Optical control of electric-field poling in LiTaO₃

We present a room temperature technique for optically inducing periodic domain-inverted structures in bulk (0.2mm thick) LiTaO3. By simultaneous application of an electric field and patterned illumination using UV wavelengths (351nm and 364nm) we demonstrate modulation of the resulting domain profile. We discuss the origins of the observed optical effect and describe our results from repeated domain switching, by cycling the electric field

Effect of initial correlations on short-time decoherence

We study the effect of initial correlations on the short-time decoherence of a particle linearly coupled to a bath of harmonic oscillators. We analytically evaluate the attenuation coefficient of a Schroedinger cat state both for a free and a harmonically bound particle, with and without initial thermal correlations between the particle and the bath. While short-time decoherence appears to be independent of the system in the absence of initial correlations, we find on the contrary that, for initial thermal correlations, decoherence becomes system dependent even for times much shorter than the characteristic time of the system. The temperature behavior of this system dependence is discussed.Comment: 7 pages, 1 figur

The COOH-terminal domain of agrin signals via a synaptic receptor in central nervous system neurons

Agrin is a motor neuron–derived factor that directs formation of the postsynaptic apparatus of the neuromuscular junction. Agrin is also expressed in the brain, raising the possibility that it might serve a related function at neuron–neuron synapses. Previously, we identified an agrin signaling pathway in central nervous system (CNS) neurons, establishing the existence of a neural receptor that mediates responses to agrin. As a step toward identifying this agrin receptor, we have characterized the minimal domains in agrin that bind and activate it. Structures required for agrin signaling in CNS neurons are contained within a 20-kD COOH-terminal fragment of the protein. Agrin signaling is independent of alternative splicing at the z site, but requires sequences that flank it because their deletion results in a 15-kD fragment that acts as an agrin antagonist. Thus, distinct regions within agrin are responsible for receptor binding and activation. Using the minimal agrin fragments as affinity probes, we also studied the expression of the agrin receptor on CNS neurons. Our results show that both agrin and its receptor are concentrated at neuron–neuron synapses. These data support the hypothesis that agrin plays a role in formation and/or function of CNS synapses

Empirical analyses of the length, weight, and condition of adult Atlantic salmon on return to the Scottish coast between 1963 and 2006

Sea age, size, and condition of adult Atlantic salmon (Salmo salar) are prime determinants of individual, and hence population, productivity. To elucidate potential mechanisms, 151 000 records of salmon returning to six Scottish coastal sites over 44 years were analysedfor length, weight, and condition, by site, sex, sea age, and river age. After correcting for capture effort biases, all sites showed seasonal increases in length and weight for both 1 sea winter (1SW) and 2SW fish. However, whereas condition increased slightly with season for 2SW, it decreased notably for 1SW. Sites showed common decadal trends in length, weight, and condition. Within years, length and weight residuals from trends were coherent across sites, but residuals from condition trends were not. Rates of seasonal condition change also showed decadal trends, dramatically different between sea ages, but common across sites within sea-age groups. Longer salmon were disproportionately heavy in all seasons. 1SW condition was markedly lower in 2006. Detrended correlations withoceanic environmental variables were generally not significant, and always weak. A published correlation between the condition of 1SW salmon caught at a single site and sea surface temperatures in the Northeast Atlantic could not be substantiated for any of the six fisheries over the wider time-scales examined

Finding a state in a haystack

We consider the problem to single out a particular state among $2^n$ orthogonal pure states. As it turns out, in general the optimal strategy is not to measure the particles separately, but to consider joint properties of the $n$-particle system. The required number of propositions is $n$. There exist $2^n!$ equivalent operational procedures to do so. We enumerate some configurations for three particles, in particular the Greenberger-Horne-Zeilinger (GHZ)- and W-states, which are specific cases of a unitary transformation For the GHZ-case, an explicit physical meaning of the projection operators is discussed.Comment: 11 page

Are Causality Violations Undesirable?

Causality violations are typically seen as unrealistic and undesirable features of a physical model. The following points out three reasons why causality violations, which Bonnor and Steadman identified even in solutions to the Einstein equation referring to ordinary laboratory situations, are not necessarily undesirable. First, a space-time in which every causal curve can be extended into a closed causal curve is singularity free--a necessary property of a globally applicable physical theory. Second, a causality-violating space-time exhibits a nontrivial topology--no closed timelike curve (CTC) can be homotopic among CTCs to a point, or that point would not be causally well behaved--and nontrivial topology has been explored as a model of particles. Finally, if every causal curve in a given space-time passes through an event horizon, a property which can be called "causal censorship", then that space-time with event horizons excised would still be causally well behaved.Comment: Accepted in October 2008 by Foundations of Physics. Latex2e, 6 pages, no figures. Presented at a seminar at the Universidad Nacional Autonoma de Mexico. Version 2 was co-winner of the QMUL CTC Essay Priz

Environmentally conscious closed-loop aqueous and semi-aqueous cleaning systems for defluxing and degreasing

The purpose of this project was to develop an environmentally conscious closed-loop cleaning process which would meet the cleaning needs of ATC, reduce worker exposure to hazardous chemicals, and eliminate or reduce their hazardous waste. In order to accomplish this, new cleaning materials needed to be tested for cleaning efficacy as compared to trichloroethylene. The project work plan was broken down into five phases including establishing a baseline cleaning level, evaluating alternative cleaners, specifying and purchasing closed-loop cleaning equipment, installing and evaluating the new equipment, and publicizing the results. In general, it was the responsibility of the KCP to perform cleaning efficacy measurements on sample panels and actual parts that were processed by ATC. The cleaners chosen were evaluated for their abilities to remove the potential contaminants using an ultrasonic cleaning process at the KCP. The cleaning abilities of 20 different cleaners were compared to that of trichloroethylene, the baseline cleaning material. At least nine alternative cleaners produced cleaning results which exceeded trichloroethylene for this application. After evaluating the alternative cleaners and as new cleaning equipment was being tested, ATC terminated the Cooperative Agreement. Further equipment evaluations were suspended

Modeling hypertrophic cardiomyopathy: Mechanistic insights and pharmacological intervention

Hypertrophic cardiomyopathy (HCM) is a prevalent and complex cardiovascular disease where cardiac dysfunction often associates with mutations in sarcomeric genes. Various models based on tissue explants, isolated cardiomyocytes, skinned myofibrils, and purified actin/myosin preparations have uncovered disease hallmarks, enabling the development of putative therapeutics, with some reaching clinical trials. Newly developed human pluripotent stem cell (hPSC)-based models could be complementary by overcoming some of the inconsistencies of earlier systems, whilst challenging and/or clarifying previous findings. In this article we compare recent progress in unveiling multiple HCM mechanisms in different models, highlighting similarities and discrepancies. We explore how insight is facilitating the design of new HCM therapeutics, including those that regulate metabolism, contraction and heart rhythm, providing a future perspective for treatment of HCM

Erbium fibre laser pumped nanosecond optical parametric oscillator

We report a periodically-poled lithium niobate optical parametric oscillator pumped by a frequency doubled Q-switched erbium-fibre laser. Pump tuning of the OPO signal with thresholds below 10µJ was demonstrated. Signal tuning range was 0.99-1.45µm