Изучение влияния аланина на накопление фенольных соединений в листьях цикория обыкновенного (Cichorium intybus L.)

Common chicory (Cichorium intybus L.) is a promising source of raw materials for both food (roots) and pharmaceutical industries (leaves). One of the ways to increase the biologically active compounds content in medicinal plant materials is the use of various growth stimulants, which include amino acids. The article presents the results of an experimental study conducted in 2021-2022 which study the effect of of L-alanine and a racemic mixture of alanine (DL) on the accumulation and qualitative composition of phenolic compounds (PC) in the leaves of chicory.Results. It was found that the use of alanine in different concentrations did not have a significant effect on the increase of phenolic compounds content, and also did not affect the on their accumulation dynamics. The use of alanine enantiomers did not affect the qualitative composition of phenolic compounds, but led to a change in the ratio of hydroxycinnamic acids to each other. It has been established that during the growing season the percentage ratio between the main phenolic compounds in chicory leaves changes - the content of chlorogenic acid increases in proportion to the decrease in chicory acid. Treatment with L-alanine at a concentration of 25 mg/l during the study period in both varieties led to the largest reduction in the content of chicory acid compared to others. It was noted that the total content of PC is higher in a year with warmer and more arid weather, it was higher on average by 0,7 %.Цикорий обыкновенный (Cichorium intybus L.) является перспективным источником получения сырья для нужд как пищевой (корни), так и фармацевтической промышленности (листья). Одним из способов увеличения содержания биологически активных соединений в лекарственном растительном сырье является использование различных стимуляторов роста, к которым относятся аминокислоты. В статье приведены результаты экспериментального исследования, проводившегося в 2021-2022 годов по изучению действия раствора L-аланина и рацемической смеси аланина (DL) на накопление и качественный состав фенольных соединений (ФС) в листьях цикория обыкновенного.Было установлено, что применение аланина в разных концентрациях не оказало значительного влияния на увеличение содержания фенольных соединений, а также не повлияло на динамику их накопления. Применение растворов энантиомеров аланина не повлияло на качественный состав фенольных соединений, но привело к изменению соотношения гидроксикоричных кислот между собой. Установлено, что в течение вегетационного периода в листьях цикория изменяется процентное соотношение между основными фенольными соединениями – содержание хлорогеновой кислоты увеличивается пропорционально снижению цикориевой кислоты. Обработка L-аланином в концентрации 25 мг/л за период исследования на обоих сортах привела к наибольшему снижению содержания цикориевой кислоты по сравнению с другими вариантами. Отмечено, что общее содержание ФС выше в год с более теплой и засушливой погодой – в среднем на 0,7 %

Loschmidt Echo and Lyapunov Exponent in a Quantum Disordered System

We investigate the sensitivity of a disordered system with diffractive scatterers to a weak external perturbation. Specifically, we calculate the fidelity M(t) (also called the Loschmidt echo) characterizing a return probability after a propagation for a time $t$ followed by a backward propagation governed by a slightly perturbed Hamiltonian. For short-range scatterers we perform a diagrammatic calculation showing that the fidelity decays first exponentially according to the golden rule, and then follows a power law governed by the diffusive dynamics. For long-range disorder (when the diffractive scattering is of small-angle character) an intermediate regime emerges where the diagrammatics is not applicable. Using the path integral technique, we derive a kinetic equation and show that M(t) decays exponentially with a rate governed by the classical Lyapunov exponent.Comment: 9 pages, 7 figure

Data processing in high-performance computing systems

The paper integrates the results of a large group of authors working in different areas that are important in the scope of big data, including but not limited to: overview of the basic solutions for the development of data centers; storage and processing; decomposition of a problem into sub-problems of lower complexity (such as applying divide and conquer algorithms); models and methods allowing broad parallelism to be realized; alternative techniques for potential acceleration; programming languages; and practical applications

Volume III. DUNE far detector technical coordination

The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay-these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- A nd dual-phase DUNE liquid argon TPC far detector modules. Volume III of this TDR describes how the activities required to design, construct, fabricate, install, and commission the DUNE far detector modules are organized and managed. This volume details the organizational structures that will carry out and/or oversee the planned far detector activities safely, successfully, on time, and on budget. It presents overviews of the facilities, supporting infrastructure, and detectors for context, and it outlines the project-related functions and methodologies used by the DUNE technical coordination organization, focusing on the areas of integration engineering, technical reviews, quality assurance and control, and safety oversight. Because of its more advanced stage of development, functional examples presented in this volume focus primarily on the single-phase (SP) detector module

Prospects for beyond the Standard Model physics searches at the Deep Underground Neutrino Experiment: DUNE Collaboration

The Deep Underground Neutrino Experiment (DUNE) will be a powerful tool for a variety of physics topics. The high-intensity proton beams provide a large neutrino flux, sampled by a near detector system consisting of a combination of capable precision detectors, and by the massive far detector system located deep underground. This configuration sets up DUNE as a machine for discovery, as it enables opportunities not only to perform precision neutrino measurements that may uncover deviations from the present three-flavor mixing paradigm, but also to discover new particles and unveil new interactions and symmetries beyond those predicted in the Standard Model (SM). Of the many potential beyond the Standard Model (BSM) topics DUNE will probe, this paper presents a selection of studies quantifying DUNE’s sensitivities to sterile neutrino mixing, heavy neutral leptons, non-standard interactions, CPT symmetry violation, Lorentz invariance violation, neutrino trident production, dark matter from both beam induced and cosmogenic sources, baryon number violation, and other new physics topics that complement those at high-energy colliders and significantly extend the present reach

Методика одновременного определения карбамазепина и карбамазепин-10,11-эпоксида методом ВЭЖХ-МС/МС

Carbamazepine is the drug of first choice in the treatment of trigeminal neuralgia, epilepsy and other neurological diseases. Carbamazepine is known to have a narrow therapeutic range, and hereby the auto-induction of its metabolism with prolonged use cause the reduction of its therapeutic efficacy. Phenotyping of patients by the rate of carbamazepine metabolism allows to perform individual drug dose adjustment and to avoid the occurrence of adverse drug effects. In order to implement the mentioned approach, the method for simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide in human serum using HPLC-MS/MS was developed.Карбамазепин является препаратом первого выбора при лечении невралгии тройничного нерва, эпилепсии и других неврологических заболеваний. Известно, что карбамазепин имеет узкий терапевтический диапазон, при этом на фоне постоянного приема наблюдается автоиндукция его метаболизма и снижение эффективности препарата. Фенотипирование больных по скорости метаболизма карбамазепина позволяет провести индивидуальный подбор дозы препарата и избежать проявления нежелательных лекарственных явлений. Для реализации данного подхода разработана методика одновременного определения карбамазепина и карбамазепин-10,11-эпоксида(СBZ-Б) в сыворотке крови человека с использованием метода высокоэффективной жидкостной хроматографии с тандемным масс-спектрометрическим детектированием (ВЭЖХ-МС/МС)

Volume I. Introduction to DUNE

The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay-these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- A nd dual-phase DUNE liquid argon TPC far detector modules. This TDR is intended to justify the technical choices for the far detector that flow down from the high-level physics goals through requirements at all levels of the Project. Volume I contains an executive summary that introduces the DUNE science program, the far detector and the strategy for its modular designs, and the organization and management of the Project. The remainder of Volume I provides more detail on the science program that drives the choice of detector technologies and on the technologies themselves. It also introduces the designs for the DUNE near detector and the DUNE computing model, for which DUNE is planning design reports. Volume II of this TDR describes DUNE\u27s physics program in detail. Volume III describes the technical coordination required for the far detector design, construction, installation, and integration, and its organizational structure. Volume IV describes the single-phase far detector technology. A planned Volume V will describe the dual-phase technology