The Apoptosome: Emerging Insights and New Potential Targets for Drug Design

Apoptosis plays a crucial role in tissue homeostasis, development and many diseases. The relevance of Apaf1, the molecular core of apoptosome, has been underlined in mitochondria-dependent apoptosis, which according to a growing body of evidence, is involved in various pathologies where the equilibrium of life-and-death is dysregulated, such as heart attack, stroke, liver failure, cancer and autoimmune diseases. Consequently, great interest has emerged in devising therapeutic strategies for regulating the key molecules involved in the life-and-death decision. Here we review recent progress in apoptosis-based pharmacological therapies and, in particular, we point out a possible role of the apoptosome as an emerging and promising pharmacological target

Some Lexical Groups of Speech Etiquette in Swahili Language and Their Characteristics

The article deals with Swahili language speech etiquette lexical groups which are the most typical for every day communication. The main focus is put on the basic words and word combinations of each group and their grammatical forms. Particular attention is also drawn to the meaning of some interjections for speech communication

NURS 311 Collaborative Role

Course syllabus template for NURS 311 Collaborative Role Course description: This course focuses on collaboration among health care professionals in the delivery of health care and its impact on professional nursing practice. It further examines the role of the professional nurse functioning in the health care delivery system in a changing society. Also explored is the emerging role of the nurse from an historical perspective

Computer science. Иностранный язык

Учебно-методическое пособие.Доступ к полному тексту открыт из сети СФУ, вне сети доступ возможен для читателей Научной библиотеки СФУ или за плату.Учебно-методическое пособие включает в себя тексты по специальности и ряд упражнений грамматического и лексического характера. Предназначено для аудиторной и самостоятельной работы студентов второго курса направления 15.03.05 «Конструкторско-технологическое обеспечение машиностроительных производств»

Monitoring of Blood Phagocyte Functional State by Cyclic Dielectric Spectroscopy

The study of functional state of blood phagocytes adhering to capacity sensor surface has been carried out by cyclic dielectric spectroscopy method. The sensor dielectric coating consists of Langmuir-Blodgett monolayers with multiwall modified carbon nanotubes. The nonliner dependence of sensor capacity on cell concentration was registered. At cellular monolayer formation the Helmholtz double layer electrical field shielding effect was shown to arise. It has been established that capacity characteristics of the sensor with adhering monocytes depend on a number and cell continuity as well as ability of cells to generate reactive oxygen species. It has been shown that cell activation by adhesion and fMLP chemotactic peptide leads to increase of capacity of sensor coated by dense monocyte monolayer

Monitoring of Blood Phagocyte Functional State by Cyclic Dielectric Spectroscopy

The study of functional state of blood phagocytes adhering to capacity sensor surface has been carried out by cyclic dielectric spectroscopy method. The sensor dielectric coating consists of Langmuir-Blodgett monolayers with multiwall modified carbon nanotubes. The nonliner dependence of sensor capacity on cell concentration was registered. At cellular monolayer formation the Helmholtz double layer electrical field shielding effect was shown to arise. It has been established that capacity characteristics of the sensor with adhering monocytes depend on a number and cell continuity as well as ability of cells to generate reactive oxygen species. It has been shown that cell activation by adhesion and fMLP chemotactic peptide leads to increase of capacity of sensor coated by dense monocyte monolayer