Предупреждение ошибок, обусловленных человеческим фактором, при использовании толерантных к отказам систем управления полетом

The article presents suggestions on the synthesis of tolerant digital systems of management flight based on algorithmic resiliency methods. Implementation of tolerant digital flight control systems will prevent the negative consequences of failures of various aircraft systems and aircraft units.В статье приведены предложения по синтезу толерантных цифровых систем управления полетом, основанные на методах алгоритмического обеспечения отказоустойчивости. Реализация толерантных цифровых систем управления полетом позволит предупредить негативные последствия отказов различных бортовых систем и агрегатов самолета

RESULTS AND PERSPECTIVES OF STUDYING THE OCCUPATIONAL DISEASES IN WORKERS OF AIRCRAFT INDUSTRY IN EAST SIBERIA

The materials of the long-studies among the employees working in the aircraft industry, of both the patients with occupational diseases and the practically healthy persons are discussed in the paper. Using the method of the biological feedback for the vibration-induced disease prevention has been grounded. The preliminary results of the experimental studies using the animals are presented in this paper

Роль нутриентов и пробиотических препаратов в терапии депрессии

Currently, a growing amount of data is emerging on the role of various environmental factors (nutrients, gut microbiota, etc.) on formation of depression. The impact on these factors can be effective not only in treatment of major depressive disorder, but also in its early prevention. Therefore, a more detailed study of environmental factors in depression can lead both to a better understanding of the etiology and pathogenesis of the disorder and to optimization of approaches to its treatment. The aim of the review was to assess the potential role of a number of environmental factors associated with nutritional aspects and characteristics of individual microflora, as well as to review the prospects of a strategy for affecting these factors in treatment and prevention of depression. В настоящее время появляется все больше сведений о роли различных экологических факторов (особенностей питания, бактериальной флоры человека и проч.) в формировании депрессии. Воздействие на указанные факторы может быть эффективно не только в лечении депрессивного расстройства, но и его ранней профилактике. Таким образом, более подробное изучение роли экологических факторов в формировании депрессии может способствовать как лучшему пониманию этиопатогенеза данного заболевания, так и оптимизации подходов по борьбе с ним.Цель обзора: оценить потенциальную роль в формировании депрессии ряда экологических факторов, связанных с нутритивными аспектами и особенностями микрофлоры индивида, а также перспективность стратегии воздействия на данные факторы в лечении и профилактике депрессивного расстройства.

Мультимедийные технологии в преподавании иностранного языка

Данная статья посвящена мультимедиа в обучении иностранным языкам. В статье раскрывается содержание понятия "мультимедийные средства". В настоящее время проблема создания искусственной иноязычной среды является достаточно актуальной, так как большинство учащихся любого возраста испытывают трудности в изучении иностранного языка. Целью данного проекта является выявление преимуществ и недостатков использования мультимедиа в образовательном процессе. Результаты исследования демонстрируют эффективность использования мультимедийных средств в обучении иностранным языкам.This article is devoted to multimedia in foreign language teaching. The paper reveals the content of the concept "multimedia tools". Nowadays the problem of creating an artificial foreign language environment is rather relevant because most of the students of any age have difficulties in learning a foreign language. The aim of this project is to identify the advantages and disadvantages of using multimedia in the educational process. The output of the research demonstrates the effectiveness of multimedia tools in foreign language teaching

The effect of prolonged spaceflight on cerebrospinal fluid and perivascular spaces of astronauts and cosmonauts

peer reviewedLong-duration spaceflight induces changes to the brain and cerebrospinal fluid compartments and visual acuity problems known as spaceflight-associated neuro-ocular syndrome (SANS). The clinical relevance of these changes and whether they equally affect crews of different space agencies remain unknown. We used MRI to analyze the alterations occurring in the perivascular spaces (PVS) in NASA and European Space Agency astronauts and Roscosmos cosmonauts after a 6-mo spaceflight on the International Space Station (ISS). We found increased volume of basal ganglia PVS and white matter PVS (WM-PVS) after spaceflight, which was more prominent in the NASA crew than the Roscosmos crew. Moreover, both crews demonstrated a similar degree of lateral ventricle enlargement and decreased subarachnoid space at the vertex, which was correlated with WM-PVS enlargement. As all crews experienced the same environment aboard the ISS, the differences in WM-PVS enlargement may have been due to, among other factors, differences in the use of countermeasures and high-resistive exercise regimes, which can influence brain fluid redistribution. Moreover, NASA astronauts who developed SANS had greater pre- and postflight WM-PVS volumes than those unaffected. These results provide evidence for a potential link between WM-PVS fluid and SANS. Copyright © 2022 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY)

Assay platform for clinically relevant metallo-beta-lactamases

Metallo-β-lactamases (MBLs) are a growing threat to the use of almost all clinically used β-lactam antibiotics. The identification of broad-spectrum MBL inhibitors is hampered by the lack of a suitable screening platform, consisting of appropriate substrates and a set of clinically relevant MBLs. We report procedures for the preparation of a set of clinically relevant metallo-β-lactamases (i.e., NDM-1 (New Delhi MBL), IMP-1 (Imipenemase), SPM-1 (São Paulo MBL), and VIM-2 (Verona integron-encoded MBL)) and the identification of suitable fluorogenic substrates (umbelliferone-derived cephalosporins). The fluorogenic substrates were compared to chromogenic substrates (CENTA, nitrocefin, and imipenem), showing improved sensitivity and kinetic parameters. The efficiency of the fluorogenic substrates was exemplified by inhibitor screening, identifying 4-chloroisoquinolinols as potential pan MBL inhibitors

PREVENTION OF MISTAKES, CAUSED BY HUMAN FACTOR WHILE USING FLIGHT CONTROL SYSTEMS TOLERANT TO FAILURES

The article presents suggestions on the synthesis of tolerant digital systems of management flight based on algorithmic resiliency methods. Implementation of tolerant digital flight control systems will prevent the negative consequences of failures of various aircraft systems and aircraft units

PREVENTION OF MISTAKES, CAUSED BY HUMAN FACTOR WHILE USING FLIGHT CONTROL SYSTEMS TOLERANT TO FAILURES

The article presents suggestions on the synthesis of tolerant digital systems of management flight based on algorithmic resiliency methods. Implementation of tolerant digital flight control systems will prevent the negative consequences of failures of various aircraft systems and aircraft units