74 research outputs found
Assessment of multiaxial fatigue life prediction methodologies for Inconel 718
Abstract Fatigue life prediction methodologies for the assessment of the structural integrity of safety critical components in modern turbine engines require a close integration of advanced multiaxial fatigue life prediction procedures and of specific multiaxial tests, representative of the service conditions of turbine engine components and materials. The objective of the research work presented in this paper is to extend currently employed methodologies for the assessment of fatigue strength of turbine engines disks by integrating suitable multiaxial fatigue criteria and test results of multiaxial fatigue experiments conducted on Inconel 718 material at temperatures similar to those experienced by the disc materials during service. Smooth tubular specimens of Inconel 718 have been employed for conducting tension/torsion strain controlled high temperature fatigue tests. Specimens have been cut out from forged parts utilised for the production of engine discs, thus preserving the typical properties of disc materials (microstructure, basic mechanical properties, etc.). Different models/criteria have been evaluated by comparing fatigue life predictions and multiaxial fatigue experiments. It's well known that agreement of life predictions with experimental life is strongly affected not only by the choice of the multiaxial fatigue criteria but also by the way the reference fatigue data are integrated in the criteria. Therefore, specific multiaxial fatigue tests have been carried out, in order to validate and to improve the assessment capabilities of the lifing procedures. Moreover, multiaxial fatigue tests permit advances in the basic understanding of materials behaviour that might be utilised in the processes of declaring component service lives
Novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2
Role of magnetic resonance imaging in the evaluation of breast cancer response to neoadjuvant chemotherapy
Exploiting lipid metabolism by HSV-1 – a challenge to rethink new therapies for Alzheimer's disease
Strigolactones as broad-spectrum antivirals against ß-coronaviruses through targeting the main protease Mpro
Accuracy of right atrial pressure estimation using a multi-parameter approach derived from inferior vena cava semi-automated edge-tracking echocardiography: a pilot study in patients with cardiovascular disorders
The echocardiographic estimation of right atrial pressure (RAP) is based on the size and inspiratory collapse of the inferior vena cava (IVC). However, this method has proven to have limits of reliability. The aim of this study is to assess feasibility and accuracy of a new semi-automated approach to estimate RAP. Standard acquired echocardiographic images were processed with a semi-automated technique. Indexes related to the collapsibility of the vessel during inspiration (Caval Index, CI) and new indexes of pulsatility, obtained considering only the stimulation due to either respiration (Respiratory Caval Index, RCI) or heartbeats (Cardiac Caval Index, CCI) were derived. Binary Tree Models (BTM) were then developed to estimate either 3 or 5 RAP classes (BTM3 and BTM5) using indexes estimated by the semi-automated technique. These BTMs were compared with two standard estimation (SE) echocardiographic methods, indicated as A and B, distinguishing among 3 and 5 RAP classes, respectively. Direct RAP measurements obtained during a right heart catheterization (RHC) were used as reference. 62 consecutive \u2018all-comers\u2019 patients that had a RHC were enrolled; 13 patients were excluded for technical reasons. Therefore 49 patients were included in this study (mean age 62.2\ua0\ub1\ua015.2\ua0years, 75.5% pulmonary hypertension, 34.7% severe left ventricular dysfunction and 51% right ventricular dysfunction). The SE methods showed poor accuracy for RAP estimation (method A: misclassification error, ME\ua0=\ua051%, R2\ua0=\ua00.22; method B: ME\ua0=\ua069%, R2\ua0=\ua00.26). Instead, the new semi-automated methods BTM3 and BTM5 have higher accuracy (ME\ua0=\ua014%, R2\ua0=\ua00.47 and ME\ua0=\ua022%, R2\ua0=\ua00.61, respectively). In conclusion, a multi-parametric approach using IVC indexes extracted by the semi-automated approach is a promising tool for a more accurate estimation of RAP
Recent Developments in Understanding Two-dimensional Turbulence and the Nastrom-Gage Spectrum
Two-dimensional turbulence appears to be a more formidable problem than
three-dimensional turbulence despite the numerical advantage of working with
one less dimension. In the present paper we review recent numerical
investigations of the phenomenology of two-dimensional turbulence as well as
recent theoretical breakthroughs by various leading researchers. We also review
efforts to reconcile the observed energy spectrum of the atmosphere (the
spectrum) with the predictions of two-dimensional turbulence and
quasi-geostrophic turbulence.Comment: Invited review; accepted by J. Low Temp. Phys.; Proceedings for
Warwick Turbulence Symposium Workshop on Universal features in turbulence:
from quantum to cosmological scales, 200
Perturbation theory for large Stokes number particles in random velocity fields
We derive a perturbative approach to study, in the large inertia limit, the
dynamics of solid particles in a smooth, incompressible and finite-time
correlated random velocity field. We carry on an expansion in powers of the
inverse square root of the Stokes number, defined as the ratio of the
relaxation time for the particle velocities and the correlation time of the
velocity field. We describe in this limit the residual concentration
fluctuations of the particle suspension, and determine the contribution to the
collision statistics produced by clustering. For both concentration
fluctuations and collision velocities, we analyze the differences with the
compressible one-dimensional case.Comment: Latex, 12 pages, 2 eps figures include
- …