1,262 research outputs found
Characteristics and coastal effects of a destructive marine storm in the Gulf of Naples (southern Italy)
Destructive marine storms bring large waves and unusually high surges of water to coastal areas, resulting in significant damages and economic loss. This study analyses the characteristics of a destructive marine storm on the strongly inhabited coastal area of Gulf of Naples, along the Italian coasts of the Tyrrhenian Sea. This is highly vulnerable to marine storms due to the accelerated relative sea level rise trend and the increased anthropogenic impact on the coastal area. The marine storm, which occurred on 28 December 2020, was analyzed through an unstructured wind-wave coupled model that takes into account the main marine weather components of the coastal setup. The model, validated with in situ data, allowed the establishment of threshold values for the most significant marine and atmospheric parameters (i.e., wind intensity and duration) beyond which an event can produce destructive effects. Finally, a first assessment of the return period of this event was evaluated using local press reports on damage to urban furniture and port infrastructures
Contralateral prophylactic mastectomies. Correlations between primary tumor and histological findings of controlateral breast
Backgound: In Italy in 2015 48,000 new cases of breast carcinomas were diagnosed. Women who are diagnosed with breast cancer have a significant risk of developing contralateral breast cancer during the rest of their lives and this risk is closely associated to the family history, to the onset of breast cancer at a young age and is expressed at about 0.5 to 1% of metachronous tumors per
year. The purpose of this work was to evaluate which and how many neoplastic lesions were seen in the contralateral breast that underwent prophylactic mastectomy and to understand what factors predict the appearance of such lesions.
Methods: 168 bilateral mastectomies were analyzed in patients with an average age of 47 years, carried out from July 2008 to April 2016, at the Breast Unit of the Sant’Andrea Hospital. We considered women of any age suffering from unilateral breast cancer without either clinical or radiological evidence of a malignant lesion in the contralateral breast and negative for mutations of the BRCA1-BRCA2 genes test. Of the 168 bilateral mastectomies 35 patients were excluded from the study because they underwent neoadjuvant chemotherapy, another 35 patients because they were suffering from a bilateral neoplasia and 7 cases because they had mutated BRCA1 or BRCA2 genes. Therefore the remaining 91 patients were included in the study.
Results: Both the histological features of the primary tumor and any lesions found in the contralateral prophylactic breast were analyzed. Histological examination of the main breast showed 59 cases of Invasive Ductal Carcinoma (IDC), 17 cases of Invasive Lobular Carcinoma (ILC), 9 cases of In Situ Ductal Carcinoma (ISDC), 3 microinvasive ductal, 1 invasive tubular carcinoma, 1 in situ lobular and 1 widespread in situ. In the contralateral breast, the definitive histological examination revealed that 47 patients had an occult lesion in the prophylactic contralateral breast; in particular 2 cases of LIN 1, 7 cases of LIN2, 6 cases of lobular carcinoma in situ, 26 between DIN1A/DIN1A-B/DIN1B, 4 cases of carcinoma in situ and 2 cases of Invasive Ductal Carcinoma. The correlation obtained from the observation of the main tumor has shown that in a total of 59 invasive ductal carcinoma 32 have a controlateral occult lesions
and in a total of 17 cases of invasive lobular carcinoma 9 have an occult lesion in the prophylactic breast. Of these lesions, the multicentric relationship is that 50% of invasive ductal and invasive lobular carcinoma of the main breast have a contralateral lesion.
Conclusion: In conclusion we would like to remind, as demonstrated by our follow-up data and as the literature reiterates, that this surgery does not improve patient survival. Certainly patients with unilateral breast cancer have many surgical therapies to be able to deal with not only having a bilateral mastectomy. The end point of this work is try to understand the risk factors of having a contralateral breast lesion to reduce the probability of a metachronous cance
Consumption Taxation and Endogenous Growth in a Model with New Generations
This article studies the implications of consumption taxation on capital accumulation in a one-sector endogenous growth model with finite horizons. A tax on consumption, when tax revenues are lump-sum rebated to consumers, redistributes income between living generations and future, still unborn, generations, and therefore depresses aggregate consumption and raises saving, stimulating capital accumulation and economic growth. If however the resources from taxation are used for financing unproductive public spending, the effect of the consumption tax on the endogenous growth rate disappears as no intergenerational redistribution of income occurs. Finally, a consumption tax hike accompanied by a compensatory reduction of public debt increases long-run economic growth and reduces the consumption-output ratio. Our results on consumption taxation differ substantially from those obtained within the endogenous growth literature.This article studies the implications of consumption taxation on capital accumulation in a one-sector endogenous growth model with finite horizons. A tax on consumption, when tax revenues are lump-sum rebated to consumers, redistributes income between living generations and future, still unborn, generations, and therefore depresses aggregate consumption and raises saving, stimulating capital accumulation and economic growth. If however the resources from taxation are used for financing unproductive public spending, the effect of the consumption tax on the endogenous growth rate disappears as no intergenerational redistribution of income occurs. Finally, a consumption tax hike accompanied by a compensatory reduction of public debt increases long-run economic growth and reduces the consumption-output ratio. Our results on consumption taxation differ substantially from those obtained within the endogenous growth literature.Refereed Working Papers / of international relevanc
Body image dissatisfaction and eating disorder symptomatology: a latent structural equation modeling examination of moderators among adolescent girls
Introduction
According to meta-analytic review, body dissatisfaction (BD) is recognized as the strongest risk factor of all forms of eating disorders (EDs).Yet, it has been found that BD is so prevalent among adolescent girls and young adult women that it is “normative”. The present study investigates why only a minority of adolescents girls report severe levels of ED symptomatology, when so many are body dissatisfied?
Aims
Five theoretically relevant variables are investigated as potential moderators of the BD-ED symptomatology relationship (drive for thinness and bulimic behaviours).
Methods
A sample of 401 Italian adolescent girls completed questionnaire measures of BD, drive for thinness, bulimic behaviours, as well as the proposed moderating variables of body checking, perfectionism, appearance control beliefs, internalization of socio-cultural standards of beauty, and self-esteem.
Results
Structural equation modeling with latent factor interactions indicated that body checking, perfectionism, appearance control beliefs and internalization of socio-cultural standards of beauty intensified the primary BD-ED symptomatology, such that BD was strongly related to drive for thinness and bulimic behaviours when levels of each moderator were higher. By contrast self-esteem buffered the deleterious effects of BD, such that when levels of the moderator were higher, the relationship between BD and each criterion variable representing female's ED symptomatology was weaker
Charged particle's flux measurement from PMMA irradiated by 80 MeV/u carbon ion beam
Hadrontherapy is an emerging technique in cancer therapy that uses beams of
charged particles. To meet the improved capability of hadrontherapy in matching
the dose release with the cancer position, new dose monitoring techniques need
to be developed and introduced into clinical use. The measurement of the fluxes
of the secondary particles produced by the hadron beam is of fundamental
importance in the design of any dose monitoring device and is eagerly needed to
tune Monte Carlo simulations. We report the measurements done with charged
secondary particles produced from the interaction of a 80 MeV/u fully stripped
carbon ion beam at the INFN Laboratori Nazionali del Sud, Catania, with a
Poly-methyl methacrylate target. Charged secondary particles, produced at
90 with respect to the beam axis, have been tracked with a drift
chamber, while their energy and time of flight has been measured by means of a
LYSO scintillator. Secondary protons have been identified exploiting the energy
and time of flight information, and their emission region has been
reconstructed backtracking from the drift chamber to the target. Moreover a
position scan of the target indicates that the reconstructed emission region
follows the movement of the expected Bragg peak position. Exploting the
reconstruction of the emission region, an accuracy on the Bragg peak
determination in the submillimeter range has been obtained. The measured
differential production rate for protons produced with 83 MeV and emitted at 90 with respect to the beam line is: .Comment: 13 pages, 9 figure
Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory.
Different pathological tau species are involved in memory loss in Alzheimer’s disease, the most common
cause of dementia among older people. However, little is known about how tau pathology directly affects
adult hippocampal neurogenesis, a unique form of structural plasticity implicated in hippocampusdependent
spatial learning and mood-related behavior. To this aim, we generated a transgenic mouse
model conditionally expressing a pathological tau fragment (26e230 aa of the longest human tau isoform,
or N-tau) in nestin-positive stem/progenitor cells. We found that N-tau reduced the proliferation
of progenitor cells in the adult dentate gyrus, reduced cell survival and increased cell death by a caspase-
3eindependent mechanism, and recruited microglia. Although the number of terminally differentiated
neurons was reduced, these showed an increased dendritic arborization and spine density. This resulted
in an increase of anxiety-related behavior and an impairment of episodic-like memory, whereas less
complex forms of spatial learning remained unaltered. Understanding how pathological tau species
directly affect neurogenesis is important for developing potential therapeutic strategies to direct
neurogenic instructive cues for hippocampal function repair
NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death
Neurotrophin receptor-interacting MAGE homolog (NRAGE) has been recently identified as a cell-death inducer, involved in molecular events driving cells through apoptotic networks during neuronal development. Recently, we have focused on the functional role of Che-1, also known as apoptosis-antagonizing transcription factor (AATF), a protein involved in cell cycle control and gene transcription. Increasing evidence suggests that Che-1 is involved in apoptotic signalling in neural tissues. In cortical neurons Che-1 exhibits an anti-apoptotic activity, protecting cells from neuronal damage induced by amyloid β-peptide. Here, we report that Che-1 interacts with NRAGE and that an EGFP-NRAGE fusion protein inhibits nuclear localization of Che-1, by sequestering it within the cytoplasmic compartment. Furthermore, NRAGE overexpression downregulates endogenous Che-1 by targeting it for proteasome-dependent degradation. Finally, we propose that Che-1 is a functional antagonist of NRAGE, because its overexpression completely reverts NRAGE-induced cell-death
Electromagnetic propagation features of ground-penetrating radars for the exploration of Martian subsurface
In this work, the effects of magnetic inclusions in a Mars-like soil are considered with reference to
the electromagnetic propagation features of ground-penetrating radars (GPRs). Low-frequency and
time-domain techniques, using L-C-R meters and TDR instruments, respectively, are implemented
in laboratory experimental set-ups in order to evaluate complex permittivity and permeability and
wave velocity for different scenarios of a dielectric background medium (silica) with magnetic
inclusions (magnetite). Attenuation and maximum detection ranges have also been evaluated by taking
into account a realistic GPR environment, which includes the transmitting/receiving antenna
performance and the complex structure of the subsurface. The analysis and the interpretation of
these results shed new light on the significant influence of magnetic inclusions on the performance
of Martian orbiting and rover-driven GPRs.Published5-11reserve
Role of a Novel Heparanase Inhibitor on the Balance between Apoptosis and Autophagy in U87 Human Glioblastoma Cells
Background: Heparanase (HPSE) is an endo-& beta;-glucuronidase that cleaves heparan sulfate side chains, leading to the disassembly of the extracellular matrix, facilitating cell invasion and metastasis dissemination. In this research, we investigated the role of a new HPSE inhibitor, RDS 3337, in the regulation of the autophagic process and the balance between apoptosis and autophagy in U87 glioblastoma cells. Methods: After treatment with RDS 3337, cell lysates were analyzed for autophagy and apoptosis-related proteins by Western blot. Results: We observed, firstly, that LC3II expression increased in U87 cells incubated with RDS 3337, together with a significant increase of p62/SQSTM1 levels, indicating that RDS 3337 could act through the inhibition of autophagic-lysosomal flux of LC3-II, thereby leading to accumulation of lipidated LC3-II form. Conversely, the suppression of autophagic flux could activate apoptosis mechanisms, as revealed by the activation of caspase 3, the increased level of cleaved Parp1, and DNA fragmentation. Conclusions: These findings support the notion that HPSE promotes autophagy, providing evidence that RDS 3337 blocks autophagic flux. It indicates a role for HPSE inhibitors in the balance between apoptosis and autophagy in U87 human glioblastoma cells, suggesting a potential role for this new class of compounds in the control of tumor growth progression
Study of the time and space distribution of beta+ emitters from 80 MeV/u carbon ion beam irradiation on PMMA
Proton and carbon ion therapy is an emerging technique used for the treatment
of solid cancers. The monitoring of the dose delivered during such treatments
and the on-line knowledge of the Bragg peak position is still a matter of
research. A possible technique exploits the collinear 511\ \kilo\electronvolt
photons produced by positrons annihilation from emitters created by
the beam. This paper reports rate measurements of the 511\ \kilo\electronvolt
photons emitted after the interactions of a 80\ \mega\electronvolt / u fully
stripped carbon ion beam at the Laboratori Nazionali del Sud (LNS) of INFN,
with a Poly-methyl methacrylate target. The time evolution of the
rate was parametrized and the dominance of emitters over the other
species (, , ) was observed, measuring the fraction of
carbon ions activating emitters . The
average depth in the PMMA of the positron annihilation from emitters
was also measured, D_{\beta^+}=5.3\pm1.1\ \milli\meter, to be compared to the
expected Bragg peak depth D_{Bragg}=11.0\pm 0.5\ \milli\meter obtained from
simulations
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