72 research outputs found
Seebeck effect in the conducting LaAlO_{3}/SrTiO_{3} interface
The observation of metallic behavior at the interface between insulating
oxides has triggered worldwide efforts to shed light on the physics of these
systems and clarify some still open issues, among which the dimensional
character of the conducting system. In order to address this issue, we measure
electrical transport (Seebeck effect, Hall effect and conductivity) in
LaAlO_{3}/SrTiO_{3} interfaces and, for comparison, in a doped SrTiO_{3} bulk
single crystal. In these experiments, the carrier concentration is tuned, using
the field effect in a back gate geometry. The combined analysis of all
experimental data at 77 K indicates that the thickness of the conducting layer
is ~7 nm and that the Seebeck effect data are well described by a
two-dimensional (2D) density of states. We find that the back gate voltage is
effective in varying not only the charge density, but also the thickness of the
conducting layer, which is found to change by a factor of ~2, using an electric
field between -4 and +4MV/m at 77K. No enhancement of the Seebeck effect due to
the electronic confinement and no evidence for two-dimensional quantization
steps are observed at the interfaces.Comment: 15 pages, 5 figure
Epitaxial growth and thermodynamic stability of SrIrO3/SrTiO3 heterostructures
Obtaining high-quality thin films of 5d transition metal oxides is essential
to explore the exotic semimetallic and topological phases predicted to arise
from the combination of strong electron correlations and spin-orbit coupling.
Here, we show that the transport properties of SrIrO3 thin films, grown by
pulsed laser deposition, can be optimized by considering the effect of
laser-induced modification of the SrIrO3 target surface. We further demonstrate
that bare SrIrO3 thin films are subject to degradation in air and are highly
sensitive to lithographic processing. A crystalline SrTiO3 cap layer deposited
in-situ is effective in preserving the film quality, allowing us to measure
metallic transport behavior in films with thicknesses down to 4 unit cells. In
addition, the SrTiO3 encapsulation enables the fabrication of devices such as
Hall bars without altering the film properties, allowing precise
(magneto)transport measurements on micro- and nanoscale devices.Comment: 5 pages, 3 figure
Two-dimensional superconductivity at a Mott-Insulator/Band-Insulator interface: LaTiO3/SrTiO3
Transition metal oxides display a great variety of quantum electronic
behaviours where correlations often play an important role. The achievement of
high quality epitaxial interfaces involving such materials gives a unique
opportunity to engineer artificial structures where new electronic orders take
place. One of the most striking result in this area is the recent observation
of a two-dimensional electron gas at the interface between a strongly
correlated Mott insulator LaTiO3 and a band insulator SrTiO3. The mechanism
responsible for such a behaviour is still under debate. In particular, the
influence of the nature of the insulator has to be clarified. Here we show that
despite the expected electronic correlations, LaTiO3/SrTiO3 heterostructures
undergo a superconducting transition at a critical temperature Tc=300 mK. We
have found that the superconducting electron gas is confined over a typical
thickness of 12 nm. We discuss the electronic properties of this system and
review the possible scenarios
The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication
Human interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular DNA, modulates various cell functions, however, its role in regulating virus growth remains unresolved. Here, we adopt two approaches to investigate whether IFI16 exerts pro- and/or anti-viral actions. First, the IFI16 gene was silenced using specific small interfering RNAs (siRNA) in human embryo lung fibroblasts (HELF) and replication of DNA and RNA viruses evaluated. IFI16-knockdown resulted in enhanced replication of Herpesviruses, in particular, Human Cytomegalovirus (HCMV). Consistent with this, HELF transduction with a dominant negative form of IFI16 lacking the PYRIN domain (PYD) enhanced the replication of HCMV. Second, HCMV replication was compared between HELFs overexpressing either the IFI16 gene or the LacZ gene. IFI16 overexpression decreased both virus yield and viral DNA copy number. Early and late, but not immediate-early, mRNAs and proteins were strongly down-regulated, thus IFI16 may exert its antiviral effect by impairing viral DNA synthesis. Constructs with the luciferase reporter gene driven by deleted or site-specific mutated forms of the HCMV DNA polymerase (UL54) promoter demonstrated that the inverted repeat element 1 (IR-1), located between â54 and â43 relative to the transcription start site, is the target of IFI16 suppression. Indeed, electrophoretic mobility shift assays and chromatin immunoprecipitation demonstrated that suppression of the UL54 promoter is mediated by IFI16-induced blocking of Sp1-like factors. Consistent with these results, deletion of the putative Sp1 responsive element from the HCMV UL44 promoter also relieved IFI16 suppression. Together, these data implicate IFI16 as a novel restriction factor against HCMV replication and provide new insight into the physiological functions of the IFN-inducible gene IFI16 as a viral restriction factor
Comportamiento de los cultivares de papaya Sunset, Sunrise y de los genotipos Baixinho de Santa Amalia y BH - 65 en la zona sur de la isla de Tenerife
A Review of Dietary Prevention of Human Papillomavirus-Related Infection of the Cervix and Cervical Intraepithelial Neoplasia
The natural history of cervical cancer suggests that prevention can be achieved by modification of the host's immune system through a nutrient-mediated program. This study reviews the preventive role of dietary intake on cervical intraepithelial neoplasia (CIN) induced by human papillomavirus (HPV). Electronic databases were searched using relevant keywords such as, but not limited to, human papillomavirus infection, cervical intraepithelial neoplasia, lifestyle factors, nutrients intake, and diet. High consumption of fruit and vegetables appears to be protective against CIN. The findings also highlight the possibility of consuming high levels of specific nutrients, vitamins, and minerals, and retaining sufficient level of these elements in the body, especially those with high antioxidants and antiviral properties, to prevent progression of transient and persistent HPV infections to high-grade CIN 2 and 3 (including in situ cervical cancer). The protective effect is not significant for high-risk HPV persistent infections and invasive cervical cancer. Although it appears that intake of specific nutrients, vitamins, and minerals may be good in CIN prevention, there is lack of evidence from controlled trial to confirm this. Health professionals shall focus on implementation of a balanced-diet prevention strategy at an early stage for cervical cancer prevention
Virtual Classrooms in Brazil: teachers' difficulties and anxieties towards technology in language learning
EstimaciĂłn de horas de frio para localidad de Sauce Viejo (Santa Fe, Argentina): diferentes modelos
CaracterĂsticas FisicoquĂmicas de los Frutos de Tres Variedades de Manzanas Cultivadas en la RegiĂłn Centro-Este de la Provincia de Santa Fe
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