The decomposition of organic matter in soils

Thesis (M.S.)--Massachusetts Agricultural College, 1917.Mode of access: Internet

PDFS: Practical Data Feed Service for Smart Contracts

Smart contracts are a new paradigm that emerged with the rise of the blockchain technology. They allow untrusting parties to arrange agreements. These agreements are encoded as a programming language code and deployed on a blockchain platform, where all participants execute them and maintain their state. Smart contracts are promising since they are automated and decentralized, thus limiting the involvement of third trusted parties, and can contain monetary transfers. Due to these features, many people believe that smart contracts will revolutionize the way we think of distributed applications, information sharing, financial services, and infrastructures. To release the potential of smart contracts, it is necessary to connect the contracts with the outside world, such that they can understand and use information from other infrastructures. For instance, smart contracts would greatly benefit when they have access to web content. However, there are many challenges associated with realizing such a system, and despite the existence of many proposals, no solution is secure, provides easily-parsable data, introduces small overheads, and is easy to deploy. In this paper we propose PDFS, a practical system for data feeds that combines the advantages of the previous schemes and introduces new functionalities. PDFS extends content providers by including new features for data transparency and consistency validations. This combination provides multiple benefits like content which is easy to parse and efficient authenticity verification without breaking natural trust chains. PDFS keeps content providers auditable, mitigates their malicious activities (like data modification or censorship), and allows them to create a new business model. We show how PDFS is integrated with existing web services, report on a PDFS implementation and present results from conducted case studies and experiments.Comment: Blockchain; Smart Contracts; Data Authentication; Ethereu

Lower bounds for the first eigenvalue of the magnetic Laplacian

We consider a Riemannian cylinder endowed with a closed potential 1-form A and study the magnetic Laplacian with magnetic Neumann boundary conditions associated with those data. We establish a sharp lower bound for the first eigenvalue and show that the equality characterizes the situation where the metric is a product. We then look at the case of a planar domain bounded by two closed curves and obtain an explicit lower bound in terms of the geometry of the domain. We finally discuss sharpness of this last estimate.Comment: Replaces in part arXiv:1611.0193

Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression

background: There is an acute need to uncover biomarkers that reflect the molecular pathologies, underpinning prostate cancer progression and poor patient outcome. We have previously demonstrated that in prostate cancer cell lines PDE4D7 is downregulated in advanced cases of the disease. To investigate further the prognostic power of PDE4D7 expression during prostate cancer progression and assess how downregulation of this PDE isoform may affect disease outcome, we have examined PDE4D7 expression in physiologically relevant primary human samples. methods: About 1405 patient samples across 8 publically available qPCR, Affymetrix Exon 1.0 ST arrays and RNA sequencing data sets were screened for PDE4D7 expression. The TMPRSS2-ERG gene rearrangement status of patient samples was determined by transformation of the exon array and RNA seq expression data to robust z-scores followed by the application of a threshold >3 to define a positive TMPRSS2-ERG gene fusion event in a tumour sample. results: We demonstrate that PDE4D7 expression positively correlates with primary tumour development. We also show a positive association with the highly prostate cancer-specific gene rearrangement between TMPRSS2 and the ETS transcription factor family member ERG. In addition, we find that in primary TMPRSS2-ERG-positive tumours PDE4D7 expression is significantly positively correlated with low-grade disease and a reduced likelihood of progression after primary treatment. Conversely, PDE4D7 transcript levels become significantly decreased in castration resistant prostate cancer (CRPC). conclusions: We further characterise and add physiological relevance to PDE4D7 as a novel marker that is associated with the development and progression of prostate tumours. We propose that the assessment of PDE4D7 levels may provide a novel, independent predictor of post-surgical disease progression

Distributed Management of Massive Data: an Efficient Fine-Grain Data Access Scheme

This paper addresses the problem of efficiently storing and accessing massive data blocks in a large-scale distributed environment, while providing efficient fine-grain access to data subsets. This issue is crucial in the context of applications in the field of databases, data mining and multimedia. We propose a data sharing service based on distributed, RAM-based storage of data, while leveraging a DHT-based, natively parallel metadata management scheme. As opposed to the most commonly used grid storage infrastructures that provide mechanisms for explicit data localization and transfer, we provide a transparent access model, where data are accessed through global identifiers. Our proposal has been validated through a prototype implementation whose preliminary evaluation provides promising results

Unifying Parsimonious Tree Reconciliation

Evolution is a process that is influenced by various environmental factors, e.g. the interactions between different species, genes, and biogeographical properties. Hence, it is interesting to study the combined evolutionary history of multiple species, their genes, and the environment they live in. A common approach to address this research problem is to describe each individual evolution as a phylogenetic tree and construct a tree reconciliation which is parsimonious with respect to a given event model. Unfortunately, most of the previous approaches are designed only either for host-parasite systems, for gene tree/species tree reconciliation, or biogeography. Hence, a method is desirable, which addresses the general problem of mapping phylogenetic trees and covering all varieties of coevolving systems, including e.g., predator-prey and symbiotic relationships. To overcome this gap, we introduce a generalized cophylogenetic event model considering the combinatorial complete set of local coevolutionary events. We give a dynamic programming based heuristic for solving the maximum parsimony reconciliation problem in time O(n^2), for two phylogenies each with at most n leaves. Furthermore, we present an exact branch-and-bound algorithm which uses the results from the dynamic programming heuristic for discarding partial reconciliations. The approach has been implemented as a Java application which is freely available from http://pacosy.informatik.uni-leipzig.de/coresym.Comment: Peer-reviewed and presented as part of the 13th Workshop on Algorithms in Bioinformatics (WABI2013

Effect of CO2 on the Processing of Y-Ba-Cu-O Superconductors

The superconducting properties of YBa2Cu3O6+x reacted with various known ratios of O2/CO2 gas mixtures during sintering at different temperatures were studied. Jc was found to decrease drastically upon reaction with CO2, becoming zero at certain CO2 activities. The stability region for the 123 superconductor, as a function of CO2 activity and temperature, was empirically formulated as follows: log pCO2 \u3c (−45,000)/T + 33.4. The grain boundaries in sintered samples with Jc = 0 were investigated with HRTEM in conjunction with EDS. Two distinct types of grain boundaries were observed. Approximately 10% of the grain boundaries were wet by a thin layer of a second phase, deduced to be BaCuO2. The remaining boundaries were sharp grain boundaries. The grain structure near the sharp grain boundaries was tetragonal. These two types of grain boundaries are thought to be responsible for Jc being zero

Estimation of lower-bound K{sub Jc} on pressure vessel steels from invalid data

Statistical methods are currently being introduced into the transition temperature characterization of ferritic steels. Objective is to replace imprecise correlations between empirical impact test methods and universal K{sub Ic} or K{sub Ia} lower-bound curves with direct use of material-specific fracture mechanics data. This paper introduces a computational procedure that couples order statistics, weakest-link statistical theory, and a constraint model to arrive at estimates of lower-bound K{sub Jc} values. All of the above concepts have been used before to meet various objectives. In the present case, scheme is to make a best estimate of lower-bound fracture toughness when resource K{sub Jc} data are too few to use conventional statistical analyses. Utility of the procedure is of greatest value in the middle-to-high toughness part of the transition range where specimen constraint loss and elevated lower-bound toughness interfere with conventional statistical analysis methods

Progress with American Chestnut Somatic Embryogenesis

American chestnut (Castanea dentata), once the dominant forest species of the Appalachian Mountains in the eastern United States, was devastated during the early twentieth century by the introduction of the chestnut blight fungus. As part of an effort to restore the species to the forest, we have been working with embryogenic cultures of the species, aiming to establish a reliable somatic embryogenesis system for mass clonal propagation, as well as for genetic transformation with potential anti-fungal genes. While initiation of embryogenic cultures from immature ovules of American chestnut has become routine, bottlenecks still remain for embryo maturation, germination and conversion. Effects of cold stratification, gellan gum concentration and activated charcoal on somatic seedling production were investigated. Studies of other variables, such as the effects of light quality on germination and conversion, are underway. Using five genotypes, clusters of proembryogenic masses maintained on WPM with 2 mg/l 2,4-D were transferred to basal WPM for somatic embryo development. Individual cotyledonary-stage embryos (2-4 mm) were cultured for 10 days on basal medium prior to storage at 4o C for 12 weeks in the dark. These embryos germinated at an average frequency of 23% following transfer to WPM basal medium in GA7 vessels in the light. Embryos that did not receive cold treatment or were stored for only 6 weeks failed to germinate. Embryos on WPM with 5 g/l activated charcoal (AC) germinated at the same frequencies as those cultured without AC, but AC prevented darkening of taproots. Embryos cultured on 3 or 6 g/l Phytagel germinated at higher frequencies following 12 weeks cold storage than did those cultured on 10 g/l Phytagel. To date, over 30 somatic seedlings representing 3 genotypes have been transferred successfully to greenhouse conditions.Papers and abstracts from the 27th Southern Forest Tree Improvement Conference held at Oklahoma State University in Stillwater, Oklahoma on June 24-27, 2003

Cellular Internalization of Human Calcitonin Derived Peptides in MDCK Monolayers: A Comparative Study with Tat(47-57) and Penetratin(43-58)

ISSN:0724-8741ISSN:1573-904