54 research outputs found
Advanced brain dopamine transporter imaging in mice using small-animal SPECT/CT
Abstract. The stable marriage problem has recently been studied in its general setting, where both ties and incomplete lists are allowed. It is NP-hard to find a stable matching of maximum size, while any stable matching is a maximal matching and thus trivially a factor two approximation. In this paper, we give the first nontrivial result for approximation of factor less than two. Our algorithm achieves an approximation ratio of 2/(1+L ā2) for instances in which only men have ties of length at most L. When both men and women are allowed to have ties, we show a ratio of 13/7(< 1.858) for the case when ties are of length two. We also improve the lower bound on the approximation ratio to 2
A randomized study of intermediate versus conventional-dose cytarabine as intensive induction for acute myelogenous leukaemia
The optimal dose of cytarabine for induction chemotherapy is unknown. Most studies have utilized doses of 100ā200 mg/m2/d, although higher doses have been proposed to increase the concentration of the active metabolite araāCTP within leukaemia cells. To address this question 101 adults with newly diagnosed acute myeloid leukaemia were randomized to receive treatment with daunorubicin and either conventionalādose cytarabine (200 mg/m2/d by continuous infusion) or an intermediateādose of cytarabine (500 mg/m2 every 12 h). 36/51 (71%) patients assigned to conventionalādose cytarabine achieved complete remission compared to 37/50 (74%) who achieved remission with intermediateādose cytarabine (P = 0.9). Patient age significantly affected remission rate. 8/17 patients age >60 assigned to conventionalādose cytarabine and 10/17 assigned to intermediateādose cytarabine achieved complete remission compared to 27/33 patients under age 60 assigned to the conventional dose and 28/34 patients assigned to the intermediate dose arm (P=0.004). Actuarial 4āyear diseaseāfree survival for patients assigned to conventionalādose cytarabine was 20.16% versus 28.17% for patients assigned to intermediateādose cytarabine (P=0ā9). We conclude that intermediate dose cytarabine did not substantially improve results of induction chemotherapy for acute myeloid leukaemia
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