Novel approach for health monitoring of earthen embankments

This paper introduces a novel modular approach for the monitoring of desiccation-induced deterioration in earthen embankments (levees), which are typically used as flood-defense structures. The approach is based on the use of a combination of geotechnical and noninvasive geophysical probes for the continuous monitoring of the water content in the ground. The level of accuracy of the monitoring is adaptable to the available financial resources. The proposed methodology was used and validated on a recently built, 2-km-long river embankment in Galston (Scotland, United Kingdom). A suite of geotechnical probes was installed to monitor the seasonal variation of water content over a 2-year period. Most devices were calibrated in situ. A novel procedure to extrapolate the value of water content from the geotechnical and geophysical probes at any point of the embankment is shown. Desiccation fissuring degrades the resistance of embankments against several failure mechanisms. An index of susceptibility is proposed here. The index is a useful tool to assess the health state of the structure and prioritize remedial interventions

Novel approach for health monitoring of earthen embankments

This paper introduces a novel modular approach for the monitoring of desiccation-induced deterioration in earthen embankments (levees), which are typically used as flood-defense structures. The approach is based on the use of a combination of geotechnical and noninvasive geophysical probes for the continuous monitoring of the water content in the ground. The level of accuracy of the monitoring is adaptable to the available financial resources. The proposed methodology was used and validated on a recently built, 2-km-long river embankment in Galston (Scotland, U.K.). A suite of geotechnical probes was installed to monitor the seasonal variation of water content over a 2-year period. Most devices were calibrated in situ. A novel procedure to extrapolate the value of water content from the geotechnical and geophysical probes at any point of the embankment is shown. Desiccation fissuring degrades the resistance of embankments against several failure mechanisms. An index of susceptibility is proposed here. The index is a useful tool to assess the health state of the structure and prioritize remedial intervention

Implicitly learning when to be ready:From instances to categories

There is growing appreciation for the role of long-term memory in guiding temporal preparation in speeded reaction time tasks. In experiments with variable foreperiods between a warning stimulus (S1) and a target stimulus (S2), preparation is affected by foreperiod distributions experienced in the past, long after the distribution has changed. These effects from memory can shape preparation largely implicitly, outside of participants' awareness. Recent studies have demonstrated the associative nature of memory-guided preparation. When distinct S1s predict different foreperiods, they can trigger differential preparation accordingly. Here, we propose that memory-guided preparation allows for another key feature of learning: the ability to generalize across acquired associations and apply them to novel situations. Participants completed a variable foreperiod task where S1 was a unique image of either a face or a scene on each trial. Images of either category were paired with different distributions with predominantly shorter versus predominantly longer foreperiods. Participants displayed differential preparation to never-before seen images of either category, without being aware of the predictive nature of these categories. They continued doing so in a subsequent Transfer phase, after they had been informed that these contingencies no longer held. A novel rolling regression analysis revealed at a fine timescale how category-guided preparation gradually developed throughout the task, and that explicit information about these contingencies only briefly disrupted memory-guided preparation. These results offer new insights into temporal preparation as the product of a largely implicit process governed by associative learning from past experiences

La serialità animata statunitense per adulti. Percorsi storici e traiettorie contemporanee.

Negli Stati Uniti, l’animazione è rimasta tipicamente associata, fin dalle sue origini, al mondo dell’infanzia, e soprattutto alla Walt Disney. Il target dei prodotti animati, tuttavia, si può oggi considerare decisamente più esteso, soprattutto con l’avvento di diversi prodotti seriali di grande impatto, i quali hanno scardinato molti luoghi comuni legati all’animazione. Questo lavoro intende condurre una ricerca che ha come obiettivo quello di fornire al lettore un quadro complessivo dello sviluppo della serialità televisiva animata per adulti, dagli anni Novanta fino alle tendenze attuali. A partire da un caso emblematico come The Simpsons, che ha consolidato il nostro modo di intendere l’animazione per adulti, e le ha permesso non solo di sdoganare sulla broadcast TV, ma anche di diventare estremamente popolare, questa ricerca intende comprendere in che modo i prodotti successivi hanno portato avanti le fondamenta che The Simpsons avevano costruito

Stereospecific synthesis of syn-alpha-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids

A stereospecific multicomponent reaction among isocyanides, nitrile N-oxides and carboxylic acids provides an efficient synthesis of biologically relevant syn \u3b1-oximinoimides

Malectin Participates in a Backup Glycoprotein Quality Control Pathway in the Mammalian ER

Malectin is a conserved, endoplasmic reticulum (ER)-resident lectin that recognizes high mannose oligosaccharides displaying terminal glucose residues. Here we show that Malectin is an ER stress-induced protein that selectively associates with glycopolypeptides without affecting their entry and their retention in the Calnexin chaperone system. Analysis of the obligate Calnexin client influenza virus hemagglutinin (HA) revealed that Calnexin and Malectin associated with different timing to different HA conformers and that Malectin associated with misfolded HA. Analysis of the facultative Calnexin clients NHK and α1-antitrypsin (α1AT) revealed that induction of Malectin expression to simulate conditions of ER stress resulted in persistent association between the ER lectin and the model cargo glycoproteins, interfered with processing of cargo-linked oligosaccharides and reduced cargo secretion. We propose that Malectin intervention is activated upon ER stress to inhibit secretion of defective gene products that might be generated under conditions of aberrant functioning of the ER quality control machinery

High performance liquid chromatography preparation of the molecular species of GM1 and GD1a gangliosides with homogeneous long chain base composition.

A semi-preparative, analytical high performance liquid chromatographic (HPLC) procedure is described for the isolation of molecular species of GM1 and GD1a gangliosides containing a single long chain base, C18 or C20 sphingosine, C18 or C20 sphinganine, each in its natural erythro or unnatural threo form. The threo forms were obtained from 2,3-dichloro-5,6-dicyanobenzoquinone/NaBH4 -treated gangliosides. The ganglioside molecular species separated by HPLC were analyzed for carbohydrate, fatty acid, and long chain base composition. In particular, long chain bases were submitted to gas-liquid chromatographic-mass spectrometric analyses as their trimethylsilyl (TMS) or N-acetyl-TMS derivatives, and chain length, presence or absence of C4-C5 double bond, and C-3 steric configuration were ascertained. The final preparations of individual molecular species of GM1 and GD1a gangliosides were more than 99% homogeneous in their saccharide moiety, contained a single long chain base (homogeneity higher than 99%), and had a fatty acid composition primarily of stearic acid (92 to 97%). All the individual molecular species of GM1 and GD1a gangliosides were also prepared in radioactive form by selective tritiation at C-3 of the long chain base. Their specific radioactivity ranged from 1.3 to 1.45 Ci/mmol. The availability of these molecular species of gangliosides is expected to facilitate studies aimed at ascertaining the role played by the hydrophobic portion in the functional behavior of gangliosides

Retroperitoneoscopic single site renal biopsy surgery: right indicatioBMC Urology ns for the right technique.

Bacground: Laparoendoscopic single-site surgery (LESS) has been developed in an attempt to further reduce the morbidity and scarring associated with laparoscopic surgery. In patients in whom there are indications to perform a laparoscopic renal biopsy, LESS surgery is a valid alternative to mini invasive surgery and is becoming more common. We report our experience on 14 renal biopsy procedures performed in a retroperitoneal LESS. Methods: LESS renal biopsy was performed in 14 patients 18 to 80 years old (mean age 58.3 years) during a 36 month period. All procedures were performed by a single operator. The patient was in a standard flank position. The procedure was performed using a 2.5 cm, single incision via a retroperitoneal access at the Petit ’ s triangle. A 5 mm biopsy forceps was used to collect the specimen under direct vision, and haemostasis was obtained with an Argon beam probe and the application of oxidized regenerated cellulose gauze. Results: Biopsy was performed successfully in all cases. Mean operative time was 52.64 min, blood loss was minimal, and the hospital stay ranged from 12 to 24 hours. None of the patients required narcotics or additional analgesia in the postoperative period. No postoperative complications occurred. Conclusions: The LESS technique is safe, reliable (100% success), easy to learn, and offers subjective cosmetic benefits to the patient. Minimal hospitalization requirement following retroperitoneal LESS biopsy is an additional timely advantage over laparoscopic renal biopsy. We think that with the right indications (marked obesity, failure of previous percutaneous biopsy attempts, a solitary kidney and coagulopathy) LESS renal biopsy is a good alternative to laparoscopy. Our next step will be a randomized prospective study of LESS compared with laparoscopy for renal biopsy to support our findings