The effect of a multi-component school-based social network intervention on children's body mass index:a four-arm intervention study

Objective: Schools are considered an important setting for stimulating healthy weight. The current study is unique in examining effects of a multi-component school-based social network intervention on children’s body mass index z-scores (zBMI).Methods: Four schools were randomly allocated to one of four conditions: a social network intervention using influence agents focusing on water consumption, physical activity, a combination of the two, or a passive control condition. Participants included a total of 201 6- to-11-year-old children (53.7% girls; Mage = 8.51, SDage = 0.93). At baseline, 149 (76.0%) participants had a healthy weight, 29 (14.8%) had overweight and 18 (9.2%) had obesity.Results: Linear mixed effect models indicated that a multi-component school-based social network intervention targeting both water consumption and physical activity was most effective in decreasing children’s zBMI.Conclusion: This study suggests that schools can contribute to the intervention of childhood obesity—even without involving the parents—by targeting both children’s water consumption and physical activity through influential peers, but more research is needed to identify mechanisms of change

Three Dimensional Hydrodynamic Modeling Study, Craney Island eastward expansion, lower James River and Elizabeth River, Virginia

The Craney Island Eastward Expansion Hydrodynamic Model Study was conducted in three phases: 1) model calibration and verification for the Elizabeth River, 2) model testing of four Craney Island expansion options using single variable runs (using a single variable, tidal range, for model input), 3) model testing of two expansion options using historical runs (using multiple variables in real time for model input). The expansion option designs were evaluated for both global and local hydrodynamic change through simulation comparisons with the Base Case condition

Areas of natural occurrence of melipona scutellaris Latreille, 1811(Hymenoptera: Apidae) in the state of Bahia, Brazil.

The bee Melipona scutellaris is considered the reared meliponine species with the largest distribution in the North and Northeast regions of Brazil, with records from the state of Rio Grande do Norte down to the state of Bahia. Considering the importance of this species in the generation of income for family agriculture and in the preservation of areas with natural vegetation, this study aimed at providing knowledge on the distribution of natural colonies of M. scutellaris in the state of Bahia. Literature information, interviews with stinglessbee beekeepers, and expeditions were conducted to confirm the natural occurrence of the species. A total of 102 municipalities showed records for M. scutellaris, whose occurrence was observed in areas ranging from sea level up to 1,200-meter height. The occurrence of this species in the state of Bahia is considered to be restricted to municipalities on the coastal area and the Chapada Diamantina with its rainforests. Geographic coordinates, elevation, climate and vegetation data were obtained, which allowed a map to be prepared for the area of occurrence in order to support conservation and management policies for the species

Reconstructing historic Glacial Lake Outburst Floods through numerical modelling and geomorphological assessment:Extreme events in the Himalaya

Recession of high‐mountain glaciers in response to climatic change frequently results in the development of moraine‐dammed glacial lakes. Moraine dam failure is often accompanied by the release of large volumes of water and sediment, termed a Glacial Lake Outburst Flood (GLOF). Chukhung Glacier is a small (~3 km2) receding valley glacier in Mt. Everest (Sagarmatha) National Park, Nepal. Unlike many Himalayan glaciers, which possess a thick mantle of supraglacial debris, its surface is relatively clean. The glacier terminus has receded 1.3 km from its maximum Holocene position, and in doing so provided the space for an ice‐contact moraine‐dammed lake to develop. The lake had a maximum volume of 5.5 × 105 m3 and drained as a result of breaching of the terminal moraine. An estimated 1.3 × 105 m3 of material was removed from the terminal moraine during breach development. Numerical dam‐breach modelling, implemented within a Generalised Likelihood Uncertainty Estimation (GLUE) framework, was used to investigate a range of moraine‐dam failure scenarios. Reconstructed outflow peak discharges, including failure via overtopping and piping mechanisms, are in the range 146–2200 m3 s‐1. Results from two‐dimensional hydrodynamic GLOF modelling indicate that maximum local flow depths may have exceeded 9 m, with maximum flow velocities exceeding 20 m s‐1 within 700 m of the breach. The floodwaters mobilised a significant amount of material, sourced mostly from the expanding breach, forming a 300 m long and 100 m wide debris fan originating at the breach exit. moraine‐dam. These results also suggest that inundation of the entire floodplain may have been achieved within ten minutes of initial breach development, suggesting that debris fan development was rapid. We discuss the key glaciological and geomorphological factors that have determined the evolution of a hazardous moraine‐dammed lake complex and the subsequent generation of a GLOF and its geomorphological impact

ECU-oriented models for NOx prediction. Part 1: a mean value engine model for NOx prediction

The implantation of nitrogen oxide sensors in diesel engines was proposed in order to track the emissions at the engine exhaust, with applications to the control and diagnosis of the after-treatment devices. However, the use of models is still necessary since the output from these sensors is delayed and filtered. The present paper deals with the problem of nitrogen oxide estimation in turbocharged diesel engines combining the information provided by both models and sensors. In Part 1 of this paper, a control-oriented nitrogen oxide model is designed. The model is based on the mapping of the nitrogen oxide output and a set of corrections which account for the variations in the intake and ambient conditions, and it is designed for implementation in commercial electronic control units. The model is sensitive to variations in the engine's air path, which is solved through the engine volumetric efficiency and the first-principle equations but disregards the effect of variation in the injection settings. In order to consider the effect of the thermal transients on the in-cylinder temperature, the model introduces a dynamic factor. The model behaves well in both steady-state operation and transient operation, achieving a mean average error of 7% in the steady state and lower than 10% in an exigent sportive driving mountain profile cycle. The relatively low calibration effort and the model accuracy show the feasibility of the model for exhaust gas recirculation control as well as onboard diagnosis of the nitrogen oxide emissions.Guardiola, C.; Pla Moreno, B.; Blanco-Rodriguez, D.; Calendini, PO. (2015). ECU-oriented models for NOx prediction. Part 1: a mean value engine model for NOx prediction. Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering. 229(8):992-1015. doi:10.1177/0954407014550191S9921015229

Clinical, Cellular, and Molecular Effects of Corticosteroids on the Response to Intradermal Lipopolysaccharide Administration in Healthy Volunteers

The intradermal lipopolysaccharide (LPS) challenge in healthy volunteers has proven to be a valuable tool to study local inflammation in vivo. In the current study the inhibitory effects of oral and topical corticosteroid treatment on intradermal LPS responses were evaluated to benchmark the challenge for future investigational drugs. Twenty-four healthy male volunteers received a two-and-a-half-day twice daily (b.i.d.) pretreatment with topical clobetasol propionate 0.05% and six healthy volunteers received a two-and-a-half-day b.i.d. pretreatment with oral prednisolone at 0.25 mg/kg body weight per administration. Participants received one injection regimen of either 0, 2, or 4 intradermal LPS injections (5 ng LPS in 50 µL 0.9% sodium chloride solution). The LPS response was evaluated by noninvasive (perfusion, skin temperature, and erythema) and invasive assessments (cellular and cytokine responses) in suction blister exudate. Both corticosteroids significantly suppressed the clinical inflammatory response (erythema P = 0.0001 for clobetasol and P = 0.0016 for prednisolone; heat P = 0.0245 for clobetasol, perfusion P < 0.0001 for clobetasol and P = 0.0036 for prednisolone). Clobetasol also significantly reduced the number of monocytes subsets, dendritic cells, natural killer cells, and T cells in blister exudate. A similar effect was observed for prednisolone. No relevant corticosteroid effects were observed on the cytokine response to LPS. We successfully demonstrated that the anti-inflammatory effects of corticosteroids can be detected using our intradermal LPS challenge model, validating it for evaluation of future investigational drugs, as an initial assessment of the anti-inflammatory effects of such compounds in a minimally invasive manner

Superconformal Flavor Simplified

A simple explanation of the flavor hierarchies can arise if matter fields interact with a conformal sector and different generations have different anomalous dimensions under the CFT. However, in the original study by Nelson and Strassler many supersymmetric models of this type were considered to be 'incalculable' because the R-charges were not sufficiently constrained by the superpotential. We point out that nearly all such models are calculable with the use of a-maximization. Utilizing this, we construct the simplest vector-like flavor models and discuss their viability. A significant constraint on these models comes from requiring that the visible gauge couplings remain perturbative throughout the conformal window needed to generate the hierarchies. However, we find that there is a small class of simple flavor models that can evade this bound.Comment: 43 pages, 1 figure; V3: small corrections and clarifications, references adde