Kişiselleştirilmiş tıp uygulamaları ve bir örnek

Kalp krizinden sonra ölüm sebeplerinde ikinci sırayı alan kanser modern çağın en önemli problemlerinden biridir. Buna rağmen kanser hastalarının sadece %25’nin aldığı tedavi beklenen etkiyi göstermektedir. Bu dramatik tablo kişiselleştirilmiş tıp uygulamalarının önemini ortaya koymaktadır. Bu çalışma kapsamında kişiselleştirilmiş tıp konusunda son çalışmalardan faydalanılarak genel bir bakış ortaya konulmuş ve geliştirdiğimiz kişiselleştirilebilir in-silico tümör modeli anlatılmıştır. Çalışmada öncelikle ideal in-silico tümör modeli tarif edilmiş ve kurulan modelin teorik altyapısı anlatılmıştır. Sonrasında modelin hangi yöntemlerle kişiselleştirilebileceği üzerinde durulmuş ve bu konudaki çalışmalar anlatılmıştır. Son olarak modelin nasıl doğrulandığı konusundaki bulgular irdelenmiş ve elde edilen sonuçlar grafik ve resimler ile sunulmuştur. Bu çalışma ile, kişiselleştirilmiş tıp uygulamalarında somut bir örnek ortaya koyarak, konu ile ilgilenen araştırmacılara bir yol açmayı hedefledik

The effects of a continuous 1-h a day 900-MHz electromagnetic field applied throughout early and mid-adolescence on hippocampus morphology and learning behavior in late adolescent male rats

Yildirim, Mehmet/0000-0003-1798-5478WOS: 000452817000006PubMed: 30189239The purpose of this study was to investigate hippocampus morphology and changes in learning behavior in male rats in late adolescence exposed to the effect of a continuous 1-h a day 900-megahertz (MHz) electromagnetic field (EMF). Twenty-four male Sprague Dawley rats aged 3-weeks were divided equally into control, sham and EMF groups. EMF group rats were exposed to a 900-MHz EMF inside an EMF cage, while the sham group rats were placed in the same cage but were not exposed to such an effect. No procedure was performed on the control group. Following 25-day application of EMF, passive avoidance, 8-arm radial maze and Y-maze tests were applied to determine rats' learning and memory performances. Open field and rotarod tests were applied to assess locomotor activity. At the end of the tests, the animals' brains were removed. Sections were taken and stained with toluidine blue. The regions of the hippocampus were subjected to histopathological evaluation. At histopathological examination, impairments of pyramidal and granular cell structures were observed in the EMF group hippocampus. No significant change was observed in learning, memory or locomotor behavior in any group. In conclusion, 900-MHz EMF applied in early and mid-adolescence causes no changes in learning, memory or locomotor behavior.Scientific and Technological Research Council of Turkey (TUBITAK) 2214-A PhD Research Scholarship Program AbroadThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) 2214-A PhD Research Scholarship Program Abroad

Personalized Tumor Growth Prediction Using Multiscale Modeling

Purpose: Cancer is one of the most complex phenomena in biology and medicine. Extensive attempts have been made to work around this complexity. In this study, we try to take a selective approach; not modeling each particular facet in detail but rather only the pertinent and essential parts of the tumor system are simulated and followed by optimization, revealing specific traits. This leads us to a pellucid personalized model which is noteworthy as it closely approximates existing experimental results

The effects of edaravone in ketamine-induced model of mania in rats

Bipolar disorder is a chronic disease characterized by recurring episodes of mania and depression that can lead to disability. This study investigates the protective effects of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a drug with well-known antioxidant properties, in a model of mania induced by ketamine in rats. Locomotor activity was assessed in the open-field test. Superoxide dismutase (SOD), catalase (CAT) and thiobarbituric acid reactive substances (TBARS) levels were measured in order to evaluate oxidative damage in the rat hippocampus and prefrontal cortex. Increased locomotor activity (hyperlocomotion) was observed at the open-field test with ketamine treatment (25 mg/kg, i.p., 8 days). Edaravone (18 mg/kg) treatment did not prevent hyperlocomotion in the mania model induced with ketamine in rats, but lithium chloride (47.5 mg/kg, i.p., positive control) did prevent hyperlocomotion. Edaravone and lithium chloride treatments were found to reduce the increase in SOD and CAT activity following ketamine administration in a non-significant manner but caused no change in TBARS levels