Properties of bright squeezed vacuum at increasing brightness

A bright squeezed vacuum (BSV) is a nonclassical macroscopic state of light, which is generated through high-gain parametric down-conversion or four-wave mixing. Although the BSV is an important tool in quantum optics and has a lot of applications, its theoretical description is still not complete. In particular, the existing description in terms of Schmidt modes with gain-independent shapes fails to explain the spectral broadening observed in the experiment as the mean number of photons increases. Meanwhile, the semiclassical description accounting for the broadening does not allow us to decouple the intermodal photon-number correlations. In this work, we present a new generalized theoretical approach to describe the spatial properties of a multimode BSV. In the multimode case, one has to take into account the complicated interplay between all involved modes: each plane-wave mode interacts with all other modes, which complicates the problem significantly. The developed approach is based on exchanging the (k, t ) and (ω, z) representations and solving a system of integrodifferential equations. Our approach predicts correctly the dynamics of the Schmidt modes and the broadening of the angular distribution with the increase in the BSV mean photon number due to a stronger pumping. Moreover, the model correctly describes various properties of a widely used experimental configuration with two crystals and an air gap between them, namely, an SU(1,1) interferometer. In particular, it predicts the narrowing of the intensity distribution, the reduction and shift of the side lobes, and the decline in the interference visibility as the mean photon number increases due to stronger pumping. The presented experimental results confirm the validity of the new approach. The model can be easily extended to the case of the frequency spectrum, frequency Schmidt modes, and other experimental configurations

Projective filtering of a single spatial radiation eigenmode

Lossless filtering of a single coherent (Schmidt) mode from spatially multimode radiation is a problem crucial for optics in general and for quantum optics in particular. It becomes especially important in the case of nonclassical light that is fragile to optical losses. An example is bright squeezed vacuum generated via high-gain parametric down conversion or four-wave mixing. Its highly multiphoton and multimode structure offers a huge increase in the information capacity provided that each mode can be addressed separately. However, the nonclassical signature of bright squeezed vacuum, photon-number correlations, are highly susceptible to losses. Here we demonstrate lossless filtering of a single spatial Schmidt mode by projecting the spatial spectrum of bright squeezed vacuum on the eigenmode of a single-mode fiber. Moreover, we show that the first Schmidt mode can be captured by simply maximizing the fiber-coupled intensity. Importantly, the projection operation does not affect the targeted mode and leaves it usable for further applications.Comment: 10 pages, 9 figure

Humanitarization geographic education in universities

© 2015, Mediterranean Center of Social and Educational Research. All rights reserved. This article discusses the structure of science. Highlighted border integration and cross-cutting areas. Considered the most important priorities of the Russian geographical education; humanization, aimed at the development of common cultural components in the content of education in the formation of personality; humanization, expressed by an emphasis on personal factors, the social aspects of the development of society; sociologization, object of study is sociosphere - a set of geographic and socio-economic factors, with increased attention to the social aspects of development; greening, reflecting spatial processes and forms of organization of the productive forces, in order to optimize and improve production efficiency; regionalization, promoting deeper identifying the structure, function, increased understanding of the regions, the study and development of a geographical approach to the management of the region; greening, characteristic of the whole complex of geographical sciences dealing with the interaction of society and nature. Presents the contribution of prominent scientistsgeographers: V.M.Maksakovskogo - his recommendations for the Study of the greening of industry and spatial aspects; YD Demetrius, releasing a comprehensive study of the major issues of geo-ecological problems; A.M.Trofimova, MD Sharygina on the role of general geography - basic science, which considers all aspects of the development of an integrated system of "nature-economy-population" in the space-time aspect, as well as trends in long-term development of geographical education. The contribution of scientists CFI and the Institute of Ecology and Mineral Sciences of the Republic of Tatarstan in the environmental mapping

Non-Waste Alternative Technologies in the Production of Heterologous Anti-Rabies Immunoglobulin

Presented is a comprehensive approach to utilization of the wastes that appear in the process of heterologous anti-rabies immunoglobulin production (packed red cells, fibrin, and alcohol-containing products). Specific immunoglobulin is extracted from the surface of red blood cells using desorption technique. Additional yields of immunoglobulin after exposure of erythrocytes to non-ionic detergent amount to 10-19 % of the output. Rich protein supplement feeding for horses-producers is obtained from spray-dried packed red cells. Solid nutritious substrate for microbiological media production is obtained from fibrin using enzymic hydrolysis method. The efficiency of the fibrin hydrolysate-based media is 1.5-2 times higher in comparison with that of the media based on the digest of meat and casein, as demonstrated by the results of Vibrio cholerae scaled cultivation. Furthermore, worked out is the technology of ethanol regeneration after the rivanol-ethanolic precipitation of gamma globulin, alcohol content by volume being (93±1) % after the regeneration. It is demonstrated that the regenerated alcohol can be used as a precipitator in the process of anti-rabies serum fractioning. All in all, the developed techniques make it possible to utilize the wastes of anti-rabies immunoglobulin production and provide for further use of derivatives while producing medical immunobiological preparations

Activated phosphoinositide 3-kinase δ syndrome: Update from the ESID Registry and comparison with other autoimmune-lymphoproliferative inborn errors of immunity

Background: Activated phosphoinositide-3-kinase d syndrome (APDS) is an inborn error of immunity (IEI) with infection susceptibility and immune dysregulation, clinically overlapping with other conditions. Management depends on disease evolution, but predictors of severe disease are lacking. Objectives: This study sought to report the extended spectrum of disease manifestations in APDS1 versus APDS2; compare these to CTLA4 deficiency, NFKB1 deficiency, and STAT3 gain of-function (GOF) disease; and identify predictors of severity in APDS. Methods: Data was collected from the ESID (European Society for Immunodeficiencies)-APDS registry and was compared with published cohorts of the other IEIs. Results: The analysis of 170 patients with APDS outlines high penetrance and early onset of APDS compared to the other IEIs. The large clinical heterogeneity even in individuals with the same PIK3CD variant E1021K illustrates how poorly the genotype predicts the disease phenotype and course. The high clinical overlap between APDS and the other investigated IEIs suggests relevant pathophysiological convergence of the affected pathways. Preferentially affected organ systems indicate specific pathophysiology: bronchiectasis is typical of APDS1; interstitial lung disease and enteropathy are more common in STAT3 GOF and CTLA4 deficiency. Endocrinopathies are most frequent in STAT3 GOF, but growth impairment is also common, particularly in APDS2. Early clinical presentation is a risk factor for severe disease in APDS. Conclusions: APDS illustrates how a single genetic variant can result in a diverse autoimmune-lymphoproliferative phenotype. Overlap with other IEIs is substantial. Some specific features distinguish APDS1 from APDS2. Early onset is a risk factor for severe disease course calling for specific treatment studies in younger patients. (J Allergy Clin Immunol 2023;152:984-96.

Humanitarization geographic education in universities

© 2015, Mediterranean Center of Social and Educational Research. All rights reserved. This article discusses the structure of science. Highlighted border integration and cross-cutting areas. Considered the most important priorities of the Russian geographical education; humanization, aimed at the development of common cultural components in the content of education in the formation of personality; humanization, expressed by an emphasis on personal factors, the social aspects of the development of society; sociologization, object of study is sociosphere - a set of geographic and socio-economic factors, with increased attention to the social aspects of development; greening, reflecting spatial processes and forms of organization of the productive forces, in order to optimize and improve production efficiency; regionalization, promoting deeper identifying the structure, function, increased understanding of the regions, the study and development of a geographical approach to the management of the region; greening, characteristic of the whole complex of geographical sciences dealing with the interaction of society and nature. Presents the contribution of prominent scientistsgeographers: V.M.Maksakovskogo - his recommendations for the Study of the greening of industry and spatial aspects; YD Demetrius, releasing a comprehensive study of the major issues of geo-ecological problems; A.M.Trofimova, MD Sharygina on the role of general geography - basic science, which considers all aspects of the development of an integrated system of "nature-economy-population" in the space-time aspect, as well as trends in long-term development of geographical education. The contribution of scientists CFI and the Institute of Ecology and Mineral Sciences of the Republic of Tatarstan in the environmental mapping

Humanitarization geographic education in universities

© 2015, Mediterranean Center of Social and Educational Research. All rights reserved. This article discusses the structure of science. Highlighted border integration and cross-cutting areas. Considered the most important priorities of the Russian geographical education; humanization, aimed at the development of common cultural components in the content of education in the formation of personality; humanization, expressed by an emphasis on personal factors, the social aspects of the development of society; sociologization, object of study is sociosphere - a set of geographic and socio-economic factors, with increased attention to the social aspects of development; greening, reflecting spatial processes and forms of organization of the productive forces, in order to optimize and improve production efficiency; regionalization, promoting deeper identifying the structure, function, increased understanding of the regions, the study and development of a geographical approach to the management of the region; greening, characteristic of the whole complex of geographical sciences dealing with the interaction of society and nature. Presents the contribution of prominent scientistsgeographers: V.M.Maksakovskogo - his recommendations for the Study of the greening of industry and spatial aspects; YD Demetrius, releasing a comprehensive study of the major issues of geo-ecological problems; A.M.Trofimova, MD Sharygina on the role of general geography - basic science, which considers all aspects of the development of an integrated system of "nature-economy-population" in the space-time aspect, as well as trends in long-term development of geographical education. The contribution of scientists CFI and the Institute of Ecology and Mineral Sciences of the Republic of Tatarstan in the environmental mapping