brushless DC motor. The distinct features of the proposed motor as compared to those of the conventional PM brushless DC motor are as follows. First, the multipole magnetic circuit arrangement enables the minimization of the magnetic yoke, resulting in the reduction of motor volume and weight. Second, the coil span is purposely designed to be equal to one slot pitch, thus saving the amount of copper used. Third, by using a fractional number of slots per pole per phase, the arrangement of the numbers of poles and slots is so unique that the magnetic force between the stator and the rotor at any rotating position is uniform, hence eliminating the cogging torque that usually occurs in PM motors. Finally, the motor can be controlled to operate at a constant torque region and a constant power region with field weakening, thus both high starting torque and high cruising speed can be achieved. Therefore, as the proposed motor drive possesses the distinct advantages of high power density, high efficiency, and superior dynamic performance, it is very suitable for EV applications. A prototype of a five-phase 22-pole 5 kW motor drive has been designed for an experimental EV.published_or_final_versio
Crystal structure and properties of electroless silver plating on polyester fabric
2009-2010 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
Zn-impurity effect and interplay of s± and s++ pairings in iron-based superconductors
published_or_final_versio
Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers
published_or_final_versio
Synthesis and application of environmental friendly waterborne polyurethane
2010-2011 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
Feedback control architecture and the bacterial chemotaxis network.
PMCID: PMC3088647This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Bacteria move towards favourable and away from toxic environments by changing their swimming pattern. This response is regulated by the chemotaxis signalling pathway, which has an important feature: it uses feedback to 'reset' (adapt) the bacterial sensing ability, which allows the bacteria to sense a range of background environmental changes. The role of this feedback has been studied extensively in the simple chemotaxis pathway of Escherichia coli. However it has been recently found that the majority of bacteria have multiple chemotaxis homologues of the E. coli proteins, resulting in more complex pathways. In this paper we investigate the configuration and role of feedback in Rhodobacter sphaeroides, a bacterium containing multiple homologues of the chemotaxis proteins found in E. coli. Multiple proteins could produce different possible feedback configurations, each having different chemotactic performance qualities and levels of robustness to variations and uncertainties in biological parameters and to intracellular noise. We develop four models corresponding to different feedback configurations. Using a series of carefully designed experiments we discriminate between these models and invalidate three of them. When these models are examined in terms of robustness to noise and parametric uncertainties, we find that the non-invalidated model is superior to the others. Moreover, it has a 'cascade control' feedback architecture which is used extensively in engineering to improve system performance, including robustness. Given that the majority of bacteria are known to have multiple chemotaxis pathways, in this paper we show that some feedback architectures allow them to have better performance than others. In particular, cascade control may be an important feature in achieving robust functionality in more complex signalling pathways and in improving their performance
Dust-free quasars in the early Universe
The most distant quasars known, at redshifts z=6, generally have properties
indistinguishable from those of lower-redshift quasars in the rest-frame
ultraviolet/optical and X-ray bands. This puzzling result suggests that these
distant quasars are evolved objects even though the Universe was only seven per
cent of its current age at these redshifts. Recently one z=6 quasar was shown
not to have any detectable emission from hot dust, but it was unclear whether
that indicated different hot-dust properties at high redshift or if it is
simply an outlier. Here we report the discovery of a second quasar without
hot-dust emission in a sample of 21 z=6 quasars. Such apparently hot-dust-free
quasars have no counterparts at low redshift. Moreover, we demonstrate that the
hot-dust abundance in the 21 quasars builds up in tandem with the growth of the
central black hole, whereas at low redshift it is almost independent of the
black hole mass. Thus z=6 quasars are indeed at an early evolutionary stage,
with rapid mass accretion and dust formation. The two hot-dust-free quasars are
likely to be first-generation quasars born in dust-free environments and are
too young to have formed a detectable amount of hot dust around them.Comment: To be published in Nature on the 18 March 2010
Tuning a Circular p-n Junction in Graphene from Quantum Confinement to Optical Guiding
The motion of massless Dirac-electrons in graphene mimics the propagation of
photons. This makes it possible to control the charge-carriers with components
based on geometrical-optics and has led to proposals for an all-graphene
electron-optics platform. An open question arising from the possibility of
reducing the component-size to the nanometer-scale is how to access and
understand the transition from optical-transport to quantum-confinement. Here
we report on the realization of a circular p-n junction that can be
continuously tuned from the nanometer-scale, where quantum effects are
dominant, to the micrometer scale where optical-guiding takes over. We find
that in the nanometer-scale junction electrons are trapped in states that
resemble atomic-collapse at a supercritical charge. As the junction-size
increases, the transition to optical-guiding is signaled by the emergence of
whispering-gallery modes and Fabry-Perot interference. The creation of tunable
junctions that straddle the crossover between quantum-confinement and
optical-guiding, paves the way to novel design-architectures for controlling
electronic transport.Comment: 16 pages, 4 figure
Valsartan Improves Adipose Tissue Function in Humans with Impaired Glucose Metabolism: A Randomized Placebo-Controlled Double-Blind Trial
<div><h3>Background</h3><p>Blockade of the renin-angiotensin system (RAS) reduces the incidence of type 2 diabetes mellitus. In rodents, it has been demonstrated that RAS blockade improved adipose tissue (AT) function and glucose homeostasis. However, the effects of long-term RAS blockade on AT function have not been investigated in humans. Therefore, we examined whether 26-wks treatment with the angiotensin II type 1 receptor blocker valsartan affects AT function in humans with impaired glucose metabolism (IGM).</p> <h3>Methodology/Principal Findings</h3><p>We performed a randomized, double-blind, placebo-controlled parallel-group study, in which 38 subjects with IGM were treated with valsartan (VAL, 320 mg/d) or placebo (PLB) for 26 weeks. Before and after treatment, an abdominal subcutaneous AT biopsy was collected for measurement of adipocyte size and AT gene/protein expression of angiogenesis/capillarization, adipogenesis, lipolytic and inflammatory cell markers. Furthermore, we evaluated fasting and postprandial AT blood flow (ATBF) (<sup>133</sup>Xe wash-out), systemic inflammation and insulin sensitivity (hyperinsulinemic-euglycemic clamp). VAL treatment markedly reduced adipocyte size (<em>P</em><0.001), with a shift toward a higher proportion of small adipocytes. In addition, fasting (<em>P</em> = 0.043) and postprandial ATBF (<em>P</em> = 0.049) were increased, whereas gene expression of angiogenesis/capillarization, adipogenesis and macrophage infiltration markers in AT was significantly decreased after VAL compared with PLB treatment. Interestingly, the change in adipocyte size was associated with alterations in insulin sensitivity and reduced AT gene expression of macrophage infiltration markers. VAL did not alter plasma monocyte-chemoattractant protein (MCP)-1, TNF-α, adiponectin and leptin concentrations.</p> <h3>Conclusions/Significance</h3><p>26-wks VAL treatment markedly reduced abdominal subcutaneous adipocyte size and AT macrophage infiltration markers, and increased ATBF in IGM subjects. The VAL-induced decrease in adipocyte size was associated with reduced expression of macrophage infiltration markers in AT. Our findings suggest that interventions targeting the RAS may improve AT function, thereby contributing to a reduced risk of developing cardiovascular disease and type 2 diabetes.</p> <h3>Trial Registration</h3><p>Trialregister.nl NTR721 (ISRCTN Registry: ISRCTN<a href="http://www.controlled-trials.com/isrctn/pf/42786336">42786336</a>)</p> </div
GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity
RATIONALE: Albuminuria is an early clinical feature in the progression of diabetic nephropathy (DN). Podocyte insulin resistance is a main cause of podocyte injury, playing crucial roles by contributing to albuminuria in early DN. G protein-coupled receptor 43 (GPR43) is a metabolite sensor modulating the cell signalling pathways to maintain metabolic homeostasis. However, the roles of GPR43 in podocyte insulin resistance and its potential mechanisms in the development of DN are unclear. METHODS: The experiments were conducted by using kidney tissues from biopsied DN patients, streptozotocin (STZ) induced diabetic mice with or without global GPR43 gene knockout, diabetic rats treated with broad-spectrum oral antibiotics or fecal microbiota transplantation, and cell culture model of podocytes. Renal pathological injuries were evaluated by periodic acid-schiff staining and transmission electron microscopy. The expression of GPR43 with other podocyte insulin resistance related molecules was checked by immunofluorescent staining, real-time PCR, and Western blotting. Serum acetate level was examined by gas chromatographic analysis. The distribution of gut microbiota was measured by 16S ribosomal DNA sequencing with faeces. RESULTS: Our results demonstrated that GPR43 expression was increased in kidney samples of DN patients, diabetic animal models, and high glucose-stimulated podocytes. Interestingly, deletion of GPR43 alleviated albuminuria and renal injury in diabetic mice. Pharmacological inhibition and knockdown of GPR43 expression in podocytes increased insulin-induced Akt phosphorylation through the restoration of adenosine 5'-monophosphate-activated protein kinase α (AMPKα) activity. This effect was associated with the suppression of AMPKα activity through post-transcriptional phosphorylation via the protein kinase C-phospholipase C (PKC-PLC) pathway. Antibiotic treatment-mediated gut microbiota depletion, and faecal microbiota transplantation from the healthy donor controls substantially improved podocyte insulin sensitivity and attenuated glomerular injury in diabetic rats accompanied by the downregulation of the GPR43 expression and a decrease in the level of serum acetate. CONCLUSION: These findings suggested that dysbiosis of gut microbiota-modulated GPR43 activation contributed to albuminuria in DN, which could be mediated by podocyte insulin resistance through the inhibition of AMPKα activity
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