363 research outputs found
Relaxation time spectrum of low-energy excitations in one- and two-dimensional materials with charge or spin density waves
The long-time thermal relaxation of (TMTTF)Br, SrCuO
and SrCaCuO single crystals at temperatures below 1 K
and magnetic field up to 10 T is investigated. The data allow us to determine
the relaxation time spectrum of the low energy excitations caused by the
charge-density wave (CDW) or spin-density wave (SDW). The relaxation time is
mainly determined by a thermal activated process for all investigated
materials. The maximum relaxation time increases with increasing magnetic
field. The distribution of barrier heights corresponds to one or two Gaussian
functions. The doping of SrCaCuO with Ca leads to
a drastic shift of the relaxation time spectrum to longer time. The maximum
relaxation time changes from 50 s (x = 0) to 3000 s (x = 12) at 0.1 K and 10 T.
The observed thermal relaxation at x=12 clearly indicates the formation of the
SDW ground state at low temperatures
The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132
miRNAs are small RNAs that are key regulators of gene expression in eukaryotic organisms. The processing of miRNAs is regulated by structural characteristics of the RNA and is also tightly controlled by auxiliary protein factors. Among them, RNA binding proteins play crucial roles to facilitate or inhibit miRNA maturation and can be controlled in a cell, tissue and species-specific manners or in response to environmental stimuli. In this study we dissect the molecular mechanism that promotes the overexpression of miR-132 in mice over its related, co-transcribed and co-regulated miRNA, miR-212. We have shown that the loop structure of miR-132 is a key determinant for its efficient processing in cells. We have also identified a range of RNA binding proteins that recognize the loop of miR-132 and influence both miR-132 and miR-212 processing. The DEAD box helicase p72/DDX17 was identified as a factor that facilitates the specific processing of miR-132
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Heat capacity signature of frustrated trimerons in magnetite
Recently it has been proposed that the long-range electronic order formed by trimerons in magnetite should be frustrated due to the great degeneracy of arrangements linking trimerons. This result has important consequences as charge ordering from the condensed minority band electrons leads to a complex 3D antiferro orbital order pattern. Further more, the corner sharing tetrahedra structure of spinel B-sites supports frustration for antiferromagnetic alignments. Therefore frustration due to competing interactions will itself induce disorder and very likely frustration in the spin orientations. Here we present very low temperature specific heat data that show two deviations to the magnons and phonons contributions, that we analyze in terms of Schottky-type anomalies. The first one is associated with the thermal activation across both ferroelastic twin and ferromagnetic anti-phase domains. The second Schottky-type anomaly displays an inverse (1/H) field dependence which is a direct indication of the disordered glassy network with macroscopically degenerated singular ground states. © 2020, The Author(s)
Interplay between phase defects and spin polarization in the specific heat of the spin density wave compound (TMTTF)_2Br in a magnetic field
Equilibrium heat relaxation experiments provide evidence that the ground
state of the commensurate spin density wave (SDW) compound (TMTTF)Br after
the application of a sufficient magnetic field is different from the
conventional ground state. The experiments are interpreted on the basis of the
local model of strong pinning as the deconfinement of soliton-antisoliton pairs
triggered by the Zeeman coupling to spin degrees of freedom, resulting in a
magnetic field induced density wave glass for the spin carrying phase
configuration.Comment: 4 pages, 5 figure
Post-Disaster Housing Reconstruction in Sri Lanka: What Methodology?
Research methodology is the procedural framework within which the research is conducted. This includes the overall
approach to a problem that could be put into practice in a research process, from the theoretical underpinning to the
collection and analysis of data. Choice of methodology depends on the primary drivers: topic to be researched and the
specific research questions. Hence, methodological perspectives of managing stakeholder expectations of PDHR context
are composed of research philosophies, research strategy, research design, and research techniques. This research belonged
to social constructivism or interpretivism within a philosophical continuum. The nature of the study was more toward
subjectivism where human behavior favored voluntary stance. Ontological, methodological, epistemological, and axiological
positioning carried the characteristics of idealism, ideographic, anti-positivism, and value laden, respectively. Data collection
comprises two phases, preliminary and secondary. Exploratory interviews with construction experts in the United Kingdom
and Sri Lanka were carried out to refine the interview questions and identify the case studies. Case study interviews during
the secondary phase took place in Sri Lanka. Data collected at the preliminary stage were used to assess the attributes of
power, legitimacy/proximity, and urgency of stakeholders to the project using Stakeholder Circle™ software. Moreover,
the data collected at secondary phase via case studies will be analyzed with NVivo 8. This article aims to discuss these
methodological underpinnings in detail applied in a post-disaster housing reconstruction context in Sri Lanka
Magnetic Field Dependence Of Anisotropy Of In-plane Angular Magnetoresistance Of Electron-doped Sr1-xLaxCuO2 Thin Films
We studied the normal state magnetoresistance of underdoped superconducting epitaxial Sr1-xLaxCuO2 thin films by applying a high magnetic field up to 22 T parallel to the CuO2 planes and by varying the orientation of a field of given intensity in order to probe the underlying spin system. This infinite layer compound which has the simplest structure of all the cuprates presents a monotonic negative in-plane magnetoresistance with an anisotropic angular dependence which depends on the doping level [1] and on the field intensity [2]. Angular dependence of the in-plane magnetoresistance at highest magnetic fields is the same for films with different doping levels [2]. We compare our observations with the corresponding ones for the other electron-doped family Ln2-xCexCuO4 (Ln=Nd, Pr, La) and we attribute them to a manifestation of antiferromagnetism which appears to be only due to spins in the CuO2 planes
Strong-Pinning Effects in Low-Temperature Creep: Charge-Density Waves in TaS_3
Nonlinear conduction in the quasi-one dimensional conductor o-TaS_3 has been
studied in the low-temperature region down to 30 mK. It was found that at
temperatures below a few Kelvins the current-voltage (I-V) characteristics
consist of several branches. The temperature evolution of the I-V curve
proceeds through sequential freezing-out of the branches. The origin of each
branch is attributed to a particular strong pinning impurity type.
Similar behavior is expected for other physical systems with collective
transport (spin-density waves, Wigner crystals, vortex lattices in type-II
superconductors etc.) in the presence of strong pinning centers.Comment: 11 pages, 3 ps figures, Revtex, To be published in Phys. Rev. Letters
(1997
miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity
miR-132 and miR-212 are two closely related miRNAs encoded in the same intron of a small non-coding gene, which have been suggested to play roles in both immune and neuronal function. We describe here the generation and initial characterisation of a miR-132/212 double knockout mouse. These mice were viable and fertile with no overt adverse phenotype. Analysis of innate immune responses, including TLR-induced cytokine production and IFNβ induction in response to viral infection of primary fibroblasts did not reveal any phenotype in the knockouts. In contrast, the loss of miR-132 and miR-212, while not overtly affecting neuronal morphology, did affect synaptic function. In both hippocampal and neocortical slices miR-132/212 knockout reduced basal synaptic transmission, without affecting paired-pulse facilitation. Hippocampal long-term potentiation (LTP) induced by tetanic stimulation was not affected by miR-132/212 deletion, whilst theta burst LTP was enhanced. In contrast, neocortical theta burst-induced LTP was inhibited by loss of miR-132/212. Together these results indicate that miR-132 and/or miR-212 play a significant role in synaptic function, possibly by regulating the number of postsynaptic AMPA receptors under basal conditions and during activity-dependent synaptic plasticity
Distinct clinical characteristics of myeloproliferative neoplasms with calreticulin mutations
Somatic insertions/deletions in the calreticulin gene have recently been discovered to be causative alterations in myeloproliferative neoplasms. A combination of qualitative and quantitative allele-specific polymerase chain reaction, fragment-sizing, high resolution melting and Sanger-sequencing was applied for the detection of three driver mutations (in Janus kinase 2, calreticulin and myeloproliferative leukemia virus oncogene genes) in 289 cases of essential thrombocythemia and 99 cases of primary myelofibrosis. In essential thrombocythemia, 154 (53%) Janus kinase 2 V617F, 96 (33%) calreticulin, 9 (3%) myeloproliferative leukemia virus oncogene gene mutation-positive and 30 triple-negative (11%) cases were identified, while in primary myelofibrosis 56 (57%) Janus kinase 2 V617F, 25 (25%) calreticulin, 7 (7%) myeloproliferative leukemia virus oncogene gene mutation-positive and 11 (11%) triple-negative cases were identified. Patients positive for the calreticulin mutation were younger and had higher platelet counts compared to Janus kinase 2 mutation-positive counterparts. Calreticulin mutation-positive patients with essential thrombocythemia showed a lower risk of developing venous thrombosis, but no difference in overall survival. Calreticulin mutation-positive patients with primary myelofibrosis had a better overall survival compared to that of the Janus kinase 2 mutation-positive (P=0.04) or triple-negative cases (P=0.01). Type 2 calreticulin mutation occurred more frequently in essential thrombocythemia than in primary myelofibrosis (P=0.049). In essential thrombocythemia, the calreticulin mutational load was higher than the Janus kinase 2 mutational load (P<0.001), and increased gradually in advanced stages. Calreticulin mutational load influenced blood counts even at the time point of diagnosis in essential thrombocythemia. We confirm that calreticulin mutation is associated with distinct clinical characteristics and explored relationships between mutation type, load and clinical outcome
The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132
miRNAs are small RNAs that are key regulators of gene expression in eukaryotic organisms. The processing of miRNAs is regulated by structural characteristics of the RNA and is also tightly controlled by auxiliary protein factors. Among them, RNA binding proteins play crucial roles to facilitate or inhibit miRNA maturation and can be controlled in a cell, tissue and species-specific manners or in response to environmental stimuli. In this study we dissect the molecular mechanism that promotes the overexpression of miR-132 in mice over its related, co-transcribed and co-regulated miRNA, miR-212. We have shown that the loop structure of miR-132 is a key determinant for its efficient processing in cells. We have also identified a range of RNA binding proteins that recognize the loop of miR-132 and influence both miR-132 and miR-212 processing. The DEAD box helicase p72/DDX17 was identified as a factor that facilitates the specific processing of miR-132
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