Визуализация амплитудно-фазовых параметров биоритмов в процессе их синхронизации

Настоящее исследование по визуализации амплитудно-фазовых параметров биоритмов в процессе их синхронизации основано на выделении последовательных временных интервалов [3], которые позволяют прослеживать поведение различных параметров любого ритмичного компонента спектра в течение времени, которое включает промежутки до, в течение и после любого синхронизационного (десинхронизационного) случая. Есть простой неинвазивный метод для того, чтобы приобрести информацию относительно визуализации амплитудно-фазовых корреляций. Метод использует математический и графический анализ одновременной визуализации динамики амплитуды, ее статистического значения и величины акрофазы в процессах захвата. Так же были разработаны три модификации последовательных секций: процедура добавляющих логарифмов достоверных матриц, двух- и трехмерные изображения процессов. В качестве иллюстрации использовались последовательные ряды, которые включали: автоматические измерения кровяного давления (BP), его систолической (S) и диастолической (D) компоненты, а также частоту сердечных сокращений (ЧСС). Были проанализированы хронобиологические показатели сердечно-сосудистой системы во время пяти полетов из Миннеаполиса (США) в Санкт-Петербург (Россия), с пересечением 9 часовых поясов и четырех полетов в противоположном направлении. Одновременное понижение амплитуды и быстрые изменения в акрофазе, связанные с полетом «c запада на восток», и более постепенные изменения аналогичных показателей в направлении полетов «с востока на запад» привели авторов к гипотезе, что быстрые изменения могут вызывать «поломку» изучаемых биоритмологических характеристик. Применение настоящего метода позволило авторам выполнять визуализируемый динамический контроль хронобиологических параметров сердечно-сосудистой системы. Таким образом, данный метод характеризуется более высокой прогностической ценностью по сравнению с известными способами, применяемыми в хронобиологии.In the present research the visualization of amplitude-phase relationships in entrainment processes is based on the expression serial time sections [3] allow tracing the behavior of different parameters of any rhythmical component of spectrum during a time which includes spans before, during and after any synchronizing (desynchronizing) event. There is a simple and noninvasive method for acquiring information on the visualization of amplitude-phase relationships. The method used the mathematical and graphic analysis simultaneously visualization the dynamics of amplitude, its statistical significance and acrophase in entrainment processes, the three modifications of serial sections was elaborated: procedure of adding logarithms of P-values-matrices, plotting 2D image and 3D image. As examples for illustration serial section method, automatic measurements of blood pressure (BP), both systolic (S) and diastolic (D), and heart rate (HR) were used. Five flights from Minneapolis (USA) to Saint-Petersburg (Russia) crossing 9 time zones and 4 flights in the opposite direction were performed during that time (during the second return flight, no measurements were taken). The simultaneous drop in amplitude and the rapid shift in acrophase associated with West-to-East flights, and more gradual changes for East-to-the-West flights led to the hypothesis that the rapid entrainment is performed by collapse of the rhythm at a singularity time point. Application of the present method has allowed the authors to carry out visualised dynamic chronobiological the control parameters of cardiovascular system. The method has higher diagnostic value in comparison with well-known procedures of an estimation of chronomedicine

Feedsidewards: Intermodulation (strictly) among Time Structures, Chronomes, in and around us, and Cosmo-vasculo-neuroimmunity

The spectrum of biological rhythms is extended far beyond circadians, circannuals, and ultradians, such as 1.5-hourly melatonin and 8-hourly endothelin-1 (ET-1) rhythms by statistics of natality, growth, morbidity, and mortality, some covering decades or centuries on millions of individuals. These reveal infradian cycles to be aligned with half-weekly rhythms in ET-1, weekly and half-yearly ones in melatonin, and even longer--about 50-, about 20-, and about 10-year cycles found in birth statistics. About daily, weekly, yearly, and ten-yearly patterns are also found in mortality from myocardial infarctions; the 10-yearly ones are also in heart rate and its variability; in steroid excretion, an aspect of resistance, for example, to bacteria; and in the genetic changes of the bacteria themselves. Automatic physiological measurements cover years and, in one case, cover a decade; the latter reveal an about 10-year (circadecennial) cycle. ECGs, covering months beat-to-beat, reveal circaseptans, gaining prominence in response to magnetic storms or after coronary artery bypass grafting. A spectrum including cycles from fractions of 1 Hz to circasemicentennians is just one element in biological time structures, chronomes. Chaos, trends, and any unresolved variability are the second to fourth elements of chronomes. Intermodulations, feedsidewards, account for rhythmically and thus predictably recurring quantitive differences and even for opposite treatment effects of the same total dose(s) of (1) immunomodulators inhibiting or stimulating DNA labeling of bone in health or speeding up versus slowing down a malignant growth and thus shortening or lengthening survival time, or (2) raising or lowering blood pressure or heart rate in the vascular aspect of the body's defense. Latitude-dependent competing photic and nonphotic solar effects upon the pineal are gauged by alternating yearly (by daylight) and half-yearly (by night) signatures of circulating melatonin at middle latitudes and by half-yearly signatures at noon near the pole. These many (including novel near 10-yearly) changes, for example, in 17-ketosteroid excretion, heart rate, heart rate variability, and myocardial infarction in us and those galactic, solar, and geophysical ones around us have their own special signatures and contribute to a cosmo-vasculo-immunity and, if that fails, to a cosmo(immuno?) pathology

Pre-surgical and post-surgical alterations of arterial blood pressure circadian rhythm

BP was monitored before and after 10 surgical interventions of various complexity (2003 – 2010) in GSK (a patient of 76 – 84 years) suffering from hypertension disease since 1959. Treatment up to 09.2005 was performed traditionally (T, medications in mornings and evenings), later scheduled according to chronobiological principles, based on the 24-hour blood pressure (BP) profile. Changes in the parameters of the 24- and 12-hour components were analyzed during the 7 days preceding and the 7 days following each intervention. MESORs and acrophases did not change regularly after surgeries The magnitude (extent of predictable daily change determined from the composite model) did not change or even decreased on the days of operations but later began increasing (which could provoke sudden BP peaks), returning to initial values only within 6 – 7 days. In surgeries performed after T, inconsiderable increases in magnitude did not last more than 3 days or was absent altogether. As BP peaks may lead to many unfavorable effects, their reduction or disappearance after a chronobiologically scheduled treatment was implemented should be considered as a positive factor. Unfortunately, monitoring making this approach feasible is not realistic now, even in specialized surgical hospitals. © 2014 Nova Science Publishers, Inc

Pre-surgical and post-surgical alterations of arterial blood pressure circadian rhythm

BP was monitored before and after 10 surgical interventions of various complexity (2003-2010) in GSK (a patient of 76-84 years) suffering from hypertension disease since 1959. Treatment up to 09.2005 was performed traditionally (T, medications in mornings and evenings), later scheduled according to chronobiological principles, based on the 24- hour blood pressure (BP) profile. Changes in the parameters of the 24- and 12-hour components were analyzed during the 7 days preceding and the 7 days following each intervention. MESORs and acrophases did not change regularly after surgeries The magnitude (extent of predictable daily change determined from the composite model) did not change or even decreased on the days of operations but later began increasing (which could provoke sudden BP peaks), returning to initial values only within 6-7 days. In surgeries performed after T, inconsiderable increases in magnitude did not last more than 3 days or was absent altogether. As BP peaks may lead to many unfavorable effects, their reduction or disappearance after a chronobiologically scheduled treatment was implemented should be considered as a positive factor. Unfortunately, monitoring making this approach feasible is not realistic now, even in specialized surgical hospitals. © 2016 Nova Science Publishers, Inc

Pre-surgical and post-surgical alterations of arterial blood pressure circadian rhythm

BP was monitored before and after 10 surgical interventions of various complexity (2003 – 2010) in GSK (a patient of 76 – 84 years) suffering from hypertension disease since 1959. Treatment up to 09.2005 was performed traditionally (T, medications in mornings and evenings), later scheduled according to chronobiological principles, based on the 24-hour blood pressure (BP) profile. Changes in the parameters of the 24- and 12-hour components were analyzed during the 7 days preceding and the 7 days following each intervention. MESORs and acrophases did not change regularly after surgeries The magnitude (extent of predictable daily change determined from the composite model) did not change or even decreased on the days of operations but later began increasing (which could provoke sudden BP peaks), returning to initial values only within 6 – 7 days. In surgeries performed after T, inconsiderable increases in magnitude did not last more than 3 days or was absent altogether. As BP peaks may lead to many unfavorable effects, their reduction or disappearance after a chronobiologically scheduled treatment was implemented should be considered as a positive factor. Unfortunately, monitoring making this approach feasible is not realistic now, even in specialized surgical hospitals. © 2014 Nova Science Publishers, Inc

Pre-surgical and post-surgical alterations of arterial blood pressure circadian rhythm

BP was monitored before and after 10 surgical interventions of various complexity (2003-2010) in GSK (a patient of 76-84 years) suffering from hypertension disease since 1959. Treatment up to 09.2005 was performed traditionally (T, medications in mornings and evenings), later scheduled according to chronobiological principles, based on the 24- hour blood pressure (BP) profile. Changes in the parameters of the 24- and 12-hour components were analyzed during the 7 days preceding and the 7 days following each intervention. MESORs and acrophases did not change regularly after surgeries The magnitude (extent of predictable daily change determined from the composite model) did not change or even decreased on the days of operations but later began increasing (which could provoke sudden BP peaks), returning to initial values only within 6-7 days. In surgeries performed after T, inconsiderable increases in magnitude did not last more than 3 days or was absent altogether. As BP peaks may lead to many unfavorable effects, their reduction or disappearance after a chronobiologically scheduled treatment was implemented should be considered as a positive factor. Unfortunately, monitoring making this approach feasible is not realistic now, even in specialized surgical hospitals. © 2016 Nova Science Publishers, Inc

Near 10 years and longer periods modulate circadians: intersecting anti aging and chronoastrobiological research

Biological cycles with relatively long and some unusual periods in the range of the half-week, the half-year, years, or decades are being discovered. Their prior neglect constituted a confounder in aging and much other research, which then \u201cflew blind\u201d concerning the uncertainties associated with these cycles when they are not assessed. The resolution of more about 10-year and other cycles, some reported herein, replaces the admission of complete unpredictability, implied by using the label \u201csecularity.\u201d Heretofore unaccounted-for variability becomes predictable insofar as it proves to be rhythmic and is mapped systematically to serve as a battery of useful reference values. About 10-year cycles in urinary 17-ketosteroid excretion and in heart rate and its variability, among others, are aligned with cycles of similar length in mortality from myocardial infarction. Associations accumulate between cycles of natural physical time structures, chronomes such as the 10.5-year (circadecennian) Schwabe and the 21-year (circavigintunennian) Hale cycles of solar activity, and chronomes in biota. There are about 50-year (circasemicentennian) cycles in mortality from stroke in Minnesota and in the Czech Republic and also in human morphology at birth, the latter result reducing the likelihood that these cycles are purely human made. Associations among large populations warrant long-term systematic coordinated sampling of natural physical and biological variables of interest for the design of countermeasures against already documented elevated risks of stroke, myocardial infarction, and other catastrophic diseases, notably in elderly adults. New findings will be introduced against the background of the documented value of mapping rhythms in medicine and gerontology. In both these fields, rhythms promise the seeming paradox of better care for less

Chronobiology: time structures, chronomes, gauge aging, disease risk syndromes and the cosmos

For dealing with everyday physiology, that is, with respect to physiological variation in the normal range, the prevailing position corresponds to that in preatomic physics. The "a-tom" was then the smallest known particle that could not be further split. Breaking the atom opened the door to a new universe of particles governed by new forces and physical laws. Nuclear physics evolved and brought new knowledge, a new energy source and a wealth of practical applications. The analogy applies to the splitting of the normal range into the time structures of everyday physiology. From picking different times of day and seasons for study, a trans-disciplinary science, chronobiology, emerged. Chronobiology objectively maps chronomes (portmanteau'd from chronos = time and nomos = rule), time structures quantifying the relations among cycles and other events. The chronomes of variables in and around us intermodulate with each other; thus, we start exploring organisms as dynamic systems open to their environments near and far, and dependent upon them, beyond air and food. Entering the realm of everyday physiology allowed us to quantify, with refined indices, associations of life with remote drummers. The intermodulating feedsideward mechanisms involved in cosmophysical associations of life on earth may be in part endocrine responses to factors far beyond visible light and temperature. Pertinent knowledge may serve to optimize the quality and duration of life