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Modulation of voltage-dependent sodium and potassium currents by charged amphiphiles in cardiac ventricular myocytes. Effects via modification of surface potential.
Modulation of voltage-dependent sodium and potassium currents by charged amphiphiles was investigated in cardiac ventricular myocytes using the patch-clamp technique. Negatively charged sodium dodecylsulfate (SDS) increased amplitude of INa, whereas positively charged dodecyltrimethylammonium (DDTMA) decreased INa. Furthermore, SDS shifted the steady-state activation and inactivation of INa in the negative direction, whereas DDTMA shifted the curves in the opposite direction. These shifts provided an explanation for the changes in current amplitude. Activation and inactivation kinetics of INa were accelerated by SDS but slowed by DDTMA. These changes in both steady-state gating and kinetics of INa are consistent with a decrease of the intramembrane field by SDS and an increase of the field by DDTMA due to an alteration of surface potential after their insertion into the outer monolayer of the sarcolemma. The effect of SDS on the steady-state inactivation of INa was concentration dependent and partially reversed by screening surface charges with increased extracellular [Ca2+]. These amphiphiles also altered the activation of the delayed rectifier K+ current (IK,del), producing a shift in the negative direction by SDS but in the positive direction by DDTMA. These results suggest that the insertion of charged amphiphiles into the cell membrane alters the behavior of voltage-dependent INa and IK,del by changing the surface charge density, and consequently the surface potential and implies, although indirectly, that the lipid surface charges are important to the voltage-dependent gating of these channels
Noncommutative geometry and stochastic processes
The recent analysis on noncommutative geometry, showing quantization of the
volume for the Riemannian manifold entering the geometry, can support a view of
quantum mechanics as arising by a stochastic process on it. A class of
stochastic processes can be devised, arising as fractional powers of an
ordinary Wiener process, that reproduce in a proper way a stochastic process on
a noncommutative geometry. These processes are characterized by producing
complex values and so, the corresponding Fokker-Planck equation resembles the
Schroedinger equation. Indeed, by a direct numerical check, one can recover the
kernel of the Schroedinger equation starting by an ordinary Brownian motion.
This class of stochastic processes needs a Clifford algebra to exist. In four
dimensions, the full set of Dirac matrices is needed and the corresponding
stochastic process in a noncommutative geometry is easily recovered as is the
Dirac equation in the Klein-Gordon form being it the Fokker--Planck equation of
the process.Comment: 16 pages, 2 figures. Updated a reference. A version of this paper
will appear in the proceedings of GSI2017, Geometric Science of Information,
November 7th to 9th, Paris (France
Micrometeorological simulations to predict the impacts of heat mitigation strategies on pedestrian thermal comfort in a Los Angeles neighborhood
The urban heat island impacts the thermal comfort of pedestrians in cities. In this paper, the effects of four heat mitigation strategies on micrometeorology and the thermal comfort of pedestrians were simulated for a neighborhood in eastern Los Angeles County. The strategies investigated include solar reflective 'cool roofs', vegetative 'green roofs', solar reflective 'cool pavements', and increased street-level trees. A series of micrometeorological simulations for an extreme heat day were carried out assuming widespread adoption of each mitigation strategy. Comparing each simulation to the control simulation assuming current land cover for the neighborhood showed that additional street-trees and cool pavements reduced 1.5 m air temperature, while cool and green roofs mostly provided cooling at heights above pedestrian level. However, cool pavements increased reflected sunlight from the ground to pedestrians at a set of unshaded receptor locations. This reflected radiation intensified the mean radiant temperature and consequently increased physiological equivalent temperature (PET) by 2.2°C during the day, reducing the thermal comfort of pedestrians. At another set of receptor locations that were on average 5 m from roadways and underneath preexisting tree cover, cool pavements caused significant reductions in surface air temperatures and small changes in mean radiant temperature during the day, leading to decreases in PET of 1.1°C, and consequent improvements in thermal comfort. For improving thermal comfort of pedestrians during the afternoon in unshaded locations, adding street trees was found to be the most effective strategy. However, afternoon thermal comfort improvements in already shaded locations adjacent to streets were most significant for cool pavements. Green and cool roofs showed the lowest impact on the thermal comfort of pedestrians since they modify the energy balance at roof level, above the height of pedestrians
Stellar Population Diagnostics of Elliptical Galaxy Formation
Major progress has been achieved in recent years in mapping the properties of
passively-evolving, early-type galaxies (ETG) from the local universe all the
way to redshift ~2. Here, age and metallicity estimates for local cluster and
field ETGs are reviewed as based on color-magnitude, color-sigma, and
fundamental plane relations, as well as on spectral-line indices diagnostics.
The results of applying the same tools at high redshifts are then discussed,
and their consistency with the low-redshift results is assessed. Most low- as
well as high-redshift (z~1) observations consistently indicate 1) a formation
redshift z>~3 for the bulk of stars in cluster ETGs, with their counterparts in
low-density environments being on average ~1-2 Gyr younger, i.e., formed at
z>~1.5-2, 2) the duration of the major star formation phase anticorrelates with
galaxy mass, and the oldest stellar populations are found in the most massive
galaxies. With increasing redshift there is evidence for a decrease in the
number density of ETGs, especially of the less massive ones, whereas existing
data appear to suggest that most of the most-massive ETGs were already fully
assembled at z~1. Beyond this redshift, the space density of ETGs starts
dropping significantly, and as ETGs disappear, a population of massive,
strongly clustered, starburst galaxies progressively becomes more and more
prominent, which makes them the likely progenitors to ETGs.Comment: To appear on Annual Review of Astronomy & Astrophysics, Vol. 44
(2006). 46 pages with 16 figures. Replaced version includes updated
references, few typos less, and replaces Fig. 11 and Fig. 16 which had been
skrewed u
An improved parameter estimation and comparison for soft tissue constitutive models containing an exponential function
Motivated by the well-known result that stiffness of soft tissue is proportional to the stress, many of the constitutive laws for soft tissues contain an exponential function. In this work, we analyze properties of the exponential function and how it affects the estimation and comparison of elastic parameters for soft tissues. In particular, we find that as a consequence of the exponential function there are lines of high covariance in the elastic parameter space. As a result, one can have widely varying mechanical parameters defining the tissue stiffness but similar effective stress–strain responses. Drawing from elementary algebra, we propose simple changes in the norm and the parameter space, which significantly improve the convergence of parameter estimation and robustness in the presence of noise. More importantly, we demonstrate that these changes improve the conditioning of the problem and provide a more robust solution in the case of heterogeneous material by reducing the chances of getting trapped in a local minima. Based upon the new insight, we also propose a transformed parameter space which will allow for rational parameter comparison and avoid misleading conclusions regarding soft tissue mechanics
Valley-spin blockade and spin resonance in carbon nanotubes
Manipulation and readout of spin qubits in quantum dots made in III-V
materials successfully rely on Pauli blockade that forbids transitions between
spin-triplet and spin-singlet states. Quantum dots in group IV materials have
the advantage of avoiding decoherence from the hyperfine interaction by
purifying them with only zero-spin nuclei. Complications of group IV materials
arise from the valley degeneracies in the electronic bandstructure. These lead
to complicated multiplet states even for two-electron quantum dots thereby
significantly weakening the selection rules for Pauli blockade. Only recently
have spin qubits been realized in silicon devices where the valley degeneracy
is lifted by strain and spatial confinement. In carbon nanotubes Pauli blockade
can be observed by lifting valley degeneracy through disorder. In clean
nanotubes, quantum dots have to be made ultra-small to obtain a large energy
difference between the relevant multiplet states. Here we report on
low-disorder nanotubes and demonstrate Pauli blockade based on both valley and
spin selection rules. We exploit the bandgap of the nanotube to obtain a large
level spacing and thereby a robust blockade. Single-electron spin resonance is
detected using the blockade.Comment: 31 pages including supplementary informatio
Impact of Microvascular Invasion on Clinical Outcomes After Curative-Intent Resection for Intrahepatic Cholangiocarcinoma
Background: Microvascular invasion (MiVI) is a histological feature of intrahepatic cholangiocarcinoma (ICC) that may be associated with biological behavior. We sought to investigate the impact of MiVI on long-term survival of patients undergoing curative-intent resection for ICC.
Methods: A total of 1089 patients undergoing curative-intent resection for ICC were identified. Data on clinicopathological characteristics, disease-free survival (DFS), and overall survival (OS) were compared among patients with no vascular invasion (NoVI), MiVI, and macrovascular invasion (MaVI).
Results: A total of 249 (22.9%) patients had MiVI, while 149 (13.7%) patients had MaVI (±MiVI). MiVI was associated with higher incidence of perineural, biliary and adjacent organ invasion, and satellite lesions (all P 18 months) prognosis.
Conclusions: Roughly 1 out of 5 patients with resected ICC had MiVI. MiVI was associated with advanced tumor characteristics and a higher risk of tumor recurrence.info:eu-repo/semantics/publishedVersio
Defining Long-Term Survivors Following Resection of Intrahepatic Cholangiocarcinoma
BACKGROUND:
Intrahepatic cholangiocarcinoma (ICC) is an aggressive primary tumor of the liver. While surgery remains the cornerstone of therapy, long-term survival following curative-intent resection is generally poor. The aim of the current study was to define the incidence of actual long-term survivors, as well as identify clinicopathological factors associated with long-term survival.
METHODS:
Patients who underwent a curative-intent liver resection for ICC between 1990 and 2015 were identified using a multi-institutional database. Overall, 679 patients were alive with ≥ 5 years of follow-up or had died during follow-up. Prognostic factors among patients who were long-term survivors (LT) (overall survival (OS) ≥ 5) were compared with patients who were not non-long-term survivors (non-LT) (OS < 5).
RESULTS:
Among the 1154 patients who underwent liver resection for ICC, 5- and 10-year OS were 39.6 and 20.3% while the actual LT survival rate was 13.3%. After excluding 475 patients who survived  5 cm (OR 2.40, 95% CI, 1.54-3.74, p < 0.001), and direct invasion of an adjacent organ (OR 3.98, 95% CI, 1.18-13.4, p = 0.026). However, a subset of patients (< 10%) who had these pathological characteristics were LT.
CONCLUSION:
While ICC is generally associated with a poor prognosis, some patients will be LT. In fact, even a subset of patients with traditional adverse prognostic factors survived long term.info:eu-repo/semantics/publishedVersio
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