Representaciones del Estado colombiano y construcción de ciudadanía en los márgenes

Colombian State Representations and Citizenship Construction at the MarginsBased on ethnographic fieldwork done in a Colombian settlement of houses built on stilts (palafitos), this article studies what the form and significance are of being a citizen at the margins of the state. The peripheral forms used in the construction of citizenship, the legitimacy of certain social practices – oscillating between legality and illegality – that constitute the daily experience of state representation at the margins is examined. It is argued that the simulation of state power is more important than its actual practices at the margins, as this affects the reality that determines daily life there. It follows that the margins are not spaces where social processes have been curtailed because the state has not yet fully arrived, but are places in which these processes take place in the gaps allowed by the simulation of it. Resumen: El artículo, basado en un trabajo de campo etnográfico realizado en un poblado palafito colombiano, estudia la forma en que se le da sentido a la idea del Estado desde los márgenes. El texto examina las formas periféricas de construcción de ciudadanía y la legitimidad que tienen ciertas prácticas sociales, oscilantes entre la legalidad y la ilegalidad, que son las que constituyen la experiencia cotidiana de representación del Estado en los márgenes. Se argumenta que más que la realidad del Estado lo que tiene importancia en los márgenes es su simulacro, pues éste tiene efectos de realidad que determinan allí la vida cotidiana. Se concluye que los márgenes no son espacios que tienen detenidos sus procesos sociales porque el Estado aún no ha llegado, sino que son lugares en los cuales esos procesos tienen lugar a partir de los resquicios que deja el simulacro de aquel

Test-bed of a real time detection system for L/H and H/L transitions implemented with the ITMS platform

A basic requirement of the data acquisition systems used in long pulse fusion experiments is to detect events of interest in the acquired signals in real time. Developing such applications is usually a complex task, so it is necessary to develop a set of hardware and software tools that simplify their implementation. An example of these tools is the Intelligent Test and Measurement System (ITMS), which offers distributed data acquisition, distribution and real time processing capabilities with advanced, but easy to use, software tools that simplify application development and system setup. This paper presents the application of the ITMS platform to solve the problem of detecting L/H and H/L transitions in real time based on the use of efficient pattern recognition algorithms

Nonlinear dynamical model for the assessment of the seismic behaviour of ferrocement houses

En este trabajo se evalúa el comportamiento cíclico de un prototipo de vivienda de ferrocemento, ensamblado mediante muros prefabricados de pared delgada, con la finalidad de identificar sus parámetros estructurales y proponer un modelo dinámico no lineal para simular el comportamiento de viviendas bajo movimientos sísmicos. Para ello se construyó un prototipo a escala real 1:1 y se probó bajo carga cíclica. De los resultados experimentales se obtuvieron: el comportamiento histerético, la rigidez elástica, la resistencia a cortante, la resistencia máxima, la ductilidad, la capacidad de disipación de energía, el amortiguamiento y el coeficiente de capacidad de disipación de energía; todos ellos, parámetros necesarios para la evaluación dinámica de la vivienda de ferrocemento bajo movimientos sísmicos. Al final se implementó el modelo dinámico no lineal de Bouc-Wen-Baber-Noori (BWBN). Este modelo permitió realizar la evaluación sísmica de la vivienda prefabricada de ferrocemento bajo sismos ocurridos.This article evaluates the cyclic behaviour of a prototype of a precast ferrocement house, which is assembled using precast thin walls, in order to identify its structural parameters and propose a nonlinear dynamical model which is able to simulate the behaviour of those houses when subjected to seismic loading. For this purpose, a full-scale precast ferrocement house was tested under cyclic loading conditions. From the experimental results, the hysteretic behaviour, the elastic stiffness, the shear resistance, the maximum strength, the ductility, the energy dissipation, the equivalent damping and its coefficient of energy dissipation were assessed; those parameters are needed in order to evaluate the dynamic behaviour of ferrocement dwellings when subjected to earthquakes. At the end, the Bouc-Wen-Baber-Noori (BWBN) model of hysteresis was implemented. The model allowed performing the seismic evaluation of the precast ferrocement house under seismic activity.Peer Reviewe

Real time plasma disruptions detection in JET implemented with the ITMS platform using FPGA based IDAQ

The use of FPGAs in data acquisition cards for processing purposes allows an efficient real time pattern recognition algorithm implementation. Using 13 JETs database waveforms an algorithm for detecting incoming plasma disruptions has been implemented. This algorithm is written in MATLAB using floating point representation. In this work we show the methodology used to implement the real time version of the algorithm using Intelligent Data Acquisition Cards (IDAQ), DAQ devices with field programmable gate array (FPGA) for local processing. This methodology is based on the translation of the MATLAB code to LabVIEW and the final coding of specific pieces of code in LabVIEW for FPGA in fixed point format. The whole system for evaluating the real time disruption detection (RTDD) has been implemented using the Intelligent Test and Measurement System (ITMS) platform. ITMS offers distributed data acquisition, distribution and real time processing capabilities with advanced, but easy to use, software tools that simplify application development and system setup. The RTDD implementation uses a standard PXI/PXIe architecture. Two 8 channel analog output cards play JETs database signals, two 8 channel DAQ with FPGA acquire signals and computes a feature vector based in FFT analysis. Finally the vector acquired is used by the system CPU to execute a pattern recognition algorithm to estimate an incoming disruption

Resistance mechanism to Notch inhibition and combination therapy in human T-cell acute lymphoblastic leukemia.

Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T-cell acute lymphoblastic leukemia (T-ALL), highlighting the Notch signaling pathway as a promising therapeutic target for personalized medicine. Yet, a major limitation for long-term success of targeted therapy is relapse due to tumor heterogeneity or acquired resistance. Thus, we performed a genome-wide CRISPR-Cas9 screen to identify prospective resistance mechanisms to pharmacological NOTCH inhibitors and novel targeted combination therapies to efficiently combat T-ALL. Mutational loss of phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) causes resistance to Notch inhibition. PIK3R1 deficiency leads to increased PI3K/AKT signaling, which regulates cell cycle and the spliceosome machinery, both at the transcriptional and posttranslational level. Moreover, several therapeutic combinations have been identified, in which simultaneous targeting of the cyclin-dependent kinases 4 and 6 (CDK4/6) and NOTCH proved to be the most efficacious in T-ALL xenotransplantation models

Evaluation of metabolic and biochemical blood parameters in lactating cows with Cystic Ovarian Disease

The aim of the study was to determine and evaluate different blood parameters associated to energetic, protein, mineral and liver metabolic processes together with productive and reproductive parameters in dairy cows of Santa Fe province (Argentina) that were diagnosed with cystic ovarian disease (COD). Lactating Argentine Holstein cows from five dairy herds with spontaneous COD (n= 80) diagnosed by ultrasound and control cows (n= 124) were included in the study. Blood samples were obtained from all cows to determine serum concentrations of: growth hormone, insulin-like growth factor (IGF-1), insulin, aspartate aminotransferase, alkalin phosphatase, gamma glutamiltransferase, albumin, total proteins, albumin: globulin ratio, total and direct bilirrubin, ?-hidroxibutirate, colesterol, glucose, urea, creatinin, calcium, phosphorus and magnesium. Serum concentrations of insulin and IGF-1 were lower (P<0.05) in COD than control cows. No significant differences among groups were observed in any other variables studied, however, the calving to conception interval was higher in cows with COD compared to controls. These results allowed us to conclude that there would be an association between blood concentrations of IGF-1 and insulin and COD that, ultimately, compromise the reproductive performance of the cow.Fil: Cattaneo, L. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Cátedra de Teriogenología. Santa Fe, ArgentinaFil: Barberis, F.C. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Cátedra de Teriogenología. Santa Fe, ArgentinaFil: Stangaferro, M.L. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Cátedra de Teriogenología. Santa Fe, ArgentinaFil: Signorini, M.L. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. ArgentinaFil: Signorini, M.L. CONICET. ArgentinaFil: Ruiz, M.F. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Hospital de Salud Animal. Santa Fe, ArgentinaFil: Zimmermann, R. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Hospital de Salud Animal. Santa Fe, ArgentinaFil: Bo, G.A. Instituto de Reproducción Animal Córdoba (IRAC). ArgentinaFil: Hein, G.J. CONICET - Universidad Nacional del Litoral. Instituto de Ciencias Veterinarias del Litoral (ICiVet-Litoral). Esperanza, ArgentinaFil: Ortega, H.H. CONICET - Universidad Nacional del Litoral. Instituto de Ciencias Veterinarias del Litoral (ICiVet-Litoral). Esperanza, ArgentinaEl objetivo de este trabajo fue determinar y evaluar indicadores bioquímicos sanguíneos asociados a procesos metabólicos energéticos, proteicos, minerales y de funcionalidad hepática, junto con parámetros productivos y reproductivos en vacas lecheras que fueron diagnosticadas con enfermedad quística ovárica (COD) y controles. Se emplearon vacas Holando Argentino en lactancia de 5 rebaños de la provincia de Santa Fe (Argentina) que presentaban COD (n= 80) diagnosticada mediante ultrasonografía y controles clínicamente sanas (n= 124). De las vacas se obtuvo sangre coccígea para determinar las concentraciones séricas de las hormonas de crecimiento (GH), factor de crecimiento similar a la insulina-1 (IGF-1) e insulina, la actividad sérica de AST, FA, GGT y las concentraciones séricas de albúmina, proteínas totales, relación albúmina: globulinas, bilirrubina total y directa, ?-hidroxibutirato, colesterol, glucosa, urea, creatinina, calcio, fósforo y magnesio. Las concentraciones séricas de insulina e IGF-1 fueron menores (P<0,05) en las vacas con COD que en las controles. No se observaron diferencias significativas (P>0,05) entre ambos grupos en las demás variables séricas y productivas evaluadas, sin embargo, el intervalo parto-concepción fue mayor en vacas que presentaron COD. Los resultados nos permitieron concluir que habría una asociación entre los valores séricos de IGF-1 e insulina y la COD, y que ésta comprometería el futuro reproductivo de las vacas

Efficacy of celecoxib in treating symptoms of viral pharyngitis: A double-blind, randomized study of celecoxib versus diclofenac

This study compared the efficacy and safety of the cyclooxygenase-2 specific inhibitor celecoxib with the conventional non-steroidal anti-inflammatory drug diclofenac in the symptomatic treatment of viral pharyngitis. Adult patients from 27 study centers in Latin America were treated with oral doses of celecoxib 200 mg once daily or 200 mg twice daily, or diclofenac 75 mg twice daily for 5 days in a double-blind, randomized study. The primary efficacy assessment was 'Throat Pain on Swallowing' on day 3. In addition, secondary quality-of-life assessments were performed on days 3 and 5. All adverse events and treatment-emergent signs and symptoms were recorded. Data from 313 patients were evaluable for efficacy (105 celecoxib 200 mg once daily, 107 celecoxib 200 mg twice daily, 101 diclofenac 75 mg twice daily). The upper 95% confidence limits for the visual analog scale of 'Throat Pain on Swallowing' on day 3 for celecoxib 200 mg once daily relative to diclofenac 75 mg twice daily, and celecoxib 200 mg twice daily relative to diclofenac 75 mg twice daily were 9.26 and 7.83, respectively. All secondary efficacy and quality-of-life measures were clinically similar for the three treatment groups, and no statistically significant differences were detected. The incidences of treatment-emergent adverse events and withdrawals due to adverse events were similar for all groups, but numerically higher among patients taking diclofenac than celecoxib. More patients in the diclofenac group reported gastrointestinal complaints (7.3%) compared with those in the celecoxib groups (4.3% in the celecoxib 200 mg once-daily group and 3.4% in the celecoxib 200 mg twice-daily group). In conclusion, 5 days of treatment with celecoxib 200 mg once daily is as effective as diclofenac 75 mg twice daily in the symptomatic treatment of viral pharyngitis. Celecoxib 200 mg once daily is also as effective as celecoxib 200 mg twice daily in this condition

Design of an advanced intelligent instrument with waveform recognition based on the ITMS platform

Searching for similar behavior in previous data plays a key role in fusion research, but can be quite challenging to implement from a practical point of view. This paper describes the design of an intelligent measurement instrument that uses similar waveform recognition systems (SWRS) to extract knowledge from the signals it acquires. The system is perceived as an Ethernet measurement instrument that permits to acquire several waveforms simultaneously and to identity similar behaviors by searching in previous data using distributed SWRS. The implementation is another example of the advantages that local processing capabilities can provide in data acquisition applications

Resolving the Azimuthal Ambiguity in Vector Magnetogram Data with the Divergence-Free Condition: Application to Discrete Data

We investigate how the divergence-free property of magnetic fields can be exploited to resolve the azimuthal ambiguity present in solar vector magnetogram data, by using line-of-sight and horizontal heliographic derivative information as approximated from discrete measurements. Using synthetic data we test several methods that each make different assumptions about how the divergence-free property can be used to resolve the ambiguity. We find that the most robust algorithm involves the minimisation of the absolute value of the divergence summed over the entire field of view. Away from disk centre this method requires the sign and magnitude of the line-of-sight derivatives of all three components of the magnetic field vector.Comment: Solar Physics, in press, 20 pages, 11 figure

In situ or ex situ synthesis for electrochemical detection of hydrogen peroxide—an evaluation of Co2SnO4/RGO nanohybrids

Nowadays, there is no doubt about the high electrocatalytic efficiency that is obtained when using hybrid materials between carbonaceous nanomaterials and transition metal oxides. However, the method to prepare them may involve differences in the observed analytical responses, making it necessary to evaluate them for each new material. The goal of this work was to obtain for the first time Co2SnO4 (CSO)/RGO nanohybrids via in situ and ex situ methods and to evaluate their performance in the amperometric detection of hydrogen peroxide. The electroanalytical response was evaluated in NaOH pH 12 solution using detection potentials of −0.400 V or 0.300 V for the reduction or oxidation of H2O2. The results show that for CSO there were no differences between the nanohybrids either by oxidation or by reduction, unlike what we previously observed with cobalt titanate hybrids, in which the in situ nanohybrid clearly had the best performance. On the other hand, no influence in the study of interferents and more stable signals were obtained when the reduction mode was used. In conclusion, for detecting hydrogen peroxide, any of the nanohybrids studied, i.e., in situ or ex situ, are suitable to be used, and more efficiency is obtained using the reduction mode