46 research outputs found
Anharmonic collective excitation in a solvable model
We apply the time-dependent variational principle, the nuclear field theory,
and the boson expansion method to the Lipkin model to discuss anharmonicities
of collective vibrational excitations. It is shown that all of these approaches
lead to the same anharmonicity to leading order in the number of particles.
Comparison with the exact solution of the Lipkin model shows that these
theories reproduce it quite well.Comment: RevTex, 18 pages, 4 postscript figure
Does normal lymphocyte DNA synthesis in response to PHA exclude cell-mediated immunodepression?
Allergy to beer in LTP-sensitized patients: beers are not all the same
BACKGROUND:
Most cases of beer allergy reported so far have been associated with hypersensitivity to the non-specific lipid transfer protein (LTP). In view of the marked differences in brewing processes we assessed IgE reactivity as well as tolerance to many different beers in an allergic patient.
METHODS:
A 45 year-old man hypersensitive to grass pollen, cat dander and Alternaria tenuis with a history of urticaria and dyspnoea after drinking beer and a weak skin reactivity to commercial corn extract was studied. The patient underwent SPT with 36 different brands of beer and an open challenge with those scoring negative was performed. An immunoblot analysis was carried out using 2 SPT-positive beers, 2 SPT-negative beers, and barley, wheat, and maize extracts using both patient's serum and a maize LTP-specific in-house developed polyclonal antibody from rabbit. Further, the immune reactive LTP of one beer was separated by HPLC and the chromatogram was compared to that of purified maize LTP.
RESULTS:
Beer SPT scored positive in 30/36 cases. The immunoblot analysis showed IgE reactivity at about 10 kDa against the two SPT-positive beers and against maize with both patient's serum and the polyclonal anti-LTP rabbit serum, whereas the two SPT-negative beers, and barley extract scored negative. The immunodetected protein co-migrated with maize LTP.
CONCLUSION:
In beer-allergic patients the diagnostic workup may point to the detection of some tolerated products that can be consumed risk-free
Cryoglobulinemia in elderly patients with HCV-related chronic hepatitis.
Hepatitis C virus (HCV) infection affects about 3% of
the world’s population and often leads to chronic liver
disease. In some industrialized countries, HCV prevalence
increases with age, but the optimal management of older
patients has not been accurately defined. HCV infection
can also lead to lymphoproliferative disorders, the most
common being mixed cryoglobulinemia (MC), and also
for this condition that frequently affects elderly patients,
the optimal therapeutic strategy is still debated. We report
the case of a 77-year-old Caucasian woman with
HCV-related chronic hepatitis and cutaneous manifestations
consisting of urticaria and pruritus related to MC resistant
to antihistamines. The patient underwent a treatment
with interferon and ribavirin. Such a treatment led
to early biochemical and virological response associated
with the resolution of cryoglobulinemia and cutaneous
symptoms. After the end of treatment, HCV replication relapsed, but cryoglobulinemia and cutaneous symptoms
did not recur. In the absence of definite treatment guidelines
in this particular context, our experience suggests
that the presence of symptoms related to HCV-infection
that deeply affect patient quality of life warrants antiviral
therapy even beyond the age limits that currently exclude
patients from treatment
Hepatitis B Virus Markers in Hematologic Patients: Relation to Transfusion Treatment and Hospitalization
Suppression of craving for gamma-hydroxybutyric acid by naltrexone administration: three case reports
Suppression of craving for gamma-hydroxybutyric acid by naltrexone administration: three case reports.
Evidence of Complex Degrees of Freedom in Multinucleon Transfer Reactions of <sub>48</sub>Ca + <sub>124</sub>Sn
Strong isotopic dependence of the fusion of Ca + Zr
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