КРАУДФАНДИНГОВІ ТЕХНОЛОГІЇ У РОЗВИТКУ НАЦІОНАЛЬНОЇ ТУРИСТИЧНОЇ СИСТЕМИ

The article substantiates the sense of crowdfunding and determines a list of participants of crowdfunding projects. The author has proposed a scheme for implementation of a crowdfunding tourism project, indicating the main stakeholders. The author has substantiated directions of implementation of projects, using crowdfunding in the national tourism system. The author has suggested a “house” of crowdfunding for projects of the national tourism system. The article determines advantages and disadvantages of crowdfunding for the main stakeholders and the society.    В статье обоснована сущность краудфандинга и краудфандинговых технологий, определен круг их участников. Предложено процесс реализации краудфандинга туристического проекта с указанием основных стейкхолдеров. Обоснованы направления реализации проектов с помощью краудфандинга в туристической системе. Предложено «архитектонику» краудфандинга проектов национальной туристической системы. Определены преимущества и недостатки краудфандинга для основных стейкхолдеров и общества.У статті обґрунтовано сутність краудфандингу та краудфандингових технологій, визначено коло їх учасників. Запропоновано процес реалізації краудфандингу туристичного проекту із зазначенням основних стейкхолдерів. Обгрунтовані напрямами реалізації проектів за допомогою краудфандингу в туристичній системі. Запропоновано «архітектоніку» краудфандингу проектів національної туристичної системи. Визначено переваги та недоліки краудфандингу для основних стейкхолдерів та суспільства

On the electronic properties of GaSb irradiated with reactor neutrons and its charge neutrality level

The electronic properties and the limiting position of the Fermi level in p-GaSb crystals irradiated with full-spectrum reactor neutrons at up to a fluence of 8.6 × 1018 cm−2 are studied. It is shown that the irradiation of GaSb with reactor neutrons results in an increase in the concentration of free holes to p lim = (5−6) × 1018 cm−3 and in pinning of the Fermi level at the limiting position F lim close to E V + 0.02 eV at 300 K. The effect of the annealing of radiation defects in the temperature range 100–550°C is explored

On the Application of a Monolithic Array for Detecting Intensity-Correlated Photons Emitted by Different Source Types

It is not widely appreciated that many subtleties are involved in the accurate measurement of intensity-correlated photons; even for the original experiments of Hanbury Brown and Twiss (HBT). Using a monolithic 4x4 array of single-photon avalanche diodes (SPADs), together with an off-chip algorithm for processing streaming data, we investigate the difficulties of measuring second-order photon correlations g2 in a wide variety of light fields that exhibit dramatically different correlation statistics: a multimode He-Ne laser, an incoherent intensity-modulated lamp-light source and a thermal light source. Our off-chip algorithm treats multiple photon-arrivals at pixel-array pairs, in any observation interval, with photon fluxes limited by detector saturation, in such a way that a correctly normalized g2 function is guaranteed. The impact of detector background correlations between SPAD pixels and afterpulsing effects on second-order coherence measurements is discussed. These results demonstrate that our monolithic SPAD array enables access to effects that are otherwise impossible to measure with stand-alone detectors.Comment: 17 pages, 6 figure

Search for double beta decay of 136^{136}Ce and 138^{138}Ce with HPGe gamma detector

Search for double $\beta$ decay of $^{136}$Ce and $^{138}$Ce was realized with 732 g of deeply purified cerium oxide sample measured over 1900 h with the help of an ultra-low background HPGe $\gamma$ detector with a volume of 465 cm$^3$ at the STELLA facility of the Gran Sasso National Laboratories of the INFN (Italy). New improved half-life limits on double beta processes in the cerium isotopes were set at the level of $\lim T_{1/2}\sim 10^{17}-10^{18}$~yr; many of them are even two orders of magnitude larger than the best previous results.Comment: 21 pages, 6 figures, 3 tables; version accepted for publication on Nucl. Phys.

New limits on 2ε2\varepsilon, εβ+\varepsilon\beta^+ and 2β+2\beta^+ decay of 136^{136}Ce and 138^{138}Ce with deeply purified cerium sample

A search for double electron capture ($2\varepsilon$), electron capture with positron emission ($\varepsilon\beta^+$), and double positron emission $2\beta^+$) in $^{136}$Ce and $^{138}$Ce was realized with a 465 cm$^3$ ultra-low background HP Ge $\gamma$ spectrometer over 2299 h at the Gran Sasso underground laboratory. A 627 g sample of cerium oxide deeply purified by liquid-liquid extraction method was used as a source of $\gamma$ quanta expected in double $\beta$ decay of the cerium isotopes. New improved half-life limits were set on different modes and channels of double $\beta$ decay of $^{136}$Ce and $^{138}$Ce at the level of $T_{1/2}>10^{17}-10^{18}$ yr.Comment: 19 pages, 6 figures, 2 table

Joule Heating and Current-Induced Instabilities in Magnetic Nanocontacts

We consider the electrical current through a magnetic point contact in the limit of a strong inelastic scattering of electrons. In this limit local Joule heating of the contact region plays a decisive role in determining the transport properties of the point contact. We show that if an applied constant bias voltage exceeds a critical value, the stationary state of the system is unstable, and that periodic, non-harmonic oscillations in time of both the electrical current through the contact and the local temperature in the contact region develop spontaneously. Our estimations show that the necessary experimental conditions for observing such oscillations with characteristic frequencies in the range $10^8 \div 10^9$ Hz can easily be met. We also show a possibility to manipulate upon the magnetization direction of a magnetic grain coupled through a point contact to a bulk ferromagnetic by exciting the above-mentioned thermal-electric oscillations.Comment: 9 pages, 6 figures, submitted to Physical Review

Маркетинговий аналіз вітчизняного фармацевтичного ринку протигерпетичних лікарських засобів

Aim. To conduct the marketing research of the pharmaceutical market of Ukraine in the segment of medicinal products (MP) used for the treatment and prevention of infections caused by HSV-1 and HSV-2. Materials and methods. To achieve this aim, methods of logical and meaningful problem formation, desk marketing research, content analysis of publications in scientific and practice-oriented medical and pharmaceutical literature, comparative analysis were used. Results. The paper presents the results of the marketing analysis of the Ukrainian pharmaceutical market of antiherpetic MP. For the study, according to the ATC classification, 5 groups of medicines registered at the domestic market were selected. In the drug package leaflets for these medicines herpes infection was one of the indications for use. As of October 1, 2021, the range of antiherpetic MP includes 194 trade names for systemic and local use. The market segmentation of these groups of medicines by manufacturing countries, drug form, conditions of dispensing, origin and composition was carried out. It has been found that the share of herbal medicinal products is 14.43 % (6 positions) and is represented by products for systemic use. Conclusions. The research of the market of antiherpetic medicines conducted can be considered as the basis for the search and development of new effective antiviral herbal medicinal products of domestic production for the local treatment of the herpes virus.Мета – маркетингове дослідження фармацевтичного ринку України у сегменті лікарських засобів (ЛЗ), застосовуваних для лікування та профілактики інфекцій, спричинених вірусом простого герпесу 1 та 2 типів (ВПГ-1 та ВПГ-2). Матеріали та методи. Для досягнення визначеної мети було використано методи логіко-змістовного формування проблеми, кабінетних маркетингових досліджень, контент-аналізу публікацій у наукових та практично-орієнтованих медичних і фармацевтичних виданнях, порівняльного аналізу. Результати дослідження. У роботі наведено результати маркетингового аналізу фармацевтичного ринку України протигерпетичних ЛЗ. Для вивчення було відібрано 5 груп ЛЗ за АТС-класифікацією, зареєстрованих на вітчизняному ринку, в інструкціях до яких герпетична інфекція (ГІ) є одним із показань до застосування. Станом на 01.10.2021 року асортимент протигерпетичних ЛЗ нараховував 194 торгові найменування для системного та місцевого застосування. Проведено сегментування ринку цих груп ЛЗ за країнами-виробниками, формою випуску, умовами видання з аптек, походженням та складом. Визначено, що частка фітопрепаратів становить 14,43 % (6 позицій) і представлена засобами для системного застосування. Висновки. Проведені дослідження ринку протигерпетичних ЛЗ можна вважати підґрунтям для пошуку й розроблення нових ефективних противірусних фітозасобів вітчизняного виробництва для місцевого лікування ГІ

Influence of Different Catalysts and Solvents on the General Base Catalytical Esterification of Polyoxyethylene Sorbitan Trioleate with Maleic Anhydride and Styrene-Co-Maleic Anhydride

The general base catalitycal esterification of Polyoxyethylene sorbitane Trioleate with maleic anhydride (Ma) and styrene-co-maleic anhydride (Sma) using pyridine as catalyst is described. We investigated the effect of different factors on the yield of reaction product. The analysis of the effect of different factors on the process of catalytical esterification showed that the catalysts and solvents can be arranged by their activity in the following order: sulfuric acid > toluene sulfonic acid > triethylamine > pyridine > without a catalyst and dimethylsulfoxide (DMSO) > O-xylene > dimethylformamide (DMF), respectively. It should be noted that pyridine to its activity is not significantly inferior to the traditional catalysts and with DMSO using the yield of product is increasing. It is concluded that the reaction proceeds by 2nd order. It was found that decreasing the temperature of reaction to a lower temperature, where there is an intensive incubation period, leads to decreasing of yield of polyesters. The rate constant and activation energy were calculated. It was found that the process occurred on 98% at 130 °С and 80 minutes for PoesTo/Ma and on 88% at 150 °С and 40 minutes for PoesTo/Sma. For preparation of reaction product to analysis new methods were developed. It was shown, that on 1H and 13C spectra an overlap of the individual peaks or their close concentration in one area is observed, which makes it not possible to complete the analysis of the spectra. 1H and 13C spectra give a preliminary idea of the structure of the reaction products. It is concluded that 2-D NMR measurements more useful for further confirming of structure of PoesTo/Ma and PoesTo/Sma. HLB shown that we obtained two different surfactants where by catalytical esterification the hydrophilic part of Tween in PoesTo/Ma and the lipophilic part in PoesTo/Sma was increased

Evidence for Narrow N*(1685) Resonance in Quasifree Compton Scattering on the Neutron

The first study of quasi-free Compton scattering on the neutron in the energy range of $E_{\gamma}=0.75 - 1.5$ GeV is presented. The data reveals a narrow peak at $W\sim 1.685$ GeV. This result, being considered in conjunction with the recent evidence for a narrow structure at $W\sim 1.68$GeV in the $\eta$ photoproduction on the neutron, suggests the existence of a new nucleon resonance with unusual properties: the mass $M\sim 1.685$GeV, the narrow width $\Gamma \leq 30$MeV, and the much stronger photoexcitation on the neutron than on the proton.Comment: Replaced with the version published in Phys. Rev.

Changes in Body Fat and Related Biochemical Parameters Associated With Atypical Antipsychotic Drug Treatment in Schizophrenia Patients With or Without Metabolic Syndrome

Background: Metabolic syndrome (MetS) is a common problem in schizophrenia patients and associated with increased mortality due to cardiovascular disease. Second-generation antipsychotics (SGAs) play an important role in facilitating MetS. Objective: The study aimed to assess weight changes and alterations of indicators of body fat composition and lipid-glucose metabolism induced by reinitiating atypical antipsychotics in patients with schizophrenia when with or without MetS. Methods: After giving informed consent, newly admitted patients with a clinical diagnosis of schizophrenia (ICD-10: F20) and an age between 18 and 55 years were included. MetS was diagnosed according to International Diabetes Federation (IDF) criteria. At entry and after 6 weeks of treatment, anthropometry and biochemical analysis were carried out. Total and visceral fats were measured with the use of non-invasive bioimpedance analysis and subcutaneous fat with calculation of total adipose tissue with the use of caliperometry. Based on biochemical assessments low density (LDL) and very low-density lipoproteins (VLDL), atherogenic index and Homeostatic Model Assessment of Insulin Resistance (IR-HOMA) were calculated. Statistical analysis was conducted using Wilcoxon signed-rank test, Mann-Whitney U-test, and chi-squared test. Differences were considered statistically significant at p < 0.05. Results: A total of 114 patients (59M/55F) with schizophrenia were examined; they were divided into two groups with (n = 43; 37.7%) and without (n = 71; 62.3%) MetS. After a 6-week SGA treatment, only the total fat fold, waist circumference, triglyceride level, and atherogenic index underwent statistically significant changes in patients with MetS. In those without MetS, statistically significant changes across all fat indicators were noted. Also, a significant increase in blood glucose and HOMA-IR parameters, triglyceride, and VLDL levels and atherogenic index was observed in this group. Discussion: The study illustrates the benefits of estimating both anthropometric and biochemical parameters shortly after (re)installing treatment of schizophrenia in order to minimize the risk of MetS development