389 research outputs found
A phase II study of cell cycle inhibitor UCN-01 in patients with metastatic melanoma: a California Cancer Consortium trial
- Author
- A Barth
- A Jimeno
- AM Senderowicz
- AS Yang
- David R. Gandara
- E Fuse
- E Lazar-Molnar
- E Vuhahula
- EA Sausville
- EA Sausville
- EC Dees
- FS Hodi
- G Palmieri
- GA Porter
- HA Tawbi
- I Sauroja
- I Takahashi
- I Takahashi
- Kim A. Margolin
- M Rodolfo
- MR Middleton
- N Kurata
- P Therasse
- Paul H. Frankel
- Philip C. Mack
- PN Lara Jr
- Primo N. Lara
- R Mouawad
- S Abe
- S Kummar
- S Welch
- Sanjiv S. Agarwala
- Scott D. Christensen
- SJ Hotte
- T Akiyama
- T Akiyama
- Thehang Luu
- Tianhong Li
- WA High
- Publication venue
- Springer US
- Publication date
- 01/01/2010
- Field of study
Background Genetic abnormalities in cell cycle control are common in malignant melanoma. UCN-01 (7-hydroxystaurosporine) is an investigational agent that exhibits antitumor activity by perturbing the cancer cell cycle. A patient with advanced melanoma experienced a partial response in a phase I trial of single agent UCN-01. We sought to determine the activity of UCN-01 against refractory metastatic melanoma in a phase II study. Patients and methods Patients with advanced melanoma received UCN-01 at 90 mg/m2 over 3 h on cycle 1, reduced to 45 mg/m2 over 3 h for subsequent cycles, every 21 days. Primary endpoint was tumor response. Secondary endpoints included progression-free survival (PFS) and overall survival (OS). A two-stage (17 + 16), single arm phase II design was employed. A true response rate of ≥20% (i.e., at least one responder in the first stage, or at least four responders overall) was to be considered promising for further development of UCN-01 in this setting. Results Seventeen patients were accrued in the first stage. One patient was inevaluable for response. Four (24%) patients had stable disease, and 12 (71%) had disease progression. As there were no responders in the first stage, the study was closed to further accrual. Median PFS was 1.3 months (95% CI, 1.2–3.0) while median OS was 7.3 months (95% CI, 3.4–18.4). One-year and two year OS rates were 41% and 12%, respectively. A median of two cycles were delivered (range, 1–18). Grade 3 treatment-related toxicities include hyperglycemia (N = 2), fatigue (N = 1), and diarrhea (N = 1). One patient experienced grade 4 creatinine elevation and grade 4 anemia possibly due to UCN-01. No dose modification was required as these patients had disease progression. Conclusion Although well tolerated, UCN-01 as a single agent did not have sufficient clinical activity to warrant further study in refractory melanoma
Order of invasion affects the spatial distribution of a reciprocal intraguild predator
- Author
- A Janssen
- A Janssen
- A Janssen
- André M. de Roos
- Arne Janssen
- BK Agarwala
- DL Finke
- DL Finke
- F Faraji
- F Faraji
- F Sergio
- GA Polis
- JA Rosenheim
- JAM Ferreira
- K McCann
- M Arim
- M Montserrat
- M Venzon
- Maurice W. Sabelis
- MD Moran
- MJ Crawley
- MP Daugherty
- MR Heithaus
- P Amarasekare
- P Morin
- PCJ Rijn Van
- R HilleRisLambers
- RD Holt
- RD Holt
- RE Snyder
- RM May
- S Diehl
- S Diehl
- S Magalhaes
- S Magalhaes
- SD Mylius
- T Namba
- Tessa van der Hammen
- VHW Rudolf
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2010
- Field of study
When intraguild predation is reciprocal, i.e. two predator species kill and feed on each other, theory predicts that well-mixed populations of the two species cannot coexist. At low levels of the shared resource, only the best competitor exists, whereas if the level of the common resource is high, the first species to arrive on a patch can reach high numbers, which prevents the invasion of the second species through intraguild predation. The order of invasion may therefore be of high importance in systems with reciprocal intraguild predation with high levels of productivity, with the species arriving first excluding the other species. However, natural systems are not well mixed and usually have a patchy structure, which gives individuals the possibility to choose patches without the other predator, thus reducing opportunities for intraguild predation. Such avoidance behaviour can cause spatial segregation between predator species, which, in turn, may weaken the intraguild interaction strength and facilitate their co-occurrence in patchy systems. Using a simple set-up, we studied the spatial distribution of two reciprocal intraguild predators when either of them was given priority on a patch with food. We released females of two predatory mite species sequentially and found that both species avoided patches on which the other species was resident. This resulted in partial spatial segregation of the species and thus a lower chance for the two species to encounter each other. Such behaviour reinforces segregation, because heterospecifics avoid patches with established populations of the other species. This may facilitate coexistence of two intraguild predators that would exclude each other in well-mixed populations
Transcriptional Analysis Implicates Endoplasmic Reticulum Stress in Bovine Spongiform Encephalopathy
- Author
- A Ashok
- A Singh
- AR Brown
- B Chesebro
- B Fazi
- C Ersdal
- C He
- C Hetz
- C Hetz
- D Gavier-Widen
- D Lindholm
- D Theil
- E Ferreiro
- E Kuang
- E Lai
- EJ Ryu
- EL Eskelinen
- F Borovecki
- F Lisbona
- GA Ngoh
- GA Wells
- GAH Wells
- GP Sawiris
- Hans A. Kretzschmar
- I Wada
- J Groenendyk
- JA Marteijn
- JC Sanchez
- JK Jin
- JW Ironside
- JW Wilesmith
- K Doh-ura
- K Sasaki
- KF Winklhofer
- KL Agarwala
- LA Vonk
- Linda Terry
- LS Chin
- M Dron
- M Holgado-Madruga
- M Jeffrey
- M Jeffrey
- M Kristiansen
- ME Bruce
- MT Lindenmeyer
- Neil A. Mabbott
- NK Sharma
- NL Lehman
- Otto Windl
- PJ Skinner
- PW Bates
- Q Wan
- R Capobianco
- RJ Keith
- RV Rao
- S Booth
- S Collins
- S Kamauchi
- S Patschan
- S Sundar Rajan
- SB Prusiner
- SD Spassieva
- SE Lloyd
- SX Tan
- T Saito
- TH Kuo
- W Xiang
- W Xiang
- Wei Xiang
- Y Okushima
- Y Tang
- Yue Tang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Bovine spongiform encephalopathy (BSE) is a fatal, transmissible, neurodegenerative disease of cattle. To date, the disease process is still poorly understood. In this study, brain tissue samples from animals naturally infected with BSE were analysed to identify differentially regulated genes using Affymetrix GeneChip Bovine Genome Arrays. A total of 230 genes were shown to be differentially regulated and many of these genes encode proteins involved in immune response, apoptosis, cell adhesion, stress response and transcription. Seventeen genes are associated with the endoplasmic reticulum (ER) and 10 of these 17 genes are involved in stress related responses including ER chaperones, Grp94 and Grp170. Western blotting analysis showed that another ER chaperone, Grp78, was up-regulated in BSE. Up-regulation of these three chaperones strongly suggests the presence of ER stress and the activation of the unfolded protein response (UPR) in BSE. The occurrence of ER stress was also supported by changes in gene expression for cytosolic proteins, such as the chaperone pair of Hsp70 and DnaJ. Many genes associated with the ubiquitin-proteasome pathway and the autophagy-lysosome system were differentially regulated, indicating that both pathways might be activated in response to ER stress. A model is presented to explain the mechanisms of prion neurotoxicity using these ER stress related responses. Clustering analysis showed that the differently regulated genes found from the naturally infected BSE cases could be used to predict the infectious status of the samples experimentally infected with BSE from the previous study and vice versa. Proof-of-principle gene expression biomarkers were found to represent BSE using 10 genes with 94% sensitivity and 87% specificity
Contemporary experience with high-dose interleukin-2 therapy and impact on survival in patients with metastatic melanoma and metastatic renal cell carcinoma
- Author
- A Hauschild
- Ajjai Alva
- Asim Amin
- B Escudier
- BI Rini
- BI Rini
- Brendan Curti
- C Robert
- C Robert
- C Robert
- C Robert
- David F. McDermott
- DF McDermott
- DY Heng
- EM Allen Van
- FD Birkhauser
- FS Hodi
- G Fyfe
- GA Daniels
- GA McArthur
- Gerald Miletello
- Gregory A. Daniels
- H Shi
- HL Kaufman
- Hong Hua
- Howard L. Kaufman
- J Larkin
- James N. Lowder
- Janice P. Dutcher
- John M. Kirkwood
- Joseph I. Clark
- K Trunzer
- KT Flaherty
- M Hanzly
- MA Morse
- MA Postow
- Mayer Fishman
- MB Atkins
- Michael A. Morse
- Michael K. K. Wong
- Neeraj Agarwal
- O Hamid
- R Payne
- R Siegel
- Ralph J. Hauke
- Rene Gonzalez
- RI Fisher
- RJ Motzer
- RJ Motzer
- Sandra Aung
- Sanjiv S. Agarwala
- SL Topalian
- Theodore F. Logan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cues of intraguild predators affect the distribution of intraguild prey
- Author
- A Janssen
- A Janssen
- A Sih
- AL Rypstra
- Arne Janssen
- BK Agarwala
- D Stephens
- F Faraji
- GA Polis
- GA Polis
- GA Polis
- GJ Moraes De
- JA Rosenheim
- L Persson
- M Montserrat
- M Montserrat
- M Montserrat
- M Venzon
- Maurice W. Sabelis
- MH Persons
- MR Heithaus
- PCJ Rijn van
- R HilleRisLambers
- RD Holt
- S Magalhães
- SD Fretwell
- SD Fretwell
- SD Mylius
- SL Lima
- SL Lima
- SM Wilder
- Tessa van der Hammen
- Y Nakashima
- Yasuyuki Choh
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Constructing perfect phylogenies and proper triangulations for three-state characters
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Measurement of the tt¯tt¯ production cross section in pp collisions at √s=13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abed Abud A
- Abeling K
- Abhayasinghe DK
- Abidi SH
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Achkar B
- Adam Bourdarios C
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akbiyik M
- Akimov AV
- Al Khoury K
- Alberghi GL
- Albert J
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alunno Camelia E
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Andari N
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Andrei V
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Aranzabal N
- Araujo Ferraz V
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Arrubarrena Tame ZP
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Atmasiddha PA
- Augsten K
- Auricchio S
- Austrup VA
- Avolio G
- Ayoub MK
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Backman F
- Badea A
- Bagnaia P
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Bakos E
- Bakshi Gupta D
- Balaji S
- Balasubramanian R
- Baldin EM
- Balek P
- Ballabene E
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Barak L
- Barberio EL
- Barberis D
- Barbero M
- Barbour G
- Barends KN
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barranco Navarro L
- Barreiro Guimarães da Costa J
- Barreiro F
- Barron U
- Barsov S
- Bartels F
- Bartoldus R
- Bartolini G
- Barton AE
- Bartos P
- Basalaev A
- Basan A
- Bashta I
- Bassalat A
- Basso MJ
- Basson CR
- Bates RL
- Batlamous S
- Batley JR
- Batool B
- Battaglia M
- Bauce M
- Bauer F
- Bauer P
- Bawa HS
- Bayirli A
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HP
- Becker K
- Becot C
- Beddall AJ
- Bednyakov VA
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beirao Da Cruz E Silva C
- Beirer JF
- Beisiegel F
- Belfkir M
- Bella G
- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Belotskiy K
- Belyaev NL
- Benchekroun D
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Bergeaas Kuutmann E
- Berger N
- Bergmann B
- Bergsten LJ
- Beringer J
- Berlendis S
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Berthold A
- Bertram IA
- Bessidskaia Bylund O
- Bethke S
- Betti A
- Bevan AJ
- Bhatta S
- Bhattacharya DS
- Bhattarai P
- Bhopatkar VS
- Bi R
- Bianchi RM
- Biebel O
- Bielski R
- Biesuz NV
- Biglietti M
- Billoud TRV
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Birch-sykes CJ
- Bird GA
- Birman M
- Bisanz T
- Biswal JP
- Biswas D
- Bitadze A
- Bittrich C
- Bjørke K
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Bomben M
- Bona M
- Boonekamp M
- Booth CD
- Borbély AG
- Borecka-Bielska HM
- Borgna LS
- Borissov G
- Bortoletto D
- Boscherini D
- Bosman M
- Bossio Sola JD
- Bouaouda K
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bouquet R
- Boveia A
- Boyd J
- Boye D
- Boyko IR
- Bozson AJ
- Bracinik J
- Brahimi N
- Brandt G
- Brandt O
- Braren F
- Brau B
- Brau JE
- Breaden Madden WD
- Brendlinger K
- Brener R
- Brenner L
- Brenner R
- Bressler S
- Brickwedde B
- Briglin DL
- Britton D
- Britzger D
- Brock I
- Brock R
- Brooijmans G
- Brooks WK
- Brost E
- Bruckman de Renstrom PA
- Bruncko D
- Bruni A
- Bruni G
- Bruschi M
- Bruscino N
- Bryngemark L
- Brüers B
- Buanes T
- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Bugge MK
- Bulekov O
- Bullard BA
- Burch TJ
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burr JTP
- Burton CD
- Burzynski JC
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Buxo Vazquez CJ
- Buzykaev AR
- Büscher V
- Cabras G
- Cabrera Urbán S
- Caforio D
- Cai H
- Cairo VMM
- Cakir O
- Calace N
- Calafiura P
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Caltabiano A
- Calvente Lopez S
- Calvet D
- Calvet S
- Calvet TP
- Calvetti M
- Camacho Toro R
- Camarda S
- Camarero Munoz D
- Camarri P
- Camerlingo MT
- Cameron D
- Camincher C
- Campanelli M
- Camplani A
- Canale V
- Canesse A
- Cano Bret M
- Cantero J
- Cao Y
- Capua M
- Carbone A
- Cardarelli R
- Cardillo F
- Carducci G
- Carli T
- Carlino G
- Carlson BT
- Carlson EM
- Carminati L
- Carnesale M
- Carney RMD
- Caron S
- Carquin E
- Carratta G
- Carrá S
- Carter JWS
- Carter TM
- Casadei D
- Casado MP
- Casha AF
- Castiglia EG
- Castillo Garcia L
- Castillo Gimenez V
- Castillo FL
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Cavaliere V
- Cavalli N
- Cavasinni V
- Celebi E
- Celli F
- Cerny K
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cervelli A
- Cetin SA
- Chadi Z
- Chakraborty D
- Chala M
- Chan J
- Chan WS
- Chan WY
- Chapman JD
- Chargeishvili B
- Charlton DG
- Charman TP
- Chatterjee M
- Chau CC
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chen A
- Chen B
- Chen C
- Chen CH
- Chen H
- Chen H
- Chen J
- Chen J
- Chen J
- Chen S
- Chen SJ
- Chen X
- Chen Y
- Chen Y-H
- Cheng CL
- Cheng HC
- Cheng HJ
- Cheplakov A
- Cheremushkina E
- Cherkaoui El Moursli R
- Cheu E
- Cheung K
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu I
- Chiu YH
- Chizhov MV
- Choi K
- Chomont AR
- Chou Y
- Chow YS
- Christopher LD
- Chu MC
- Chu X
- Chudoba J
- Chwastowski JJ
- Cieri D
- Ciesla KM
- Cindro V
- Cioară IA
- Ciocio A
- Cirotto F
- Citron ZH
- Citterio M
- Ciubotaru DA
- Ciungu BM
- Clark A
- Clark PJ
- Clavijo Columbie JM
- Clawson SE
- Clement C
- Clissa L
- Coadou Y
- Cobal M
- Coccaro A
- Cochran J
- Coelho Barrue RF
- Coelho Lopes De Sa R
- Coelli S
- Cohen H
- Coimbra AEC
- Cole B
- Collot J
- Conde Muiño P
- Connell SH
- Connelly IA
- Conroy EI
- Conventi F
- Cooke HG
- Cooper-Sarkar AM
- Cormier F
- Corpe LD
- Corradi M
- Corrigan EE
- Corriveau F
- Costa MJ
- Costanza F
- Costanzo D
- Cote BM
- Cowan G
- Cowley JW
- Crane J
- Cranmer K
- Creager RA
- Crescioli F
- Cristinziani M
- Cristoforetti M
- Croft V
- Crosetti G
- Crépé-Renaudin S
- Cueto A
- Cuhadar Donszelmann T
- Cui H
- Cukierman AR
- Cunningham WR
- Czekierda S
- Czodrowski P
- Czurylo MM
- Da Cunha Sargedas De Sousa MJ
- Da Fonseca Pinto JV
- Da Via C
- Dabrowski W
- Dado T
- Dahbi S
- Dai T
- Dallapiccola C
- Dam M
- Damp J
- Dandoy JR
- Daneri MF
- Danninger M
- Dao V
- Darbo G
- Darmora S
- Dattagupta A
- David C
- Davidek T
- Davis DR
- Davis-Purcell B
- Dawson I
- De Asmundis R
- De Beurs M
- De Castro S
- De Groot N
- de Jong P
- De la Torre H
- De Maria A
- De Pedis D
- De Salvo A
- De Sanctis U
- De Santis M
- De Santo A
- De Vivie De Regie JB
- De K
- Dedovich DV
- Degens J
- Deiana AM
- Del Peso J
- Delabat Diaz Y
- Deliot F
- Delitzsch CM
- Della Pietra M
- Della Volpe D
- Dell’Acqua A
- Dell’Asta L
- Delmastro M
- Delsart PA
- Demers S
- Demichev M
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
- Desch K
- Dette K
- Deutsch C
- Deviveiros PO
- Di Bello FA
- Di Ciaccio A
- Di Ciaccio L
- Di Donato C
- Di Girolamo A
- Di Gregorio G
- Di Luca A
- Di Micco B
- Di Nardo R
- Diaconu C
- Dias Do Vale T
- Dias FA
- Diaz Capriles FG
- Diaz MA
- Dickinson J
- Didenko M
- Diehl EB
- Dietrich J
- Diez Pardos C
- Dimitrievska A
- Ding W
- Dingfelder J
- Dinu I-M
- Dittmeier SJ
- Dittus F
- Djama F
- Djobava T
- Djuvsland JI
- Do Vale MAB
- Dodsworth D
- Doglioni C
- Dolejsi J
- Dolezal Z
- Donadelli M
- Dong B
- Donini J
- Dopke J
- Doria A
- Dova MT
- Doyle AT
- Drechsler E
- Dreyer E
- Dreyer T
- Drobac AS
- du Pree TA
- Du D
- Dubinin F
- Dubovsky M
- Dubreuil A
- Duchovni E
- Duckeck G
- Ducu OA
- Duda D
- Dudarev A
- Duflot L
- Dumitriu AE
- Dunford M
- Dungs S
- Duperrin A
- Duran Yildiz H
- Durglishvili A
- Dutta B
- Duvnjak D
- Dyckes GI
- Dyndal M
- Dysch S
- Dziedzic BS
- Díez Cornell S
- Dührssen M
- Dülsen C
- Düren M
- D’amen G
- D’Amico V
- D’Auria S
- D’Eramo L
- D’onofrio A
- D’Onofrio M
- D’uffizi M
- Eckerova B
- Eggleston MG
- Egidio Purcino De Souza E
- Ehrke LF
- Eifert T
- Eigen G
- Einsweiler K
- Ekelof T
- El Ghazali Y
- El Jarrari H
- El Moussaouy A
- Ellajosyula V
- Ellert M
- Ellinghaus F
- Elliot AA
- Ellis N
- Elmsheuser J
- Elsing M
- Emeliyanov D
- Emerman A
- Enari Y
- Erdmann J
- Ereditato A
- Erland PA
- Errenst M
- Escalier M
- Escobar C
- Estrada Pastor O
- Etzion E
- Evans G
- Evans H
- Evans MO
- Ezhilov A
- Fabbri F
- Fabbri L
- Fabiani V
- Facini G
- Fadeyev V
- Fakhrutdinov RM
- Falciano S
- Falke PJ
- Falke S
- Faltova J
- Fan Y
- Fang Y
- Fang Y
- Fanourakis G
- Fanti M
- Faraj M
- Farbin A
- Farilla A
- Farina EM
- Farooque T
- Farrington SM
- Farthouat P
- Fassi F
- Fassouliotis D
- Faucci Giannelli M
- Fawcett WJ
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- Zeißner SV
- Zemaityte G
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Ziolkowski M
- Zoccoli A
- Zoch K
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/11/2021
- Field of study
A measurement of four-top-quark production using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS detector at the Large Hadron Collider corresponding to an integrated luminosity of 139 fb−1 is presented. Events are selected if they contain a single lepton (electron or muon) or an opposite-sign lepton pair, in association with multiple jets. The events are categorised according to the number of jets and how likely these are to contain b-hadrons. A multivariate technique is then used to discriminate between signal and background events. The measured four-top-quark production cross section is found to be 26+17−15 fb, with a corresponding observed (expected) significance of 1.9 (1.0) standard deviations over the background-only hypothesis. The result is combined with the previous measurement performed by the ATLAS Collaboration in the multilepton final state. The combined four-top-quark production cross section is measured to be 24+7−6 fb, with a corresponding observed (expected) signal significance of 4.7 (2.6) standard deviations over the background-only predictions. It is consistent within 2.0 standard deviations with the Standard Model expectation of 12.0 ± 2.4 fb
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Adam Bourdarios C
- Adamczyk L
- Adamek L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
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- Affolder AA
- Afik Y
- Agaras MN
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- Aggarwal A
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- Ahmed WS
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- Busch EL
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- Buzykaev AR
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- Castillo FL
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- Cavaliere V
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- Da Cunha Sargedas De Sousa MJ
- Da Fonseca Pinto JV
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- Zhemchugov A
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- Zhulanov V
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
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- Zhang Z
- Zhao H
- Zhao T
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- Zhemchugov A
- Zheng J
- Zheng K
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- Zhong D
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- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
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- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Measurements of differential cross-sections in top-quark pair events with a high transverse momentum top quark and limits on beyond the Standard Model contributions to top-quark pair production with the ATLAS detector at √s = 13 TeV
- Author
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- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- Aboulhorma A
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- Cai Y
- Cairo VMM
- Cakir IT
- Cakir O
- Calace N
- Calafiura P
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Calvet D
- Calvet S
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- Calvetti M
- Camarda S
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- Camelia EA
- Camerlingo MT
- Cameron D
- Camincher C
- Campanelli M
- Camplani A
- Canale V
- Canesse A
- Cantero J
- Cao Y
- Capocasa F
- Capriles FGD
- Capua M
- Carbone A
- Cardarelli R
- Cardenas JCJ
- Cardillo F
- Carducci G
- Carli T
- Carlino G
- Carlson BT
- Carlson EM
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- Carter JWS
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- Casadei D
- Casado MP
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- Castillo FL
- Castillo LRF
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- Catmore JR
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- Chen A
- Chen B
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- Chen X
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- Cheplakov A
- Cheremushkina E
- Cherepanova E
- Cheu E
- Cheung K
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu YH
- Chizhov MV
- Choi K
- Chomont AR
- Chou Y
- Chow YS
- Chowdhury T
- Christopher LD
- Chu MC
- Chu X
- Chudoba J
- Chwastowski JJ
- Cieri D
- Ciesla KM
- Cindro V
- Ciocio A
- Cirotto F
- Citron ZH
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- Ciubotaru DA
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- Clark A
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- Clawson SE
- Clement C
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- Coadou Y
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- Coelli S
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- Cornell SD
- Corpe LD
- Corradi M
- Correia AMH
- Corrigan EE
- Corriveau F
- Costa MJ
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- da Costa JBG
- Da Via C
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- Dam M
- Damazio DO
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- de Renstrom PAB
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- De Souza EEP
- Dedovich DV
- Degens J
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- Deviveiros PO
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- Di Girolamo A
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- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou H
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Cross-section measurements of top-quark pair production where the hadronically decaying top quark has transverse momentum greater than 355 GeV and the other top quark decays into ℓνb are presented using 139 fb−1 of data collected by the ATLAS experiment during proton-proton collisions at the LHC. The fiducial cross-section at s = 13 TeV is measured to be σ = 1.267 ± 0.005 ± 0.053 pb, where the uncertainties reflect the limited number of data events and the systematic uncertainties, giving a total uncertainty of 4.2%. The cross-section is measured differentially as a function of variables characterising the tt¯ system and additional radiation in the events. The results are compared with various Monte Carlo generators, including comparisons where the generators are reweighted to match a parton-level calculation at next-to-next-to-leading order. The reweighting improves the agreement between data and theory. The measured distribution of the top-quark transverse momentum is used to search for new physics in the context of the effective field theory framework. No significant deviation from the Standard Model is observed and limits are set on the Wilson coefficients of the dimension-six operators OtG and Otq(8), where the limits on the latter are the most stringent to date. [Figure not available: see fulltext.]
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